PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
HDAC2	1	MYCN	2	affinity chromatography technology	Marshall GM (2010)	1
MYCN	2	HDAC9	7	imaging technique	Shahbazi J (2014)	1
CSNK2A1	15	MAX	0	enzymatic study	Wenzel A (1991)	1
EP400	19	HDAC2	1	biochemical	Wan C (2015)	1
WDR5	2	MYCN	2	pull down, affinity chromatography technology, affinity chromatography technology	Sun Y (2015), Sun Y (2015), Sun Y (2015)	3
YEATS4	0	EP400	19	affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Wan C (2015), Hein MY (2015), Huttlin EL (2017), Cheng J (2017)	5
MYCN	2	SKP2	2	affinity chromatography technology	Cowling VH (2008)	1
MYC	2	TRRAP	31	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, genetic interference, pull down	Liu X (2003), McMahon SB (2000), McMahon SB (1998), Park J (2002), Bres V (2009), Cowling VH (2006), Frank SR (2001), Kim J (2010), Kim J (2010), Koch HB (2007), Toyoshima M (2012), Liu X (2003)	12
HDAC5	4	LRPPRC	7	affinity chromatography technology	Greco TM (2011)	1
FBXW7	2	MYC	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, enzymatic study	Thompson BJ (2007), Welcker M (2004), Welcker M (2004), Yada M (2004), Yada M (2004), Yada M (2004), Koch HB (2007), Kim BY (2010), Cho HJ (2010), Popov N (2007), Fujii M (2006), Yumimoto K (2012), Diefenbacher ME (2015), Kourtis N (2015), Kourtis N (2015), Li J (2017), Wang Y (2017), Reiterer V (2017), Chandra S (2013), Chandra S (2013), Chandra S (2013), Chandra S (2013)	22
FOXR1	3	EP400	19	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Li X (2015), Huttlin EL (2017)	3
HDAC5	4	MYCN	2	affinity chromatography technology, affinity chromatography technology	Sun Y (2013), Sun Y (2013)	2
MAX	0	TRRAP	31	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical	McMahon SB (2000), McMahon SB (1998), Kim J (2010), Kim J (2010), Cheng J (2017), Cheng J (2017)	6
SIRT1	3	YBX1	1	affinity chromatography technology	Law IK (2009)	1
FBXW7	2	YBX1	1	affinity chromatography technology	Kourtis N (2015)	1
SIRT1	3	CSNK2A1	15	affinity chromatography technology, affinity chromatography technology	Holloway KR (2010), Kang H (2009)	2
MYC	2	MYCN	2	affinity chromatography technology	Li X (2015)	1
AURKA	1	LRPPRC	7	affinity chromatography technology	Fogeron ML (2013)	1
HDAC5	4	CSNK2A1	15	affinity chromatography technology	Greco TM (2011)	1
GRK5	7	LRPPRC	7	affinity chromatography technology	Wu Z (2012)	1
YEATS4	0	TRRAP	31	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Hein MY (2015), Hein MY (2015), Huttlin EL (2017)	4
SP1	0	HDAC2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Won J (2002), Zhang Y (2002), Sun JM (2002), Glasspool RM (2005), Duan H (2005), Sekhavat A (2007), Itoh Y (2007), Marshall GM (2010), Tsai PF (2011), Schnur N (2007)	10
CDKN2A	1	MYC	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe	Herkert B (2010), Amente S (2007), Zhang Q (2013), Ivanov AA (2017)	4
CDKN2A	1	NMI	3	two hybrid, affinity chromatography technology, affinity chromatography technology, pull down	Li Z (2012), Li Z (2012), Li Z (2012), Li Z (2012)	4
NONO	3	HDAC2	1	affinity chromatography technology	Zhang C (2008)	1
PRMT1	3	SIRT1	3	affinity chromatography technology, enzymatic study	Lai Y (2017), Lai Y (2017)	2
CSNK2A1	15	WDR5	2	affinity chromatography technology, affinity chromatography technology	Hauri S (2016), Hauri S (2016)	2
AURKA	1	HDAC2	1	pull down	Pugacheva EN (2007)	1
NEDD4	2	UBC	7	x-ray crystallography, pull down, unspecified method, enzymatic study, x-ray crystallography, enzymatic study, pull down, pull down	Maspero E (2011), Maspero E (2011), Ernst A (2013), Maspero E (2013), Mari S (2014), Mari S (2014), Mari S (2014), Kathman SG (2015)	8
