Gene-drug interactions (data source: DGIdb)
Gene Name Entrez ID Drug Name Chembl ID Interaction Types Sources publications
MYC 4609 NADROPARIN CALCIUM CHEMBL2109204 inhibitor DrugBank 19261492, 19757196
MYC 4609 AMIFOSTINE CHEMBL1006 NCI 9450496
MYC 4609 ESTRONE CHEMBL1405 NCI 12520970, 12567859
MYC 4609 VORINOSTAT CHEMBL98 NCI 15583844
MYC 4609 PREXASERTIB CHEMBL3544911 CIViC 28490518
MYC 4609 METHYLPREDNISOLONE CHEMBL650 NCI 9169090
MYC 4609 N-METHYL-N-NITROSUREA CHEMBL288958 NCI 16616109
MYC 4609 VERAPAMIL CHEMBL6966 NCI 1511424
MYC 4609 ALISERTIB CHEMBL483158 ClearityFoundationBiomarkers
MYC 4609 ADOZELESIN CHEMBL35493 NCI 10933811
MYC 4609 DIETHYLSTILBESTROL CHEMBL411 NCI 15545218
MYC 4609 GONADOTROPIN, CHORIONIC CHEMBL1201509 NCI 9071960
MYC 4609 AMG-900 CHEMBL2140408 ClearityFoundationBiomarkers
MYC 4609 DINACICLIB CHEMBL2103840 ClearityFoundationBiomarkers
MYC 4609 Roniciclib CHEMBL3544942 ClearityFoundationBiomarkers
MYC 4609 BIZELESIN CHEMBL284642 NCI 10933811
MYC 4609 BROMOCRIPTINE CHEMBL493 NCI 11680511
MYC 4609 ELSAMITRUCIN CHEMBL2106409 NCI 14529449
MYC 4609 INDOMETHACIN CHEMBL6 NCI 10403534
MYC 4609 LITHIUM CHEMBL2146126 NCI 15286700
MYC 4609 CHEMBL35482 CHEMBL35482 NCI 11196459
MYC 4609 SODIUM beta-NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE CHEMBL295069 NCI 12005453
MYC 4609 TEMOZOLOMIDE CHEMBL810 CGI
MYC 4609 AZACITIDINE CHEMBL1489 NCI 9006118
MYC 4609 FOLIC ACID CHEMBL1622 NCI 3479800
MYC 4609 GLUTAMINE CHEMBL930 NCI 16898871
MYC 4609 TROGLITAZONE CHEMBL408 NCI 11344222
MYC 4609 4'-HYDROXYTAMOXIFEN CHEMBL486 NCI 11369200
MYC 4609 THIOGUANINE CHEMBL727 NCI 1988936
MYC 4609 ANTIBIOTIC CHEMBL606111 NCI 2654492
MYC 4609 BRYOSTATIN CHEMBL449158 NCI 10918054
MYC 4609 CALCITRIOL CHEMBL846 NCI 15598784, 8490200
MYC 4609 HYPOXANTHINE CHEMBL1427 NCI 3528863
MYC 4609 NOVOBIOCIN CHEMBL36506 NCI 3528175
MYC 4609 QUINAPRIL CHEMBL1592 NCI 9370386
MYC 4609 SULINDAC CHEMBL15770 NCI 12414619
MYC 4609 THYROTROPIN CHEMBL1201532 NCI 3125035, 3726540
MYC 4609 CHEMBL100014 CHEMBL100014 NCI 8348968
MYC 4609 PERILLYL ALCOHOL CHEMBL236687 NCI 16439861
MYC 4609 ACIVICIN CHEMBL1231101 NCI 1596574, 1997162
MYC 4609 AMINOPTERIN CHEMBL376180 NCI 11410244
MYC 4609 IMATINIB CHEMBL941 NCI 15517875
MYC 4609 CILMOSTIM CHEMBL2108239 NCI 3877730
MYC 4609 MELATONIN CHEMBL45 NCI 7629697
MYC 4609 PHORBOL MYRISTATE ACETATE CHEMBL279115 NCI 10918054
MYC 4609 PREDNISONE CHEMBL635 NCI 11911117
MYC 4609 THROMBIN CHEMBL2108110 NCI 3023371
MYC 4609 CHEMBL1213492 CHEMBL1213492 NCI 15474507

Variant-drug associations (data source: PharmGKB)
Gene Name Variant Alleles Chemical Phenotype Category Significance Notes Sentence Publications Annotation ID
MYC rs4645943 CT + TT warfarin dosage yes This variant was found to be significant in the multivariate analysis and accounted for approximately 2.8% of variability in warfarin dose. Genotypes CT + TT is associated with increased dose of warfarin in people with heart valve replacement as compared to genotype CC. 26249541 1447680210
MYC rs4645962 CT warfarin dosage yes There were no CC homozygotes observed. "Patients with TC alleles of c-Myc rs4645962 required a 30% dose reduction compared with patients carrying TT alleles." Genotype CT is associated with decreased dose of warfarin in people with heart valve replacement as compared to genotype TT. 26249541 1447680201
MYC rs4645974 CC warfarin dosage yes This variant was found to be significant in the multivariate analysis and accounted for approximately 2.4% of variability in warfarin dose. Genotype CC is associated with increased dose of warfarin in people with heart valve replacement as compared to genotypes CT + TT. 26249541 1447680216