PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
RPS6KA5	2	MAPK1	1	genetic interference	Deak M (1998)	1
STK39	3	MBP	0	enzymatic study	Johnston AM (2000)	1
MAPK14	0	MBP	0	enzymatic study, enzymatic study, enzymatic study, enzymatic study	Sudo T (2000), Plun-Favreau H (2007), Ge B (2003), Chen G (2000)	4
MUS81	1	MBP	0	genetic interference	Vizeacoumar FJ (2013)	1
LIMK1	3	LIMK2	0	affinity chromatography technology, enzymatic study	Hiraoka J (1996), Smolich B (1997)	2
MAPK14	0	MAPK1	1	affinity chromatography technology, affinity chromatography technology, protein complementation assay, affinity chromatography technology	Sanz-Moreno V (2003), Tanoue T (2001), Srivastav RK (2011), Chan PM (2008)	4
CTDSP1	0	CTDSPL	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
PRKCA	7	MBP	0	enzymatic study	Rininsland F (2005)	1
PRKCA	7	DDX58	3	enzymatic study, affinity chromatography technology, affinity chromatography technology	Maharaj NP (2011), Maharaj NP (2011), Maharaj NP (2011)	3
CDK1	0	STK3	1	enzymatic study	Chen X (2016)	1
LRRK2	5	PRKDC	12	affinity chromatography technology, affinity chromatography technology	Daechsel JC (2007), Sen S (2009)	2
MAPK14	0	LIMK1	3	enzymatic study	Kobayashi M (2006)	1
HNRNPL	3	CTDSPL	1	affinity chromatography technology	Fei T (2017)	1
TBK1	1	IKBKE	2	affinity chromatography technology, pull down, affinity chromatography technology, pull down	Li S (2011), Ikeda F (2007), Liu D (2015), Liu D (2015)	4
LIMK2	0	MBP	0	enzymatic study	Okano I (1995)	1
MAPK13	1	SQSTM1	0	enzymatic study	Linares JF (2015)	1
MAP3K1	4	MBP	0	enzymatic study	Ninomiya-Tsuji J (2003)	1
LRRK2	5	MBP	0	enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study	Ito G (2007), West AB (2005), Luzon-Toro B (2007), Sen S (2009), Guo L (2007), Webber PJ (2011)	6
PRKCI	1	SQSTM1	0	two hybrid, pull down, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, unspecified method, affinity chromatography technology, fluorescent resonance energy transfe	Sanchez P (1998), Sanchez P (1998), Sanchez P (1998), Sanchez P (1998), Behrends C (2010), Brajenovic M (2004), Lamark T (2003), Lamark T (2003), Lamark T (2003), Yang JQ (2010), Yang JQ (2010), Erdogan E (2006), Milan E (2015), Tsai LC (2015), Tsai LC (2015), Tsai LC (2015)	16
HNRNPL	3	MBP	0	affinity chromatography technology	Fei T (2017)	1
HNRNPL	3	PRKCI	1	affinity chromatography technology	Fei T (2017)	1
CDK1	0	MBP	0	enzymatic study	Plun-Favreau H (2007)	1
MAPK14	0	SQSTM1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Sudo T (2000), Sudo T (2000), Kawai K (2008), Kawai K (2008)	4
MAPK3	4	MBP	0	enzymatic study, enzymatic study, enzymatic study, enzymatic study	Plun-Favreau H (2007), Momose H (2003), Wasserman T (2010), Tresini M (2001)	4
SQSTM1	0	PRKCD	2	affinity chromatography technology	Linares JF (2011)	1
HNRNPL	3	TLK1	5	affinity chromatography technology	Fei T (2017)	1
CDK5	0	MBP	0	enzymatic study	Plun-Favreau H (2007)	1
PRKCD	2	MBP	0	enzymatic study	Ren J (2002)	1
ABL1	9	PRKCZ	5	affinity chromatography technology	Lasfer M (2006)	1
PTPRA	3	MBP	0	enzymatic study	Wang J (2013)	1
PRKCD	2	PRKCB	4	affinity chromatography technology	Varjosalo M (2013)	1
MBP	0	PLP1	0	biochemical, pull down	Wood DD (1984), Edwards AM (1989)	2
HNRNPL	3	TBK1	1	affinity chromatography technology	Fei T (2017)	1
MAPK12	1	MBP	0	enzymatic study	Plun-Favreau H (2007)	1
MBP	0	DDX58	3	affinity chromatography technology, affinity chromatography technology	Feng M (2012), Feng M (2012)	2
SQSTM1	0	MAP3K3	3	affinity chromatography technology, pull down, affinity chromatography technology, imaging technique, pull down, affinity chromatography technology	Nakamura K (2010), Nakamura K (2010), Nakamura K (2010), Nakamura K (2010), Nakamura K (2010), Yamazaki K (2009)	6
