Gene-drug interactions (data source: DGIdb)
Gene Name Entrez ID Drug Name Chembl ID Interaction Types Sources publications
MTR 4548 CYANOCOBALAMIN CHEMBL2110563 cofactor DrugBank 19904199, 18709879
MTR 4548 SULFASALAZINE CHEMBL421 PharmGKB
MTR 4548 METHIONINE CHEMBL42336 product of DrugBank 16788729, 16618098, 17615995, 17052662, 17222188
MTR 4548 FOLIC ACID CHEMBL1622 PharmGKB
MTR 4548 HYDROXOCOBALAMIN CHEMBL2103737 cofactor DrugBank 7599160, 18565, 9587031, 1744096, 3812589
MTR 4548 CYCLOPHOSPHAMIDE CHEMBL88 PharmGKB
MTR 4548 DACTINOMYCIN CHEMBL1554 PharmGKB
MTR 4548 VINCRISTINE CHEMBL90555 PharmGKB
MTR 4548 TETRAHYDROFOLATE CHEMBL2074655 cofactor DrugBank 11237340, 10978155, 9398303, 11169015, 9730838

Variant-drug associations (data source: PharmGKB)
Gene Name Variant Alleles Chemical Phenotype Category Significance Notes Sentence Publications Annotation ID
MTR rs1805087 A folic acid efficacy yes Allele A is associated with increased response to folic acid, hydroxychloroquine, methotrexate and sulfasalazine in people with Arthritis, Rheumatoid as compared to allele G. 18322994 769171236
MTR rs1805087 AG + GG benazepril efficacy yes Carriers of the G allele had a significantly smaller drop in diastolic blood pressure between baseline and after 15 days of treatment with benazepril, compared to AA homozygotes. Genotypes AG + GG are associated with decreased response to benazepril in people with Essential hypertension as compared to genotype AA. 15148588 982034333
MTR rs1805087 AG + GG benazepril efficacy no No significant differences in the reduction of systolic blood pressure were seen between the genotypes. Change in systolic blood pressure was measured between baseline and after 15 days of treatment with benazepril. Genotypes AG + GG are not associated with response to benazepril in people with Essential hypertension as compared to genotype AA. 15148588 982034351
MTR rs1805087 AA methotrexate efficacy yes Non-response was classified by DAS28 >3.2 at two consecutive evaluations (minimum period of at least 6 months of MTX therapy). Genotype AA is associated with decreased response to methotrexate in people with Arthritis, Rheumatoid as compared to genotypes AG + GG. 27676277 1448266150
MTR rs1805087 A methotrexate toxicity no Discontinuation due to adverse effects. Allele A is not associated with discontinuation of methotrexate in people with Arthritis, Rheumatoid as compared to allele G. 27217051 1449164942