SIRT1	3	MYCN	2	affinity chromatography technology, affinity chromatography technology, pull down	Marshall GM (2011), Marshall GM (2011), Marshall GM (2011)	3
MYC	2	HDAC2	1	affinity chromatography technology, affinity chromatography technology	Koch HB (2007), Hwang IY (2012)	2
CSNK2A1	15	HDAC2	1	enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study, biochemical, enzymatic study, biochemical	Sun JM (2002), Sun JM (2007), Adenuga D (2010), Tsai SC (2002), Havugimana PC (2012), Zhang M (2011), Wan C (2015)	7
MAX	0	EP400	19	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical	Fuchs M (2001), Kim J (2010), Kim J (2010), Li X (2015), Cheng J (2017), Cheng J (2017), Cheng J (2017)	7
AURKA	1	YBX1	1	affinity chromatography technology	Fogeron ML (2013)	1
RUNX3	1	MYCN	2	affinity chromatography technology, affinity chromatography technology, pull down, pull down	Yu F (2014), Yu F (2014), Yu F (2014), Yu F (2014)	4
MYCN	2	GRSF1	1	affinity chromatography technology, unspecified method	Cobbold LC (2008), Cobbold LC (2008)	2
FBXW7	2	MAX	0	affinity chromatography technology	Kourtis N (2015)	1
MYC	2	NMI	3	affinity chromatography technology, pull down, two hybrid	Li H (2002), Li H (2002), Bannasch D (1999)	3
FOXR1	3	YEATS4	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Li X (2015), Huttlin EL (2017)	3
SIRT1	3	MYC	2	pull down, affinity chromatography technology	Menssen A (2012), Menssen A (2012)	2
MYC	2	AURKA	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
FBXW7	2	AURKA	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Otto T (2009), Kwon YW (2012), Kwon YW (2012), Wang Y (2017)	4
CSNK1E	0	MYCN	2	genetic interference	Toyoshima M (2012)	1
MYC	2	EP400	19	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique	Fuchs M (2001), Fuchs M (2001), Kim J (2010), Kim J (2010), Agrawal P (2010), Tworkowski KA (2008), Tworkowski KA (2008), Tworkowski KA (2008)	8
CDKN2A	1	SP1	0	affinity chromatography technology, affinity chromatography technology	Li DQ (2011), Li DQ (2011)	2
MYCN	2	TRRAP	31	affinity chromatography technology	Cowling VH (2008)	1
CSNK1E	0	WDR5	2	affinity chromatography technology	Varjosalo M (2013)	1
TRIM32	2	UBC	7	enzymatic study, pull down	Streich FC (2013), Zhang X (2017)	2
ZBTB17	2	MAX	0	pull down	Staller P (2001)	1
SKP2	2	MYC	2	affinity chromatography technology, affinity chromatography technology, pull down, protein complementation assay, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	von der Lehr N (2003), von der Lehr N (2003), von der Lehr N (2003), von der Lehr N (2003), von der Lehr N (2003), Zhang Q (2013), Kim TA (2013), Jamal A (2015), Fujii M (2006)	9
MYCN	2	MAX	0	pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, pull down, affinity chromatography technology, protein complementation assay	Blackwood EM (1991), FitzGerald MJ (1999), Kim J (2010), Amente S (2007), Zhao X (2008), Zhao X (2008), Cheng J (2017), Wenzel A (1991), Wenzel A (1991), Wenzel A (1991), Mueller I (2014)	11
HDAC5	4	PRMT1	3	affinity chromatography technology	Greco TM (2011)	1
AURKA	1	CSNK2A1	15	affinity chromatography technology	Fogeron ML (2013)	1
LRPPRC	7	SIRT1	3	affinity chromatography technology	Hein MY (2015)	1
ZBTB17	2	MYC	2	pull down, two hybrid, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Staller P (2001), Peukert K (1997), Peukert K (1997), Peukert K (1997), Herold S (2008), Si J (2010), Si J (2010), Gordan JD (2007), Gordan JD (2007), Hervouet E (2009), Hervouet E (2009), Patel JH (2006), Patel JH (2006), Staller P (2001), Vo BT (2016), Vo BT (2016)	16
