Gene Name	Entrez ID	Drug Name	Chembl ID	Interaction Types	Sources	publications
MTTP	4547	LOMITAPIDE	CHEMBL354541	antagonist, inhibitor	TdgClinicalTrial, DrugBank, TTD
MTTP	4547	IMPLITAPIDE	CHEMBL2105804	inhibitor	TdgClinicalTrial, DrugBank, TTD	15684478
MTTP	4547	LOMITAPIDE MESYLATE	CHEMBL2105662	inhibitor	ChemblInteractions
MTTP	4547	HESPERETIN	CHEMBL399121	antagonist	DrugBank	11352979

Gene Name	Variant	Alleles	Chemical	Phenotype Category	Significance	Notes	Sentence	Publications	Annotation ID
MTTP	rs1800591	TT	atorvastatin	efficacy	no	No association was seen between genotype and plasma lipids or apolipoprotein B levels after atorvastatin treatment in women. Log triglyceride levels were significantly lower in women with the TT genotype compared to other genotypes, both before and after treatment. This variant was described as MTP -493 GT.	Genotype TT is not associated with increased response to atorvastatin in women with Hyperlipoproteinemia Type II as compared to genotype GG.	15864113	982042181
MTTP	rs1800591	TT	atorvastatin	efficacy	yes	as measured by a larger decreased in log triglyceride levels, compared to patients with the GT and GG genotypes which was minimal. Changes in other parameters were not significantly associated with genotype. This variant was described as MTP -493 GT.	Genotype TT is associated with increased response to atorvastatin in men with Hyperlipoproteinemia Type II.	15864113	982042116
MTTP	rs1800591	GT + TT	pravastatin	efficacy	not stated	In the placebo treated group, men with the TT and GT genotypes had a significantly increased risk of coronary heart disease events compared to those with the GG genotype. This risk was not seen in men with the TT and GT genotypes who were treated with pravastatin, indicating the drug was beneficial in patients with these genotypes. This variant was described as MTP -493G/T.	Genotypes GT + TT are associated with response to pravastatin in men.	15136504	982041062