PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
CIITA	4	TBP	0	affinity chromatography technology	Beaulieu YB (2016)	1
HDAC1	4	EP400	19	biochemical	Wan C (2015)	1
PML	7	CCNT1	3	affinity chromatography technology, pull down, fluorescent resonance energy transfe, imaging technique	Marcello A (2003), Marcello A (2003), Marcello A (2003), Forlani G (2017)	4
EP300	36	CDK1	0	affinity chromatography technology, enzymatic study	Wang SA (2014), Wang SA (2014)	2
PSMC3	0	CIITA	4	affinity chromatography technology	Bhat KP (2010)	1
EP400	19	HDAC2	1	biochemical	Wan C (2015)	1
CIITA	4	GTF2B	1	pull down	Mahanta SK (1997)	1
SMARCA4	19	HDAC2	1	biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, genetic interference	Sif S (2001), Qiu Z (2008), Xu Z (2006), Pal S (2003), Battaglioli E (2002), Tando T (2010), Hang CT (2010), Shen JP (2017)	8
HDAC4	10	CIITA	4	affinity chromatography technology, affinity chromatography technology	Wang AH (2005), Wang AH (2005)	2
CIITA	4	SIN3B	5	affinity chromatography technology	Xu Y (2008)	1
HDAC5	4	CIITA	4	affinity chromatography technology	Wang AH (2005)	1
HDAC1	4	SIN3B	5	biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Zhang Y (1999), Koipally J (1999), Romm E (2005), Humphrey GW (2001), Terhune SS (2010), Joshi P (2013), Wan C (2015), Hein MY (2015), Hein MY (2015), Huttlin EL (2017)	10
CIITA	4	HDAC2	1	affinity chromatography technology, enzymatic study, pull down, affinity chromatography technology	Kong X (2009), Kong X (2009), Zika E (2003), Xu Y (2008)	4
CCNT1	3	KAT2B	2	pull down	Bres V (2002)	1
HDAC5	4	PSMC5	4	affinity chromatography technology	Greco TM (2011)	1
EP300	36	HDAC1	4	affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology	Han Y (2008), Mayanil CS (2006), Simone C (2004), Simone C (2004), Simone C (2004), Liu Y (2012), Mizuguchi Y (2012)	7
PSMC3	0	PSMC5	4	pull down, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology	Ishizuka T (2001), Ishizuka T (2001), Um JW (2010), Lee SH (2012), Lee SH (2012), Divald A (2010), Havugimana PC (2012), Huttlin EL (2015), Wan C (2015), Huttlin EL (2017)	10
HDAC5	4	CDK1	0	affinity chromatography technology	Greco TM (2011)	1
XPO1	8	CIITA	4	pull down, affinity chromatography technology	Raval A (2003), Voong LN (2008)	2
KAT2B	2	TAF9	2	affinity chromatography technology, affinity chromatography technology	Ogryzko VV (1998), Ogryzko VV (1998)	2
CUL3	17	PSMC2	2	affinity chromatography technology	Bennett EJ (2010)	1
HDAC1	4	HDAC2	1	biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, imaging technique, affinity chromatography technology	Hakimi MA (2002), Yao YL (2003), Yao YL (2003), Hakimi MA (2003), Fischle W (2002), Johnson CA (2002), Fischle W (2001), Fischer DD (2002), Fischer DD (2002), Ashburner BP (2001), Zhang Y (1999), Tong JK (1998), Tong JK (1998), Hassig CA (1998), Hassig CA (1998), Zhang Y (1997), van der Vlag J (1999), van der Vlag J (1999), Noh EJ (2009), Noh EJ (2009), Galasinski SC (2002), Galasinski SC (2002), Galasinski SC (2002), He S (2005), Humphrey GW (2001), Park JH (2004), Park JH (2004), Sekhavat A (2007), Zhang Y (1998), Zhang Y (1998), Adenuga D (2010), Xue Y (1998), Xue Y (1998), Martinez FP (2012), Martinez FP (2012), Cui S (2011), Havugimana PC (2012), Bantscheff M (2011), Bantscheff M (2011), Joshi P (2013), Joshi P (2013), Schnur N (2007), Schnur N (2007), Oh YM (2009), Wan C (2015), Hein MY (2015), Chen TC (2014), Huttlin EL (2017)	48