FBXW7	2	EP400	19	affinity chromatography technology	Kourtis N (2015)	1
HUWE1	22	ZBTB17	2	affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology	Adhikary S (2005), Adhikary S (2005), Lee CK (2015), Lee CK (2015)	4
MYC	2	NONO	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method	Koch HB (2007), Agrawal P (2010), Cobbold LC (2008), Cobbold LC (2008)	4
SP1	0	MYCN	2	affinity chromatography technology, pull down	Iraci N (2011), Iraci N (2011)	2
MYCN	2	PRMT1	3	pull down, enzymatic study, affinity chromatography technology	Eberhardt A (2016), Eberhardt A (2016), Eberhardt A (2016)	3
YEATS4	0	MYCN	2	affinity chromatography technology, two hybrid	Piccinni E (2011), Piccinni E (2011)	2
MAX	0	HDAC2	1	affinity chromatography technology	Hauri S (2016)	1
WDR5	2	HDAC2	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2017), Hauri S (2016)	2
MYCN	2	LRPPRC	7	affinity chromatography technology	Zhao X (2008)	1
GRK5	7	MYCN	2	affinity chromatography technology	Wu Z (2012)	1
HUWE1	22	MYC	2	pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Adhikary S (2005), Adhikary S (2005), Adhikary S (2005), Koch HB (2007), Fan L (2015), Zhao X (2008)	6
HUWE1	22	HDAC2	1	affinity chromatography technology, enzymatic study	Zhang J (2011), Zhang J (2011)	2
MAX	0	WDR5	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kim J (2010), Hauri S (2016), Hauri S (2016)	3
FOXR1	3	MAX	0	affinity chromatography technology	Li X (2015)	1
MYCN	2	TRIM32	2	affinity chromatography technology, affinity chromatography technology, enzymatic study	Izumi H (2014), Izumi H (2014), Izumi H (2014)	3
RUNX3	1	HDAC5	4	affinity chromatography technology	Jin YH (2004)	1
CSNK2A1	15	MYCN	2	enzymatic study	Hagiwara T (1992)	1
EP400	19	MYCN	2	affinity chromatography technology	Cheng J (2017)	1
UBC	7	CDKN2A	1	pull down, imaging technique	Zhang X (2017), Zhang X (2017)	2
AURKA	1	MYCN	2	affinity chromatography technology	Otto T (2009)	1
MYC	2	CSNK1E	0	genetic interference	Toyoshima M (2012)	1
MYCN	2	NMI	3	two hybrid	Bannasch D (1999)	1
HDAC5	4	NONO	3	affinity chromatography technology	Greco TM (2011)	1
HUWE1	22	NONO	3	affinity chromatography technology	Thompson JW (2014)	1
HDAC5	4	WDR5	2	affinity chromatography technology	Greco TM (2011)	1
MYC	2	MAX	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, pull down, pull down, pull down, two hybrid, two hybrid, two hybrid, pull down, x-ray crystallography, pull down, two hybrid, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, pull down, biochemical, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ewing RM (2007), McMahon SB (2000), McMahon SB (1998), Cheng SW (1999), Mac Partlin M (2003), Mac Partlin M (2003), Blackwood EM (1991), Lee CM (2002), Billin AN (1999), Gupta K (1998), Meroni G (1997), Nair SK (2003), Nair SK (2003), FitzGerald MJ (1999), Meroni G (2000), Hatakeyama S (2005), Bandyopadhyay S (2010), Matsuoka Y (2009), Cowling VH (2006), Wang Z (2006), Faiola F (2005), Siegel PM (2003), Veldman T (2003), Patel JH (2004), Liu T (2007), Zhang Y (2007), Gordan JD (2007), Gordan JD (2007), Gargano B (2007), Zippo A (2007), Zippo A (2007), Zhang P (2010), Kim J (2010), Kim J (2010), Kim J (2010), Kim J (2010), Koch HB (2007), Koch HB (2007), Patel JH (2006), Lavigne P (1998), Amente S (2007), Ayer DE (1993), Huang Z (2004), Huang Z (2004), Okano HJ (1999), Agrawal P (2010), Agrawal P (2010), Wong WJ (2013), Wang J (2011), Yu L (2009), Liu X (2003), Hein MY (2015), Li X (2015), Li X (2015), Kalkat M (2014), Hauri S (2016)	56
