PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
ORC5	0	CDC6	0	pull down	Ramachandran N (2004)	1
MCM5	1	ORC1	3	pull down	Ramachandran N (2004)	1
MCMBP	3	MCM5	1	affinity chromatography technology, affinity chromatography technology, biochemical	Taipale M (2014), Taipale M (2014), Wan C (2015)	3
CDK2	0	CDC7	2	enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study	Martin L (2007), Martin L (2007), Martin L (2007), Masai H (2000)	4
MCM3	2	DBF4	2	two hybrid, two hybrid	Kneissl M (2003), Kneissl M (2003)	2
DBF4	2	MCM2	3	two hybrid, enzymatic study	Kneissl M (2003), Masai H (2000)	2
MCM2	3	RPS4X	0	two hybrid, affinity chromatography technology	Stelzl U (2005), Drissi R (2015)	2
MCM5	1	NCL	1	affinity chromatography technology	Drissi R (2015)	1
HIST1H2BA	0	MMS22L	6	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
H2AFX	1	HIST1H4A	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Du YC (2006), Lee HS (2010), Yang X (2010)	3
MCM4	3	ORC5	0	two hybrid, two hybrid	Kneissl M (2003), Kneissl M (2003)	2
CDC7	2	MCM2	3	two hybrid, two hybrid, enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study	Kneissl M (2003), Kneissl M (2003), Gerard A (2006), Martin L (2007), Martin L (2007), Montagnoli A (2006), Suzuki T (2012), Masai H (2000)	8
CCL2	0	CDC6	0	affinity chromatography technology, affinity chromatography technology	Bronze-da-Rocha E (2011), Bronze-da-Rocha E (2011)	2
CDC7	2	MCM6	5	enzymatic study	Masai H (2000)	1
ILF2	3	MCM7	5	affinity chromatography technology	Karmakar S (2010)	1
H2AFX	1	MMS22L	6	affinity chromatography technology	Huttlin EL (2017)	1
ILF2	3	RPS4X	0	biochemical	Havugimana PC (2012)	1
HSP90AB1	2	MCM5	1	biochemical, biochemical, affinity chromatography technology	Havugimana PC (2012), Kristensen AR (2012), Drissi R (2015)	3
HIST1H3E	0	ASF1A	0	affinity chromatography technology, affinity chromatography technology	Drane P (2010), Drane P (2010)	2
ASF1A	0	MCM7	5	affinity chromatography technology, affinity chromatography technology	Ask K (2012), Huttlin EL (2017)	2
MCM2	3	HIST1H3A	3	affinity chromatography technology, affinity chromatography technology	Drissi R (2015), Huttlin EL (2017)	2
MCM5	1	SF3B1	12	biochemical, affinity chromatography technology	Wan C (2015), Drissi R (2015)	2
L3MBTL1	1	MCM5	1	affinity chromatography technology, affinity chromatography technology	Gurvich N (2010), Gurvich N (2010)	2
DBF4	2	ORC4	1	affinity chromatography technology	Kneissl M (2003)	1
SPIN2B	0	MCM6	5	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
MCM2	3	MCM7	5	pull down, pull down, two hybrid, two hybrid, biochemical, affinity chromatography technology, affinity chromatography technology, biochemical, pull down, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Yabuta N (2003), Yabuta N (2003), Kneissl M (2003), Kneissl M (2003), You Z (1999), Fujita M (1997), You Z (2002), Havugimana PC (2012), Ramachandran N (2004), Kristensen AR (2012), Huttlin EL (2015), Wan C (2015), Drissi R (2015), Boldt K (2016)	14
HIST1H4A	0	MCM4	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Saade E (2009), Saade E (2009), Huttlin EL (2017)	3
MCM5	1	ORC5	0	pull down	Ramachandran N (2004)	1
CCL2	0	MCM7	5	affinity chromatography technology, affinity chromatography technology	Bronze-da-Rocha E (2011), Bronze-da-Rocha E (2011)	2
CDK2	0	RPS4X	0	affinity chromatography technology	Neganova I (2011)	1
DBF4	2	ORC1	3	two hybrid	Kneissl M (2003)	1
MMS22L	6	MCM6	5	affinity chromatography technology, biochemical	OConnell BC (2010), Duro E (2010)	2
HSD17B10	1	MCM4	3	affinity chromatography technology	Malty RH (2017)	1
MCM2	3	H2AFX	1	affinity chromatography technology, affinity chromatography technology	Drissi R (2015), Huttlin EL (2017)	2
H2AFX	1	HSD17B10	1	affinity chromatography technology	Yang X (2010)	1
