PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
MAP2K6	2	MAPK14	0	enzymatic study, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, pull down, enzymatic study, fluorescent resonance energy transfe	Sanz-Moreno V (2003), Raingeaud J (1996), Stein B (1996), Chen Z (2001), Casar B (2007), Xia Y (1998), ter Haar E (2007), Ivanov AA (2017)	8
HDAC6	0	ATM	9	affinity chromatography technology	New M (2013)	1
HDAC1	4	STRAP	2	affinity chromatography technology	Jin L (2014)	1
RNF111	2	SMAD6	9	affinity chromatography technology	Koinuma D (2003)	1
NR4A1	4	RNF111	2	affinity chromatography technology	Zhou F (2014)	1
TGFBR1	2	BAMBI	3	pull down, affinity chromatography technology	Yan X (2009), Yan X (2009)	2
ATM	9	SMAD7	1	affinity chromatography technology	Zhang S (2006)	1
SIRT1	3	MYOD1	0	imaging technique	Amat R (2009)	1
EP300	36	SMAD3	1	affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Qiu P (2006), Furumatsu T (2005), Itoh S (2000), Akiyoshi S (1999), Abecassis L (2004), Kaimori A (2010), Janknecht R (1998), Janknecht R (1998), Nishihara A (1999), Nishihara A (1999), Furumatsu T (2005), Ghosh AK (2004), Shen X (1998), Shen X (1998), Ghosh AK (2001), Postigo AA (2003), Postigo AA (2003), Yang WS (2005), Lim JY (2012), Lim JY (2012), Jinnin M (2007), Wang G (2005)	22
MAP3K7	2	SMAD6	9	affinity chromatography technology, affinity chromatography technology	Kimura N (2000), Yanagisawa M (2001)	2
TGFBR2	0	ACVR1	4	two hybrid	Kawabata M (1995)	1
CTNNB1	30	HDAC6	0	affinity chromatography technology	Li Y (2008)	1
SMAD1	0	PIAS4	5	two hybrid, affinity chromatography technology, two hybrid	Long J (2003), Long J (2003), Colland F (2004)	3
PIAS4	5	SMAD7	1	two hybrid, affinity chromatography technology, two hybrid	Imoto S (2003), Imoto S (2003), Colland F (2004)	3
MAPK14	0	SMAD7	1	affinity chromatography technology, affinity chromatography technology	Edlund S (2003), Zhang S (2006)	2
SMAD7	1	CTNNB1	30	affinity chromatography technology, imaging technique, affinity chromatography technology	Edlund S (2005), Edlund S (2005), Tang Y (2008)	3
SMAD6	9	SMAD7	1	two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology	Topper JN (1997), Topper JN (1997), Topper JN (1997), Yan X (2016)	4
ATM	9	NR4A1	4	two hybrid	Arroyo R (2015)	1
WWP2	7	WWP1	3	affinity chromatography technology, affinity chromatography technology	Chaudhary N (2014), Chaudhary N (2014)	2
MAP3K7	2	ATM	9	affinity chromatography technology	Yang Y (2011)	1
BMPR1A	5	FKBP1A	0	two hybrid	Kurozumi K (1998)	1
SMAD7	1	ERBIN	5	pull down	Warner DR (2003)	1
ACVR1B	1	ACVR1	4	affinity chromatography technology, affinity chromatography technology	De Winter JP (1996), Huttlin EL (2015)	2
AKT1	1	NR4A1	4	affinity chromatography technology, enzymatic study	Pekarsky Y (2001), Pekarsky Y (2001)	2
USP15	4	BMPR1A	5	affinity chromatography technology, imaging technique, enzymatic study	Herhaus L (2014), Herhaus L (2014), Herhaus L (2014)	3
SMAD7	1	KDM2A	4	two hybrid	Colland F (2004)	1
SMAD7	1	TGFBR1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Mochizuki T (2004), Asano Y (2004), Koinuma D (2003), Kavsak P (2000), Hayashi H (1997), Hayashi H (1997), Datta PK (2000), Wicks SJ (2005), Lallemand F (2005), Seong HA (2007), Yan X (2011), Cai Y (2012), Cai Y (2012), Seo SR (2004), Zhu L (2012), Zhu L (2012), Nakao A (1997), Yan X (2009), Kamiya Y (2010), Suzuki C (2002), Hsu HY (2014)	21
ERBIN	5	CBL	7	affinity chromatography technology	Yao S (2015)	1
MAP3K7	2	ITCH	1	affinity chromatography technology	Kathania M (2015)	1
MYOD1	0	EP300	36	pull down, genetic interference, pull down, pull down, pull down, affinity chromatography technology, imaging technique, affinity chromatography technology, pull down	Lau P (1999), Sartorelli V (1997), Sartorelli V (1997), Sartorelli V (1997), Magenta A (2003), Serra C (2007), Jin W (2011), Yuan W (1996), Yuan W (1996)	9
MAPK14	0	TOLLIP	3	affinity chromatography technology	Yagasaki Y (2004)	1
EP300	36	SMAD4	9	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, unspecified method, affinity chromatography technology	Kim RH (2000), Luciakova K (2008), Janknecht R (1998), Chung CL (2011), Shen X (1998), Dornan D (2003), Yang Y (2015)	7
MAP3K7	2	TAB2	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Cheung PC (2004), Cheung PC (2004), Takaesu G (2000), Takaesu G (2001), Ishitani T (2003), Ishitani T (2003), Ea CK (2006), Broglie P (2010), Liu XY (2008), Li S (2011), Li S (2011), Jiang Z (2003), Mendoza H (2008), Ear T (2010), Criollo A (2011), Kim SY (2012), Jiang Z (2002), Jiang Z (2002), Hong S (2007), Shibuya H (1996), Minoda Y (2009), Li M (2010), Scholz R (2010), Kim SI (2009), Yong Kim S (2013), Liu R (2014), Wang J (2015), Moon G (2015), Wade EM (2016), Min Y (2016), Zhang J (2017)	31
ACVR1	4	SMURF1	4	affinity chromatography technology	Murakami G (2003)	1
ACVR2B	0	ACVR1B	1	biochemical, affinity chromatography technology	Attisano L (1996), De Winter JP (1996)	2
STRAP	2	TGFBR1	2	affinity chromatography technology, affinity chromatography technology	Datta PK (1998), Datta PK (2000)	2
TP53	0	MAP2K3	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
EP300	36	PIAS1	4	pull down, affinity chromatography technology	Ledsaak M (2016), Ledsaak M (2016)	2
SMAD9	0	KAT2B	2	affinity chromatography technology	Kahata K (2004)	1
