PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
MAGEA11	1	PHYH	1	two hybrid	Rual JF (2005)	1
CSNK2A1	15	MAGEA11	1	two hybrid	Rolland T (2014)	1
ALDH5A1	5	MAGEA11	1	two hybrid	Corominas R (2014)	1
MAGEA11	1	TRIM51	0	two hybrid	Rual JF (2005)	1
MAGEA11	1	4105	0	affinity chromatography technology	Laiseca JE (2017)	1
PNKD	2	MAPK3	4	affinity chromatography technology	Huttlin EL (2015)	1
MAGEA11	1	MED28	2	two hybrid	Rual JF (2005)	1
OTUB2	0	TRIM27	2	two hybrid	Hayes SD (2012)	1
VTA1	1	MAPK3	4	biochemical	Wan C (2015)	1
IL6ST	0	MAGEA11	1	two hybrid	Rolland T (2014)	1
PNKP	3	MYOZ1	1	two hybrid	Rual JF (2005)	1
EGLN3	0	MAGEA11	1	affinity chromatography technology	Aprelikova O (2009)	1
TRIM27	2	SH2D4A	0	two hybrid	Rolland T (2014)	1
MAGEA11	1	WTAP	0	two hybrid	Rual JF (2005)	1
EGLN3	0	PSMF1	0	affinity chromatography technology	Rodriguez J (2016)	1
MAGEA11	1	MXD3	1	two hybrid	Rual JF (2005)	1
MAGEA11	1	PNKD	2	two hybrid, two hybrid	Rual JF (2005), Rolland T (2014)	2
ZBTB16	4	NR3C1	2	pull down	Martin PJ (2003)	1
EP300	36	E2F1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ji W (2014), Ianari A (2004), Aoki I (2012)	3
EGLN3	0	CSNK2A1	15	affinity chromatography technology	Rodriguez J (2016)	1
RB1	2	AR	3	pull down, pull down, two hybrid, affinity chromatography technology	Lu J (1998), Yeh S (1998), Yeh S (1998), Gamble SC (2007)	4
MAGEA11	1	RBL1	1	affinity chromatography technology	Su S (2013)	1
TRIM27	2	RB1	2	two hybrid, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology	Kruetzfeldt M (2005), Kruetzfeldt M (2005), Kruetzfeldt M (2005), Kruetzfeldt M (2005), Kruetzfeldt M (2005)	5
MAGEA11	1	OTUB2	0	two hybrid	Rual JF (2005)	1
MAGEA11	1	PSMF1	0	two hybrid	Rual JF (2005)	1
MAGEA11	1	GNPDA1	1	two hybrid	Rolland T (2014)	1
SH2D4A	0	CEP76	1	two hybrid	Rolland T (2014)	1
TPM3	0	CCDC146	3	two hybrid	Rolland T (2014)	1
MAGEA11	1	TEX37	1	two hybrid	Rual JF (2005)	1
ILF3	5	MAGEA11	1	two hybrid	Rual JF (2005)	1
MAGEA11	1	TCF25	0	two hybrid, two hybrid	Rual JF (2005), Rolland T (2014)	2
MAGEA11	1	CCDC185	3	two hybrid	Rual JF (2005)	1
AR	3	E2F1	0	affinity chromatography technology, affinity chromatography technology	Li Y (2012), Li Y (2012)	2
AR	3	RBL1	1	affinity chromatography technology	Su S (2013)	1
MAGEA11	1	CEP76	1	two hybrid	Rual JF (2005)	1
PDE4B	3	MAGEA11	1	two hybrid	Corominas R (2014)	1
SKP1	0	PSMF1	0	affinity chromatography technology	Hauri S (2016)	1
MAGEA11	1	MYOZ1	1	two hybrid	Rual JF (2005)	1
MAGEA11	1	AKR1C3	1	two hybrid	Rual JF (2005)	1
EGLN1	3	MAGEA11	1	two hybrid, pull down, affinity chromatography technology	Aprelikova O (2009), Aprelikova O (2009), Aprelikova O (2009)	3
MAGEA11	1	ZBTB16	4	two hybrid	Rual JF (2005)	1
AR	3	NCOA2	2	two hybrid, pull down, affinity chromatography technology, unspecified method, affinity chromatography technology	Song LN (2004), Ishitani K (2003), Wang Q (2004), He B (2003), Bai S (2005)	5
IL11	1	MAGEA11	1	two hybrid, two hybrid	Rual JF (2005), Rolland T (2014)	2