ASF1A	0	ASF1B	0	affinity chromatography technology, affinity chromatography technology	Ask K (2012), Hein MY (2015)	2
MCM4	3	MCM7	5	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, pull down, biochemical, biochemical, affinity chromatography technology	Yabuta N (2003), Fujita M (1997), Ishimi Y (1996), You Z (2002), Havugimana PC (2012), Ramachandran N (2004), Kristensen AR (2012), Wan C (2015), Boldt K (2016)	9
FANCD2	3	MCM5	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Lossaint G (2013), Lossaint G (2013), Lossaint G (2013)	3
MCM3	2	MCM2	3	two hybrid, two hybrid, pull down, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kneissl M (2003), Kneissl M (2003), Ramachandran N (2004), Wan C (2015), Drissi R (2015), Huttlin EL (2017), Lossaint G (2013), Mulvaney KM (2016)	8
FANCD2	3	MCM6	5	affinity chromatography technology	Lossaint G (2013)	1
MCM5	1	CDC7	2	two hybrid, two hybrid	Kneissl M (2003), Kneissl M (2003)	2
HIST1H3E	0	ASF1B	0	affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology	Drane P (2010), Campos EI (2015), Campos EI (2015), Campos EI (2015)	4
MCM4	3	CDC7	2	two hybrid, two hybrid, enzymatic study	Kneissl M (2003), Kneissl M (2003), Masai H (2000)	3
CAP1	1	MCM6	5	biochemical	Kristensen AR (2012)	1
MCM4	3	ANK3	16	affinity chromatography technology	Boldt K (2016)	1
ILF2	3	MCM6	5	affinity chromatography technology	Karmakar S (2010)	1
H2AFX	1	ILF2	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Yang X (2010), Huttlin EL (2015), Huttlin EL (2017)	3
HIST1H2BA	0	MCM6	5	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
ILF2	3	ORC2	0	affinity chromatography technology	Karmakar S (2010)	1
NCL	1	RPS4X	0	biochemical, affinity chromatography technology	Havugimana PC (2012), Salvetti A (2016)	2
HIST1H2BA	0	MCM7	5	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
H2AFX	1	HIST1H3A	3	affinity chromatography technology, imaging technique	Lee HS (2010), Soldi M (2013)	2
ASF1B	0	TONSL	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ewing RM (2007), Piwko W (2010), Piwko W (2010), Duro E (2010), Huttlin EL (2017)	5
ORC4	1	ORC5	0	two hybrid, two hybrid, affinity chromatography technology, biochemical, pull down	Kneissl M (2003), Kneissl M (2003), Quintana DG (1998), Dhar SK (2001), Ramachandran N (2004)	5
HIST1H3E	0	MCM2	3	affinity chromatography technology, affinity chromatography technology	Campos EI (2015), Drissi R (2015)	2
MCM4	3	ORC2	0	two hybrid, two hybrid	Kneissl M (2003), Kneissl M (2003)	2
KEAP1	0	MCMBP	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Taipale M (2014), Taipale M (2014), Mulvaney KM (2016)	4
CDK2	0	HIST1H4A	0	enzymatic study	Yuan WC (2011)	1
CDC6	0	CDK2	0	affinity chromatography technology, enzymatic study	Saha P (1998), Jiang W (1999)	2
HIST1H3A	3	MCM6	5	affinity chromatography technology	Huttlin EL (2017)	1
CCL2	0	ORC2	0	affinity chromatography technology, affinity chromatography technology	Bronze-da-Rocha E (2011), Bronze-da-Rocha E (2011)	2
MCM3	2	MCM4	3	biochemical, biochemical, affinity chromatography technology, affinity chromatography technology	Havugimana PC (2012), Wan C (2015), Huttlin EL (2017), Mulvaney KM (2016)	4
MCM4	3	SF3B1	12	biochemical	Wan C (2015)	1
CDK2	0	MCM6	5	affinity chromatography technology	Neganova I (2011)	1
HIST1H3A	3	FANCD2	3	pull down, enzymatic study, pull down	Sato K (2012), Sato K (2012), Sato K (2012)	3
HIST1H3E	0	HIST1H4A	0	affinity chromatography technology	Shuaib M (2010)	1
MCM5	1	MCM6	5	affinity chromatography technology, biochemical, biochemical, affinity chromatography technology	DaFonseca CJ (2001), Havugimana PC (2012), Wan C (2015), Drissi R (2015)	4
SSRP1	1	MCM6	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Tan BC (2006), OConnell BC (2010), Huttlin EL (2017)	3
HSD17B10	1	ILF2	3	affinity chromatography technology	Malty RH (2017)	1
