PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
FBXO7	1	MPP3	0	enzymatic study	Teixeira FR (2016)	1
MPP3	0	LIN7A	1	two hybrid	Rolland T (2014)	1
MPP3	0	TRAF2	1	two hybrid	Rolland T (2014)	1
MPP3	0	MDH1	0	two hybrid	Stelzl U (2005)	1
ARL2BP	0	MPP3	0	two hybrid	Wang J (2011)	1
TRIM25	5	APP	1	affinity chromatography technology	Choudhury NR (2017)	1
HSH2D	1	MPP3	0	two hybrid	Wang J (2011)	1
MCM2	3	TRIM25	5	affinity chromatography technology	Drissi R (2015)	1
TRIM25	5	FBXO7	1	affinity chromatography technology	Choudhury NR (2017)	1
SRPK2	1	MPP3	0	enzymatic study	Varjosalo M (2013)	1
MPP3	0	NOA1	1	two hybrid	Stelzl U (2005)	1
MCM2	3	EZR	8	affinity chromatography technology	Drissi R (2015)	1
MPP3	0	ZPR1	1	two hybrid	Wang J (2011)	1
CADM1	3	MPP3	0	two hybrid, affinity chromatography technology, pull down	Fukuhara H (2003), Fukuhara H (2003), Fukuhara H (2003)	3
TRIM25	5	RPS2	3	affinity chromatography technology, affinity chromatography technology	Choudhury NR (2017), Choudhury NR (2017)	2
MPP3	0	PLK2	0	two hybrid	Stelzl U (2005)	1
MPP3	0	TIRAP	1	two hybrid	Wang J (2011)	1
MPP3	0	RRAGC	3	two hybrid	Wang J (2011)	1
TRAF2	1	FBXO7	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kuiken HJ (2012), Chen CM (2014), Huttlin EL (2017)	3
MPP3	0	CCDC137	1	two hybrid	Stelzl U (2005)	1
MPP3	0	RPS2	3	two hybrid	Stelzl U (2005)	1
LIN7A	1	APP	1	pull down	Olah J (2011)	1
FBXO7	1	RPS2	3	affinity chromatography technology, enzymatic study	Teixeira FR (2016), Teixeira FR (2016)	2
TRIM25	5	SRPK2	1	affinity chromatography technology	Choudhury NR (2017)	1
TRIM25	5	MDH1	0	affinity chromatography technology, affinity chromatography technology	Choudhury NR (2017), Choudhury NR (2017)	2
TRIM25	5	L3MBTL2	1	affinity chromatography technology	Choudhury NR (2017)	1
MPP3	0	APP	1	pull down	Olah J (2011)	1
TRIM25	5	EZR	8	affinity chromatography technology	Choudhury NR (2017)	1
LIN7A	1	CADM1	3	affinity chromatography technology	Hauri S (2013)	1
ERBIN	5	MPP3	0	unspecified method	Boisguerin P (2004)	1
TRIM25	5	MPP3	0	affinity chromatography technology	Choudhury NR (2017)	1
FBXO7	1	MCM2	3	enzymatic study	Teixeira FR (2016)	1
MCM2	3	APP	1	pull down	Olah J (2011)	1
MPP3	0	GNG7	0	two hybrid	Stelzl U (2005)	1
FAM171B	3	MPP3	0	two hybrid	Wang J (2011)	1
SRPK2	1	APP	1	pull down	Olah J (2011)	1
APP	1	TIRAP	1	two hybrid	Wang J (2011)	1
MPP3	0	MCM2	3	two hybrid	Stelzl U (2005)	1
PLK2	0	APP	1	pull down	Olah J (2011)	1
L3MBTL2	1	MPP3	0	two hybrid	Wang J (2011)	1
MPP3	0	SNTG2	2	two hybrid	Rolland T (2014)	1
EZR	8	MPP3	0	two hybrid	Wang J (2011)	1
MPP3	0	HAP1	1	two hybrid	Stelzl U (2005)	1
LIN7C	0	MPP3	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
MPP3	0	KRTAP10-3	1	two hybrid	Rolland T (2014)	1
MPP3	0	TMEM37	2	two hybrid	Wang J (2011)	1