PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
MAP3K7	2	SMAD6	9	affinity chromatography technology, affinity chromatography technology	Kimura N (2000), Yanagisawa M (2001)	2
SPOP	1	TRAF6	0	pull down	Zapata JM (2001)	1
SARM1	3	IRAK1	1	affinity chromatography technology	Li S (2011)	1
BTK	1	IRAK1	1	affinity chromatography technology	Jefferies CA (2003)	1
MYD88	1	TLR7	1	two hybrid	Wang J (2011)	1
IL1RL1	1	MYD88	1	affinity chromatography technology	Schmitz J (2005)	1
CYLD	2	PRDX1	1	affinity chromatography technology	Elliott PR (2016)	1
TRAF6	0	IRAK2	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology	Wesche H (1999), Muzio M (1997), Keating SE (2007), Li S (2011), Li S (2011), Wang J (2011), Wang H (2015), Huttlin EL (2017)	8
TLR9	2	TRAF6	0	affinity chromatography technology	Yang M (2011)	1
MYD88	1	IRF5	0	fluorescent resonance energy transfe, affinity chromatography technology	Takaoka A (2005), Takaoka A (2005)	2
TRAF6	0	IRAK3	0	affinity chromatography technology	Wesche H (1999)	1
STAP2	3	MYD88	1	affinity chromatography technology, pull down	Sekine Y (2006), Sekine Y (2006)	2
TLR4	5	TRAF6	0	affinity chromatography technology	Yang M (2011)	1
MYD88	1	PRDX1	1	two hybrid	Wang J (2011)	1
MYD88	1	IRAK4	0	affinity chromatography technology, protein complementation assay, protein complementation assay, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid	Li S (2002), Ulrichts P (2008), Ulrichts P (2008), Zhou J (2011), Zhou J (2011), Burns K (2003), Burns K (2003), Strelow A (2003), Loiarro M (2007), Jeon J (2014), Rolland T (2014)	11
IL1RL1	1	TRAF6	0	affinity chromatography technology	Schmitz J (2005)	1
IKBKE	2	TRAF3	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ng MH (2011), Charoenthongtrakul S (2013), Peng Y (2014), Gu L (2017), Fang R (2017)	5
MYD88	1	SIAH2	0	two hybrid	Wang J (2011)	1
MYD88	1	IRAK1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, genetic interference, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Chen BC (2002), Wesche H (1999), Li S (2002), Fitzgerald KA (2001), Fitzgerald KA (2001), Li S (2011), Neumann D (2007), Zhou J (2011), Burns K (2003), Mizobe T (2007), Loiarro M (2007), Choi KC (2006), Rao N (2005), Rao N (2005), Li CH (2006)	15
TNFRSF13B	0	TRAF6	0	two hybrid, affinity chromatography technology, affinity chromatography technology	Xia XZ (2000), Xia XZ (2000), He B (2010)	3
CYLD	2	HDAC6	0	affinity chromatography technology, pull down, affinity chromatography technology	Wickstroem SA (2010), Wickstroem SA (2010), Sun L (2010)	3
TLR3	2	FADD	1	affinity chromatography technology	Zinngrebe J (2016)	1
CYLD	2	SQSTM1	0	affinity chromatography technology, affinity chromatography technology	Kim JY (2009), Kim JY (2009)	2
MAP3K7	2	IRAK1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Liu XY (2008), Jiang Z (2002), Jiang Z (2002), Lee HJ (2012), Yao J (2007)	5
TNFRSF13B	0	TRAF3	1	affinity chromatography technology	Xu LG (2002)	1
PELI1	1	MYD88	1	affinity chromatography technology	Choi KC (2006)	1
TLR4	5	IRAK1	1	affinity chromatography technology	Yang M (2011)	1
TLR3	2	TRAF3	1	affinity chromatography technology	Li S (2011)	1
IKBKG	0	TRAF3	1	affinity chromatography technology	Belgnaoui SM (2012)	1
SQSTM1	0	HDAC6	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Tanji K (2012), Yan J (2013), Yan J (2013), Chen Q (2015)	4