FANCD2	3	MCM4	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Panneerselvam J (2014), Lossaint G (2013), Lossaint G (2013)	3
MCM5	1	H2AFX	1	affinity chromatography technology	Drissi R (2015)	1
ORC1	3	MCM2	3	two hybrid, two hybrid	Kneissl M (2003), Kneissl M (2003)	2
FANCD2	3	H2AFX	1	affinity chromatography technology, affinity chromatography technology	Bogliolo M (2007), Bogliolo M (2007)	2
MCM7	5	ORC1	3	two hybrid, two hybrid	Kneissl M (2003), Kneissl M (2003)	2
MCM7	5	ORC4	1	pull down	Ramachandran N (2004)	1
HIST1H3A	3	ASF1B	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid, affinity chromatography technology	Tagami H (2004), Tagami H (2004), Groth A (2005), Groth A (2005), Lambert JP (2015), Huttlin EL (2017)	6
FANCD2	3	MCM3	2	affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Panneerselvam J (2014), Panneerselvam J (2014), Panneerselvam J (2014), Panneerselvam J (2014), Lossaint G (2013), Lossaint G (2013), Lossaint G (2013)	7
CCL2	0	MCM3	2	affinity chromatography technology, affinity chromatography technology	Bronze-da-Rocha E (2011), Bronze-da-Rocha E (2011)	2
MCMBP	3	MCM7	5	affinity chromatography technology, affinity chromatography technology, two hybrid, biochemical	Taipale M (2014), Taipale M (2014), Rolland T (2014), Wan C (2015)	4
HIST1H3E	0	MMS22L	6	biochemical	Campos EI (2015)	1
ASF1B	0	MMS22L	6	affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Ewing RM (2007), Duro E (2010), Duro E (2010), Huttlin EL (2017)	4
SPIN2B	0	SSRP1	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
MCM2	3	MCM2	3	two hybrid, affinity chromatography technology	Kneissl M (2003), Drissi R (2015)	2
HIST1H4A	0	MCM7	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Saade E (2009), Saade E (2009), Huttlin EL (2017)	3
CDC7	2	MCM3	2	enzymatic study, pull down	Sato N (1997), Ramachandran N (2004)	2
ORC1	3	ORC2	0	two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kneissl M (2003), Kneissl M (2003), Fujita M (2002), Vashee S (2001), Vashee S (2001), Mendez J (2002), Mendez J (2002), Ramachandran N (2004), Vermeulen M (2010), Hein MY (2015), Hein MY (2015)	11
HIST1H2BA	0	SSRP1	1	affinity chromatography technology, biochemical, affinity chromatography technology	Huttlin EL (2015), Wan C (2015), Huttlin EL (2017)	3
HIST1H3A	3	MCM4	3	affinity chromatography technology	Huttlin EL (2017)	1
CCL2	0	MCM2	3	affinity chromatography technology, affinity chromatography technology	Bronze-da-Rocha E (2011), Bronze-da-Rocha E (2011)	2
ORC2	0	ORC4	1	two hybrid, two hybrid, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Kneissl M (2003), Kneissl M (2003), Kneissl M (2003), Dhar SK (2001), Quintana DG (1997), Vashee S (2001), Vashee S (2001), Sibani S (2005), Keller C (2002), Ramachandran N (2004), Vermeulen M (2010)	11
H2AFX	1	SSRP1	1	affinity chromatography technology, pull down, affinity chromatography technology	Du YC (2006), Heo K (2008), Huttlin EL (2017)	3
ORC5	0	MCM2	3	two hybrid, two hybrid, pull down	Kneissl M (2003), Kneissl M (2003), Ramachandran N (2004)	3
HSP90AB1	2	RPS4X	0	affinity chromatography technology	Falsone SF (2005)	1
CDK2	0	ORC2	0	enzymatic study, pull down	Mendez J (2002), Ramachandran N (2004)	2
ILF2	3	MCM5	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Karmakar S (2010), Karmakar S (2010), Karmakar S (2010), Drissi R (2015)	4
H2AFX	1	MCM4	3	affinity chromatography technology	Huttlin EL (2017)	1
MMS22L	6	ASF1A	0	biochemical	Duro E (2010)	1
L3MBTL1	1	MCM7	5	affinity chromatography technology, affinity chromatography technology	Gurvich N (2010), Hauri S (2016)	2
RPA1	0	ILF2	3	affinity chromatography technology	Marechal A (2014)	1
HIST1H4A	0	ASF1A	0	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Saade E (2009), Akai Y (2010), Ask K (2012), Groth A (2005)	4
ASF1B	0	MCM4	3	affinity chromatography technology, affinity chromatography technology	Campos EI (2015), Huttlin EL (2017)	2