TRIM22	2	CCNT1	3	imaging technique	Forlani G (2017)	1
EP300	36	KAT2B	2	enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kiernan R (2003), Kim JH (2011), Lee M (2010), Santos-Rosa H (2003), Yang XJ (1996), Yang XJ (1996), Yang XJ (1996), Mizuguchi Y (2012)	8
HDAC1	4	PML	7	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, pull down, pull down, affinity chromatography technology, imaging technique, affinity chromatography technology	Khan MM (2001), Khan MM (2001), Wu WS (2001), Wu WS (2001), Wu WS (2001), Wu WS (2001), Wu WS (2001), Morey L (2008), Kuo HY (2013), Kim YE (2015)	10
RFXANK	0	RFX5	0	two hybrid, unspecified method, x-ray crystallography, affinity chromatography technology, affinity chromatography technology	Nekrep N (2000), Xu C (2012), Xu C (2012), Nie J (2015), Huttlin EL (2017)	5
RFXANK	0	CIITA	4	pull down, affinity chromatography technology, affinity chromatography technology	Nekrep N (2001), Nekrep N (2001), Hake SB (2000)	3
CIITA	4	MAPK3	4	affinity chromatography technology	Voong LN (2008)	1
HDAC4	10	MAPK1	1	affinity chromatography technology, enzymatic study	Zhou X (2000), Zhou X (2000)	2
HDAC4	10	RFXANK	0	pull down, affinity chromatography technology, unspecified method	Wang AH (2005), Wang AH (2005), Xu C (2012)	3
TBP	0	EP300	36	affinity chromatography technology	Dallas PB (1997)	1
PML	7	MAPK1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Warren DT (2010), Lim JH (2011), Lim JH (2011)	3
HDAC4	10	MAPK3	4	affinity chromatography technology, enzymatic study	Zhou X (2000), Zhou X (2000)	2
CUL3	17	PSMC5	4	affinity chromatography technology	Bennett EJ (2010)	1
PPARG	0	HDAC4	10	pull down, affinity chromatography technology, pull down	Franco PJ (2003), Yang Y (2011), Yang Y (2011)	3
TBP	0	TAF9	2	biochemical, affinity chromatography technology, pull down, affinity chromatography technology, biochemical	Bellorini M (1997), Martinez E (2001), Knuesel MT (2009), Liu X (2008), Havugimana PC (2012)	5
HDAC1	4	TBP	0	affinity chromatography technology	Wu Y (2001)	1
HDAC1	4	CIITA	4	pull down	Zika E (2003)	1
CDK1	0	CIITA	4	enzymatic study	Voong LN (2008)	1
PPARG	0	SMARCA4	19	affinity chromatography technology	Debril MB (2004)	1
PSMC2	2	PSMC5	4	biochemical, biochemical, affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, affinity chromatography technology	Tipler CP (1997), Kim YC (2011), Lee SH (2012), Lee SH (2012), Havugimana PC (2012), Wan C (2015), Huttlin EL (2017)	7
GSK3B	1	HDAC4	10	enzymatic study	Cernotta N (2011)	1
CUL3	17	SMARCA4	19	affinity chromatography technology	Bennett EJ (2010)	1
NCOA1	6	TBP	0	pull down	Takeshita A (1996)	1
HDAC5	4	RFXANK	0	pull down, affinity chromatography technology	Wang AH (2005), Wang AH (2005)	2
CIITA	4	CCNT1	3	imaging technique	Forlani G (2017)	1
