PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
BRCA1	7	ARIH1	3	affinity chromatography technology	Ertych N (2016)	1
ATF2	1	SRA1	0	far western blotting	Chooniedass-Kothari S (2010)	1
CREB1	1	NFIL3	1	affinity chromatography technology, affinity chromatography technology	Li X (2015), Huttlin EL (2017)	2
CAMK2A	6	CREB1	1	enzymatic study	Shimomura A (1996)	1
SSH1	1	ATF1	0	affinity chromatography technology	Li X (2016)	1
HNF1B	3	ATF1	0	two hybrid	Soubt MK (1998)	1
CSNK2B	5	BRCA1	7	pull down, two hybrid, pull down	OBrien KA (1999), OBrien KA (1999), OBrien KA (1999)	3
BRCA1	7	HSPA8	4	two hybrid, affinity chromatography technology	Yu X (1998), Ertych N (2016)	2
ATF2	1	CREB1	1	biochemical	Wan C (2015)	1
DNMT3L	2	NFIL3	1	pull down	Pacaud R (2014)	1
ARHGAP22	0	CREB1	1	affinity chromatography technology	Huttlin EL (2017)	1
DNMT3L	2	ATF2	1	pull down	Pacaud R (2014)	1
JUNB	0	ATF2	1	affinity chromatography technology	Huttlin EL (2017)	1
CSGALNACT2	0	CREB1	1	affinity chromatography technology	Huttlin EL (2017)	1
CREB1	1	SRA1	0	far western blotting	Chooniedass-Kothari S (2010)	1
FOSL2	2	SRA1	0	far western blotting	Chooniedass-Kothari S (2010)	1
NFIL3	1	ATF1	0	affinity chromatography technology	Huttlin EL (2017)	1
IDO2	3	ATF1	0	affinity chromatography technology	Huttlin EL (2017)	1
CSNK2A1	15	SPI1	1	enzymatic study	Mao C (1996)	1
FOSL2	2	JUNB	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Mathas S (2009), Huttlin EL (2015), Hein MY (2015), Huttlin EL (2017)	4
RPS6KA5	2	CREB1	1	enzymatic study, pull down, enzymatic study	Deak M (1998), Wang X (2001), New L (1999)	3
MIA2	5	ATF1	0	affinity chromatography technology	Huttlin EL (2017)	1
CREB1	1	ATF1	0	affinity chromatography technology	Li X (2015)	1
CREBBP	29	ATF1	0	pull down	Shimomura A (1996)	1
ATF1	0	CSNK2A1	15	pull down, affinity chromatography technology, far western blotting, enzymatic study	Yamaguchi Y (1998), Yamaguchi Y (1998), Yamaguchi Y (1998), Yamaguchi Y (1998)	4
MAPKAPK2	1	ATF1	0	enzymatic study	Mayo LD (2001)	1
DNMT3L	2	FOSL2	2	pull down	Pacaud R (2014)	1
DNMT3L	2	JUNB	0	pull down	Pacaud R (2014)	1
BRCA1	7	CREB1	1	genetic interference	Houvras Y (2000)	1
TRPV5	2	ATF1	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
CSNK2A1	15	CSNK2B	5	pull down, affinity chromatography technology, far western blotting, two hybrid, two hybrid, two hybrid, pull down, enzymatic study, affinity chromatography technology, two hybrid, enzymatic study, biochemical, far western blotting, far western blotting, x-ray crystallography, enzymatic study, two hybrid, affinity chromatography technology, two hybrid, biochemical, pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology	Kim MS (1998), Kim MS (1998), Marin O (1997), Bosc DG (2000), Ahn BH (2001), Kusk M (1999), Benitez MJ (2001), Uhle S (2003), Olsen BB (2008), Son MY (1999), Son MY (1999), Havugimana PC (2012), Llorens F (2003), Llorens F (2003), Niefind K (2001), Lee NY (2009), Wang J (2011), So J (2015), Wallach T (2013), Wan C (2015), Gao Z (2014), Ren K (2011), Goetz C (1999), Hauri S (2016)	24
TFAP4	3	ATF1	0	affinity chromatography technology	Huttlin EL (2017)	1
CSNK2A1	15	BRCA1	7	pull down	OBrien KA (1999)	1
GABPA	0	ATF1	0	pull down	Sawada J (1999)	1
TFAP4	3	BRCA1	7	affinity chromatography technology	Ku WC (2009)	1
DNMT3L	2	CREB1	1	pull down	Pacaud R (2014)	1
CCDC97	3	ATF1	0	affinity chromatography technology	Huttlin EL (2017)	1
NFATC1	12	CREB1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Li X (2015), Gabriel CH (2016), Gabriel CH (2016)	3
ARIH1	3	ATF1	0	affinity chromatography technology	Huttlin EL (2017)	1
ATF2	1	ARIH1	3	affinity chromatography technology	Huttlin EL (2017)	1
NFATC1	12	JUNB	0	affinity chromatography technology	Gabriel CH (2016)	1
RPS6KA5	2	ATF2	1	imaging technique	Chen TC (2014)	1
CREBBP	29	CSNK2A1	15	pull down, far western blotting, affinity chromatography technology	Yamaguchi Y (1998), Yamaguchi Y (1998), Jung SY (2005)	3
NFATC1	12	CREBBP	29	affinity chromatography technology	Gabriel CH (2016)	1