MMS22L	6	MCM4	3	affinity chromatography technology	OConnell BC (2010)	1
HIST1H3A	3	TONSL	4	bioid, affinity chromatography technology	Lambert JP (2015), Huttlin EL (2017)	2
RPA1	0	SF3B1	12	affinity chromatography technology	Marechal A (2014)	1
DBF4	2	ORC5	0	two hybrid	Kneissl M (2003)	1
CAP1	1	MCM2	3	biochemical, affinity chromatography technology	Kristensen AR (2012), Drissi R (2015)	2
HSP90AB1	2	MCM2	3	biochemical, affinity chromatography technology	Kristensen AR (2012), Drissi R (2015)	2
RPA1	0	MCM6	5	two hybrid, two hybrid	Kneissl M (2003), Kneissl M (2003)	2
HIST1H3A	3	SSRP1	1	pull down, affinity chromatography technology	Kouskouti A (2005), Huttlin EL (2017)	2
HIST1H2BA	0	MCM2	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Drissi R (2015), Huttlin EL (2017)	3
CDC6	0	MCM5	1	affinity chromatography technology	Hubbi ME (2013)	1
HIST1H4A	0	MMS22L	6	affinity chromatography technology	Huttlin EL (2017)	1
L3MBTL1	1	AKAP8	1	affinity chromatography technology	Hauri S (2016)	1
MCM5	1	MCM4	3	affinity chromatography technology, biochemical, biochemical	DaFonseca CJ (2001), Havugimana PC (2012), Wan C (2015)	3
SPIN2B	0	MCM4	3	affinity chromatography technology	Huttlin EL (2015)	1
ASF1B	0	MCM3	2	affinity chromatography technology	Campos EI (2015)	1
HSP90AB1	2	KEAP1	0	affinity chromatography technology, two hybrid	Prince TL (2015), Prince TL (2015)	2
MCM3	2	CDK2	0	affinity chromatography technology, pull down, pull down	Li J (2011), Li J (2011), Ramachandran N (2004)	3
MCM3	2	ORC5	0	two hybrid, two hybrid, pull down	Kneissl M (2003), Kneissl M (2003), Ramachandran N (2004)	3
MCM2	3	ANK3	16	affinity chromatography technology, affinity chromatography technology	Drissi R (2015), Boldt K (2016)	2
MCM7	5	SF3B1	12	biochemical	Wan C (2015)	1
MCM6	5	HSP90AB1	2	biochemical	Kristensen AR (2012)	1
SSRP1	1	MCM7	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Tan BC (2006), OConnell BC (2010), Huttlin EL (2017)	3
MCM3	2	MCM5	1	two hybrid, two hybrid, affinity chromatography technology, biochemical, pull down, biochemical, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kneissl M (2003), Kneissl M (2003), DaFonseca CJ (2001), Havugimana PC (2012), Ramachandran N (2004), Kristensen AR (2012), Wan C (2015), Drissi R (2015), Huttlin EL (2017), Chen YH (2015), Lossaint G (2013), Lossaint G (2013), Mulvaney KM (2016)	13
CDK2	0	HSP90AB1	2	affinity chromatography technology, affinity chromatography technology	Neganova I (2011), Varjosalo M (2013)	2
MCM7	5	ORC2	0	two hybrid, two hybrid	Kneissl M (2003), Kneissl M (2003)	2
MCM4	3	MCM2	3	pull down, two hybrid, two hybrid, biochemical, affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, biochemical, affinity chromatography technology, affinity chromatography technology	Yabuta N (2003), Kneissl M (2003), Kneissl M (2003), You Z (1999), Ishimi Y (1996), Tan BC (2006), Havugimana PC (2012), Kristensen AR (2012), Wan C (2015), Drissi R (2015), Boldt K (2016)	11
MCM2	3	MCM6	5	two hybrid, pull down, pull down, two hybrid, two hybrid, two hybrid, biochemical, affinity chromatography technology, biochemical, biochemical, two hybrid, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Rual JF (2005), Yabuta N (2003), Yabuta N (2003), Yabuta N (2003), Kneissl M (2003), Kneissl M (2003), You Z (1999), You Z (2002), Havugimana PC (2012), Kristensen AR (2012), Rolland T (2014), Wan C (2015), Hein MY (2015), Drissi R (2015), Boldt K (2016)	15
ORC4	1	MCM2	3	two hybrid, two hybrid	Kneissl M (2003), Kneissl M (2003)	2
MCM5	1	HIST1H2BA	0	affinity chromatography technology	Drissi R (2015)	1
CAP1	1	MCM4	3	biochemical	Kristensen AR (2012)	1
CDK2	0	MCM2	3	enzymatic study, affinity chromatography technology	Montagnoli A (2006), Neganova I (2011)	2