RBL1	1	E2F1	0	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Dyson N (1993), Dyson N (1993), Moberg K (1996), Dhillon NK (2002), Su S (2013), Trimarchi JM (1998)	6
MAGEA11	1	ZSWIM2	1	two hybrid	Rual JF (2005)	1
AR	3	IL6ST	0	affinity chromatography technology	Xie S (2004)	1
FKBP5	0	PGR	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sinars CR (2003), Schuelke JP (2010), Su S (2012)	3
MAPK3	4	STAR	1	pull down, enzymatic study	Paz C (2009), Paz C (2009)	2
EGLN3	0	POLR1D	4	affinity chromatography technology	Rodriguez J (2016)	1
EGLN3	0	SKP1	0	affinity chromatography technology	Rodriguez J (2016)	1
MAGEA11	1	NOS3	7	two hybrid	Rolland T (2014)	1
ZBTB16	4	VTA1	1	two hybrid	Rual JF (2005)	1
NR3C1	2	EP300	36	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Amat R (2007), Wang W (2012), Kino T (2002)	3
EGLN3	0	BIRC2	1	affinity chromatography technology	Fu J (2016)	1
TRIM27	2	ZBTB16	4	two hybrid	Rual JF (2005)	1
BIRC2	1	WDYHV1	0	two hybrid, affinity chromatography technology	Rolland T (2014), Huttlin EL (2017)	2
CDKN2B	0	NIF3L1	0	two hybrid	Rolland T (2014)	1
PNKD	2	RADIL	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
EGLN3	0	EGLN2	4	affinity chromatography technology, affinity chromatography technology	Nakayama K (2007), Nakayama K (2007)	2
EGLN2	4	MAGEA11	1	affinity chromatography technology	Aprelikova O (2009)	1
MAGEA11	1	MLF1	2	two hybrid	Rual JF (2005)	1
UBE2D4	0	TRIM27	2	two hybrid, two hybrid	Markson G (2009), Napolitano LM (2011)	2
EP300	36	PGR	1	affinity chromatography technology	Shiozawa T (2003)	1
4105	0	SH2D4A	0	two hybrid	Rolland T (2014)	1
MAGEA11	1	PIN4	0	two hybrid	Rolland T (2014)	1
MAGEA11	1	UBE2D4	0	two hybrid	Rual JF (2005)	1
BIRC2	1	E2F1	0	affinity chromatography technology, affinity chromatography technology	Cartier J (2011), Cartier J (2011)	2
MAGEA11	1	NDEL1	2	two hybrid	Rual JF (2005)	1
EGLN3	0	NDEL1	2	affinity chromatography technology	Rodriguez J (2016)	1
CDKN2B	0	MAGEA11	1	two hybrid	Rual JF (2005)	1
MAGEA11	1	ZNF655	0	two hybrid	Rual JF (2005)	1
BIRC2	1	ILF3	5	affinity chromatography technology, affinity chromatography technology	Graber TE (2010), Graber TE (2010)	2
ACTN1	5	MAGEA11	1	two hybrid	Rual JF (2005)	1
MAGEA11	1	RBM23	0	two hybrid	Rolland T (2014)	1
TRIM27	2	BEX2	0	two hybrid	Rolland T (2014)	1
NR3C1	2	NCOA2	2	pull down, x-ray crystallography, affinity chromatography technology, two hybrid, pull down, bioid	Zilliacus J (2001), Bledsoe RK (2002), Fryer CJ (1998), Hong H (1999), Hong H (1999), Lempiaeinen JK (2017)	6
EP300	36	EWSR1	2	two hybrid, bioid	Wang J (2011), Elzi DJ (2014)	2
BIRC2	1	MAGEA11	1	two hybrid	Rual JF (2005)	1
MAGEA11	1	SH2D4A	0	two hybrid, affinity chromatography technology	Rual JF (2005), Rual JF (2005)	2
MAGEA11	1	NDUFB9	0	two hybrid, two hybrid	Rual JF (2005), Rolland T (2014)	2
MAGEA11	1	SNX7	0	two hybrid	Rual JF (2005)	1
MAGEA11	1	CDC20B	2	two hybrid	Rolland T (2014)	1
WDYHV1	0	TRMT1	3	affinity chromatography technology	Huttlin EL (2017)	1
RB1	2	EP300	36	affinity chromatography technology, affinity chromatography technology, enzymatic study	Iyer NG (2007), Iyer NG (2007), Chan HM (2001)	3