SMURF2	3	SMURF1	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Fukunaga E (2008), Fukunaga E (2008), Lee YS (2011), Huttlin EL (2017)	4
PIAS4	5	SMAD3	1	affinity chromatography technology, two hybrid, affinity chromatography technology, pull down, affinity chromatography technology, pull down	Imoto S (2003), Long J (2003), Long J (2003), Long J (2003), Long J (2003), Long J (2003)	6
SMAD7	1	ITCH	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Lallemand F (2005), Lallemand F (2005), Al-Salihi MA (2012), Gen Y (2017), Gen Y (2017)	5
SMAD7	1	PIAS1	4	two hybrid	Colland F (2004)	1
RNF111	2	SMAD7	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Koinuma D (2003), Koinuma D (2003), Erker Y (2013), Elkouris M (2016)	4
SMAD2	5	DVL1	5	pull down	Warner DR (2003)	1
BMPR1A	5	SMURF1	4	affinity chromatography technology	Murakami G (2003)	1
LEF1	3	SMAD3	1	pull down, affinity chromatography technology, unspecified method, pull down, affinity chromatography technology	Labbe E (2000), Labbe E (2000), Cui Q (2005), Cui Q (2005), Cui Q (2005)	5
SMAD3	1	PARD3	5	pull down	Warner DR (2003)	1
ACVR2B	0	SMAD2	5	affinity chromatography technology	Miura S (2000)	1
CTNNB1	30	KAT2B	2	pull down, pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study	Ge X (2009), Ge X (2009), Ge X (2009), Ge X (2009), Ge X (2009)	5
SMAD7	1	SMURF2	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, unspecified method, affinity chromatography technology, affinity chromatography technology, pull down, x-ray crystallography, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Asano Y (2004), Kavsak P (2000), Lee YS (2008), Komuro A (2004), Chong PA (2010), Chong PA (2010), Chong PA (2010), Cai Y (2012), Cai Y (2012), Chong PA (2006), Al-Salihi MA (2012), Ogunjimi AA (2005), Aragon E (2012), Aragon E (2012), Colland F (2004), Zhang L (2013), Chandhoke AS (2015), Iyengar PV (2015), Elkouris M (2016)	19
CTNNB1	30	SIRT1	3	affinity chromatography technology	Holloway KR (2010)	1
DVL1	5	CTNNB1	30	affinity chromatography technology, imaging technique	Song DH (2000), Chen TC (2014)	2
AKT1	1	PIAS1	4	two hybrid	Depaux A (2007)	1
NR4A1	4	CTNNB1	30	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sun Z (2011), Sun Z (2011), Lu WJ (2015)	3
MAPK14	0	KAT2B	2	pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study	Pillai VB (2011), Pillai VB (2011), Pillai VB (2011), Pillai VB (2011)	4
SMAD6	9	WWP2	7	affinity chromatography technology	Herhaus L (2014)	1
TAB2	5	TAB1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, pull down, two hybrid, affinity chromatography technology	Bouwmeester T (2004), Cheung PC (2004), Cheung PC (2004), Takaesu G (2000), Li S (2011), Li S (2011), Mendoza H (2008), Shin MS (2009), Suzuki S (2007), Jiang Z (2002), Wang J (2011), Xia ZP (2009), Charlaftis N (2014), St-Denis N (2016)	14
NEDD4	2	SMURF2	3	affinity chromatography technology, affinity chromatography technology	Kuratomi G (2005), Huttlin EL (2017)	2
YAP1	0	SMAD2	5	affinity chromatography technology	Pefani DE (2016)	1
SMAD4	9	SMAD9	0	two hybrid, affinity chromatography technology, affinity chromatography technology	Rual JF (2005), Nishita M (1999), Li X (2015)	3
SMAD2	5	UCHL5	1	pull down	Wicks SJ (2005)	1
SMAD4	9	SMAD2	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, x-ray crystallography, pull down, affinity chromatography technology, two hybrid, two hybrid, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Moren A (2003), Wotton D (1999), Mori N (2001), Wu JW (2002), Wu JW (2002), Nakao A (1997), Wicks SJ (2000), Wu JW (2001), Chen X (1997), Hanai J (1999), Lebrun JJ (1999), Poncelet AC (2001), Razani B (2001), Razani B (2001), Wang B (2008), Moren A (2005), Kurisaki K (2003), Prunier C (2003), Kato Y (2002), Xu J (2000), Wang L (2011), He W (2006), He W (2006), Dupont S (2009), Brown JD (1999), Pardali K (2000), Fu G (2011), Chen W (2007), Gao S (2009), Lin X (2003), Seo SR (2006), Brown KA (2008), Brown KA (2008), Halder SK (2005), Barrios-Rodiles M (2005), Barrios-Rodiles M (2005), Dai F (2007), Chacko BM (2004), Chacko BM (2004), Chacko BM (2004), Wu RY (1997), Wu RY (1997), Tomita M (2004), Colland F (2004), Tang Y (2003), Ding L (2009), Fattet L (2013), Wang J (2011), Ali A (2013), Yamakawa N (2002), Yamakawa N (2002), Li X (2015), Zhou F (2014), Yang Y (2015), Yan X (2016), Zhou F (2017)	56
KAT2B	2	AKT1	1	enzymatic study, affinity chromatography technology	Sundaresan NR (2011), Sundaresan NR (2011)	2
MAPK14	0	HDAC3	5	affinity chromatography technology, affinity chromatography technology, enzymatic study	Pillai VB (2011), Pillai VB (2011), Pillai VB (2011)	3
CTNNB1	30	TGFBR2	0	affinity chromatography technology	Tian YC (2002)	1
ZEB1	3	SMAD1	0	affinity chromatography technology	Postigo AA (2003)	1
STRAP	2	SMAD2	5	affinity chromatography technology, affinity chromatography technology, genetic interference	Datta PK (2000), Datta PK (2000), Datta PK (2000)	3
CDH1	4	USP15	4	bioid	Guo Z (2014)	1
TOLLIP	3	ITCH	1	affinity chromatography technology	Li S (2011)	1
SMAD3	1	UCHL5	1	pull down, affinity chromatography technology	Wicks SJ (2005), Nan L (2016)	2
SMAD6	9	ACVR2B	0	affinity chromatography technology	Kamiya Y (2010)	1