L3MBTL1	1	MCM6	5	affinity chromatography technology	Gurvich N (2010)	1
TONSL	4	MCM2	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	OConnell BC (2010), Piwko W (2010), Piwko W (2010), Duro E (2010)	4
RPA1	0	AKAP8	1	affinity chromatography technology	Marechal A (2014)	1
TONSL	4	MCM5	1	affinity chromatography technology	OConnell BC (2010)	1
L3MBTL1	1	MCM3	2	affinity chromatography technology	Gurvich N (2010)	1
SSRP1	1	MCM3	2	affinity chromatography technology, affinity chromatography technology	Tan BC (2006), OConnell BC (2010)	2
MCM3	2	MCM6	5	biochemical, biochemical, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Havugimana PC (2012), Kristensen AR (2012), Wan C (2015), Hein MY (2015), Huttlin EL (2017), Mulvaney KM (2016)	6
ORC1	3	CDC7	2	two hybrid, two hybrid	Kneissl M (2003), Kneissl M (2003)	2
ORC2	0	MCM2	3	two hybrid, two hybrid, affinity chromatography technology, pull down	Kneissl M (2003), Kneissl M (2003), Kneissl M (2003), Ramachandran N (2004)	4
HIST1H3A	3	HIST1H4A	0	affinity chromatography technology, pull down, affinity chromatography technology, imaging technique, affinity chromatography technology, pull down	Tagami H (2004), Shiio Y (2003), Zippo A (2009), Soldi M (2013), Klement K (2014), Sato K (2012)	6
HSD17B10	1	MCM3	2	affinity chromatography technology	Malty RH (2017)	1
MCM7	5	HSP90AB1	2	biochemical	Kristensen AR (2012)	1
TONSL	4	SSRP1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology	OConnell BC (2010), OConnell BC (2010), OConnell BC (2010), Piwko W (2010), Hill SJ (2014), Huttlin EL (2017)	6
MCM4	3	ORC4	1	two hybrid, two hybrid	Kneissl M (2003), Kneissl M (2003)	2
ASF1A	0	MCM2	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ask K (2012), Drissi R (2015), Drissi R (2015), Huttlin EL (2017), Pchelintsev NA (2013)	5
ILF2	3	SF3B1	12	biochemical	Havugimana PC (2012)	1
DBF4	2	MCM6	5	enzymatic study	Masai H (2000)	1
CDC7	2	DBF4	2	two hybrid, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology	Kneissl M (2003), Kumagai H (1999), Jiang W (1999), Jiang W (1999), Jiang W (1999), Kumagai H (1999), Kumagai H (1999), Liu P (2006), Masai H (2000), Masai H (2000), Huttlin EL (2017)	11
ILF2	3	MCM4	3	affinity chromatography technology	Karmakar S (2010)	1
CDK2	0	ILF2	3	affinity chromatography technology	Neganova I (2011)	1
RPA1	0	NCL	1	affinity chromatography technology	Marechal A (2014)	1
HIST1H4A	0	FANCD2	3	pull down, enzymatic study, pull down	Sato K (2012), Sato K (2012), Sato K (2012)	3
H2AFX	1	TONSL	4	affinity chromatography technology	Huttlin EL (2017)	1
MCM2	3	SNF8	2	two hybrid, pull down, affinity chromatography technology	Mathews A (2009), Mathews A (2009), Mathews A (2009)	3
TONSL	4	HIST1H3E	0	affinity chromatography technology, biochemical, affinity chromatography technology	Campos EI (2015), Campos EI (2015), Campos EI (2015)	3
FANCD2	3	MCM7	5	affinity chromatography technology, affinity chromatography technology	Lossaint G (2013), Lossaint G (2013)	2
ASF1A	0	MCM6	5	affinity chromatography technology, affinity chromatography technology	Ask K (2012), Huttlin EL (2017)	2
ORC2	0	DBF4	2	two hybrid, two hybrid, affinity chromatography technology	Kneissl M (2003), Kneissl M (2003), Kneissl M (2003)	3
HIST1H4A	0	MCM6	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Saade E (2009), Saade E (2009), Huttlin EL (2017)	3
MCMBP	3	MCM2	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Taipale M (2014), Taipale M (2014), Drissi R (2015)	3
RPA1	0	MCM2	3	two hybrid, two hybrid, affinity chromatography technology	Kneissl M (2003), Kneissl M (2003), Drissi R (2015)	3
HIST1H4A	0	TONSL	4	affinity chromatography technology	Huttlin EL (2017)	1
MCMBP	3	MCM6	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology	Jagannathan M (2014), Taipale M (2014), Taipale M (2014), Wan C (2015), Hein MY (2015)	5
