PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
TP53	0	DOT1L	7	genetic interference	Xie L (2013)	1
ZNF207	2	HNRNPM	1	two hybrid, two hybrid	Hegele A (2012), Hegele A (2012)	2
DDX1	6	UBE2I	0	biochemical	Havugimana PC (2012)	1
CDC5L	2	HNRNPM	1	affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe, pull down, affinity chromatography technology	Lleres D (2010), Lleres D (2010), Lleres D (2010), Lleres D (2010), Lleres D (2010)	5
CDC5L	2	HNRNPF	5	affinity chromatography technology	Lleres D (2010)	1
SRRM2	18	HNRNPM	1	affinity chromatography technology, biochemical	McCracken S (2005), Havugimana PC (2012)	2
PLRG1	1	CDC5L	2	affinity chromatography technology, unspecified method, affinity chromatography technology, pull down, pull down, affinity chromatography technology, biochemical, far western blotting, biochemical, fluorescent resonance energy transfe, biochemical, affinity chromatography technology, affinity chromatography technology	Ewing RM (2007), Ajuh P (2003), Ajuh P (2001), Ajuh P (2001), Ajuh P (2001), Ajuh P (2000), Ajuh P (2000), Grote M (2010), Havugimana PC (2012), Lleres D (2010), Wan C (2015), Lleres D (2010), Huttlin EL (2017)	13
SRRM2	18	U2AF1	0	biochemical	Havugimana PC (2012)	1
SRRM2	18	HNRNPA1	1	affinity chromatography technology, biochemical	McCracken S (2005), Havugimana PC (2012)	2
TP53	0	WDR77	2	affinity chromatography technology	Horikawa I (2014)	1
U2AF2	7	RBM4	1	two hybrid, two hybrid	Hegele A (2012), Hegele A (2012)	2
IVNS1ABP	0	HNRNPA1	1	affinity chromatography technology	Tsai PL (2013)	1
HNRNPM	1	U2AF2	7	biochemical, fluorescent resonance energy transfe, affinity chromatography technology, affinity chromatography technology	Havugimana PC (2012), Lleres D (2010), Lleres D (2010), Whisenant TC (2015)	4
UBE2I	0	HNRNPA1	1	biochemical	Wan C (2015)	1
TP53	0	UBC	7	affinity chromatography technology, affinity chromatography technology	Ayroldi E (2014), Ke JY (2014)	2
CDC37	0	HNRNPM	1	affinity chromatography technology, affinity chromatography technology	Taipale M (2014), Taipale M (2014)	2
TP53	0	PRRC2A	10	affinity chromatography technology	Fogeron ML (2013)	1
U2AF2	7	CDC37	0	affinity chromatography technology	Whisenant TC (2015)	1
SRRM2	18	HNRNPF	5	affinity chromatography technology	McCracken S (2005)	1
U2AF2	7	SRRM2	18	affinity chromatography technology	Whisenant TC (2015)	1
U2AF2	7	HNRNPA1	1	affinity chromatography technology	Whisenant TC (2015)	1
UBC	7	HNRNPM	1	affinity chromatography technology, pull down	Matsumoto M (2005), Nathan JA (2013)	2
DDX1	6	HNRNPM	1	biochemical, biochemical	Havugimana PC (2012), Kristensen AR (2012)	2
CDC5L	2	U2AF1	0	biochemical, affinity chromatography technology	Havugimana PC (2012), Lleres D (2010)	2
HNRNPF	5	U2AF2	7	biochemical, affinity chromatography technology	Havugimana PC (2012), Whisenant TC (2015)	2
HNRNPM	1	U2AF1	0	biochemical, fluorescent resonance energy transfe, affinity chromatography technology	Havugimana PC (2012), Lleres D (2010), Lleres D (2010)	3
CDC5L	2	U2AF2	7	affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	David CJ (2011), David CJ (2011), Havugimana PC (2012), Lleres D (2010), Whisenant TC (2015)	5
TP53	0	HNRNPM	1	affinity chromatography technology, affinity chromatography technology	Fogeron ML (2013), Horikawa I (2014)	2
HNRNPA1	1	DDX1	6	affinity chromatography technology, biochemical, affinity chromatography technology	Close P (2012), Havugimana PC (2012), Roy R (2014)	3
TP53	0	LMNA	2	affinity chromatography technology	Horikawa I (2014)	1
PLRG1	1	U2AF2	7	affinity chromatography technology	David CJ (2011)	1
CDC5L	2	LMO2	2	two hybrid	Wang J (2011)	1
HNRNPM	1	LMO2	2	two hybrid, two hybrid, two hybrid	Wang J (2011), Rolland T (2014), Yu H (2011)	3
DOT1L	7	HNRNPM	1	affinity chromatography technology, affinity chromatography technology	Park G (2010), Park G (2010)	2
PLRG1	1	HNRNPM	1	affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe, pull down	Lleres D (2010), Lleres D (2010), Lleres D (2010), Lleres D (2010)	4
CDC5L	2	RTCB	1	affinity chromatography technology	Lleres D (2010)	1
IVNS1ABP	0	HNRNPM	1	affinity chromatography technology, affinity chromatography technology, biochemical	Tsai PL (2013), Tsai PL (2013), Tsai PL (2013)	3
