PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
MSH4	1	VCP	6	affinity chromatography technology	Xu Y (2013)	1
VHL	0	VBP1	0	two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology	Tsuchiya H (1996), Zhou MI (2002), Tsuchiya H (1996), Xu Y (2013)	4
MSH5	2	MSH4	1	two hybrid, two hybrid, two hybrid, two hybrid, pull down, pull down, affinity chromatography technology, pull down, affinity chromatography technology	Her C (2003), Her C (2003), Winand NJ (1998), Winand NJ (1998), Bocker T (1999), Bocker T (1999), Lee TH (2006), Yi W (2006), Yi W (2006)	9
MSH5	2	GPS2	0	two hybrid, far western blotting, pull down, affinity chromatography technology	Lee TH (2006), Lee TH (2006), Lee TH (2006), Lee TH (2006)	4
MSH4	1	EIF3F	1	two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, pull down	Chu YL (2013), Chu YL (2013), Chu YL (2013), Chu YL (2013), Chu YL (2013)	5
MSH4	1	GPS2	0	two hybrid, far western blotting, pull down, affinity chromatography technology	Lee TH (2006), Lee TH (2006), Lee TH (2006), Lee TH (2006)	4
MLH1	6	MSH4	1	affinity chromatography technology, pull down	Santucci-Darmanin S (2000), Santucci-Darmanin S (2000)	2
MSH4	1	VHL	0	affinity chromatography technology	Xu Y (2013)	1
MSH4	1	RPA1	0	imaging technique	Moens PB (2002)	1
MSH4	1	VBP1	0	two hybrid, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology	Her C (2003), Her C (2003), Her C (2003), Xu Y (2013), Xu Y (2013)	5
RAD51	3	RPA1	0	pull down, two hybrid	Sugiyama T (2002), Du Y (2009)	2
MSH4	1	RAD51	3	imaging technique	Moens PB (2002)	1
MLH3	0	MLH1	6	two hybrid, pull down, two hybrid	Kondo E (2001), Ranjha L (2014), Daakour S (2016)	3
MLH3	0	MSH4	1	affinity chromatography technology, pull down	Santucci-Darmanin S (2002), Santucci-Darmanin S (2002)	2
VBP1	0	VCP	6	affinity chromatography technology, affinity chromatography technology	Xu Y (2013), Xu Y (2013)	2