IRAK4	0	TLR4	5	affinity chromatography technology	Xiong Y (2011)	1
SARM1	3	IRAK2	3	affinity chromatography technology, pull down	Li S (2011), Li S (2011)	2
IKBKG	0	CYLD	2	two hybrid, two hybrid, affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology	Kovalenko A (2003), Kovalenko A (2003), Kovalenko A (2003), Kovalenko A (2003), Brummelkamp TR (2003), Trompouki E (2003), Chu L (2006), Shibata Y (2012), Wang J (2011), Zilberman-Rudenko J (2016), Zilberman-Rudenko J (2016)	11
IRAK4	0	SASH1	8	affinity chromatography technology	Dauphinee SM (2013)	1
TIRAP	1	BTK	1	affinity chromatography technology	Jefferies CA (2003)	1
HNRNPL	3	SMURF1	4	affinity chromatography technology	Fei T (2017)	1
IRAK2	3	PELI1	1	affinity chromatography technology	Butler MP (2007)	1
MYD88	1	IRAK2	3	affinity chromatography technology, genetic interference, affinity chromatography technology, affinity chromatography technology	Wesche H (1999), Fitzgerald KA (2001), Muzio M (1997), Zhou J (2011)	4
TRAF3	1	TNIP1	1	affinity chromatography technology	Gao L (2011)	1
MYD88	1	SPOP	1	two hybrid, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology	Rual JF (2005), Wang J (2011), Wang J (2011), Huttlin EL (2015), Huttlin EL (2017)	5
TLR9	2	TRAF3	1	affinity chromatography technology	Li S (2011)	1
USP7	14	TRAF6	0	pull down, affinity chromatography technology, enzymatic study	Zapata JM (2001), Daubeuf S (2009), Bremm A (2010)	3
MYD88	1	TNIP1	1	affinity chromatography technology, affinity chromatography technology	Zhou J (2011), Zhou J (2011)	2
IKBKG	0	IKBKE	2	affinity chromatography technology, affinity chromatography technology	Zhao T (2007), Zhou AY (2013)	2
TLR3	2	SYK	3	affinity chromatography technology	Lin YC (2013)	1
TRAF6	0	IRAK1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology	Wesche H (1999), Qian Y (2001), Cao Z (1996), Takatsuna H (2003), Li S (2002), Ling L (2000), Ling L (2000), Takaesu G (2001), Muzio M (1997), Chen F (2008), Li X (2001), Li X (2001), Xiong Y (2011), Xiong Y (2011), Tang H (2010), Muroi M (2011), Liu A (2012), Lee JY (2009), Lee JY (2009), Kollewe C (2004), Jiang Z (2002), Jensen LE (2001), Liu G (2007), Liu G (2007), Jiang Z (2003), Nguyen T (2009), Choi KC (2006), Rao N (2005), Rao N (2005), Lakshmanan U (2007), Lee HJ (2012), Lee HJ (2012), Zhang X (2013), Yao J (2007), Hu MM (2014), Jeon J (2014), Conze DB (2008), Tanishima M (2017)	38
CBLB	3	MYD88	1	affinity chromatography technology	Han C (2010)	1
IRAK4	0	PELI1	1	affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology	Butler MP (2007), Ordureau A (2008), Smith H (2009), Smith H (2011), Jiang Z (2003), Choi KC (2006)	6
MYD88	1	TRAF6	0	genetic interference, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Fitzgerald KA (2001), Zhou J (2011), Zhou J (2011), Zhang X (2013), Zhang X (2013), Hirata Y (2006)	6
TRAF6	0	IKBKE	2	affinity chromatography technology	Fang R (2017)	1
FLII	11	LRRFIP1	6	two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Liu YT (1998), Liu YT (1998), Liu YT (1998), Fong KS (1999), Dai P (2009), Dai P (2009), Kristensen AR (2012), Hein MY (2015), Huttlin EL (2017)	9
HNRNPL	3	STAP2	3	affinity chromatography technology	Fei T (2017)	1
MAP3K7	2	SMAD3	1	imaging technique	Chen TC (2014)	1
