PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
AQP1	1	MDFI	1	two hybrid, two hybrid, two hybrid	Rual JF (2005), Xin X (2009), Venkatesan K (2009)	3
SLC25A10	0	MDFI	1	two hybrid, two hybrid, two hybrid, two hybrid	Xin X (2009), Venkatesan K (2009), Rolland T (2014), Yu H (2011)	4
MDFI	1	NR1H2	2	two hybrid, two hybrid, two hybrid	Rual JF (2005), Venkatesan K (2009), Rolland T (2014)	3
MDFI	1	DCAF8	1	two hybrid, two hybrid, two hybrid, two hybrid	Rual JF (2005), Venkatesan K (2009), Rolland T (2014), Yu H (2011)	4
MDFI	1	ZNF646	12	two hybrid, two hybrid	Rual JF (2005), Venkatesan K (2009)	2
HTR1B	0	MDFI	1	two hybrid, two hybrid	Corominas R (2014), Rolland T (2014)	2
HOXB9	0	MDFI	1	two hybrid, two hybrid	Rual JF (2005), Venkatesan K (2009)	2
MDFI	1	HEYL	1	two hybrid, two hybrid	Rolland T (2014), Yu H (2011)	2
MDFI	1	PIN1	0	two hybrid, two hybrid	Rual JF (2005), Rolland T (2014)	2
FBXL18	5	MDFI	1	two hybrid, two hybrid	Venkatesan K (2009), Rolland T (2014)	2
MDFI	1	ZNF581	0	two hybrid, two hybrid	Rual JF (2005), Rolland T (2014)	2
MDFI	1	CNNM3	2	two hybrid, two hybrid	Rual JF (2005), Venkatesan K (2009)	2
NEU4	1	MDFI	1	two hybrid, two hybrid, two hybrid, two hybrid	Xin X (2009), Venkatesan K (2009), Rolland T (2014), Yu H (2011)	4
MDFI	1	ZNF101	0	two hybrid, two hybrid	Rual JF (2005), Rolland T (2014)	2
MDFI	1	TGIF1	1	two hybrid, two hybrid	Rolland T (2014), Yu H (2011)	2
MDFI	1	FAM124B	2	two hybrid, two hybrid, two hybrid	Rual JF (2005), Xin X (2009), Venkatesan K (2009)	3
MDFI	1	CCDC116	3	two hybrid, two hybrid	Rual JF (2005), Rolland T (2014)	2
MDFI	1	ZNF440	2	two hybrid, two hybrid, two hybrid	Rual JF (2005), Rolland T (2014), Yu H (2011)	3
MDFI	1	OTX1	4	two hybrid, two hybrid	Rual JF (2005), Xin X (2009)	2
MDFI	1	DKK1	1	two hybrid, two hybrid	Rual JF (2005), Venkatesan K (2009)	2
MDFI	1	PTPMT1	0	two hybrid, two hybrid	Rolland T (2014), Yu H (2011)	2
HOXB9	0	ZNF408	0	two hybrid	Ravasi T (2010)	1
MDFI	1	BAHD1	3	two hybrid, two hybrid	Rual JF (2005), Rolland T (2014)	2
MDFI	1	ZNF417	2	two hybrid, two hybrid	Rual JF (2005), Rolland T (2014)	2
MDFI	1	ZNF408	0	two hybrid, two hybrid	Rual JF (2005), Venkatesan K (2009)	2
MDFI	1	ENKD1	3	two hybrid, two hybrid, two hybrid	Rual JF (2005), Xin X (2009), Rolland T (2014)	3
MDFI	1	THEG	1	two hybrid, two hybrid	Rual JF (2005), Venkatesan K (2009)	2
MDFI	1	NPDC1	2	two hybrid, two hybrid	Rual JF (2005), Rolland T (2014)	2
MDFI	1	ZNF223	1	two hybrid, two hybrid	Rolland T (2014), Yu H (2011)	2
MDFI	1	494514	0	two hybrid, two hybrid	Rual JF (2005), Rolland T (2014)	2
MDFI	1	RABL6	3	two hybrid, affinity chromatography technology	Rual JF (2005), Rual JF (2005)	2
MDFI	1	HNRNPLL	1	two hybrid, two hybrid	Rolland T (2014), Yu H (2011)	2
MDFI	1	NECTIN2	0	two hybrid, two hybrid	Rual JF (2005), Rolland T (2014)	2
MDFI	1	MDFI	1	two hybrid, two hybrid	Rual JF (2005), Rolland T (2014)	2
APLN	0	MDFI	1	two hybrid, two hybrid	Venkatesan K (2009), Rolland T (2014)	2