JUNB	0	ARIH1	3	affinity chromatography technology	Huttlin EL (2017)	1
DNMT3L	2	ATF1	0	pull down	Pacaud R (2014)	1
ATF2	1	CSNK2A1	15	pull down, far western blotting	Yamaguchi Y (1998), Yamaguchi Y (1998)	2
MAPKAPK3	0	ATF1	0	enzymatic study	Mayo LD (2001)	1
MIA2	5	CREB1	1	affinity chromatography technology	Huttlin EL (2017)	1
CREBBP	29	JUNB	0	affinity chromatography technology	Tran NQ (2004)	1
CREBBP	29	BRCA1	7	affinity chromatography technology, pull down, affinity chromatography technology, genetic interference, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down	Pao GM (2000), Pao GM (2000), Benezra M (2003), Fan S (2002), Fan S (2002), Neish AS (1998), Nakuci E (2006), Crowe DL (2006), Chai YL (1999)	9
NFATC1	12	ATF2	1	affinity chromatography technology	Li X (2015)	1
HSPA8	4	CREBBP	29	affinity chromatography technology	Du C (2017)	1
JUNB	0	BRCA1	7	two hybrid, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Hu YF (2002), Hu YF (2002), Hu YF (2002), Kang HJ (2008), Hill SJ (2014), Huttlin EL (2017)	6
ARHGAP22	0	ATF2	1	affinity chromatography technology	Huttlin EL (2017)	1
TUFT1	1	CREB1	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
ATF1	0	CSNK2B	5	pull down	Yamaguchi Y (1998)	1
CSGALNACT2	0	ATF1	0	affinity chromatography technology	Huttlin EL (2017)	1
SPI1	1	ATF1	0	pull down	Pongubala JM (1995)	1
RPS6KA5	2	CREBBP	29	affinity chromatography technology	Janknecht R (2003)	1
ATF1	0	SRA1	0	far western blotting	Chooniedass-Kothari S (2010)	1
CSNK2B	5	MAPKAPK2	1	protein complementation assay, affinity chromatography technology	Srivastav RK (2011), Srivastav RK (2011)	2
ATF2	1	ATF1	0	biochemical	Wan C (2015)	1
CREBBP	29	CREB1	1	affinity chromatography technology, two hybrid, pull down, x-ray crystallography, pull down, pull down, affinity chromatography technology, fluorescent resonance energy transfe, pull down, pull down, pull down, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, two hybrid, affinity chromatography technology, far western blotting, pull down, far western blotting, pull down, far western blotting, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Shi Y (2004), Kim J (2005), Shimomura A (1996), Radhakrishnan I (1997), Radhakrishnan I (1997), Sano Y (1998), Sano Y (1998), Zor T (2002), Giebler HA (2000), Zhang Q (2000), Ernst P (2001), Ledo F (2002), Poon SL (2008), Best JL (2004), Best JL (2004), Chan EC (2010), Yang F (2006), Solomou EE (2001), Du K (1998), Venza I (2001), Lundblad JR (1995), Lundblad JR (1995), Arias J (1994), Chrivia JC (1993), Chrivia JC (1993), Shi Y (2004), Ramirez JA (2007), Sun HS (2003), Sun HS (2003), Wang Y (2016)	30
CREBBP	29	ATF2	1	pull down, pull down, affinity chromatography technology, two hybrid, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Sano Y (1998), Sano Y (1998), Sano Y (1998), Sano Y (1998), Deb S (2006), Merika M (1998), Johnson J (2007), Venza I (2001)	8
ARHGAP22	0	ATF1	0	affinity chromatography technology	Huttlin EL (2017)	1
HNF1B	3	CREB1	1	two hybrid	Soubt MK (1998)	1
NFATC1	12	ATF1	0	affinity chromatography technology	Li X (2015)	1
ATF1	0	JUNB	0	biochemical	Wan C (2015)	1
TUFT1	1	ATF1	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
CSNK2B	5	RPS6KA5	2	two hybrid	Wang J (2011)	1
ARIH1	3	CREB1	1	affinity chromatography technology	Huttlin EL (2017)	1
BRCA1	7	FOSL2	2	affinity chromatography technology	Hill SJ (2014)	1
FOSL2	2	ATF2	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
CREBRF	1	ATF1	0	affinity chromatography technology	Huttlin EL (2017)	1
HSPA8	4	ATF1	0	affinity chromatography technology	Huttlin EL (2017)	1
ATF1	0	FOSL2	2	biochemical	Havugimana PC (2012)	1
BRCA1	7	ATF1	0	two hybrid, pull down, affinity chromatography technology	Houvras Y (2000), Houvras Y (2000), Houvras Y (2000)	3
CACNG2	0	ATF1	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
TRPV5	2	CREB1	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
RPS6KA5	2	ATF1	0	enzymatic study	Mayo LD (2001)	1
CAMK2A	6	ATF1	0	enzymatic study	Shimomura A (1996)	1