TLR4	5	SYK	3	affinity chromatography technology	Lin YC (2013)	1
CYLD	2	TRAF6	0	enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology	Kovalenko A (2003), Bremm A (2010), Wu J (2015), Wu J (2015)	4
TRAF3	1	CBLB	3	affinity chromatography technology	Qiao G (2007)	1
TIRAP	1	IRAK2	3	genetic interference, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Fitzgerald KA (2001), Fitzgerald KA (2001), Fitzgerald KA (2001), Li S (2011)	4
IRF4	1	MYD88	1	affinity chromatography technology, imaging technique	Watanabe T (2014), Watanabe T (2014)	2
SMAD3	1	IRF7	2	pull down, affinity chromatography technology, imaging technique	Qing J (2004), Qing J (2004), Qing J (2004)	3
IL1RAP	3	MYD88	1	genetic interference	Fitzgerald KA (2001)	1
TRAF6	0	MAP3K7	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study	Ishitani T (2003), Takaesu G (2000), Ninomiya-Tsuji J (1999), Takaesu G (2001), Mochida Y (2000), Mochida Y (2000), Walsh MC (2008), Sorrentino A (2008), Frobose H (2006), Ishitani T (2003), Xia ZP (2009), Jiang Z (2003), Jiang Z (2003), Yamazaki K (2009), Yamazaki K (2009), Jiang Z (2002), Jiang Z (2002), Cui W (2012), Jiang Z (2003), Minoda Y (2009), Gao D (2009), Lee HJ (2012), Hirata Y (2006), Hu MM (2014), Fujikawa H (2013), Sun D (2011), Li W (2015), Lin J (2015), Lee Y (2016), Ji YX (2016), Ji YX (2016), Ji YX (2016), Ji YX (2016)	33
MYD88	1	SIAH1	2	affinity chromatography technology, two hybrid	Wang J (2011), Wang J (2011)	2
TLR4	5	TRAF3	1	affinity chromatography technology	Li S (2011)	1
IL1R1	0	MYD88	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Burns K (2000), Muzio M (1997), Jiang Z (2003), Chen R (2012), Burns K (1998), Jeon J (2014)	6
SYK	3	TRAF6	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Yamada T (2001), Lin YC (2013), Wu NL (2014)	3
TIRAP	1	TLR4	5	affinity chromatography technology, pull down, genetic interference, affinity chromatography technology, protein complementation assay, affinity chromatography technology, protein complementation assay, protein complementation assay, affinity chromatography technology	Horng T (2001), Horng T (2001), Fitzgerald KA (2001), Fitzgerald KA (2001), Ulrichts P (2007), Ulrichts P (2007), Ulrichts P (2008), Ulrichts P (2010), Li S (2011)	9
MYD88	1	SYK	3	affinity chromatography technology	Lin YC (2013)	1
MAP3K7	2	IKBKG	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Neil JR (2009), Yang Y (2011), Wu X (2007), Emmerich CH (2013)	4
MAL	1	MYD88	1	two hybrid	Wang J (2011)	1
MYD88	1	CYLD	2	affinity chromatography technology	Lee BC (2016)	1
TLR9	2	SYK	3	affinity chromatography technology	Lin YC (2013)	1
HNRNPL	3	PFKL	6	affinity chromatography technology	Fei T (2017)	1
MYD88	1	TLR9	2	two hybrid, affinity chromatography technology	Chuang TH (2004), Yang M (2011)	2
TNFRSF13B	0	IRAK4	0	affinity chromatography technology	He B (2010)	1
TIRAP	1	MAP3K7	2	genetic interference, affinity chromatography technology	Fitzgerald KA (2001), Ma J (2013)	2
IL1RAP	3	TIRAP	1	genetic interference	Fitzgerald KA (2001)	1
TRAF6	0	SQSTM1	0	affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sanz L (2000), Sanz L (2000), Nakamura K (2010), Kim JY (2009), Seibenhener ML (2004), Feng Y (2005), Martin P (2006), Martin P (2006), Geetha T (2012), Geetha T (2012), Linares JF (2013), Linares JF (2011), Linares JF (2015), Schimmack G (2017), Tsai WT (2016)	15