FOXR1	3	MYCN	2	affinity chromatography technology	Li X (2015)	1
MYCN	2	YBX1	1	affinity chromatography technology, unspecified method	Cobbold LC (2008), Cobbold LC (2008)	2
AURKA	1	TRRAP	31	pull down	Kamran M (2017)	1
UBC	7	CSNK2A1	15	affinity chromatography technology	Matsumoto M (2005)	1
UBC	7	HUWE1	22	pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down, enzymatic study	Nathan JA (2013), Bish RA (2007), Thompson JW (2014), Kristariyanto YA (2015), Zhang X (2017), Michel MA (2017)	6
SIRT1	3	HDAC2	1	affinity chromatography technology	Law IK (2009)	1
UBC	7	MYCN	2	affinity chromatography technology	Yu F (2014)	1
FBXW7	2	MYCN	2	affinity chromatography technology, affinity chromatography technology	Otto T (2009), Otto T (2009)	2
FOXR1	3	MYC	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Li X (2015), Huttlin EL (2017)	3
CDKN2A	1	HUWE1	22	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, unspecified method	Chen D (2005), Chen D (2005), Chen D (2005), Chen D (2005), Chio II (2012), Hein MY (2015), Lee CK (2015), Lee CK (2015), Sander B (2017)	9
TRRAP	31	EP400	19	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Fuchs M (2001), Fuchs M (2001), Fuchs M (2001), Hein MY (2015), Cheng J (2017)	5
CSNK2A1	15	MYC	2	enzymatic study	Channavajhala P (2002)	1
MYCN	2	NONO	3	affinity chromatography technology, unspecified method	Cobbold LC (2008), Cobbold LC (2008)	2
AURKA	1	CDKN2A	1	affinity chromatography technology	Ewing RM (2007)	1
SP1	0	SKP2	2	affinity chromatography technology	Tapias A (2008)	1
UBC	7	WDR5	2	affinity chromatography technology	Matsumoto M (2005)	1
MYCN	2	NEDD4	2	affinity chromatography technology, enzymatic study	Liu PY (2012), Liu PY (2012)	2
MYC	2	GRSF1	1	affinity chromatography technology, unspecified method	Cobbold LC (2008), Cobbold LC (2008)	2
NONO	3	FBXW7	2	affinity chromatography technology, affinity chromatography technology	Alfano L (2017), Alfano L (2017)	2
MYC	2	LRPPRC	7	affinity chromatography technology	Koch HB (2007)	1
MYCN	2	CDKN2A	1	affinity chromatography technology, affinity chromatography technology	Amente S (2007), Amente S (2007)	2
SP1	0	MYC	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Gartel AL (2001), Liu T (2007), Gordan JD (2007), Gordan JD (2007), Koshiji M (2005), Koshiji M (2005)	6
MYCN	2	HUWE1	22	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, enzymatic study	Zhao X (2008), Zhao X (2008), Zhao X (2008), Zhao X (2008), Zhao X (2008)	5
MYC	2	YBX1	1	affinity chromatography technology, affinity chromatography technology, unspecified method	Agrawal P (2010), Cobbold LC (2008), Cobbold LC (2008)	3
WDR5	2	MYC	2	affinity chromatography technology	Carugo A (2016)	1
FOXR1	3	TRRAP	31	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Li X (2015), Huttlin EL (2017)	3
YEATS4	0	MYC	2	pull down, affinity chromatography technology, affinity chromatography technology	Piccinni E (2011), Huttlin EL (2015), Huttlin EL (2017)	3
CSNK2A1	15	YBX1	1	enzymatic study	Zhang M (2011)	1
MAX	0	YEATS4	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Li X (2015), Boldt K (2016), Cheng J (2017)	3
MYCN	2	ZBTB17	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Akter J (2011), Akter J (2011), Iraci N (2011), Iraci N (2011)	4
CDKN2A	1	ZBTB17	2	two hybrid, affinity chromatography technology, affinity chromatography technology	Miao L (2010), Miao L (2010), Miao L (2010)	3
HUWE1	22	PRMT1	3	affinity chromatography technology	Thompson JW (2014)	1