PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
RPA1	0	APEX1	1	affinity chromatography technology	Marechal A (2014)	1
LMNA	2	AGTRAP	1	two hybrid	Dittmer TA (2014)	1
MUTYH	1	MSH6	2	pull down, affinity chromatography technology	Gu Y (2002), Gu Y (2002)	2
MUTYH	1	PCNA	0	affinity chromatography technology, pull down	Parker A (2001), Parker A (2001)	2
RPA1	0	MSH2	4	affinity chromatography technology, biochemical	Marechal A (2014), Wan C (2015)	2
LMNA	2	MUTYH	1	two hybrid	Dittmer TA (2014)	1
MSH2	4	MSH6	2	biochemical, affinity chromatography technology, pull down, pull down, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, pull down, pull down, biochemical, affinity chromatography technology, imaging technique	Wang Y (2000), Wang Y (2003), Guerrette S (1998), Bocker T (1999), Bocker T (1999), Acharya S (1996), Matton N (2000), Matton N (2000), Yang Q (2004), Havugimana PC (2012), Gradia S (1997), Owen BA (2009), Wan C (2015), Hein MY (2015), Chen TC (2014)	15
HUWE1	22	PCNA	0	enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down	Markkanen E (2011), Thompson JW (2014), Choe KN (2016), Choe KN (2016), Choe KN (2016), Choe KN (2016)	6
NANOG	0	MUTYH	1	affinity chromatography technology	Oliviero G (2015)	1
PCNA	0	APEX1	1	pull down	Dianova II (2001)	1
MMS19	5	MUTYH	1	affinity chromatography technology	Stehling O (2012)	1
NANOG	0	HUWE1	22	affinity chromatography technology	Oliviero G (2015)	1
MUTYH	1	MSH2	4	pull down, affinity chromatography technology	Gu Y (2002), Gu Y (2002)	2
HUWE1	22	MUTYH	1	enzymatic study, pull down, affinity chromatography technology	Dorn J (2014), Dorn J (2014), Dorn J (2014)	3
NME4	0	MUTYH	1	affinity chromatography technology	Floyd BJ (2016)	1
PCNA	0	RPA1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ohta S (2002), Ogi T (2010), Takasaki Y (2001), Gong Z (2011), Miccoli L (2005), Han J (2014)	6
MUTYH	1	APEX1	1	affinity chromatography technology, pull down, unspecified method, pull down	Parker A (2001), Parker A (2001), Luncsford PJ (2013), Luncsford PJ (2013)	4
MUTYH	1	AGTRAP	1	two hybrid	Rolland T (2014)	1
MSH6	2	PCNA	0	far western blotting, affinity chromatography technology, unspecified method, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, far western blotting, affinity chromatography technology, biochemical, affinity chromatography technology	Kleczkowska HE (2001), Kleczkowska HE (2001), Clark AB (2000), Ohta S (2002), Jascur T (2011), Schoepf B (2012), Havugimana PC (2012), Dzantiev L (2004), Han J (2014), Wan C (2015), Hein MY (2015)	11
MUTYH	1	RPA1	0	affinity chromatography technology, pull down	Parker A (2001), Parker A (2001)	2
LMNA	2	RPA1	0	biochemical	Wan C (2015)	1
PCNA	0	MSH2	4	affinity chromatography technology, far western blotting	Ohta S (2002), Dzantiev L (2004)	2
LMNA	2	PCNA	0	two hybrid	Dittmer TA (2014)	1