PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
BIRC2	1	MAP3K2	1	enzymatic study	Takeda AN (2014)	1
XPO1	8	YWHAG	5	affinity chromatography technology	Kirli K (2015)	1
TRAF6	0	HSPA4	3	affinity chromatography technology, enzymatic study, affinity chromatography technology	Chen H (2006), Pridgeon JW (2004), Chen H (2006)	3
MAP3K3	3	MARK2	6	affinity chromatography technology	Bouwmeester T (2004)	1
RIPK1	2	BIRC2	1	affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, pull down, pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study	Bertrand MJ (2008), Bertrand MJ (2008), Xu M (2009), Dynek JN (2010), Dynek JN (2010), Bertrand MJ (2011), Bertrand MJ (2011), Bertrand MJ (2011), Puliyappadamba VT (2013), Fu J (2016), Vu NT (2016), Vu NT (2016)	12
RIPK1	2	HSP90AA1	7	affinity chromatography technology, affinity chromatography technology	Fearns C (2006), Taipale M (2012)	2
BRCA1	7	XIAP	0	affinity chromatography technology, pull down	Martin SA (2005), Martin SA (2005)	2
MAP3K3	3	VWF	11	two hybrid	Bandyopadhyay S (2010)	1
BIRC2	1	XIAP	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Silke J (2005), Rajalingam K (2006), Rajalingam K (2006), Oberoi-Khanuja TK (2012), Huttlin EL (2017)	5
SMURF1	4	XPO1	8	affinity chromatography technology	Tajima Y (2003)	1
CDC37	0	SQSTM1	0	two hybrid, affinity chromatography technology	Vinayagam A (2011), Li J (2013)	2
PDRG1	1	PFDN2	1	biochemical, affinity chromatography technology	Havugimana PC (2012), Huttlin EL (2017)	2
FUS	0	MAP3K3	3	affinity chromatography technology	Wang T (2014)	1
CDC37	0	MTOR	14	two hybrid	Vinayagam A (2011)	1
MAP3K3	3	GAB1	3	affinity chromatography technology, pull down	Che W (2002), Che W (2002)	2
CHUK	5	RIPK1	2	biochemical	Poyet JL (2000)	1
MAP3K7	2	MAP2K4	3	enzymatic study, affinity chromatography technology	Ge B (2003), Li MG (2003)	2
GTF2I	1	TRAF6	0	two hybrid	Corominas R (2014)	1
SPAG9	5	MAP3K3	3	affinity chromatography technology	Lee CM (2002)	1
MAP3K7	2	IRAK1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Liu XY (2008), Jiang Z (2002), Jiang Z (2002), Lee HJ (2012), Yao J (2007)	5
HSP90AA1	7	BRCA1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Johnson N (2013), Johnson N (2013), Ertych N (2016)	3
BRCA1	7	YWHAE	0	affinity chromatography technology	Ertych N (2016)	1
EGFR	5	XIAP	0	affinity chromatography technology	Yao Z (2017)	1
YWHAE	0	CBY1	3	affinity chromatography technology	Boldt K (2016)	1
SQSTM1	0	RIPK1	2	pull down, affinity chromatography technology, affinity chromatography technology	Sanz L (1999), Sanz L (1999), Sanz L (1999)	3
EGFR	5	HSPA4	3	protein complementation assay, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, protein complementation assay	Deribe YL (2009), Deribe YL (2009), Citri A (2002), Tong J (2008), Kotlyar M (2015), Petschnigg J (2014)	6
NEDD4L	3	MAP3K2	1	enzymatic study	Persaud A (2009)	1
YWHAG	5	COPS5	0	two hybrid	Bandyopadhyay S (2010)	1
MAP3K3	3	IRAK1	1	affinity chromatography technology	Yao J (2007)	1
MAP3K3	3	FLNA	10	imaging technique	Chen TC (2014)	1
MAP3K3	3	NBR1	0	affinity chromatography technology, affinity chromatography technology	Hernandez ED (2014), Hernandez ED (2014)	2
BRCA1	7	SPAG9	5	affinity chromatography technology	Ertych N (2016)	1
SQSTM1	0	NBR1	0	affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down	DAgostino C (2011), Lange S (2005), Lamark T (2003), Lamark T (2003), Yang JQ (2010), Erdogan E (2006), Yamashita SI (2014), Nicot AS (2014)	8