MYC	2	EP300	36	affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, imaging technique, enzymatic study, affinity chromatography technology, affinity chromatography technology	Faiola F (2005), Faiola F (2005), Faiola F (2005), Faiola F (2005), Faiola F (2005), Zhang K (2005), Covic M (2005), Fujii M (2006)	8
SMAD6	9	ACVR1B	1	affinity chromatography technology	Kamiya Y (2010)	1
YAP1	0	SMAD6	9	affinity chromatography technology	Ferrigno O (2002)	1
SMURF2	3	UBE2L3	1	pull down, affinity chromatography technology, pull down, pull down, pull down, pull down, pull down	Wiesner S (2007), Ogunjimi AA (2005), Kim S (2010), Ogunjimi AA (2005), Anindya R (2007), Kristariyanto YA (2015), Zhang W (2016)	7
SMAD3	1	USP15	4	affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology	Inui M (2011), Inui M (2011), Inui M (2011), Eichhorn PJ (2012), Wijnhoven P (2015)	5
ACVR1B	1	SMAD2	5	affinity chromatography technology	Lebrun JJ (1999)	1
SMAD4	9	MYOD1	0	two hybrid	Colland F (2004)	1
EP300	36	HDAC1	4	affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology	Han Y (2008), Mayanil CS (2006), Simone C (2004), Simone C (2004), Simone C (2004), Liu Y (2012), Mizuguchi Y (2012)	7
PIAS4	5	SMAD6	9	two hybrid, affinity chromatography technology	Imoto S (2003), Imoto S (2003)	2
SMAD2	5	NEDD4	2	affinity chromatography technology, affinity chromatography technology	Kuratomi G (2005), Kuratomi G (2005)	2
TCF7L2	12	EP300	36	affinity chromatography technology	Shekhar MP (2006)	1
SMAD3	1	WWP1	3	affinity chromatography technology, affinity chromatography technology, two hybrid	Komuro A (2004), Seo SR (2004), Rolland T (2014)	3
HDAC1	4	SMAD7	1	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Simonsson M (2005), Simonsson M (2005), Simonsson M (2005), Laganiere J (2005)	4
HDAC3	5	AKT1	1	affinity chromatography technology	Zampetaki A (2010)	1
SMURF1	4	XRCC6	3	affinity chromatography technology	Xie Y (2013)	1
SETD7	2	SIRT1	3	affinity chromatography technology, affinity chromatography technology, pull down	Liu X (2011), Liu X (2011), Liu X (2011)	3
SMURF2	3	SMAD4	9	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Zhang L (2013), Zhou F (2017), Zhou F (2017)	3
SIRT1	3	ZEB1	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Byles V (2012), Zhang P (2014), Sun L (2015)	3
MAPK14	0	HDAC1	4	biochemical	Wan C (2015)	1
MAPK14	0	TAB2	5	affinity chromatography technology	Grimsey NJ (2015)	1
SMAD2	5	SMAD6	9	affinity chromatography technology	Topper JN (1997)	1
FKBP1A	0	ACVR1	4	affinity chromatography technology	Chaikuad A (2012)	1
SMAD7	1	HEYL	1	two hybrid	Colland F (2004)	1
SMAD7	1	CDH1	4	affinity chromatography technology	Tang Y (2008)	1
MYC	2	HDAC2	1	affinity chromatography technology, affinity chromatography technology	Koch HB (2007), Hwang IY (2012)	2
TGFBR2	0	CBL	7	pull down, affinity chromatography technology, enzymatic study	Zuo W (2013), Zuo W (2013), Zuo W (2013)	3
EP300	36	SKP2	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Kitagawa M (2008), Inuzuka H (2012), Inuzuka H (2012), Oh M (2016)	4
HDAC1	4	HDAC2	1	biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, imaging technique, affinity chromatography technology	Hakimi MA (2002), Yao YL (2003), Yao YL (2003), Hakimi MA (2003), Fischle W (2002), Johnson CA (2002), Fischle W (2001), Fischer DD (2002), Fischer DD (2002), Ashburner BP (2001), Zhang Y (1999), Tong JK (1998), Tong JK (1998), Hassig CA (1998), Hassig CA (1998), Zhang Y (1997), van der Vlag J (1999), van der Vlag J (1999), Noh EJ (2009), Noh EJ (2009), Galasinski SC (2002), Galasinski SC (2002), Galasinski SC (2002), He S (2005), Humphrey GW (2001), Park JH (2004), Park JH (2004), Sekhavat A (2007), Zhang Y (1998), Zhang Y (1998), Adenuga D (2010), Xue Y (1998), Xue Y (1998), Martinez FP (2012), Martinez FP (2012), Cui S (2011), Havugimana PC (2012), Bantscheff M (2011), Bantscheff M (2011), Joshi P (2013), Joshi P (2013), Schnur N (2007), Schnur N (2007), Oh YM (2009), Wan C (2015), Hein MY (2015), Chen TC (2014), Huttlin EL (2017)	48
XRCC6	3	HDAC6	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Subramanian C (2011), Chaudhary N (2014), Chaudhary N (2014)	3
TGFBR2	0	MAP3K7	2	affinity chromatography technology, affinity chromatography technology	Kim SI (2009), Kim SI (2009)	2
ATM	9	CXXC5	1	pull down	ZHANG M (2009)	1
SMAD4	9	AKT1	1	affinity chromatography technology	Song K (2006)	1
SMAD7	1	SMURF1	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down	Asano Y (2004), Yamaguchi T (2006), Komuro A (2004), Ebisawa T (2001), Ebisawa T (2001), Al-Salihi MA (2012), Suzuki C (2002), Aragon E (2012), Aragon E (2012), Tajima Y (2003), Fei C (2013), Fei C (2014), Wan L (2011), Elkouris M (2016)	14
BMPR1A	5	TSC22D1	1	affinity chromatography technology	Yan X (2011)	1
SMAD1	0	SMAD7	1	affinity chromatography technology	Yan X (2016)	1
EP300	36	KAT2B	2	enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kiernan R (2003), Kim JH (2011), Lee M (2010), Santos-Rosa H (2003), Yang XJ (1996), Yang XJ (1996), Yang XJ (1996), Mizuguchi Y (2012)	8
SMAD4	9	TGFB1I1	2	affinity chromatography technology	Wang H (2005)	1
SMAD7	1	WWP1	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Komuro A (2004), Seo SR (2004), Seo SR (2004), Al-Salihi MA (2012)	4
SMAD2	5	SMAD7	1	genetic interference, pull down, affinity chromatography technology	Lebrun JJ (1999), Zhang S (2007), Yan X (2016)	3