MYD88	1	MYD88	1	two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, two hybrid	Fitzgerald KA (2001), Burns K (1998), Burns K (1998), Loiarro M (2007), Wang J (2011), Rolland T (2014), Yu H (2011)	7
BTK	1	TLR9	2	two hybrid	Jefferies CA (2003)	1
IRAK1	1	IRAK2	3	affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe, fluorescent resonance energy transfe	Li S (2011), Li S (2011), Ross K (2002), Ross K (2002)	4
MAL	1	USP7	14	two hybrid	Wang J (2011)	1
SIAH1	2	TXN	1	two hybrid	Wang J (2011)	1
IKBKE	2	MYD88	1	affinity chromatography technology	Zhou AY (2013)	1
MYD88	1	RAC1	7	pull down, affinity chromatography technology	Jefferies C (2001), Jefferies C (2001)	2
SMAD3	1	USP7	14	affinity chromatography technology, two hybrid	Brown KA (2008), Wang J (2011)	2
BTK	1	SYK	3	affinity chromatography technology	Morrogh LM (1999)	1
MYD88	1	TXN	1	affinity chromatography technology, two hybrid	Wang J (2011), Wang J (2011)	2
IL1R1	0	IRAK1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Jiang Z (2003), Jiang Z (2002), Jiang Z (2002), Chen R (2012), Cao Z (1996), Cao Z (1996), Rao N (2005), Jeon J (2014)	8
MYD88	1	POLR1C	2	two hybrid	Wang J (2011)	1
SYK	3	HDAC6	0	affinity chromatography technology, pull down	Wang L (2005), Wang L (2005)	2
HNRNPL	3	MYD88	1	affinity chromatography technology	Fei T (2017)	1
IL1R1	0	IRAK4	0	affinity chromatography technology	Jiang Z (2003)	1
CD93	1	MYD88	1	two hybrid	Wang J (2011)	1
SMAD6	9	MYD88	1	affinity chromatography technology, affinity chromatography technology	Lee YS (2011), Lee YS (2011)	2
TLR3	2	MAP3K7	2	affinity chromatography technology, affinity chromatography technology	Jiang Z (2003), Cusson-Hermance N (2005)	2
MYD88	1	FLII	11	affinity chromatography technology, affinity chromatography technology	Dai P (2009), Dai P (2009)	2
MYD88	1	CISH	1	protein complementation assay, affinity chromatography technology	Lavens D (2007), Lavens D (2007)	2
TXN	1	PRDX1	1	affinity chromatography technology, biochemical	Junn E (2000), Wan C (2015)	2
MYD88	1	BTK	1	affinity chromatography technology	Jefferies CA (2003)	1
IKBKG	0	TRAF6	0	pull down, pull down, enzymatic study, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology	Lamothe B (2008), Windheim M (2008), Lamothe B (2007), Gautheron J (2010), Gautheron J (2010), Hinz M (2010), Sebban-Benin H (2007), Zotti T (2014), Sun L (2004), Emmerich CH (2013), Zhou L (2014), Chen J (2015), Kim EK (2017), Medunjanin S (2016), Xing J (2016), Bal E (2017), Bal E (2017)	17
MYD88	1	USP7	14	affinity chromatography technology, two hybrid	Wang J (2011), Wang J (2011)	2
TNFRSF13B	0	MYD88	1	affinity chromatography technology	He B (2010)	1
MYD88	1	SASH1	8	affinity chromatography technology	Dauphinee SM (2013)	1
IL1RAP	3	RAC1	7	affinity chromatography technology	Jefferies C (2001)	1
IRAK2	3	IL1R1	0	affinity chromatography technology	Muzio M (1997)	1
IRAK3	0	IRAK1	1	affinity chromatography technology, fluorescent resonance energy transfe, affinity chromatography technology	Li S (2011), Ross K (2002), Nguyen T (2009)	3
FADD	1	IRF7	2	affinity chromatography technology	Young JA (2011)	1
SMAD3	1	SMURF1	4	affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology	Komuro A (2004), Colland F (2004), Li Y (2017), Li Y (2017)	4