CDK7	0	CDK9	3	enzymatic study, biochemical, enzymatic study	Kim JB (2001), Garcia-Martinez LF (1997), Larochelle S (2012)	3
SQSTM1	0	MBP	0	pull down	Pridgeon JW (2004)	1
ATXN1	2	MBP	0	two hybrid	Lim J (2006)	1
MAPK11	1	MAPK14	0	two hybrid, affinity chromatography technology	Vinayagam A (2011), Varjosalo M (2013)	2
MAPK14	0	STK39	3	affinity chromatography technology	Piechotta K (2003)	1
CDK9	3	MBP	0	enzymatic study, enzymatic study	Pinhero R (2004), Grana X (1994)	2
DDX58	3	IKBKE	2	affinity chromatography technology	Oshiumi H (2013)	1
ATN1	2	MBP	0	two hybrid	Lim J (2006)	1
PRKCZ	5	PRKCI	1	affinity chromatography technology, affinity chromatography technology	So J (2015), Huttlin EL (2017)	2
IKBKE	2	MBP	0	enzymatic study	Ikeda F (2007)	1
MAPK1	1	MAP3K1	4	affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study	Karandikar M (2000), Karandikar M (2000), Gallagher ED (2004), Tu Z (2003), Loke J (2014)	5
MAP3K5	1	MBP	0	enzymatic study	Waak J (2009)	1
RPS6KA5	2	MBP	0	enzymatic study	New L (1999)	1
MBP	0	IDE	3	affinity chromatography technology	Huttlin EL (2017)	1
NLN	1	MBP	0	affinity chromatography technology	Huttlin EL (2017)	1
ABL1	9	PRKDC	12	pull down	Jin S (1997)	1
MAPK8	3	MBP	0	enzymatic study	Chen G (2000)	1
PRKDC	12	MBP	0	enzymatic study	Toji S (2004)	1
MAPK3	4	RPS6KA6	0	two hybrid	Vinayagam A (2011)	1
MAPK1	1	MBP	0	enzymatic study, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study	Plun-Favreau H (2007), Momose H (2003), Cavigelli M (1995), Tresini M (2001), Blaukat A (2000), Blaukat A (2000), Blaukat A (1999), Blaukat A (2001), Sang N (2003), Raskin A (2012), Egan JE (2002), Chen G (2000), Lammering G (2003), Larsson H (1999), Camps M (1998)	15
HNRNPL	3	HIPK2	0	affinity chromatography technology	Fei T (2017)	1
CDK8	1	PRMT5	3	affinity chromatography technology, affinity chromatography technology, pull down	Tsutsui T (2013), Tsutsui T (2013), Tsutsui T (2013)	3
TSSK6	0	MBP	0	enzymatic study	Spiridonov NA (2005)	1
PRKCZ	5	MBP	0	enzymatic study, enzymatic study	Pillai P (2011), Lerner-Marmarosh N (2007)	2
PRKDC	12	MAPK8	3	enzymatic study	Park SJ (2001)	1
SQSTM1	0	PRKCZ	5	affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, affinity chromatography technology, imaging technique, affinity chromatography technology	Sanz L (2000), Hirano Y (2004), Chang S (2002), Wilson MI (2003), Feng Y (2005), Kim GY (2012), Urbanczyk A (2011), Linares JF (2011), So J (2015), Tsai LC (2015), Huttlin EL (2017), Tobias IS (2016), Tobias IS (2016)	13
PRKCA	7	PRKCB	4	affinity chromatography technology	Huttlin EL (2017)	1
SQSTM1	0	ULK1	8	affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology	Ro SH (2014), Ro SH (2014), Lim J (2015), Lim J (2015)	4
LRRK2	5	SQSTM1	0	affinity chromatography technology, affinity chromatography technology	Park S (2016), Park S (2016)	2
CDK1	0	SQSTM1	0	pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology	Linares JF (2011), Linares JF (2011), Linares JF (2011), Galindo-Moreno M (2017)	4
ABL1	9	MBP	0	enzymatic study	Bae GU (2009)	1
RPS6KA5	2	MAPK11	1	genetic interference	Deak M (1998)	1
MAPK3	4	MAPK1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology	Varjosalo M (2013), Varjosalo M (2013), Wang J (2009), Wang J (2009), Wan C (2015), Hu B (2006)	6
MAPK14	0	MAPK8	3	affinity chromatography technology	Chan PM (2008)	1
TRPM7	5	MBP	0	enzymatic study	Ryazanova LV (2004)	1
LRRK2	5	STK3	1	enzymatic study	Zach S (2010)	1
PRKCB	4	DDX58	3	enzymatic study, affinity chromatography technology, affinity chromatography technology	Maharaj NP (2011), Maharaj NP (2011), Maharaj NP (2011)	3