NEDD4L	3	KIFC3	3	pull down	Persaud A (2009)	1
TRAF6	0	XIAP	0	affinity chromatography technology, two hybrid, imaging technique	Sanna MG (2002), Woodsmith J (2012), Chen TC (2014)	3
MAP3K7	2	HSP90AA1	7	affinity chromatography technology	Liu XY (2008)	1
MAP3K2	1	TRAF7	11	affinity chromatography technology	Hein MY (2015)	1
CHUK	5	TRAF6	0	affinity chromatography technology	Kishida S (2005)	1
HSP90AA1	7	XPO1	8	affinity chromatography technology	Falsone SF (2005)	1
MAP3K2	1	MAP2K3	1	enzymatic study	Deacon K (1997)	1
EGFR	5	MAP3K3	3	two hybrid, protein complementation assay	Kotlyar M (2015), Petschnigg J (2014)	2
BIRC2	1	EGFR	5	affinity chromatography technology	Puliyappadamba VT (2013)	1
BRCA1	7	XPO1	8	affinity chromatography technology	Ertych N (2016)	1
IRAK1	1	CHUK	5	affinity chromatography technology, affinity chromatography technology	Vig E (2001), Windheim M (2008)	2
MAP3K2	1	MAP2K7	5	affinity chromatography technology, biochemical, enzymatic study	Cheng J (2000), Cheng J (2000), Takeda AN (2014)	3
NEDD4L	3	MAP3K3	3	enzymatic study	Persaud A (2009)	1
SPAG9	5	MAP2K4	3	affinity chromatography technology	Lee CM (2002)	1
NEDD4	2	MAP3K2	1	enzymatic study, pull down	Persaud A (2009), Persaud A (2009)	2
SQSTM1	0	MTOR	14	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Duran A (2011), Linares JF (2015), Linares JF (2015)	3
MAP2K5	1	TRAF7	11	affinity chromatography technology	Huttlin EL (2017)	1
HSP90AA1	7	HSPA4	3	affinity chromatography technology, biochemical, affinity chromatography technology, biochemical	Kim TS (2006), Hidalgo-de-Quintana J (2008), Skarra DV (2011), Wan C (2015)	4
TRAF6	0	IRAK1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology	Wesche H (1999), Qian Y (2001), Cao Z (1996), Takatsuna H (2003), Li S (2002), Ling L (2000), Ling L (2000), Takaesu G (2001), Muzio M (1997), Chen F (2008), Li X (2001), Li X (2001), Xiong Y (2011), Xiong Y (2011), Tang H (2010), Muroi M (2011), Liu A (2012), Lee JY (2009), Lee JY (2009), Kollewe C (2004), Jiang Z (2002), Jensen LE (2001), Liu G (2007), Liu G (2007), Jiang Z (2003), Nguyen T (2009), Choi KC (2006), Rao N (2005), Rao N (2005), Lakshmanan U (2007), Lee HJ (2012), Lee HJ (2012), Zhang X (2013), Yao J (2007), Hu MM (2014), Jeon J (2014), Conze DB (2008), Tanishima M (2017)	38
NEDD4	2	KIFC3	3	pull down	Persaud A (2009)	1
FUS	0	HSP90AA1	7	affinity chromatography technology	Wang T (2014)	1
EGFR	5	HSP90AA1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, protein complementation assay	Citri A (2002), Yang S (2006), Shimamura T (2005), Lavictoire SJ (2003), Lavictoire SJ (2003), Foerster S (2013), Kotlyar M (2015), Petschnigg J (2014)	8
SQSTM1	0	MAP3K3	3	affinity chromatography technology, pull down, affinity chromatography technology, imaging technique, pull down, affinity chromatography technology	Nakamura K (2010), Nakamura K (2010), Nakamura K (2010), Nakamura K (2010), Nakamura K (2010), Yamazaki K (2009)	6
CHUK	5	MTOR	14	affinity chromatography technology, affinity chromatography technology, biochemical	Dan HC (2008), Dan HC (2008), Dan HC (2008)	3