MYD88	1	IRF7	2	affinity chromatography technology, two hybrid, affinity chromatography technology, fluorescent resonance energy transfe	Zhao J (2006), Kawai T (2004), Kawai T (2004), Kawai T (2004)	4
USP7	14	MDM2	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, unspecified method, biochemical, x-ray crystallography, pull down, unspecified method, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, x-ray crystallography, unspecified method, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Lu X (2007), Becker K (2007), Pereg Y (2006), Hu M (2006), Hu M (2006), Hu M (2006), Hu M (2006), Sarkari F (2010), Sarkari F (2010), Tang J (2006), Tang J (2006), Ma J (2010), Song MS (2008), Sheng Y (2006), Sheng Y (2006), Sheng Y (2006), Ye M (2015), Lim KH (2015), Reddy BA (2014), Rouge L (2016), Nihira NT (2017), Nihira NT (2017), Mungamuri SK (2016), Mungamuri SK (2016), Sun Y (2017)	25
TIRAP	1	MYD88	1	genetic interference, two hybrid, two hybrid, affinity chromatography technology, protein complementation assay, protein complementation assay, protein complementation assay, protein complementation assay, protein complementation assay, affinity chromatography technology	Fitzgerald KA (2001), Fitzgerald KA (2001), Fitzgerald KA (2001), Fitzgerald KA (2001), Ulrichts P (2007), Ulrichts P (2007), Ulrichts P (2008), Ulrichts P (2010), Ulrichts P (2010), Ulrichts P (2010)	10
MBIP	0	MYD88	1	two hybrid	Wang J (2011)	1
IRF4	1	IRAK1	1	affinity chromatography technology, pull down	Li S (2011), Li S (2011)	2
MDM2	2	MYD88	1	two hybrid	Wang J (2011)	1
SYK	3	TRAF3	1	affinity chromatography technology	Lin YC (2013)	1
MYD88	1	TLR4	5	two hybrid, pull down, affinity chromatography technology, genetic interference, affinity chromatography technology, protein complementation assay, protein complementation assay, affinity chromatography technology	Chuang TH (2004), Doyle SE (2003), Rhee SH (2000), Fitzgerald KA (2001), Ulrichts P (2007), Ulrichts P (2008), Ulrichts P (2010), Yang M (2011)	8
TIRAP	1	IRAK1	1	affinity chromatography technology, pull down	Li S (2011), Li S (2011)	2
SMAD6	9	SMURF1	4	affinity chromatography technology, affinity chromatography technology, unspecified method, affinity chromatography technology, affinity chromatography technology	Komuro A (2004), Ebisawa T (2001), Sangadala S (2007), Lee YS (2011), Lee YS (2011)	5
MYD88	1	LRRFIP2	2	affinity chromatography technology	Dai P (2009)	1
MAP3K7	2	BST2	1	affinity chromatography technology	Tokarev A (2013)	1
TRAF3	1	SMURF1	4	genetic interference	Li S (2010)	1
TLR3	2	TRAF6	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Yang M (2011), Jiang Z (2003), Jiang Z (2003), Cusson-Hermance N (2005), Zinngrebe J (2016)	5
TRAF6	0	IRAK4	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Li S (2002), Li S (2002), Zhang X (2013)	3
MYD88	1	MAP3K7	2	genetic interference	Fitzgerald KA (2001)	1
HDAC6	0	MYD88	1	affinity chromatography technology, affinity chromatography technology	Into T (2010), Into T (2010)	2
BTK	1	TLR4	5	two hybrid	Jefferies CA (2003)	1
POLR1C	2	MBIP	0	two hybrid	Rolland T (2014)	1
SMURF1	4	BTK	1	enzymatic study	Andrews PS (2010)	1
MDM2	2	SMURF1	4	pull down, affinity chromatography technology, affinity chromatography technology	Nie J (2010), Nie J (2010), Nie J (2010)	3
IRAK4	0	IRAK2	3	affinity chromatography technology	Li S (2011)	1