MAGEA11	1	NDUFAF1	0	two hybrid	Rual JF (2005)	1
MAGEA11	1	EP300	36	pull down, affinity chromatography technology	Askew EB (2010), Askew EB (2010)	2
TXN2	0	NR3C1	2	pull down, affinity chromatography technology	Psarra AM (2009), Psarra AM (2009)	2
EP300	36	ILF3	5	pull down	Karmakar S (2010)	1
ILF3	5	NDUFB9	0	biochemical	Havugimana PC (2012)	1
TRIM27	2	WDYHV1	0	two hybrid	Rolland T (2014)	1
EGLN3	0	PRDX3	3	affinity chromatography technology	Rodriguez J (2016)	1
MAGEA11	1	MCRS1	1	two hybrid	Rual JF (2005)	1
AR	3	EP300	36	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology	Dai Y (2008), Minges JT (2013), Zhong J (2014), Fu M (2000), McClurg UL (2016), Tan G (2017)	6
MAGEA11	1	POLR1D	4	two hybrid	Rual JF (2005)	1
EWSR1	2	NSUN4	0	two hybrid	Rual JF (2005)	1
EGLN3	0	NCOA2	2	affinity chromatography technology	Rodriguez J (2016)	1
PRDX3	3	BIRC2	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
MAGEA11	1	PRDX3	3	two hybrid	Rual JF (2005)	1
MAGEA11	1	FAM156A	0	two hybrid	Rual JF (2005)	1
MAGEA11	1	WDYHV1	0	two hybrid	Rolland T (2014)	1
AR	3	MAGEA11	1	imaging technique, two hybrid, pull down, affinity chromatography technology, biochemical, affinity chromatography technology, two hybrid, two hybrid, affinity chromatography technology, two hybrid	Bai S (2005), Bai S (2005), Bai S (2005), Bai S (2005), Bai S (2008), Liu Q (2011), Askew EB (2009), Askew EB (2009), Minges JT (2013), Corominas R (2014)	10
MAGEA11	1	TCEA2	1	two hybrid, affinity chromatography technology	Rual JF (2005), Rual JF (2005)	2
EWSR1	2	GNPDA1	1	two hybrid	Rual JF (2005)	1
MAGEA11	1	MAGEA11	1	affinity chromatography technology	Bai S (2008)	1
MAGEA11	1	SNX20	2	two hybrid, two hybrid	Rual JF (2005), Rolland T (2014)	2
MAGEA11	1	NSUN4	0	two hybrid	Rual JF (2005)	1
MAGEA11	1	KIAA0408	0	two hybrid	Rual JF (2005)	1
MAGEA11	1	DIEXF	3	two hybrid, two hybrid	Rual JF (2005), Rolland T (2014)	2
MAGEA11	1	TRIM27	2	two hybrid	Rual JF (2005)	1
LNX1	7	NDEL1	2	affinity chromatography technology	Lenihan JA (2017)	1
MAGEA11	1	NCOA2	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid	Askew EB (2010), Askew EB (2010), Askew EB (2009), Askew EB (2009), Askew EB (2009), Askew EB (2009)	6
MAPK3	4	MAGEA11	1	enzymatic study	Askew EB (2009)	1
NR3C1	2	PRDX3	3	protein complementation assay	Lievens S (2016)	1
MAGEA11	1	ZCCHC12	1	two hybrid	Rolland T (2014)	1
AR	3	ZBTB16	4	two hybrid	van de Wijngaart DJ (2009)	1
TRIM27	2	TCEA2	1	two hybrid	Rolland T (2014)	1
MAGEA11	1	PRKRIP1	0	two hybrid	Rual JF (2005)	1
HOXB5	0	MAGEA11	1	two hybrid	Rolland T (2014)	1
MAGEA11	1	ENOX2	1	two hybrid, two hybrid	Rual JF (2005), Rolland T (2014)	2
MAGEA11	1	CLUAP1	1	two hybrid, affinity chromatography technology, two hybrid	Rual JF (2005), Rual JF (2005), Rolland T (2014)	3
MAGEA11	1	USP20	3	two hybrid	Rolland T (2014)	1
LNX1	7	SUV39H2	3	two hybrid	Weimann M (2013)	1
TRIM27	2	NDEL1	2	two hybrid, affinity chromatography technology	Rolland T (2014), Huttlin EL (2017)	2
ZBTB16	4	SH2D4A	0	two hybrid	Rolland T (2014)	1
4105	0	CCDC146	3	two hybrid	Rolland T (2014)	1