TRAF6	0	MAP3K7	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study	Ishitani T (2003), Takaesu G (2000), Ninomiya-Tsuji J (1999), Takaesu G (2001), Mochida Y (2000), Mochida Y (2000), Walsh MC (2008), Sorrentino A (2008), Frobose H (2006), Ishitani T (2003), Xia ZP (2009), Jiang Z (2003), Jiang Z (2003), Yamazaki K (2009), Yamazaki K (2009), Jiang Z (2002), Jiang Z (2002), Cui W (2012), Jiang Z (2003), Minoda Y (2009), Gao D (2009), Lee HJ (2012), Hirata Y (2006), Hu MM (2014), Fujikawa H (2013), Sun D (2011), Li W (2015), Lin J (2015), Lee Y (2016), Ji YX (2016), Ji YX (2016), Ji YX (2016), Ji YX (2016)	33
XPO1	8	PRKACA	2	affinity chromatography technology	Kirli K (2015)	1
EGFR	5	RIPK1	2	affinity chromatography technology	Habib AA (2001)	1
PPP2CA	7	CHUK	5	affinity chromatography technology	Kray AE (2005)	1
SQSTM1	0	MBP	0	pull down	Pridgeon JW (2004)	1
SMURF1	4	PPP2CA	7	affinity chromatography technology	Xie Y (2013)	1
CHUK	5	CDC37	0	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Chen G (2002), Li S (2011), Taipale M (2014), Taipale M (2014), Li J (2013)	5
MAP3K7	2	CHUK	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique	Sakurai H (1999), Ninomiya-Tsuji J (1999), Lin X (1998), Lin X (1998), Ear T (2010), Huangfu WC (2006), Chen TC (2014)	7
NEDD4L	3	MARK2	6	enzymatic study	Persaud A (2009)	1
XPO1	8	CHUK	5	affinity chromatography technology	Kirli K (2015)	1
RIPK1	2	MAP3K7	2	affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bertrand MJ (2008), Li H (2006), Yang Y (2011), Yang Y (2011), Yang Y (2011), Hu MM (2014)	6
HSPA4	3	MTOR	14	affinity chromatography technology, affinity chromatography technology	Martin J (2008), Martin J (2008)	2
YWHAG	5	MAP3K2	1	affinity chromatography technology, affinity chromatography technology	Jin J (2004), Hein MY (2015)	2
XPO1	8	IRAK1	1	affinity chromatography technology	Kirli K (2015)	1
MAP2K5	1	CDC37	0	affinity chromatography technology	Huttlin EL (2017)	1
TRAF6	0	SQSTM1	0	affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sanz L (2000), Sanz L (2000), Nakamura K (2010), Kim JY (2009), Seibenhener ML (2004), Feng Y (2005), Martin P (2006), Martin P (2006), Geetha T (2012), Geetha T (2012), Linares JF (2013), Linares JF (2011), Linares JF (2015), Schimmack G (2017), Tsai WT (2016)	15
XPO1	8	NEDD4L	3	affinity chromatography technology	Kirli K (2015)	1
XPO1	8	SQSTM1	0	affinity chromatography technology	Kirli K (2015)	1
EGFR	5	FUS	0	affinity chromatography technology	Liccardi G (2014)	1
MAP3K3	3	PDRG1	1	affinity chromatography technology	Bouwmeester T (2004)	1
MAP3K3	3	RIPK1	2	affinity chromatography technology	Yang J (2001)	1
EGFR	5	IRAK1	1	affinity chromatography technology	Yao Z (2017)	1
PRKACA	2	HSP90AA1	7	affinity chromatography technology	Varjosalo M (2013)	1
MAP3K3	3	TOM1L1	1	two hybrid	Vinayagam A (2011)	1
MAP3K3	3	CHUK	5	imaging technique	Chen TC (2014)	1
BRCA1	7	MAP3K3	3	two hybrid, affinity chromatography technology	Gilmore PM (2004), Gilmore PM (2004)	2
EGFR	5	MAP2K4	3	affinity chromatography technology	Tong J (2014)	1
EGFR	5	MAP2K3	1	affinity chromatography technology	Tong J (2014)	1
MAP3K3	3	PFDN2	1	affinity chromatography technology	Bouwmeester T (2004)	1
EGFR	5	PRKACA	2	affinity chromatography technology, enzymatic study	Tortora G (1997), Piiper A (2003)	2
MAP3K3	3	MAP2K7	5	enzymatic study	Takeda AN (2014)	1
XPO1	8	MAP3K7	2	affinity chromatography technology	Kirli K (2015)	1
MAP2K4	3	MAP2K7	5	genetic interference, affinity chromatography technology, affinity chromatography technology	Fleming Y (2000), Sundarrajan M (2003), Sundarrajan M (2003)	3
MAP3K3	3	GLRX3	1	two hybrid	Rolland T (2014)	1