HDAC2	1	PML	7	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Wu WS (2001), Morey L (2008), Kraemer OH (2008), Kim YE (2015)	4
MAPK3	4	MAPK1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology	Varjosalo M (2013), Varjosalo M (2013), Wang J (2009), Wang J (2009), Wan C (2015), Hu B (2006)	6
GTF2B	1	TBP	0	biochemical, pull down, x-ray crystallography, pull down, x-ray crystallography, x-ray crystallography, pull down	Scully R (1997), Scully R (1997), Bushnell DA (2004), Friedman MJ (2007), Tsai FT (2000), Bagby S (1995), Lin Y (1997)	7
TAF9	2	GTF2B	1	two hybrid, pull down, pull down	Muscat GE (1998), Muscat GE (1998), Muscat GE (1998)	3
SIN3B	5	SMARCA4	19	pull down	Pal S (2003)	1
RFX5	0	HDAC4	10	affinity chromatography technology	Wang AH (2005)	1
MAPK1	1	PPARG	0	affinity chromatography technology, affinity chromatography technology	Jahrling JB (2014), Chen F (2003)	2
EP300	36	GTF2B	1	pull down	Felzien LK (1999)	1
CIITA	4	RFX5	0	affinity chromatography technology, two hybrid, far western blotting, pull down, affinity chromatography technology	Hake SB (2000), Scholl T (1997), Scholl T (1997), Zika E (2003), Beaulieu YB (2016)	5
PPARG	0	NCOA1	6	fluorescent resonance energy transfe, pull down, affinity chromatography technology, pull down, two hybrid, two hybrid, two hybrid, two hybrid, pull down, x-ray crystallography, unspecified method, pull down, two hybrid, pull down, two hybrid, pull down, two hybrid, pull down, unspecified method	Iannone MA (2001), Yang W (2000), Feige JN (2007), DiRenzo J (1997), Needham M (2000), Heinlein CA (1999), Qin C (2004), Chan CM (2013), Chou WL (2007), Nolte RT (1998), Lee G (2002), Agostini M (2006), Waku T (2010), Waku T (2010), Carmona MC (2007), Molnar F (2005), Chintharlapalli S (2007), Jeninga EH (2007), Koppen A (2009)	19
RFX5	0	HDAC2	1	affinity chromatography technology	Xu Y (2006)	1
NCOA1	6	GTF2B	1	pull down	Takeshita A (1996)	1
CIITA	4	EP300	36	affinity chromatography technology	Beaulieu YB (2016)	1
HDAC5	4	HDAC4	10	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Backs J (2008), Backs J (2008), Rui J (2012), Rui J (2012)	4
PSMC2	2	TBP	0	affinity chromatography technology	Yanagi S (2000)	1
SMARCA4	19	CIITA	4	pull down, pull down	Mudhasani R (2002), Mudhasani R (2002)	2
RFX5	0	PPARG	0	affinity chromatography technology, affinity chromatography technology	Xu Y (2007), Xu Y (2007)	2
KAT2B	2	CIITA	4	affinity chromatography technology, enzymatic study	Morgan JE (2017), Morgan JE (2017)	2
XPO1	8	PPARG	0	affinity chromatography technology	von Knethen A (2010)	1
MAPK1	1	CIITA	4	enzymatic study, affinity chromatography technology, affinity chromatography technology	Voong LN (2008), Voong LN (2008), Voong LN (2008)	3
CIITA	4	PPARG	0	affinity chromatography technology, affinity chromatography technology	Xu Y (2007), Xu Y (2007)	2
PML	7	MAPK3	4	affinity chromatography technology	Warren DT (2010)	1
CDK1	0	PML	7	enzymatic study	Yuan WC (2011)	1
SMARCA4	19	EP400	19	biochemical	Wan C (2015)	1
HDAC5	4	HDAC1	4	affinity chromatography technology	Greco TM (2011)	1