ILF3	5	PCBD2	0	affinity chromatography technology	Chu L (2012)	1
MAGEA11	1	SKP1	0	affinity chromatography technology	Askew EB (2009)	1
TRIM27	2	NIF3L1	0	two hybrid	Yu H (2011)	1
MAGEA11	1	PCBD2	0	two hybrid	Rolland T (2014)	1
MAGEA11	1	NR3C1	2	affinity chromatography technology	Liu Q (2011)	1
EWSR1	2	MAGEA11	1	two hybrid	Rual JF (2005)	1
TPM3	0	FKBP5	0	biochemical	Kristensen AR (2012)	1
AR	3	SUV39H2	3	two hybrid, affinity chromatography technology, affinity chromatography technology, pull down, imaging technique	Askew EB (2017), Askew EB (2017), Askew EB (2017), Askew EB (2017), Askew EB (2017)	5
MAGEA11	1	PGR	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Su S (2012), Su S (2012), Liu Q (2011)	3
FKBP5	0	MAGEA11	1	affinity chromatography technology	Su S (2012)	1
MAGEA11	1	RB1	2	affinity chromatography technology	Su S (2013)	1
CEP76	1	CSNK2A1	15	affinity chromatography technology	Fogeron ML (2013)	1
MTA1	3	EP300	36	affinity chromatography technology	Gururaj AE (2006)	1
MAGEA11	1	BEX2	0	two hybrid, two hybrid	Rual JF (2005), Rolland T (2014)	2
LNX1	7	ILF3	5	two hybrid	Guo Z (2012)	1
PGR	1	NCOA2	2	affinity chromatography technology	An BS (2006)	1
ACTN1	5	TPM3	0	biochemical	Wan C (2015)	1
MAGEA11	1	C18orf54	2	two hybrid, two hybrid	Rual JF (2005), Rolland T (2014)	2
MAGEA11	1	TCEANC	0	two hybrid	Rual JF (2005)	1
EGLN3	0	TCF25	0	affinity chromatography technology	Rodriguez J (2016)	1
LNX1	7	TRIM27	2	affinity chromatography technology, affinity chromatography technology	Lenihan JA (2017), Lenihan JA (2017)	2
MAGEA11	1	JADE3	1	two hybrid	Rolland T (2014)	1
MAGEA11	1	SUV39H2	3	affinity chromatography technology, affinity chromatography technology, two hybrid, pull down, imaging technique	Askew EB (2017), Askew EB (2017), Askew EB (2017), Askew EB (2017), Askew EB (2017)	5
AR	3	FKBP5	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Schuelke JP (2010), Ni L (2010), Luo K (2017)	3
MAGEA11	1	TMEM123	0	two hybrid, two hybrid	Rual JF (2005), Rolland T (2014)	2
TRIM27	2	CDC20B	2	two hybrid	Rolland T (2014)	1
MAGEA11	1	BCL2L11	4	two hybrid	Rolland T (2014)	1
MAGEA11	1	NIF3L1	0	two hybrid	Rual JF (2005)	1
MAGEA11	1	COX7A2L	1	two hybrid	Rual JF (2005)	1
EGLN3	0	EGLN1	3	affinity chromatography technology	Nakayama K (2007)	1
NR3C1	2	FKBP5	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Schuelke JP (2010), Taipale M (2014), Taipale M (2014)	3
ILF3	5	TXN2	0	biochemical	Havugimana PC (2012)	1
MAGEA11	1	MTA1	3	two hybrid	Rolland T (2014)	1
MAGEA11	1	PNKP	3	two hybrid	Rual JF (2005)	1
RADIL	3	CEP76	1	two hybrid	Rolland T (2014)	1
MAGEA11	1	ARHGAP29	0	two hybrid	Rual JF (2005)	1
MAGEA11	1	DOCK10	10	two hybrid	Rolland T (2014)	1
TRIM27	2	TPM3	0	two hybrid	Rolland T (2014)	1
EWSR1	2	SUV39H2	3	two hybrid	Rual JF (2005)	1
MAGEA11	1	ACMSD	0	two hybrid, two hybrid	Rual JF (2005), Rolland T (2014)	2
MAGEA11	1	TXN2	0	two hybrid	Rolland T (2014)	1
MAGEA11	1	THEM5	0	two hybrid	Rolland T (2014)	1
MAGEA11	1	NOL4	1	two hybrid	Rual JF (2005)	1
NR3C1	2	POLR1D	4	two hybrid	Wang J (2011)	1