XPO1	8	RIPK1	2	affinity chromatography technology	Kirli K (2015)	1
BRCA1	7	GTF2I	1	pull down, affinity chromatography technology, affinity chromatography technology, imaging technique	Tanikawa M (2011), Tanikawa M (2011), Tanikawa M (2011), Tanikawa M (2011)	4
GTF2I	1	MAP3K3	3	two hybrid	Wang J (2011)	1
MAP3K7	2	COPS5	0	two hybrid	Bandyopadhyay S (2010)	1
XPO1	8	MAP3K3	3	affinity chromatography technology	Kirli K (2015)	1
SQSTM1	0	MAP2K5	1	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Nakamura K (2010), Nakamura K (2010), Nakamura K (2010), Lamark T (2003), Lamark T (2003), Lamark T (2003)	6
MAP3K2	1	MAP2K4	3	affinity chromatography technology, enzymatic study, enzymatic study	Cheng J (2000), Deacon K (1997), Enomoto A (2008)	3
IP6K3	1	MAP3K3	3	affinity chromatography technology	Hein MY (2015)	1
HSP90AA1	7	CHUK	5	affinity chromatography technology, affinity chromatography technology	Qu X (2012), Gano JJ (2010)	2
MAP3K3	3	HSP90AA1	7	affinity chromatography technology, affinity chromatography technology	Fang S (2009), Fang S (2009)	2
YWHAE	0	CDC37	0	affinity chromatography technology	Zuo S (2010)	1
XIAP	0	HSPA4	3	affinity chromatography technology	Hegde R (2002)	1
MAP3K3	3	MAP2K5	1	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, pull down, enzymatic study, pull down, imaging technique, affinity chromatography technology	Sun W (2001), Bouwmeester T (2004), Sun W (2001), Nakamura K (2010), Lamark T (2003), Lamark T (2003), Erdogan E (2006), Takeda AN (2014), Takeda AN (2014), Chen TC (2014), Huttlin EL (2017)	11
XPO1	8	MAP2K7	5	affinity chromatography technology	Kirli K (2015)	1
COPS5	0	FUS	0	affinity chromatography technology	Bennett EJ (2010)	1
YWHAE	0	MAP3K2	1	pull down, affinity chromatography technology, affinity chromatography technology	Fanger GR (1998), Gloeckner CJ (2007), Hein MY (2015)	3
MAP3K3	3	MAP3K3	3	enzymatic study	Xu LG (2004)	1
TRAF6	0	FUS	0	affinity chromatography technology	Yu J (2016)	1
MAP3K3	3	YWHAG	5	affinity chromatography technology	Bouwmeester T (2004)	1
MAP3K3	3	XIAP	0	pull down, enzymatic study	Takeda AN (2014), Takeda AN (2014)	2
TRAF6	0	BIRC2	1	affinity chromatography technology, affinity chromatography technology	Mao AP (2010), Hinz M (2010)	2
MAP3K3	3	3324	0	affinity chromatography technology	Bouwmeester T (2004)	1
CHUK	5	COPS5	0	enzymatic study, affinity chromatography technology	Orel L (2010), Asare Y (2013)	2
MAP2K3	1	SPAG9	5	affinity chromatography technology	Hsu CH (2010)	1
MAP3K3	3	HSPA4	3	affinity chromatography technology	Bouwmeester T (2004)	1
BRCA1	7	CDC37	0	affinity chromatography technology	Ertych N (2016)	1
MAP3K3	3	MAP3K7	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology	Yamazaki K (2009), Yamazaki K (2009), Blonska M (2005), Blonska M (2005), Blonska M (2005)	5
CBY1	3	MARK2	6	affinity chromatography technology	Boldt K (2016)	1
MAP3K3	3	MBP	0	enzymatic study	Takeda AN (2014)	1
MAP3K3	3	TRAF7	11	affinity chromatography technology, affinity chromatography technology	Bouwmeester T (2004), Xu LG (2004)	2
KIFC3	3	MAP3K3	3	affinity chromatography technology	Hein MY (2015)	1
MAP3K2	1	CBY1	3	affinity chromatography technology	Boldt K (2016)	1
MAP3K3	3	MAP2K4	3	enzymatic study, affinity chromatography technology, pull down	Deacon K (1997), Hernandez ED (2014), Hernandez ED (2014)	3