SMAD7	1	TP53	0	affinity chromatography technology	Zhang S (2006)	1
SMAD7	1	XRCC6	3	two hybrid	Colland F (2004)	1
SMAD2	5	WWP1	3	affinity chromatography technology, affinity chromatography technology	Komuro A (2004), Seo SR (2004)	2
ITCH	1	WWP1	3	affinity chromatography technology	OConnor HF (2015)	1
SMAD7	1	SMAD3	1	genetic interference, genetic interference, affinity chromatography technology, protein complementation assay	Datta PK (2000), Lebrun JJ (1999), Yan X (2016), Yan X (2016)	4
CDH1	4	EP300	36	affinity chromatography technology, affinity chromatography technology	Turnell AS (2005), Turnell AS (2005)	2
MAP3K7	2	SMAD3	1	imaging technique	Chen TC (2014)	1
SMAD7	1	TTF2	4	two hybrid	Colland F (2004)	1
SKP2	2	AKT1	1	affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, imaging technique, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study	Lin HK (2009), Lin HK (2009), Lin HK (2009), Lin HK (2009), Lin HK (2009), Roe JS (2011), Gao D (2009), Gao D (2009), Chan CH (2013)	9
SMAD3	1	TGFBR1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study	Yan X (2009), Tang Y (2003), Tang Y (2003), Herhaus L (2015)	4
SMAD2	5	SMURF2	3	two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Lin X (2000), Lin X (2000), Bonni S (2001), Nakano A (2009), Komuro A (2004), Zhang Y (2001), Zhang Y (2001), Runyan CE (2009), Runyan CE (2009), Chong PA (2010), Brown KA (2008), Colland F (2004), Colland F (2004), Zhang Y (2017), Zhou F (2017), Zhou F (2017)	16
ACVR1	4	SMAD1	0	affinity chromatography technology, affinity chromatography technology	Pardali E (2000), Macias-Silva M (1998)	2
SMAD9	0	CXXC5	1	two hybrid	Colland F (2004)	1
SMAD7	1	LEF1	3	affinity chromatography technology, affinity chromatography technology	Edlund S (2005), Cui Q (2005)	2
TAB2	5	HDAC5	4	pull down	Baek SH (2002)	1
USP15	4	SMURF2	3	affinity chromatography technology, affinity chromatography technology, enzymatic study	Eichhorn PJ (2012), Iyengar PV (2015), Iyengar PV (2015)	3
STRAP	2	AXIN1	1	affinity chromatography technology	Kashikar ND (2011)	1
MAP2K3	1	MAP2K6	2	genetic interference, affinity chromatography technology, imaging technique, affinity chromatography technology, fluorescent resonance energy transfe	Huber TB (2001), Huttlin EL (2015), Chen TC (2014), Huttlin EL (2017), Ivanov AA (2017)	5
HDAC5	4	XRCC6	3	affinity chromatography technology	Greco TM (2011)	1
DVL1	5	ITCH	1	affinity chromatography technology	Wei W (2012)	1
CDH1	4	PARD3	5	bioid	Guo Z (2014)	1
SMAD7	1	TGFBR2	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kavsak P (2000), Nakao A (1997), Hsu HY (2014)	3
MKL2	5	SRF	1	affinity chromatography technology	Selvaraj A (2003)	1
TP53	0	SMAD2	5	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, imaging technique	Cordenonsi M (2003), Cordenonsi M (2003), Tateossian H (2009), Lu D (2013), Chen TC (2014)	5
EP300	36	HDAC6	0	affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down	Han Y (2009), Han Y (2009), Liu Y (2012), Kirilyuk A (2012), Girdwood D (2003)	5
AKT1	1	MAPK14	0	affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, pull down, fluorescent resonance energy transfe	Rane MJ (2001), Rane MJ (2001), Hartman AD (2006), Rane MJ (2001), Rane MJ (2001), Ivanov AA (2017)	6
RNF111	2	SMAD3	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Koinuma D (2003), Yuzawa H (2009), Yuzawa H (2009), Levy L (2007), Erker Y (2013), Le Scolan E (2008)	6
SETD7	2	RNF111	2	affinity chromatography technology	Elkouris M (2016)	1
SMAD3	1	HEYL	1	two hybrid	Colland F (2004)	1
SMAD7	1	MKL2	5	two hybrid	Colland F (2004)	1
SMAD7	1	MAP2K3	1	affinity chromatography technology	Edlund S (2003)	1
MYC	2	HDAC3	5	affinity chromatography technology, affinity chromatography technology	Kurland JF (2008), Zhang X (2011)	2
CTNNB1	30	SMURF1	4	affinity chromatography technology, pull down	Boonanantanasarn K (2015), Boonanantanasarn K (2015)	2
YAP1	0	USP15	4	affinity chromatography technology	Enzo E (2015)	1
TP53	0	PIAS4	5	two hybrid	Goehler H (2004)	1
TGFBR1	2	SMAD2	5	biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study	Razani B (2001), Faresse N (2008), Bai Y (2004), Tang Y (2003), Tang Y (2003), Ding L (2009), Lu D (2013), Herhaus L (2015)	8
LEF1	3	HDAC1	4	affinity chromatography technology	Billin AN (2000)	1
TP53	0	SMAD3	1	affinity chromatography technology, pull down, affinity chromatography technology, imaging technique	Cordenonsi M (2003), Cordenonsi M (2003), Lu D (2013), Ali A (2013)	4
NEDD4L	3	UBE2L3	1	pull down, pull down, pull down, pull down, pull down	Bruce MC (2008), Schwarz SE (1998), Wauer T (2015), Michel MA (2015), Zhang W (2016)	5
CTNNB1	30	HDAC1	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Vietor I (2005), Billin AN (2000), Iguchi H (2007), Iioka H (2009)	4
RNF111	2	SMAD2	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Levy L (2007), Erker Y (2013), Le Scolan E (2008)	3
ACVR1B	1	SMAD3	1	affinity chromatography technology	Lebrun JJ (1999)	1
ACVR1B	1	TSC22D1	1	affinity chromatography technology	Yan X (2011)	1
SIRT1	3	MYC	2	pull down, affinity chromatography technology	Menssen A (2012), Menssen A (2012)	2
SMAD7	1	KAT2B	2	affinity chromatography technology	Monteleone G (2005)	1
NEDD4	2	BMPR1A	5	pull down	Persaud A (2009)	1
MAP2K3	1	AKT1	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