IL1RL1	1	IRAK4	0	affinity chromatography technology	Schmitz J (2005)	1
IL1RL1	1	IRAK1	1	affinity chromatography technology	Schmitz J (2005)	1
IL1RAP	3	IRAK1	1	affinity chromatography technology, affinity chromatography technology	Huang J (1997), Jeon J (2014)	2
IRAK4	0	TIRAP	1	protein complementation assay, affinity chromatography technology, pull down	Ulrichts P (2008), Li S (2011), Li S (2011)	3
TIRAP	1	TRAF6	0	genetic interference, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Fitzgerald KA (2001), Mansell A (2004), Verstak B (2009), Verstak B (2009), Ma J (2013)	5
IKBKG	0	FADD	1	affinity chromatography technology	Biton S (2011)	1
MYD88	1	TLR2	0	two hybrid	Chuang TH (2004)	1
IRAK4	0	IRAK1	1	affinity chromatography technology, enzymatic study, protein complementation assay, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology	Li S (2002), Li S (2002), Ulrichts P (2008), Li S (2011), Neumann D (2007), Burns K (2003), Liu G (2007), Strelow A (2003), Nguyen T (2009), Choi KC (2006), Rao N (2005), Rao N (2005), Jeon J (2014)	13
MAP3K7	2	SASH1	8	affinity chromatography technology	Dauphinee SM (2013)	1
PELI1	1	IL1R1	0	affinity chromatography technology	Jiang Z (2003)	1
MYD88	1	PFKL	6	two hybrid	Wang J (2011)	1
IL1R1	0	TRAF6	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Jiang Z (2003), Jiang Z (2002), Jiang Z (2003), Rafferty BJ (2010)	4
FADD	1	MYD88	1	two hybrid	Wang J (2011)	1
TNIP1	1	IKBKE	2	affinity chromatography technology, affinity chromatography technology	Gao L (2011), Gao L (2011)	2
PELI1	1	SMAD6	9	affinity chromatography technology, affinity chromatography technology	Choi KC (2006), Choi KC (2006)	2
IRAK1	1	SASH1	8	affinity chromatography technology	Dauphinee SM (2013)	1
IKBKE	2	CYLD	2	affinity chromatography technology, affinity chromatography technology	Friedman CS (2008), Zhou AY (2013)	2
SMURF1	4	MYD88	1	affinity chromatography technology, affinity chromatography technology	Lee YS (2011), Lee YS (2011)	2
SMAD3	1	SQSTM1	0	affinity chromatography technology, two hybrid	Wang J (2011), Wang J (2011)	2
MYD88	1	BST2	1	affinity chromatography technology	Tokarev A (2013)	1
TLR3	2	IKBKG	0	affinity chromatography technology	Zinngrebe J (2016)	1
SYK	3	MAP3K7	2	affinity chromatography technology	Lin YC (2013)	1
FLII	11	LRRFIP2	2	two hybrid, affinity chromatography technology, affinity chromatography technology, biochemical	Fong KS (1999), Dai P (2009), Dai P (2009), Wan C (2015)	4
MYD88	1	TRAF3	1	affinity chromatography technology	Zhou J (2011)	1
MYD88	1	IRAK3	0	affinity chromatography technology	Wesche H (1999)	1
FADD	1	SPOP	1	two hybrid	Wang J (2011)	1
TRAF6	0	IRF7	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kawai T (2004), Young JA (2011), Hu Y (2011), Ning S (2008), Ning S (2008), Naiki Y (2015), Naiki Y (2015)	7
IRAK3	0	IRAK4	0	affinity chromatography technology	Li S (2011)	1
HDAC6	0	PFKL	6	affinity chromatography technology	New M (2013)	1
TLR2	0	IRAK1	1	affinity chromatography technology	Yang RB (1999)	1
IKBKG	0	SASH1	8	affinity chromatography technology	Dauphinee SM (2013)	1
TNFRSF13B	0	IRAK1	1	affinity chromatography technology	He B (2010)	1
MYD88	1	LRRFIP1	6	affinity chromatography technology	Dai P (2009)	1
IKBKG	0	MYD88	1	pull down	Emmerich CH (2013)	1
