PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
PAX1	0	MEOX2	2	two hybrid, pull down	Stamataki D (2001), Stamataki D (2001)	2
PRKAB2	0	MEOX2	2	two hybrid, two hybrid	Corominas R (2014), Rolland T (2014)	2
CNTNAP2	5	MEOX2	2	two hybrid, two hybrid	Corominas R (2014), Rolland T (2014)	2
MEOX2	2	RNF10	0	two hybrid, pull down, affinity chromatography technology	Lin J (2005), Lin J (2005), Lin J (2005)	3
PAX3	6	MEOX2	2	two hybrid, pull down	Stamataki D (2001), Stamataki D (2001)	2
MEOX1	0	MEOX2	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
PAX1	0	MEOX1	0	two hybrid, pull down	Stamataki D (2001), Stamataki D (2001)	2
MEOX2	2	IKBKB	1	affinity chromatography technology, affinity chromatography technology	Chen Y (2010), Chen Y (2010)	2
PAX3	6	MEOX1	0	two hybrid, pull down	Stamataki D (2001), Stamataki D (2001)	2