SMAD7	1	PARD3	5	pull down	Warner DR (2003)	1
TCF7L2	12	CTNNB1	30	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, pull down, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Lukas J (2009), Idogawa M (2007), Hong CF (2009), Del Valle-Perez B (2011), Tzeng SL (2006), Tzeng SL (2006), Satow R (2012), Satow R (2012), Graham TA (2001), Sato S (2005), Mosimann C (2006), Shekhar MP (2006), Hsu MC (2007), Loregger A (2015), Hanson AJ (2012), Kuslansky Y (2016)	16
SMAD7	1	CXXC5	1	two hybrid	Colland F (2004)	1
TGFBR1	2	TSC22D1	1	two hybrid, affinity chromatography technology, pull down	Yan X (2011), Yan X (2011), Yan X (2011)	3
SIRT1	3	DVL1	5	affinity chromatography technology	Holloway KR (2010)	1
SMAD3	1	SMURF2	3	two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Lin X (2000), Lin X (2000), Bonni S (2001), Nakano A (2009), Komuro A (2004), Zhang Y (2001), Zhang Y (2001), Tang LY (2011), Brown KA (2008), Zhang L (2013), Li Y (2017), Zhang Y (2017)	12
SMAD4	9	SMAD7	1	genetic interference, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology	Lebrun JJ (1999), Moren A (2005), Moren A (2005), Moren A (2005), Zhang S (2007), Yan X (2016)	6
XRCC6	3	TP53	0	affinity chromatography technology, affinity chromatography technology	Feki A (2005), Feki A (2005)	2
AKT1	1	CTNNB1	30	enzymatic study, enzymatic study	Tian Q (2004), Fang D (2007)	2
NEDD4L	3	BMPR1A	5	enzymatic study, pull down	Persaud A (2009), Persaud A (2009)	2
SMAD9	0	SMAD7	1	affinity chromatography technology	Yan X (2016)	1
STRAP	2	TGFBR2	0	affinity chromatography technology, affinity chromatography technology	Datta PK (1998), Datta PK (2000)	2
TAB2	5	HDAC3	5	pull down, affinity chromatography technology	Baek SH (2002), Baek SH (2002)	2
CTNNB1	30	LEF1	3	affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, pull down, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Edlund S (2005), Grueneberg DA (2003), Behrens J (1996), Behrens J (1996), Labbe E (2000), Sierra J (2006), Gomes NP (2006), Vietor I (2005), Billin AN (2000), Fischer L (2002), Tutter AV (2001), Sadot E (2002), Feigin ME (2008), Daniels DL (2005), Porfiri E (1997), Porfiri E (1997), Hamada F (2004), Vadlamudi U (2005), Lu D (2012), Lu D (2012)	20
SMAD3	1	HDAC1	4	two hybrid, pull down	Liberati NT (2001), Akiyoshi S (1999)	2
YAP1	0	CTNNB1	30	affinity chromatography technology	Boldt K (2016)	1
SMAD7	1	NR4A1	4	affinity chromatography technology, affinity chromatography technology	Zhou F (2014), Zhou F (2014)	2
SMAD3	1	CXXC5	1	two hybrid	Colland F (2004)	1
SMAD4	9	SMAD6	9	affinity chromatography technology, affinity chromatography technology	Topper JN (1997), Moren A (2005)	2
TCF7L2	12	LEF1	3	affinity chromatography technology	Jia Y (2014)	1
SMAD6	9	BMPR2	1	affinity chromatography technology	Kamiya Y (2010)	1
SMAD7	1	SOX13	4	two hybrid	Colland F (2004)	1
COPS5	0	ZEB1	3	affinity chromatography technology, imaging technique	Zhang S (2017), Zhang S (2017)	2
SMAD1	0	PARD3	5	pull down	Warner DR (2003)	1
SMAD1	0	SOX5	11	two hybrid	Colland F (2004)	1
TGFBR2	0	BMPR1A	5	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
TGFBR2	0	ACVR2B	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
SMAD7	1	MAP3K7	2	affinity chromatography technology	Edlund S (2003)	1
USP15	4	ACVR1	4	affinity chromatography technology	Herhaus L (2014)	1
ACVR1B	1	FKBP1A	0	affinity chromatography technology, protein complementation assay	Yamaguchi T (2006), Eyckerman S (2005)	2
NEDD4L	3	ACVR1B	1	enzymatic study, affinity chromatography technology	Persaud A (2009), Persaud A (2009)	2
SMAD7	1	UBE2O	5	affinity chromatography technology, affinity chromatography technology	Zhang X (2013), Zhang X (2013)	2
ATM	9	KDM2A	4	affinity chromatography technology, affinity chromatography technology	Cao LL (2016), Cao LL (2016)	2
PIAS4	5	HDAC2	1	pull down	Gross M (2004)	1
USP11	3	TP53	0	affinity chromatography technology, affinity chromatography technology, enzymatic study	Sowa ME (2009), Ke JY (2014), Ke JY (2014)	3
MYC	2	BMPR1A	5	genetic interference	Toyoshima M (2012)	1
SMAD7	1	TAB3	1	affinity chromatography technology, affinity chromatography technology	Hong S (2007), Hong S (2007)	2
CDH1	4	BMPR2	1	bioid	Guo Z (2014)	1
CBL	7	MAPK14	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Erdreich-Epstein A (1997), Shen M (2009), Shen M (2009)	3
SMAD3	1	CTNNB1	30	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Tian YC (2002), Dahle O (2010), Charbonney E (2011), Zhou B (2012)	4
MYC	2	ERBIN	5	affinity chromatography technology	Agrawal P (2010)	1
SMAD7	1	CBL	7	affinity chromatography technology, affinity chromatography technology, pull down	Ha Thi HT (2015), Ha Thi HT (2015), Ha Thi HT (2015)	3
SMAD2	5	SMURF1	4	affinity chromatography technology, affinity chromatography technology, two hybrid	Komuro A (2004), Ito I (2010), Colland F (2004)	3
YAP1	0	XRCC6	3	affinity chromatography technology	Enzo E (2015)	1
SIRT1	3	TP53	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology	Zhao W (2008), Liu X (2011), Inoue Y (2011), Jain AK (2012), Langley E (2002), Langley E (2002), Langley E (2002), Kim JE (2008), Kim JE (2008), Kim EJ (2007), Kim EJ (2007), Busch F (2012), Busch F (2012), Hasegawa K (2008), Hasegawa K (2008), Hasegawa K (2008), Zannini L (2012)	17