TOM1L1	1	EGFR	5	affinity chromatography technology, affinity chromatography technology	Liu NS (2009), Liu NS (2009)	2
HSP90AA1	7	FLNA	10	affinity chromatography technology	Falsone SF (2005)	1
MAP3K3	3	PRKACA	2	imaging technique	Chen TC (2014)	1
SQSTM1	0	HSPA4	3	pull down, affinity chromatography technology	Pridgeon JW (2004), Pridgeon JW (2004)	2
MAP3K7	2	MAP2K7	5	imaging technique	Chen TC (2014)	1
TRAF6	0	MTOR	14	affinity chromatography technology, enzymatic study	Linares JF (2013), Linares JF (2013)	2
MAP3K3	3	SMURF1	4	affinity chromatography technology, pull down	Crose LE (2009), Crose LE (2009)	2
EGFR	5	XPO1	8	affinity chromatography technology	Foerster S (2013)	1
IRAK1	1	HSP90AA1	7	affinity chromatography technology, affinity chromatography technology, biochemical	De Nardo D (2005), De Nardo D (2005), De Nardo D (2005)	3
SQSTM1	0	FUS	0	affinity chromatography technology	Tanji K (2012)	1
MAP3K3	3	MAP2K3	1	enzymatic study	Deacon K (1997)	1
MAP3K2	1	SMURF1	4	affinity chromatography technology, enzymatic study	Crose LE (2009), Andrews PS (2010)	2
COPS5	0	HSP90AA1	7	affinity chromatography technology	Bennett EJ (2010)	1
YWHAG	5	MARK2	6	affinity chromatography technology, affinity chromatography technology	Ewing RM (2007), Suzuki A (2004)	2
HSP90AA1	7	MAP2K7	5	affinity chromatography technology	Taipale M (2012)	1
BRCA1	7	FUS	0	affinity chromatography technology	Ertych N (2016)	1
BRCA1	7	MTOR	14	affinity chromatography technology	Woods NT (2012)	1
BRCA1	7	FLNA	10	affinity chromatography technology, affinity chromatography technology	Woods NT (2012), Ertych N (2016)	2
YWHAE	0	MAP3K7	2	affinity chromatography technology, affinity chromatography technology	Zuo S (2010), Zuo S (2010)	2
MAP3K7	2	XIAP	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Sanna MG (2002), Resch U (2009), Sanna MG (2002), Sanna MG (2002)	4
MAP3K3	3	ZBTB16	4	two hybrid	Stelzl U (2005)	1
MAP2K5	1	MAP2K3	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
MAP3K3	3	YWHAE	0	two hybrid, affinity chromatography technology, pull down	Fanger GR (1998), Fanger GR (1998), Fanger GR (1998)	3
MAP3K2	1	MAP3K3	3	pull down, affinity chromatography technology	Takeda AN (2014), Hein MY (2015)	2
MAP2K4	3	NBR1	0	affinity chromatography technology, affinity chromatography technology, pull down	Hernandez ED (2014), Hernandez ED (2014), Hernandez ED (2014)	3
XIAP	0	RIPK1	2	pull down	Bertrand MJ (2011)	1
IRAK1	1	CDC37	0	affinity chromatography technology, affinity chromatography technology, biochemical, biochemical	De Nardo D (2005), De Nardo D (2005), De Nardo D (2005), De Nardo D (2005)	4
YWHAG	5	NEDD4L	3	two hybrid	Bandyopadhyay S (2010)	1
BIRC2	1	MAP3K3	3	enzymatic study	Takeda AN (2014)	1
COPS5	0	HSPA4	3	affinity chromatography technology	Bennett EJ (2010)	1
TRAF6	0	SMURF1	4	genetic interference	Li S (2010)	1
IRAK1	1	PPP2CA	7	affinity chromatography technology, affinity chromatography technology	Dobierzewska A (2011), Dobierzewska A (2011)	2
COPS5	0	3324	0	affinity chromatography technology	Bennett EJ (2010)	1
MAP3K2	1	XIAP	0	affinity chromatography technology, enzymatic study, pull down, affinity chromatography technology, pull down, enzymatic study	Winsauer G (2008), Winsauer G (2008), Takeda AN (2014), Takeda AN (2014), Takeda AN (2014), Takeda AN (2014)	6
EGFR	5	CDC37	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Lavictoire SJ (2003), Foerster S (2013), Li J (2013), Li J (2013)	4