HIST1H2BA	0	MCM4	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
HIST1H3E	0	MCM7	5	biochemical, affinity chromatography technology	Campos EI (2015), Campos EI (2015)	2
MCM6	5	MCM7	5	pull down, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Yabuta N (2003), Kneissl M (2003), Kneissl M (2003), Fujita M (1997), You Z (2002), Havugimana PC (2012), Ryu MJ (2006), Wan C (2015), Hein MY (2015), Boldt K (2016)	10
L3MBTL1	1	MCM2	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Gurvich N (2010), Gurvich N (2010), Huttlin EL (2017)	3
CDK2	0	RPA1	0	enzymatic study	Pan ZQ (1993)	1
SF3B1	12	SSRP1	1	biochemical	Havugimana PC (2012)	1
MCM2	3	KEAP1	0	affinity chromatography technology, affinity chromatography technology, imaging technique	Mulvaney KM (2016), Mulvaney KM (2016), Mulvaney KM (2016)	3
SSRP1	1	HIST1H4A	0	pull down, affinity chromatography technology	Winkler DD (2011), Huttlin EL (2017)	2
MCM6	5	SF3B1	12	biochemical	Havugimana PC (2012)	1
CAP1	1	MCM3	2	biochemical	Kristensen AR (2012)	1
CAP1	1	HSP90AB1	2	biochemical	Kristensen AR (2012)	1
ASF1A	0	MCM4	3	affinity chromatography technology, affinity chromatography technology	Ask K (2012), Huttlin EL (2017)	2
MCM5	1	MCM7	5	two hybrid, affinity chromatography technology, affinity chromatography technology, biochemical, pull down, biochemical, affinity chromatography technology	Kneissl M (2003), Fujita M (1997), DaFonseca CJ (2001), Havugimana PC (2012), Ramachandran N (2004), Wan C (2015), Lossaint G (2013)	7
CCL2	0	ORC4	1	affinity chromatography technology, affinity chromatography technology	Bronze-da-Rocha E (2011), Bronze-da-Rocha E (2011)	2
H2AFX	1	NCL	1	pull down, pull down	Kobayashi J (2012), Kobayashi J (2012)	2
MCM6	5	ANK3	16	affinity chromatography technology	Boldt K (2016)	1
HIST1H3E	0	SSRP1	1	affinity chromatography technology	Campos EI (2015)	1
CDC6	0	MCM3	2	affinity chromatography technology, biochemical, pull down	Fujita M (1999), Mendez J (2000), Ramachandran N (2004)	3
MCM4	3	ORC1	3	two hybrid, two hybrid	Kneissl M (2003), Kneissl M (2003)	2
MCM6	5	ORC2	0	two hybrid, two hybrid	Kneissl M (2003), Kneissl M (2003)	2
SSRP1	1	MCM5	1	affinity chromatography technology, affinity chromatography technology	Tan BC (2006), OConnell BC (2010)	2
L3MBTL1	1	MCM4	3	affinity chromatography technology, affinity chromatography technology	Gurvich N (2010), Huttlin EL (2017)	2
MCM2	3	HSD17B10	1	affinity chromatography technology, affinity chromatography technology	Drissi R (2015), Malty RH (2017)	2
MCM7	5	DBF4	2	two hybrid, two hybrid, enzymatic study	Kneissl M (2003), Kneissl M (2003), Masai H (2000)	3
TONSL	4	MCM4	3	affinity chromatography technology, affinity chromatography technology	OConnell BC (2010), Piwko W (2010)	2
MCM6	5	ORC4	1	two hybrid, two hybrid	Kneissl M (2003), Kneissl M (2003)	2
CDK2	0	MCM4	3	enzymatic study, enzymatic study	Ishimi Y (2000), Komamura-Kohno Y (2006)	2
HIST1H3E	0	MCM5	1	affinity chromatography technology	Campos EI (2015)	1
MCM3	2	ORC4	1	two hybrid, two hybrid, pull down	Kneissl M (2003), Kneissl M (2003), Ramachandran N (2004)	3
MCMBP	3	MCM4	3	affinity chromatography technology, affinity chromatography technology	Taipale M (2014), Taipale M (2014)	2
ORC1	3	ORC4	1	two hybrid, two hybrid, affinity chromatography technology	Kneissl M (2003), Kneissl M (2003), Hein MY (2015)	3
ILF2	3	MCM3	2	affinity chromatography technology	Karmakar S (2010)	1
NCL	1	ILF2	3	affinity chromatography technology	Salvetti A (2016)	1
MCM5	1	HIST1H3A	3	affinity chromatography technology	Drissi R (2015)	1
ORC1	3	ORC5	0	two hybrid, two hybrid, pull down, affinity chromatography technology	Kneissl M (2003), Kneissl M (2003), Ramachandran N (2004), Hein MY (2015)	4
RPA1	0	MCM4	3	two hybrid, two hybrid	Kneissl M (2003), Kneissl M (2003)	2
CDK2	0	MCM7	5	affinity chromatography technology	Neganova I (2011)	1
