PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
MAZ	2	JUN	0	far western blotting, affinity chromatography technology	Kumar D (2009), Kumar D (2009)	2
JUN	0	CSNK2A1	15	pull down, far western blotting, enzymatic study	Yamaguchi Y (1998), Yamaguchi Y (1998), Uhle S (2003)	3
CDC14B	1	MAZ	2	bioid	St-Denis N (2016)	1
JUN	0	EWSR1	2	pull down, bioid	Fuchs B (2003), Elzi DJ (2014)	2
MOV10	6	MAZ	2	affinity chromatography technology	Castello A (2012)	1
BPTF	8	KEAP1	0	two hybrid, pull down, imaging technique, pull down	Strachan GD (2004), Strachan GD (2004), Strachan GD (2004), Strachan GD (2004)	4
HECW2	13	CSNK2A1	15	affinity chromatography technology	Lu L (2013)	1
CSNK2A1	15	NXF1	0	enzymatic study	Zhang M (2011)	1
EWSR1	2	OTUB1	0	bioid	Elzi DJ (2014)	1
KEAP1	0	MAZ	2	affinity chromatography technology	Sowa ME (2009)	1
FOS	0	JUN	0	pull down, two hybrid, pull down, x-ray crystallography, two hybrid, pull down, two hybrid, two hybrid, pull down, affinity chromatography technology, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, protein complementation assay, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, fluorescent resonance energy transfe, pull down, pull down, imaging technique, pull down, affinity chromatography technology, pull down, pull down, fluorescent resonance energy transfe, pull down, pull down, affinity chromatography technology, biochemical, imaging technique, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ito T (2001), Pognonec P (1997), Pognonec P (1997), Glover JN (1995), Yang X (1999), Nomura N (1993), Finkel T (1993), Finkel T (1993), Venugopal R (1998), Kumar NV (2001), Dumin E (2006), Bandyopadhyay S (2010), Asim M (2010), Asim M (2010), Srivastav RK (2011), Bossis G (2005), Bossis G (2005), Gupta K (2000), Bachmann M (2004), Reinke AW (2013), Miyagi M (2005), Subbaramaiah K (2007), Jang M (2012), Yamaguchi K (2005), Varjosalo M (2013), Miyamoto-Sato E (2010), Miyamoto-Sato E (2010), Varjosalo M (2013), Tang HY (2006), Marden NY (2005), Adler J (2010), Adler J (2010), Adler J (2010), Billiet L (2008), Huttlin EL (2015), Hein MY (2015), Li X (2015), Li X (2015), Huttlin EL (2017)	39
BPTF	8	MAZ	2	two hybrid, pull down, pull down, two hybrid	Jordan-Sciutto KL (2000), Jordan-Sciutto KL (2000), Jordan-Sciutto KL (2000), Strachan GD (2004)	4
OTUB1	0	MAZ	2	affinity chromatography technology	Scholz CC (2016)	1
EWSR1	2	MAZ	2	bioid	Elzi DJ (2014)	1
MAZ	2	DCC	3	pull down, affinity chromatography technology, two hybrid	Ugai H (2001), Ugai H (2001), Ugai H (2001)	3
CDC14B	1	CSNK2A1	15	bioid	St-Denis N (2016)	1
FOS	0	CSNK2A1	15	pull down, far western blotting	Yamaguchi Y (1998), Yamaguchi Y (1998)	2
MAZ	2	FOS	0	far western blotting, affinity chromatography technology	Kumar D (2009), Kumar D (2009)	2
CSNK2A1	15	OTUB1	0	enzymatic study	Herhaus L (2015)	1
MAZ	2	APOD	0	affinity chromatography technology	Huttlin EL (2017)	1
HECW2	13	MAZ	2	affinity chromatography technology	Lu L (2013)	1
MAPK14	0	CSNK2A1	15	affinity chromatography technology, pull down	Sayed M (2000), Sayed M (2000)	2
CSNK2A1	15	MAZ	2	enzymatic study	Tsutsui H (1999)	1
MAPK14	0	MAZ	2	affinity chromatography technology	Varjosalo M (2013)	1
MAPK14	0	JUN	0	enzymatic study	Thakur N (2014)	1
NXF1	0	MAZ	2	affinity chromatography technology	Castello A (2012)	1