SKP2	2	MYC	2	affinity chromatography technology, affinity chromatography technology, pull down, protein complementation assay, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	von der Lehr N (2003), von der Lehr N (2003), von der Lehr N (2003), von der Lehr N (2003), von der Lehr N (2003), Zhang Q (2013), Kim TA (2013), Jamal A (2015), Fujii M (2006)	9
SMAD7	1	TSC22D1	1	affinity chromatography technology, affinity chromatography technology	Yan X (2011), Yan X (2011)	2
ERBIN	5	CTNNB1	30	unspecified method	Boisguerin P (2004)	1
SMAD1	0	SMAD4	9	affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Harada J (2003), Hanai J (1999), Lopez-Rovira T (2002), Kato Y (2002), Wang L (2011), Li L (2004), Hata A (1998), Barrios-Rodiles M (2005), Wu RY (1997), Wu RY (1997), Colland F (2004), Qiu T (2007), Yan X (2016), Zhou F (2017)	14
SMAD2	5	COPS5	0	two hybrid	Colland F (2004)	1
SMAD1	0	TTF2	4	two hybrid	Colland F (2004)	1
MYC	2	SMAD2	5	affinity chromatography technology, pull down, two hybrid, fluorescent resonance energy transfe	Feng XH (2002), Feng XH (2002), Feng XH (2002), Ivanov AA (2017)	4
CDH1	4	ERBIN	5	bioid	Guo Z (2014)	1
STRAP	2	SMAD3	1	affinity chromatography technology, affinity chromatography technology, genetic interference, genetic interference	Datta PK (2000), Datta PK (2000), Datta PK (2000), Datta PK (2000)	4
SMURF2	3	RNF111	2	two hybrid	Colland F (2004)	1
SMAD1	0	WWP1	3	affinity chromatography technology, affinity chromatography technology	Komuro A (2004), Seo SR (2004)	2
TP53	0	EP300	36	pull down, genetic interference, pull down, enzymatic study, pull down, pull down, affinity chromatography technology, biochemical, enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, unspecified method, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, pull down, imaging technique, affinity chromatography technology, enzymatic study, affinity chromatography technology, x-ray crystallography, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, unspecified method, affinity chromatography technology, enzymatic study, unspecified method, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, pull down, enzymatic study, enzymatic study, x-ray crystallography, pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, unspecified method	An W (2004), Pastorcic M (2000), Livengood JA (2002), Livengood JA (2002), Grossman SR (1998), Grossman SR (1998), Grossman SR (1998), Grossman SR (1998), Tang Y (2008), Wang H (2008), Valbuena A (2008), Shi D (2009), Vega FM (2004), Finlan L (2004), Groenroos E (2004), Zhao Y (2006), Roe JS (2006), Pedeux R (2005), Sekaric P (2007), Pan X (2009), Tang Y (2006), Sen GS (2011), Li Y (2012), Li Y (2012), Gillotin S (2010), Grossman SR (2003), Issaeva N (2004), Kitagawa M (2008), Sabbatini P (2002), Burge S (2009), Zilfou JT (2001), Issaeva N (2004), Issaeva N (2004), Feng H (2009), Feng H (2009), Lill NL (1997), Dornan D (2004), Dornan D (2004), Di Agostino S (2006), Wells M (2008), Fath DM (2006), Kobet E (2000), Costanzo A (2002), Kumazawa T (2011), Borger DR (2006), Cui D (2013), Borger DR (2006), Lee SJ (2013), Tang HY (2006), Lin C (2011), Choi WI (2014), Ding G (2013), Kim MK (2013), Ali A (2013), Wu G (2014), Mizuguchi Y (2012), Sinha S (2012), Sinha S (2012), Her YR (2013), Her YR (2013), Wu SY (2009), Wu SY (2009), Liu L (1999), Sakaguchi K (1998), Harrod R (2003), Gu W (1997), Teufel DP (2007), Mantovani F (2007), Mantovani F (2007), Dornan D (2003), Dornan D (2003), Dornan D (2003), Dornan D (2003), Dornan D (2003), MacPartlin M (2005), Mujtaba S (2004), Wang YH (2003), Chen H (1999), Tang Z (2013), Graczyk A (2013), Graczyk A (2013), Chan HM (2001), Thomas MC (2005), Miller Jenkins LM (2015), Miller Jenkins LM (2015), Koh DI (2014), Koh DI (2014), Koh DI (2014), Li H (2015), Chen LF (2005), Shi D (2016), Wright DG (2016), Zhang X (2016), Procopio MG (2015), Tong Q (2015)	95
WWP2	7	UBE2L3	1	pull down, pull down, pull down, pull down, pull down, pull down	Wiesner S (2007), Xu H (2009), Anindya R (2007), Kristariyanto YA (2015), Zhang W (2016), Chen Z (2016)	6
SMAD3	1	KAT2B	2	affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology	Prokova V (2005), Itoh S (2000), Itoh S (2000), Kahata K (2004), Dai M (2012)	5
SMAD7	1	TAB2	5	affinity chromatography technology, affinity chromatography technology	Hong S (2007), Hong S (2007)	2
CTNNB1	30	COPS5	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Huang X (2009), Jumpertz S (2014), Jumpertz S (2014)	3
SMAD3	1	SMAD1	0	affinity chromatography technology, two hybrid, two hybrid	Brown KA (2008), Wu RY (1997), Wu RY (1997)	3
TP53	0	USP15	4	affinity chromatography technology, affinity chromatography technology	Liu WT (2016), Liu WT (2016)	2
KAT2B	2	TP53	0	enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, two hybrid, enzymatic study, pull down, enzymatic study, enzymatic study, pull down, enzymatic study, enzymatic study, enzymatic study	Jin Y (2002), Wang H (2008), Zhao Y (2006), Roe JS (2006), Perez RE (2010), Tang Y (2006), Zhao LY (2003), Liu L (1999), Liu L (1999), Sakaguchi K (1998), Harrod R (2003), Harrod R (2003), MacPartlin M (2005), Chen H (1999), Kang H (2009)	15
SMAD6	9	ZEB1	3	affinity chromatography technology, affinity chromatography technology	Nakahata S (2010), Nakahata S (2010)	2