MCM6	5	ORC1	3	two hybrid, two hybrid	Kneissl M (2003), Kneissl M (2003)	2
SSRP1	1	MCM2	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Tan BC (2006), OConnell BC (2010), Huttlin EL (2017)	3
TONSL	4	MCM3	2	affinity chromatography technology	OConnell BC (2010)	1
MCM4	3	MCM6	5	pull down, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, biochemical, affinity chromatography technology, affinity chromatography technology	Yabuta N (2003), Kneissl M (2003), Kneissl M (2003), Ishimi Y (1996), You Z (2002), Havugimana PC (2012), Kristensen AR (2012), Wan C (2015), Hein MY (2015), Boldt K (2016)	10
MCM5	1	ORC2	0	two hybrid, two hybrid, biochemical	Kneissl M (2003), Kneissl M (2003), Wan C (2015)	3
MMS22L	6	TONSL	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	OConnell BC (2010), OConnell BC (2010), OConnell BC (2010), OConnell BC (2010), Piwko W (2010), Piwko W (2010), Piwko W (2010), Piwko W (2010), Duro E (2010), Duro E (2010)	10
AKAP8	1	MCM2	3	two hybrid, pull down, pull down, affinity chromatography technology, affinity chromatography technology	Eide T (2003), Eide T (2003), Eide T (2003), Eide T (2003), Eide T (2003)	5
MCM7	5	CDC7	2	two hybrid, two hybrid, enzymatic study	Kneissl M (2003), Kneissl M (2003), Masai H (2000)	3
HIST1H3A	3	ASF1A	0	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid, affinity chromatography technology, affinity chromatography technology	Tagami H (2004), Tagami H (2004), Akai Y (2010), Foltz DR (2009), Ask K (2012), Groth A (2005), Groth A (2005), Lambert JP (2015), Huttlin EL (2017), Zhang H (2013)	10
CDC6	0	MCM7	5	two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology	Kneissl M (2003), Kneissl M (2003), Kneissl M (2003), Fujita M (1999), Fujita M (1999), Sugimoto N (2015), Hubbi ME (2013)	7
KEAP1	0	MCM3	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, enzymatic study, affinity chromatography technology, affinity chromatography technology	Hast BE (2013), Hast BE (2014), Hast BE (2014), Mulvaney KM (2016), Mulvaney KM (2016), Mulvaney KM (2016), Mulvaney KM (2016), Lu K (2017), Mulvaney KM (2016)	9
ORC2	0	ORC5	0	two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, biochemical, pull down, affinity chromatography technology, pull down, affinity chromatography technology, biochemical, pull down, affinity chromatography technology, affinity chromatography technology	Kneissl M (2003), Kneissl M (2003), Kneissl M (2003), Quintana DG (1998), Dhar SK (2001), Dhar SK (2001), Vashee S (2001), Vashee S (2001), Keller C (2002), Havugimana PC (2012), Ramachandran N (2004), Vermeulen M (2010), Hein MY (2015)	13
MMS22L	6	SSRP1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	OConnell BC (2010), OConnell BC (2010), OConnell BC (2010), Huttlin EL (2017)	4
HIST1H3E	0	SF3B1	12	affinity chromatography technology	Campos EI (2015)	1
FANCD2	3	RPA1	0	affinity chromatography technology	Unno J (2014)	1
HIST1H3A	3	MCM7	5	affinity chromatography technology	Huttlin EL (2017)	1
HIST1H3E	0	MCM6	5	affinity chromatography technology	Campos EI (2015)	1
ORC2	0	MCM3	2	biochemical	Mendez J (2000)	1
MCM2	3	SF3B1	12	biochemical, biochemical	Havugimana PC (2012), Wan C (2015)	2
SPIN2B	0	MCM2	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
HSD17B10	1	MCM5	1	affinity chromatography technology	Malty RH (2017)	1
RPA1	0	MCM3	2	affinity chromatography technology	Gong Z (2011)	1
ORC5	0	CDC7	2	pull down	Ramachandran N (2004)	1
ASF1A	0	TONSL	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ask K (2012), Piwko W (2010), Duro E (2010), Huttlin EL (2017)	4
RPA1	0	ORC2	0	two hybrid, two hybrid	Kneissl M (2003), Kneissl M (2003)	2
HIST1H4A	0	MCM5	1	affinity chromatography technology, affinity chromatography technology	Saade E (2009), Drissi R (2015)	2