CUL3	17	CIITA	4	affinity chromatography technology	Wimuttisuk W (2014)	1
PML	7	PPARG	0	two hybrid	Ravasi T (2010)	1
PSMC2	2	CIITA	4	affinity chromatography technology	Bhat KP (2010)	1
XPO1	8	GSK3B	1	affinity chromatography technology	Kirli K (2015)	1
PPARG	0	HDAC1	4	pull down, affinity chromatography technology, affinity chromatography technology	Yoo EJ (2006), Yoo EJ (2006), Pancione M (2010)	3
SIN3B	5	HDAC2	1	affinity chromatography technology, affinity chromatography technology	Romm E (2005), Bantscheff M (2011)	2
EP300	36	PPARG	0	pull down, fluorescent resonance energy transfe, affinity chromatography technology, pull down, two hybrid, fluorescent resonance energy transfe, affinity chromatography technology, pull down, affinity chromatography technology, unspecified method, unspecified method, affinity chromatography technology	Fajas L (2002), Iannone MA (2001), Gelman L (1999), Gelman L (1999), Gelman L (1999), Feige JN (2007), Feige JN (2007), Debril MB (2004), Subbaramaiah K (2012), Lee G (2002), Koppen A (2009), Wang C (2001)	12
NCOA1	6	KAT2B	2	pull down, two hybrid, affinity chromatography technology, two hybrid, pull down	Spencer TE (1997), Spencer TE (1997), Korzus E (1998), Korzus E (1998), Jenster G (1997)	5
PSMC2	2	GTF2B	1	affinity chromatography technology	Yanagi S (2000)	1
PSMC2	2	PSMC3	0	biochemical, biochemical, affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, biochemical, affinity chromatography technology	Tipler CP (1997), Kim YC (2011), Lee SH (2012), Lee SH (2012), Havugimana PC (2012), Kristensen AR (2012), Wan C (2015), Huttlin EL (2017)	8
PSMC5	4	CIITA	4	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology	Bhat KP (2010), Bhat KP (2010), Bhat KP (2008), Bhat KP (2008), Bhat KP (2008), Beaulieu YB (2016)	6
HDAC1	4	SMARCA4	19	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, genetic interference	Qiu Z (2008), Battaglioli E (2002), Hang CT (2010), DiRenzo J (2000)	4
TRIM22	2	CIITA	4	affinity chromatography technology, imaging technique	Forlani G (2017), Forlani G (2017)	2
HDAC5	4	XPO1	8	affinity chromatography technology, affinity chromatography technology	Greco TM (2011), Kirli K (2015)	2
SMARCA4	19	PML	7	imaging technique	Chuang YS (2011)	1
SMARCA4	19	NCOA1	6	genetic interference	DiRenzo J (2000)	1
CIITA	4	TAF9	2	pull down	Mahanta SK (1997)	1
EP300	36	MAPK1	1	affinity chromatography technology, enzymatic study, enzymatic study	Chen YJ (2007), Chen YJ (2007), Sang N (2003)	3
PSMC2	2	XPO1	8	biochemical	Havugimana PC (2012)	1
MAPK1	1	GSK3B	1	affinity chromatography technology, pull down, enzymatic study	Ding Q (2005), Ding Q (2005), Ding Q (2005)	3
TRIM22	2	PML	7	imaging technique	Forlani G (2017)	1
GSK3B	1	CIITA	4	enzymatic study	Xu Y (2008)	1
CIITA	4	NCOA1	6	affinity chromatography technology, pull down	Tzortzakaki E (2003), Tzortzakaki E (2003)	2
CIITA	4	EP400	19	affinity chromatography technology	Beaulieu YB (2016)	1
CIITA	4	PML	7	imaging technique	Forlani G (2017)	1
NCOA1	6	EP300	36	affinity chromatography technology, imaging technique, pull down, pull down	Matsuda S (2004), Wang F (2010), Kino T (2002), Nasrin N (2000)	4