BRCA1	7	HSPA4	3	affinity chromatography technology	Ertych N (2016)	1
MTOR	14	MAP3K3	3	affinity chromatography technology	Linares JF (2015)	1
PPP2CA	7	MAP3K3	3	affinity chromatography technology	Sun W (2010)	1
XPO1	8	MTOR	14	affinity chromatography technology	Kirli K (2015)	1
EGFR	5	GAB1	3	affinity chromatography technology, affinity chromatography technology, two hybrid, protein complementation assay, enzymatic study, affinity chromatography technology	Kameda H (2001), Tong J (2008), Kotlyar M (2015), Petschnigg J (2014), Lehr S (1999), Mueller KL (2012)	6
NEDD4	2	MAP3K3	3	enzymatic study, pull down	Persaud A (2009), Persaud A (2009)	2
YWHAE	0	XPO1	8	biochemical	Kristensen AR (2012)	1
SMURF1	4	MARK2	6	enzymatic study	Andrews PS (2010)	1
HSP90AA1	7	CDC37	0	x-ray crystallography, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology	Roe SM (2004), Silverstein AM (1998), Mollapour M (2010), Basso AD (2002), Tsutsumi S (2012), De Nardo D (2005), Sarkar S (2012), Gano JJ (2010), Taipale M (2012), Skarra DV (2011), Zhang H (2004), Taipale M (2014), Taipale M (2014), Mollapour M (2014), Hein MY (2015), Hein MY (2015), Li J (2013), Woodford MR (2016), Shao J (2003), Scholz GM (2001), Sun L (2012), Sun L (2012), Woodford MR (2016), Synoradzki K (2015)	24
MAP3K7	2	CDC37	0	affinity chromatography technology	Liu XY (2008)	1
IRAK1	1	HSPA4	3	affinity chromatography technology, affinity chromatography technology	De Nardo D (2005), De Nardo D (2005)	2
MAP3K2	1	MAP2K5	1	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, enzymatic study, pull down, affinity chromatography technology	Sun W (2001), Sun W (2001), Nakamura K (2010), Nakamura K (2010), Wang J (2011), Takeda AN (2014), Takeda AN (2014), Takeda AN (2014), Takeda AN (2014), Huttlin EL (2017)	10
EGFR	5	CBY1	3	affinity chromatography technology	Yao Z (2017)	1
NEDD4	2	MARK2	6	enzymatic study	Persaud A (2009)	1
SQSTM1	0	IRAK1	1	affinity chromatography technology	Sanz L (2000)	1
SMURF1	4	FLNA	10	affinity chromatography technology	Xie Y (2013)	1
BRCA1	7	PPP2CA	7	affinity chromatography technology	Woods NT (2012)	1
HSP90AA1	7	MAP3K2	1	affinity chromatography technology	Taipale M (2012)	1
MAP3K3	3	COPS5	0	two hybrid	Bandyopadhyay S (2010)	1
MAP3K3	3	CDC37	0	affinity chromatography technology	Bouwmeester T (2004)	1
GAB1	3	MARK2	6	affinity chromatography technology, affinity chromatography technology, pull down	Yang Z (2012), Yang Z (2012), Yang Z (2012)	3
YWHAG	5	YWHAE	0	two hybrid, affinity chromatography technology, two hybrid, biochemical	Bandyopadhyay S (2010), Gloeckner CJ (2007), Wang J (2011), Wan C (2015)	4
NEDD4	2	EGFR	5	enzymatic study, pull down	Persaud A (2009), Persaud A (2009)	2
MAP3K3	3	CBY1	3	affinity chromatography technology	Boldt K (2016)	1
MAP3K3	3	TRAF6	0	affinity chromatography technology, pull down, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique	Nakamura K (2010), Nakamura K (2010), Nakamura K (2010), Yamazaki K (2009), Yamazaki K (2009), Huang Q (2004), Chen TC (2014)	7
EGFR	5	MTOR	14	affinity chromatography technology	Foerster S (2013)	1
HSP90AA1	7	MAP2K5	1	affinity chromatography technology	Taipale M (2012)	1
HSP90AA1	7	PDRG1	1	affinity chromatography technology	Skarra DV (2011)	1
MARK2	6	YWHAE	0	affinity chromatography technology, affinity chromatography technology	Goeransson O (2006), Gloeckner CJ (2007)	2
PFDN2	1	FLNA	10	biochemical	Wan C (2015)	1