ASF1B	0	MCM6	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Jasencakova Z (2010), Duro E (2010), Campos EI (2015), Huttlin EL (2017)	4
MCM7	5	ORC5	0	two hybrid, two hybrid	Kneissl M (2003), Kneissl M (2003)	2
CDC6	0	ORC1	3	two hybrid, two hybrid, affinity chromatography technology, pull down, biochemical, affinity chromatography technology, pull down	Kneissl M (2003), Kneissl M (2003), Kneissl M (2003), Saha P (1998), Saha P (1998), Saha P (1998), Ramachandran N (2004)	7
HIST1H2BA	0	TONSL	4	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
TONSL	4	MCM7	5	affinity chromatography technology	OConnell BC (2010)	1
DBF4	2	MCM4	3	two hybrid, enzymatic study	Kneissl M (2003), Masai H (2000)	2
FANCD2	3	MCM2	3	imaging technique, affinity chromatography technology, affinity chromatography technology	Panneerselvam J (2014), Lossaint G (2013), Lossaint G (2013)	3
ASF1B	0	MCM2	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Jasencakova Z (2010), Campos EI (2015), Drissi R (2015), Huttlin EL (2017)	4
MMS22L	6	MCM7	5	affinity chromatography technology	OConnell BC (2010)	1
MCM3	2	MCM7	5	two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kneissl M (2003), Kneissl M (2003), Fujita M (1999), Fujita M (1997), Fujita M (2002), Havugimana PC (2012), Wan C (2015), Huttlin EL (2017), Lossaint G (2013), Mulvaney KM (2016)	10
HIST1H4A	0	MCM3	2	affinity chromatography technology	Saade E (2009)	1
MMS22L	6	MCM2	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	OConnell BC (2010), OConnell BC (2010), OConnell BC (2010)	3
CDC6	0	MCM2	3	pull down, affinity chromatography technology	Ramachandran N (2004), Hubbi ME (2013)	2
MCM5	1	MCM2	3	two hybrid, two hybrid, affinity chromatography technology, biochemical, pull down, biochemical, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology	Kneissl M (2003), Kneissl M (2003), DaFonseca CJ (2001), Havugimana PC (2012), Ramachandran N (2004), Wan C (2015), Drissi R (2015), Drissi R (2015), Huang J (2013), Lossaint G (2013)	10
HIST1H3A	3	MMS22L	6	affinity chromatography technology	Huttlin EL (2017)	1
ILF2	3	MCM2	3	affinity chromatography technology, affinity chromatography technology	Karmakar S (2010), Drissi R (2015)	2
ASF1B	0	MCM5	1	affinity chromatography technology	Campos EI (2015)	1
ASF1B	0	MCM7	5	affinity chromatography technology, affinity chromatography technology	Campos EI (2015), Huttlin EL (2017)	2
MCM2	3	NCL	1	biochemical, affinity chromatography technology	Kristensen AR (2012), Drissi R (2015)	2
H2AFX	1	MCM6	5	affinity chromatography technology	Huttlin EL (2017)	1
MCM5	1	CAP1	1	biochemical	Kristensen AR (2012)	1
MCMBP	3	MCM3	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Jagannathan M (2014), Taipale M (2014), Taipale M (2014), Wan C (2015), Huttlin EL (2017), Mulvaney KM (2016)	6
MCM2	3	HIST1H4A	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Saade E (2009), Saade E (2009), Saade E (2009), Drissi R (2015), Huttlin EL (2017)	5
MCM7	5	RPA1	0	two hybrid, two hybrid	Kneissl M (2003), Kneissl M (2003)	2
ORC1	3	CDK2	0	affinity chromatography technology, enzymatic study	Mendez J (2002), Mendez J (2002)	2
HIST1H4A	0	ASF1B	0	affinity chromatography technology	Huttlin EL (2017)	1
HIST1H3E	0	MCM4	3	affinity chromatography technology	Campos EI (2015)	1
CDK2	0	DBF4	2	enzymatic study	Masai H (2000)	1
TONSL	4	MCM6	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	OConnell BC (2010), Piwko W (2010), Duro E (2010)	3
HIST1H3E	0	MCM3	2	affinity chromatography technology	Campos EI (2015)	1
CDC6	0	ORC2	0	two hybrid, two hybrid, affinity chromatography technology, biochemical, pull down	Kneissl M (2003), Kneissl M (2003), Kneissl M (2003), Mendez J (2000), Ramachandran N (2004)	5
SSRP1	1	MCM4	3	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Tan BC (2006), Tan BC (2006), Tan BC (2006), OConnell BC (2010), Huttlin EL (2017)	5