MDFI	1	ZNF439	1	two hybrid, two hybrid, two hybrid	Rual JF (2005), Rolland T (2014), Yu H (2011)	3
MDFI	1	MYOD1	0	two hybrid, pull down, affinity chromatography technology	Chen CM (1996), Chen CM (1996), Chen CM (1996)	3
MDFI	1	MYOG	1	two hybrid, pull down	Chen CM (1996), Chen CM (1996)	2
MDFI	1	ZNF707	2	two hybrid, two hybrid	Rual JF (2005), Xin X (2009)	2
MDFI	1	ZBTB24	1	two hybrid, two hybrid, two hybrid	Rual JF (2005), Venkatesan K (2009), Rolland T (2014)	3
MDFI	1	TRPV6	0	two hybrid, two hybrid	Rual JF (2005), Rolland T (2014)	2
MDFI	1	PGLS	0	two hybrid, affinity chromatography technology, two hybrid	Rual JF (2005), Rual JF (2005), Rolland T (2014)	3
MDFI	1	PHLDA1	0	two hybrid, two hybrid	Rual JF (2005), Venkatesan K (2009)	2
AQP5	0	MDFI	1	two hybrid, two hybrid	Rual JF (2005), Venkatesan K (2009)	2
MDFI	1	CBX2	0	two hybrid, two hybrid	Rual JF (2005), Venkatesan K (2009)	2
MDFI	1	VPS72	2	two hybrid, two hybrid	Rual JF (2005), Rolland T (2014)	2
MDFI	1	ZNF490	1	two hybrid, two hybrid	Rolland T (2014), Yu H (2011)	2
MDFI	1	REX1BD	0	two hybrid, two hybrid	Rual JF (2005), Venkatesan K (2009)	2
MDFI	1	MYF5	2	two hybrid, pull down, affinity chromatography technology	Chen CM (1996), Chen CM (1996), Chen CM (1996)	3
MDFI	1	AVPI1	2	two hybrid, two hybrid	Rolland T (2014), Yu H (2011)	2
MDFI	1	ZNF136	0	two hybrid, two hybrid, two hybrid, two hybrid	Rual JF (2005), Venkatesan K (2009), Rolland T (2014), Yu H (2011)	4
LASP1	1	MDFI	1	two hybrid, two hybrid	Rual JF (2005), Venkatesan K (2009)	2
MDFI	1	GLIDR	0	two hybrid, two hybrid, two hybrid	Rual JF (2005), Rolland T (2014), Yu H (2011)	3
MDFI	1	SIX1	3	two hybrid, affinity chromatography technology	Rual JF (2005), Rual JF (2005)	2
MDFI	1	C8orf48	4	two hybrid, two hybrid	Rual JF (2005), Venkatesan K (2009)	2
MDFI	1	PIDD1	5	two hybrid, two hybrid	Rual JF (2005), Venkatesan K (2009)	2
MDFI	1	C10orf62	0	two hybrid, two hybrid, two hybrid, two hybrid	Rual JF (2005), Xin X (2009), Venkatesan K (2009), Rolland T (2014)	4
MDFI	1	ZNF559	1	two hybrid, two hybrid, two hybrid	Rual JF (2005), Rolland T (2014), Yu H (2011)	3
MDFI	1	SPG7	6	two hybrid, two hybrid	Rual JF (2005), Rolland T (2014)	2
MDFI	1	ZBTB25	2	two hybrid, affinity chromatography technology	Rual JF (2005), Rual JF (2005)	2
LRCH4	5	MDFI	1	two hybrid, two hybrid	Rual JF (2005), Venkatesan K (2009)	2
MDFI	1	CCDC120	1	two hybrid, two hybrid	Rual JF (2005), Xin X (2009)	2
PRKAB2	0	MDFI	1	two hybrid, two hybrid	Corominas R (2014), Rolland T (2014)	2
MDFI	1	AKAP17A	1	two hybrid, two hybrid	Rual JF (2005), Rolland T (2014)	2
MDFI	1	ZNF607	4	two hybrid, two hybrid	Rual JF (2005), Rolland T (2014)	2
MDFI	1	CBFA2T2	3	two hybrid, two hybrid, two hybrid	Rual JF (2005), Venkatesan K (2009), Yu H (2011)	3
MDFI	1	100131997	0	two hybrid, two hybrid	Rual JF (2005), Rolland T (2014)	2
MDFI	1	IQUB	6	two hybrid, affinity chromatography technology	Rual JF (2005), Rual JF (2005)	2
GNAI2	1	MDFI	1	two hybrid, affinity chromatography technology, two hybrid	Rual JF (2005), Rual JF (2005), Rolland T (2014)	3