Gene-drug interactions (data source: DGIdb)
Gene Name Entrez ID Drug Name Chembl ID Interaction Types Sources publications
MAPT 4137 PACLITAXEL CHEMBL428647 DrugBank 18068131
MAPT 4137 DOCETAXEL CHEMBL92 DrugBank 18068131

Variant-drug associations (data source: PharmGKB)
Gene Name Variant Alleles Chemical Phenotype Category Significance Notes Sentence Publications Annotation ID
MAPT rs1800547 G corticosteroids efficacy no The drugs were fluticasone furoate (82% of patients) and fluticasone propionate (18%). Response was assessed as change in FEV1 from baseline over 8 weeks (or 12 for HZA106837). The cohort was the meta-analysis of a combination of 7 randomized, double-blind, placebo-controlled, parallel-group, multi center studies conducted in 26 countries. They included FFA109684, FFA109685, FFA109687, FFA112059, HZA106827, HZA106829, and HZA106837. Allele G is not associated with response to corticosteroids in people with Asthma as compared to allele A. 27523435 1448258393
MAPT rs1052587 C corticosteroids efficacy no The drugs were fluticasone furoate (82% of patients) and fluticasone propionate (18%). Response was assessed as change in FEV1 from baseline over 8 weeks (or 12 for HZA106837). The cohort was the meta-analysis of a combination of 7 randomized, double-blind, placebo-controlled, parallel-group, multi center studies conducted in 26 countries. They included FFA109684, FFA109685, FFA109687, FFA112059, HZA106827, HZA106829, and HZA106837. Allele C is not associated with response to corticosteroids in people with Asthma as compared to allele T. 27523435 1448258411
MAPT rs9468 C corticosteroids efficacy no The drugs were fluticasone furoate (82% of patients) and fluticasone propionate (18%). Response was assessed as change in FEV1 from baseline over 8 weeks (or 12 for HZA106837). The cohort was the meta-analysis of a combination of 7 randomized, double-blind, placebo-controlled, parallel-group, multi center studies conducted in 26 countries. They included FFA109684, FFA109685, FFA109687, FFA112059, HZA106827, HZA106829, and HZA106837. Allele C is not associated with response to corticosteroids in people with Asthma as compared to allele T. 27523435 1448258402