SETD7	2	MYOD1	0	pull down, affinity chromatography technology	Tao Y (2011), Tao Y (2011)	2
YAP1	0	EP300	36	imaging technique	Strano S (2005)	1
WWP2	7	SMAD7	1	affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology	Soond SM (2011), Soond SM (2011), Soond SM (2011), Al-Salihi MA (2012)	4
TGFB1I1	2	SMAD3	1	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Wang H (2005), Wang H (2005), Wang H (2005), Shibanuma M (2004)	4
AXIN1	1	AXIN2	1	affinity chromatography technology	Sue Ng S (2010)	1
NR4A1	4	AXIN2	1	affinity chromatography technology	Zhou F (2014)	1
LEF1	3	SMAD4	9	pull down	Labbe E (2000)	1
HDAC5	4	TP53	0	affinity chromatography technology	Greco TM (2011)	1
STRAP	2	SMAD7	1	genetic interference, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Datta PK (2000), Datta PK (2000), Datta PK (2000), Seong HA (2007)	4
CDH1	4	MKL2	5	bioid	Guo Z (2014)	1
SMAD7	1	ZNF107	2	two hybrid	Colland F (2004)	1
SMAD6	9	USP11	3	affinity chromatography technology, affinity chromatography technology	Herhaus L (2014), Herhaus L (2014)	2
ERBIN	5	ACVR2B	0	unspecified method	Boisguerin P (2004)	1
MAP3K7	2	COPS5	0	two hybrid	Bandyopadhyay S (2010)	1
ACVR1B	1	SMURF1	4	affinity chromatography technology, affinity chromatography technology	Yamaguchi T (2006), Murakami G (2003)	2
TAB3	1	TAB2	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ishitani T (2003), Ishitani T (2003), Li S (2011), Li S (2011)	4
KAT2B	2	MYOD1	0	enzymatic study, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology	Polesskaya A (2000), Serra C (2007), Jin W (2011), Bharathy N (2016), Bharathy N (2016)	5
CDH1	4	CTNNB1	30	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid	Davies G (2001), Kucerova D (2001), Oyama T (1994), Hazan RB (1997), Kinch MS (1995), Jiang MC (2002), Hazan RB (1998), Bonvini P (2001), Li Y (1998), Wendeler MW (2004), Shibata T (2003), Piedra J (2003), Oneyama C (2002), Navarro P (1993), Takahashi K (1997), Dobrosotskaya IY (2000), Dobrosotskaya IY (2000), Geng L (2000), Shibamoto S (1995), Rao RK (2002), Rao RK (2002), Huber AH (2001), Schmeiser K (1999), Pai R (2008), Tu LC (2007), Tu LC (2007), Smyth D (2012), Xue B (2005), Xue B (2005), Catimel B (2005), Huang Z (2012), Yan HX (2006), Yan HX (2006), Figueiredo J (2013), Ponce E (2014), Ponce E (2014), Ponce E (2014), Ribeiro AS (2013), Pinheiro H (2012), Geng F (2012), Lee HK (2007), Guo Z (2014)	42
SMAD6	9	TGFBR1	2	affinity chromatography technology, affinity chromatography technology	Hata A (1998), Kamiya Y (2010)	2
TAB1	1	MAPK14	0	pull down, affinity chromatography technology, two hybrid, affinity chromatography technology, imaging technique, affinity chromatography technology	Ge B (2002), Ge B (2002), Vinayagam A (2011), Ge B (2003), Chen TC (2014), Grimsey NJ (2015)	6
WWP2	7	DVL1	5	affinity chromatography technology	Chaudhary N (2014)	1
WWP2	7	SMAD2	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Soond SM (2011), Soond SM (2011), Brown KA (2008)	3
TGFBR1	2	SMURF1	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Koinuma D (2003), Ebisawa T (2001), Murakami G (2003)	3
AKT1	1	EP300	36	affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down	Lin WN (2008), Lee IT (2010), Sundaresan NR (2011), Howie HL (2011), Chen J (2004), Chen J (2004)	6
TGFBR1	2	MAPK14	0	affinity chromatography technology	Sorrentino A (2008)	1
ACVR1	4	BMPR1A	5	fluorescent resonance energy transfe, fluorescent resonance energy transfe, affinity chromatography technology, affinity chromatography technology	Lavery K (2008), Lavery K (2008), Huttlin EL (2015), Huttlin EL (2017)	4
SMAD6	9	TSC22D1	1	affinity chromatography technology	Yan X (2011)	1
TP53	0	MAPK14	0	protein complementation assay, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology	Srivastav RK (2011), Zhang S (2006), Mo JS (2010), Gong X (2010), Perfettini JL (2005), Perfettini JL (2005), Bulavin DV (1999), Bulavin DV (1999)	8
HDAC6	0	SMAD7	1	affinity chromatography technology, affinity chromatography technology	Simonsson M (2005), Laganiere J (2005)	2
SMURF1	4	USP15	4	affinity chromatography technology	Xie Y (2013)	1
ACVR1B	1	SMAD7	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Liu X (2002), Yamaguchi T (2006), Yamaguchi T (2006), Kamiya Y (2010)	4
SMAD7	1	AKT1	1	affinity chromatography technology	Song K (2006)	1
MYC	2	UBE2L3	1	affinity chromatography technology	Shimura H (2001)	1
SMAD6	9	STRAP	2	affinity chromatography technology, affinity chromatography technology	Datta PK (2000), Datta PK (2000)	2
TSC22D1	1	TP53	0	two hybrid, affinity chromatography technology	Yoon CH (2012), Yoon CH (2012)	2
SMAD3	1	HDAC5	4	affinity chromatography technology, pull down	Kang JS (2005), Kang JS (2005)	2
SMAD6	9	BMPR1A	5	affinity chromatography technology	Kamiya Y (2010)	1
ZEB1	3	ATM	9	affinity chromatography technology, enzymatic study	Zhang P (2014), Zhang P (2014)	2
SMAD7	1	UCHL5	1	pull down, affinity chromatography technology	Wicks SJ (2005), Wicks SJ (2005)	2
SIRT1	3	SMAD7	1	affinity chromatography technology, affinity chromatography technology, pull down	Kume S (2007), Kume S (2007), Kume S (2007)	3
SMURF2	3	TGFBR2	0	affinity chromatography technology, affinity chromatography technology	Kavsak P (2000), Hsu HY (2014)	2
