PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
TIMP2	1	MMP14	0	affinity chromatography technology, pull down, pull down	Zucker S (1998), Zucker S (1998), Sato H (1996)	3
MMP14	0	RRAD	2	two hybrid	Wang J (2011)	1
MMP14	0	TIMP1	0	pull down	Sato H (1996)	1
MMP14	0	MMP3	2	pull down, enzymatic study	Sato H (1996), Sato H (1996)	2
FURIN	2	MMP14	0	enzymatic study, pull down	Sato H (1996), Sato H (1996)	2
SPOCK3	4	MMP14	0	affinity chromatography technology, affinity chromatography technology	Nakada M (2001), Nakada M (2001)	2
MMP14	0	PLLP	0	two hybrid	Wang J (2011)	1
MMP14	0	C1QBP	0	unspecified method	Rozanov DV (2002)	1
TIMP1	0	MMP3	2	x-ray crystallography	Gomis-Rueth FX (1997)	1
LRP1	25	MMP14	0	affinity chromatography technology	Rozanov DV (2004)	1
SPOCK3	4	MMP3	2	affinity chromatography technology	Nakada M (2001)	1
BCAR1	6	MMP14	0	affinity chromatography technology	Gingras D (2008)	1
MMP14	0	CCDC155	2	two hybrid	Rolland T (2014)	1
MMP14	0	LUM	0	enzymatic study	Li Y (2004)	1