SARM1	3	TRAF6	0	affinity chromatography technology	Murata H (2013)	1
MYD88	1	TLR5	1	two hybrid	Chuang TH (2004)	1
TLR9	2	IRAK1	1	affinity chromatography technology	Yang M (2011)	1
SIAH1	2	SIAH2	0	affinity chromatography technology, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Depaux A (2006), Depaux A (2006), Depaux A (2006), Huttlin EL (2017)	5
TRAF3	1	MAP3K7	2	affinity chromatography technology, affinity chromatography technology, enzymatic study	Wang PX (2016), Wang PX (2016), Wang PX (2016)	3
TRAF6	0	SMURF1	4	genetic interference	Li S (2010)	1
IL1R1	0	IL1RAP	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Huang J (1997), Huang J (1997), Jeon J (2014)	3
IKBKG	0	IRAK1	1	pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Conze DB (2008), Conze DB (2008), Windheim M (2008), Windheim M (2008), Ordureau A (2008), Xiong Y (2011), Jeon J (2014), Emmerich CH (2013)	8
SMAD3	1	TLR4	5	two hybrid	Wang J (2011)	1
MYD88	1	SMAD3	1	affinity chromatography technology, two hybrid	Wang J (2011), Wang J (2011)	2
IRF7	2	IRAK1	1	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe, enzymatic study	Li S (2011), Li S (2011), Uematsu S (2005), Uematsu S (2005), Uematsu S (2005), Uematsu S (2005)	6
IRAK3	0	IRAK2	3	affinity chromatography technology	Li S (2011)	1
TLR3	2	IRAK2	3	affinity chromatography technology	Keating SE (2007)	1
HDAC6	0	USP7	14	affinity chromatography technology	Joshi P (2013)	1
USP7	14	TRAF3	1	pull down	Zapata JM (2001)	1
TRAF6	0	CBLB	3	affinity chromatography technology	Qiao G (2007)	1
IKBKG	0	SQSTM1	0	affinity chromatography technology, affinity chromatography technology	Martin P (2006), Zotti T (2014)	2
IKBKG	0	IRAK4	0	pull down	Emmerich CH (2013)	1
PELI1	1	TRAF6	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Jiang Z (2003), Jiang Z (2003), Choi KC (2006), Jensen LE (2003)	4
IKBKG	0	TNIP1	1	affinity chromatography technology, affinity chromatography technology, two hybrid	Ashida H (2010), Wagner S (2008), Wang J (2011)	3
IKBKG	0	USP7	14	affinity chromatography technology, affinity chromatography technology	Daubeuf S (2009), Li T (2014)	2
TLR2	0	TIRAP	1	protein complementation assay, protein complementation assay	Ulrichts P (2007), Ulrichts P (2008)	2
SARM1	3	MYD88	1	protein complementation assay	Ulrichts P (2007)	1
IRF4	1	TRAF6	0	affinity chromatography technology, imaging technique	Watanabe T (2014), Watanabe T (2014)	2
BTK	1	CBLB	3	affinity chromatography technology	Yasuda T (2002)	1
SQSTM1	0	IRAK1	1	affinity chromatography technology	Sanz L (2000)	1
CYLD	2	HNRNPL	3	affinity chromatography technology	Elliott PR (2016)	1
TRAF6	0	IRF5	0	affinity chromatography technology	Takaoka A (2005)	1
TLR3	2	MYD88	1	pull down	Doyle SE (2003)	1
MAP3K7	2	CYLD	2	affinity chromatography technology, affinity chromatography technology	Koga T (2008), Elliott PR (2016)	2
PELI1	1	IRAK1	1	affinity chromatography technology, enzymatic study, pull down, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Butler MP (2007), Ordureau A (2008), Lin CC (2008), Smith H (2009), Smith H (2011), Jiang Z (2003), Choi KC (2006), Choi KC (2006), Butler MP (2005), Schauvliege R (2006), Murphy M (2015)	11
SQSTM1	0	MYD88	1	affinity chromatography technology	Into T (2010)	1
CBLB	3	SYK	3	affinity chromatography technology, enzymatic study	Elly C (1999), Wirnsberger G (2016)	2