RTCB	1	HNRNPM	1	biochemical, biochemical	Kristensen AR (2012), Wan C (2015)	2
SRRM2	18	LMNA	2	affinity chromatography technology, affinity chromatography technology	McCracken S (2005), Depreux FF (2015)	2
HNRNPA1	1	PRRC2A	10	two hybrid, two hybrid	Lehner B (2004), Lehner B (2004)	2
TP53	0	HNRNPF	5	affinity chromatography technology	Fogeron ML (2013)	1
UBC	7	WDR77	2	affinity chromatography technology	Matsumoto M (2005)	1
SRRM2	18	CDC5L	2	affinity chromatography technology, biochemical	McCracken S (2005), Havugimana PC (2012)	2
CDC5L	2	LMNA	2	affinity chromatography technology, affinity chromatography technology	Lleres D (2010), Depreux FF (2015)	2
LMNA	2	HNRNPA1	1	bioid, affinity chromatography technology	Roux KJ (2012), Roy R (2014)	2
RBM4	1	HNRNPF	5	two hybrid, two hybrid	Hegele A (2012), Hegele A (2012)	2
ZNF207	2	WDR77	2	two hybrid, two hybrid	Hegele A (2012), Hegele A (2012)	2
SRRM2	18	DDX1	6	affinity chromatography technology	McCracken S (2005)	1
IVNS1ABP	0	HNRNPF	5	affinity chromatography technology	Tsai PL (2013)	1
HNRNPM	1	LMNA	2	biochemical, affinity chromatography technology	Havugimana PC (2012), Depreux FF (2015)	2
WDR77	2	HNRNPM	1	two hybrid, two hybrid	Hegele A (2012), Hegele A (2012)	2
HNRNPM	1	RPL19	1	biochemical, biochemical	Havugimana PC (2012), Kristensen AR (2012)	2
LMO2	2	UBE2I	0	two hybrid	Rolland T (2014)	1
UBE2I	0	CDC37	0	enzymatic study	Jakobs A (2007)	1
UBE2I	0	HNRNPM	1	enzymatic study, enzymatic study	Matafora V (2009), Gocke CB (2005)	2
U2AF1	0	U2AF2	7	two hybrid, affinity chromatography technology, pull down, biochemical, two hybrid, two hybrid, two hybrid, two hybrid, biochemical, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Rual JF (2005), Rual JF (2005), Zhang M (1992), Havugimana PC (2012), Hegele A (2012), Hegele A (2012), Wang J (2011), Rolland T (2014), Wan C (2015), Yu H (2011), Whisenant TC (2015), Whisenant TC (2015), Huttlin EL (2017)	13
HNRNPA1	1	HNRNPF	5	affinity chromatography technology, affinity chromatography technology, biochemical	Close P (2012), Roy R (2014), Wan C (2015)	3
UBE2I	0	TCERG1	3	enzymatic study	Gocke CB (2005)	1
RTCB	1	DDX1	6	biochemical, biochemical, biochemical, affinity chromatography technology	Havugimana PC (2012), Kristensen AR (2012), Wan C (2015), Boldt K (2016)	4
TCERG1	3	HNRNPM	1	affinity chromatography technology, biochemical	Lin KT (2004), Havugimana PC (2012)	2
HNRNPM	1	PRRC2A	10	two hybrid, two hybrid	Lehner B (2004), Lehner B (2004)	2
TCERG1	3	U2AF2	7	affinity chromatography technology, pull down, pull down	Lin KT (2004), Ingham RJ (2005), Lin KT (2004)	3
HNRNPA1	1	RTCB	1	affinity chromatography technology	Roy R (2014)	1
HNRNPA1	1	CDC5L	2	affinity chromatography technology, affinity chromatography technology	Close P (2012), Huttlin EL (2015)	2
LMNA	2	U2AF2	7	affinity chromatography technology	Depreux FF (2015)	1
TP53	0	RPL19	1	affinity chromatography technology	Fogeron ML (2013)	1
CDC5L	2	RBM4	1	affinity chromatography technology	Lleres D (2010)	1
HNRNPA1	1	HNRNPM	1	affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Jeronimo C (2007), Close P (2012), Havugimana PC (2012), Roy R (2014), Hein MY (2015)	5
UBE2I	0	TP53	0	two hybrid, two hybrid, two hybrid, enzymatic study, two hybrid, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study	Minty A (2000), Gallagher WM (1999), Shen Z (1996), Bernier-Villamor V (2002), Wang J (2008), Spektor TM (2011), Jakobs A (2007), Mohideen F (2009), Lin JY (2004), Bennett RL (2012), Heo KS (2013), Morimoto M (2003), Rodriguez MS (1999), Muller S (2000), Fernandez-Lloris R (2006), Mohan RD (2007), Brandt M (2013), Weger S (2005)	18
TP53	0	HNRNPA1	1	affinity chromatography technology, affinity chromatography technology	Fogeron ML (2013), Horikawa I (2014)	2
HNRNPF	5	HNRNPM	1	biochemical, two hybrid	Havugimana PC (2012), Rolland T (2014)	2
RBM4	1	HNRNPM	1	two hybrid, two hybrid	Hegele A (2012), Hegele A (2012)	2
UBE2I	0	LMNA	2	two hybrid, affinity chromatography technology, enzymatic study	Zhong N (2005), Zhong N (2005), Matafora V (2009)	3
DDX1	6	RBM4	1	biochemical	Havugimana PC (2012)	1
UBC	7	HNRNPF	5	affinity chromatography technology	Matsumoto M (2005)	1