FKBP5	0	EGLN1	3	affinity chromatography technology, affinity chromatography technology	Taipale M (2014), Taipale M (2014)	2
ACTN1	5	MYOZ1	1	two hybrid	Rual JF (2005)	1
MAGEA11	1	CCDC146	3	two hybrid	Rolland T (2014)	1
MAGEA11	1	E2F1	0	affinity chromatography technology	Su S (2013)	1
EP300	36	ZBTB16	4	affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology	Guidez F (2005), Guidez F (2005), Choi WI (2014), Choi WI (2014)	4
TRIM27	2	RBM23	0	two hybrid	Rolland T (2014)	1
MAGEA11	1	TPM3	0	two hybrid	Rolland T (2014)	1
NCOA2	2	EP300	36	affinity chromatography technology, two hybrid, enzymatic study	Askew EB (2010), Hong H (1999), Chen H (1999)	3
MAGEA11	1	LNX1	7	two hybrid	Rual JF (2005)	1
MAPK3	4	PRDX3	3	affinity chromatography technology	Galli S (2009)	1
EGLN3	0	RADIL	3	affinity chromatography technology	Rodriguez J (2016)	1
MAGEA11	1	RADIL	3	two hybrid, two hybrid	Rual JF (2005), Rolland T (2014)	2
MAGEA11	1	MGME1	1	two hybrid	Rual JF (2005)	1
MAGEA11	1	VTA1	1	two hybrid	Rual JF (2005)	1
RBM23	0	PGR	1	pull down	Dowhan DH (2005)	1
MAGEA11	1	CCDC14	2	two hybrid, two hybrid	Rual JF (2005), Rolland T (2014)	2
MAPK3	4	BCL2L11	4	affinity chromatography technology, affinity chromatography technology	He C (2014), He C (2014)	2
MAGEA11	1	STAR	1	two hybrid	Rolland T (2014)	1
MAGEA11	1	TRMT1	3	two hybrid, two hybrid, two hybrid	Rual JF (2005), Rolland T (2014), Yu H (2011)	3
RB1	2	E2F1	0	affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, pull down, affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, pull down, affinity chromatography technology, pull down, affinity chromatography technology, x-ray crystallography, pull down, two hybrid, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, pull down, pull down, affinity chromatography technology, affinity chromatography technology	Nicolas E (2001), Pardo PS (2002), Choubey D (1996), Fajas L (2000), Dyson N (1993), Dyson N (1993), Wu CL (1995), Taniura H (1998), Dai Y (2003), Fedele M (2006), Fedele M (2006), Brown VD (2002), De Blasio A (2005), Chau CM (2008), Dasgupta P (2004), Yang L (2011), Kruetzfeldt M (2005), Harbour JW (1999), Lee SJ (1998), Gao D (2009), Delston RB (2011), Gupta K (2000), Sdek P (2004), Flemington EK (1993), Chang YH (2012), Inoue Y (2007), Inoue Y (2007), Inoue Y (2007), Liu X (2006), Moberg K (1996), Knudsen ES (1996), Brown VD (1999), Brown VD (1999), Whitaker LL (1998), Whitaker LL (1998), Hagemeier C (1993), Bhat UG (1999), Xiao B (2003), Xiao B (2003), Vidal M (1996), Markham D (2006), Markham D (2006), Ianari A (2009), Ianari A (2009), Dhillon NK (2002), Knudsen ES (1997), Knudsen ES (1997), Gery S (2004), Gery S (2004), Kashuba E (2008), Kashuba E (2008), Pearson A (1997), Ginsberg D (1994), Welch PJ (1995), Wang J (2009), Aoki I (2012), Trimarchi JM (1998), Kumari A (2015), Gamell C (2017), Chen TT (2000), Chen TT (2000), Chen TT (2000), Chen TT (2000)	63
EGLN3	0	PNKD	2	affinity chromatography technology	Rodriguez J (2016)	1
MAGEA11	1	DNAJC10	3	two hybrid, two hybrid	Rual JF (2005), Rolland T (2014)	2