APTX	3	MBP	0	two hybrid	Lim J (2006)	1
MAPK11	1	MBP	0	enzymatic study	Plun-Favreau H (2007)	1
IRAK4	0	MBP	0	enzymatic study	Rininsland F (2005)	1
MAP3K1	4	MAPK8	3	affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, imaging technique	Xu S (1997), Xu S (1997), Xu S (1997), Xu S (1997), Ryoo K (2004), Tu Z (2003), Sun BK (2011), Gallagher ED (2002), Chen TC (2014)	9
LRRK2	5	PRKCZ	5	enzymatic study	Zach S (2010)	1
PRKCI	1	CDK7	0	enzymatic study	Pillai P (2011)	1
MAP3K1	4	MAPK3	4	enzymatic study, imaging technique	Loke J (2014), Chen TC (2014)	2
MAPK14	0	RPS6KA5	2	affinity chromatography technology, two hybrid, affinity chromatography technology, pull down, affinity chromatography technology	Tanoue T (2001), Bandyopadhyay S (2010), Huttlin EL (2015), Smith JA (2000), Huttlin EL (2017)	5
MAP3K3	3	MBP	0	enzymatic study	Takeda AN (2014)	1
ULK1	8	MBP	0	enzymatic study	Nazio F (2013)	1
CDK8	1	MBP	0	enzymatic study	Pinhero R (2004)	1
HNRNPL	3	IDE	3	affinity chromatography technology	Fei T (2017)	1
MELK	1	MBP	0	enzymatic study	Beullens M (2005)	1
PPP2R5C	3	MBP	0	enzymatic study	Dozier C (2004)	1
TBK1	1	SQSTM1	0	enzymatic study, enzymatic study	Matsumoto G (2015), Richter B (2016)	2
HNRNPL	3	CDK8	1	affinity chromatography technology	Fei T (2017)	1
MAPK13	1	MBP	0	enzymatic study	Plun-Favreau H (2007)	1
CDK1	0	ABL1	9	enzymatic study	Kipreos ET (1990)	1
HNRNPL	3	ATXN1	2	affinity chromatography technology	Fei T (2017)	1
HNRNPL	3	PKN1	4	affinity chromatography technology	Fei T (2017)	1
PKN1	4	MAPK12	1	enzymatic study, affinity chromatography technology	Takahashi M (2003), Takahashi M (2003)	2
HNRNPL	3	PRKCZ	5	affinity chromatography technology	Fei T (2017)	1
SQSTM1	0	MAPK1	1	affinity chromatography technology	Linares JF (2011)	1
PKN1	4	MBP	0	enzymatic study	Isagawa T (2005)	1
DDX58	3	TBK1	1	affinity chromatography technology	Oshiumi H (2013)	1
TLK1	5	MBP	0	enzymatic study	Krause DR (2003)	1
PRKCB	4	CDK1	0	affinity chromatography technology	Chiarini A (2002)	1
CDK1	0	CDK7	0	enzymatic study	Garrett S (2001)	1
MAPK12	1	MAPK13	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
MYH6	12	MBP	0	affinity chromatography technology	Hein MY (2015)	1
TBK1	1	MBP	0	enzymatic study	Ikeda F (2007)	1
MBP	0	CTDSPL	1	affinity chromatography technology	Huttlin EL (2017)	1
CDK9	3	PRKDC	12	genetic interference	Shen JP (2017)	1
MAPK1	1	PPP2R5C	3	enzymatic study	Letourneux C (2006)	1
HLA-DRA	2	MBP	0	x-ray crystallography	Smith KJ (1998)	1
MAPK14	0	MAPK3	4	affinity chromatography technology, protein complementation assay	Sanz-Moreno V (2003), Srivastav RK (2011)	2
PRKCI	1	MBP	0	enzymatic study	Pillai P (2011)	1
MAP3K1	4	HIPK2	0	affinity chromatography technology, imaging technique	Ritterhoff S (2010), Ritterhoff S (2010)	2
PRMT5	3	MBP	0	enzymatic study	Rho J (2001)	1
HIPK2	0	ABL1	9	affinity chromatography technology, pull down, enzymatic study	Reuven N (2015), Reuven N (2015), Reuven N (2015)	3
HIPK2	0	MBP	0	enzymatic study	Hofmann TG (2000)	1
MAPK1	1	MAPK12	1	affinity chromatography technology	Varjosalo M (2013)	1
LIMK1	3	MBP	0	enzymatic study	Okano I (1995)	1
MBP	0	DDX54	1	affinity chromatography technology	Zhan R (2013)	1
STK3	1	MBP	0	enzymatic study	Kilili GK (2010)	1
PKN1	4	MAPK11	1	affinity chromatography technology	Takahashi M (2003)	1
CDK9	3	SQSTM1	0	biochemical	Garcia-Martinez LF (1997)	1
CDK7	0	MBP	0	enzymatic study	Pinhero R (2004)	1
MBP	0	CTDSP1	0	two hybrid, affinity chromatography technology	Rolland T (2014), Huttlin EL (2017)	2
RPS6KA6	0	MBP	0	biochemical	Havugimana PC (2012)	1
PRKCB	4	MBP	0	enzymatic study	Sato T (2014)	1