EP300	36	HDAC3	5	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down	Kadeppagari RK (2009), Gregoire S (2007), Gregoire S (2007), Sankar N (2008), Sankar N (2008)	5
TOLLIP	3	NEDD4L	3	affinity chromatography technology	Li S (2011)	1
SMURF2	3	TGFBR1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kavsak P (2000), Yan X (2011), Cai Y (2012), Cai Y (2012), Zhang L (2013), Chandhoke AS (2015), Hsu HY (2014)	7
COPS5	0	TP53	0	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, far western blotting, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Zhang XC (2008), Zhang XC (2008), Zhang XC (2008), Wang J (2006), Bech-Otschir D (2001), Bech-Otschir D (2001), Oh W (2006), Bhansali M (2014), Bhansali M (2014)	9
SMURF1	4	TP53	0	affinity chromatography technology	Nie J (2010)	1
UBE2L3	1	SMAD7	1	unspecified method	Ogunjimi AA (2005)	1
SMAD7	1	SOX5	11	two hybrid	Colland F (2004)	1
YAP1	0	ITCH	1	affinity chromatography technology	Levy D (2007)	1
TGFBR2	0	TSC22D1	1	affinity chromatography technology	Yan X (2011)	1
SMAD9	0	SMAD2	5	two hybrid	Colland F (2004)	1
AXIN2	1	RNF111	2	affinity chromatography technology	Zhou F (2014)	1
ITCH	1	CBL	7	affinity chromatography technology	Azakir BA (2009)	1
BMPR2	1	TGFBR1	2	two hybrid, two hybrid	Liu F (1995), Kawabata M (1995)	2
SMAD7	1	NEDD4L	3	affinity chromatography technology, pull down, x-ray crystallography, affinity chromatography technology	Al-Salihi MA (2012), Aragon E (2012), Aragon E (2012), Aragon E (2012)	4
SMAD4	9	USP15	4	affinity chromatography technology, affinity chromatography technology	Inui M (2011), Eichhorn PJ (2012)	2
SKP2	2	CDH1	4	affinity chromatography technology, enzymatic study	Chen JY (2011), Liu YQ (2015)	2
TOLLIP	3	SMAD7	1	affinity chromatography technology, affinity chromatography technology, imaging technique	Zhu L (2012), Zhu L (2012), Zhu L (2012)	3
SMAD7	1	ACVR2B	0	affinity chromatography technology	Kamiya Y (2010)	1
STAMBP	2	SMAD6	9	affinity chromatography technology, two hybrid, two hybrid	Itoh F (2001), Itoh F (2001), Itoh F (2001)	3
SMAD3	1	SMURF1	4	affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology	Komuro A (2004), Colland F (2004), Li Y (2017), Li Y (2017)	4
ITCH	1	UBE2L3	1	pull down, pull down, pull down, pull down, pull down, affinity chromatography technology, pull down, pull down, pull down, affinity chromatography technology, pull down, enzymatic study, pull down, pull down	Wiesner S (2007), Ishihara T (2011), Scialpi F (2008), Bai Y (2004), Oberst A (2007), Mouchantaf R (2006), Rossi M (2005), Zhang P (2010), Anindya R (2007), Kathania M (2015), Kristariyanto YA (2015), Riling C (2015), Riling C (2015), Zhang W (2016)	14
MAPK14	0	MYC	2	fluorescent resonance energy transfe	Ivanov AA (2017)	1
TGFBR2	0	ACVR1B	1	affinity chromatography technology	Huttlin EL (2015)	1
CDH1	4	YAP1	0	bioid	Guo Z (2014)	1
SMAD7	1	ASH1L	20	two hybrid	Colland F (2004)	1
CDH1	4	HDAC2	1	biochemical, affinity chromatography technology, imaging technique	Yoon YM (2004), Yoon YM (2004), Chen TC (2014)	3
SMAD7	1	USP15	4	affinity chromatography technology	Eichhorn PJ (2012)	1
YAP1	0	HDAC2	1	affinity chromatography technology	Enzo E (2015)	1
SETD7	2	TP53	0	enzymatic study, enzymatic study, x-ray crystallography, two hybrid	Huang J (2006), Chuikov S (2004), Chuikov S (2004), Wang J (2011)	4
TGFBR1	2	USP11	3	affinity chromatography technology	Al-Salihi MA (2012)	1
SMURF2	3	STAMBP	2	affinity chromatography technology, affinity chromatography technology	Li H (2004), Li H (2004)	2
SKP2	2	UBE2L3	1	affinity chromatography technology	Ma X (2017)	1
NR4A1	4	TP53	0	affinity chromatography technology, pull down, pull down	Zhao BX (2006), Zhao BX (2006), Zhao BX (2006)	3
WWP2	7	SMAD3	1	affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study, two hybrid	Soond SM (2011), Soond SM (2011), Soond SM (2011), Brown KA (2008), Soond SM (2013), Yu H (2011)	6
EP300	36	SMAD7	1	affinity chromatography technology, pull down, affinity chromatography technology, enzymatic study	Groenroos E (2002), Groenroos E (2002), Groenroos E (2002), Groenroos E (2002)	4
WWP1	3	UBE2L3	1	pull down, pull down, pull down, pull down, pull down	Peschiaroli A (2010), Anindya R (2007), Kristariyanto YA (2015), Courivaud T (2015), Zhang W (2016)	5
SMURF1	4	AXIN1	1	enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down	Fei C (2013), Fei C (2013), Fei C (2014), Fei C (2014), Fei C (2014)	5
KAT2B	2	MYC	2	enzymatic study	Patel JH (2004)	1
TGFBR1	2	TGFBR2	0	two hybrid, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, genetic interference, two hybrid, affinity chromatography technology	Kawabata M (1995), Razani B (2001), Yan X (2011), Yan X (2009), Kim SI (2009), Kim SI (2009), Datta PK (2000), Perlman R (2001), Cho W (2015)	9
SMAD1	0	LEF1	3	affinity chromatography technology	Cui Q (2005)	1
SMAD1	0	HDAC1	4	affinity chromatography technology	Takeda M (2004)	1
YAP1	0	PARD3	5	affinity chromatography technology	Couzens AL (2013)	1
NR4A1	4	SMAD3	1	two hybrid	Wang J (2011)	1
SMAD1	0	TTF1	3	two hybrid	Colland F (2004)	1
SMAD2	5	AKT1	1	affinity chromatography technology	Song K (2006)	1
SMAD1	0	PIAS1	4	two hybrid	Colland F (2004)	1
SMAD6	9	SMURF1	4	affinity chromatography technology, affinity chromatography technology, unspecified method, affinity chromatography technology, affinity chromatography technology	Komuro A (2004), Ebisawa T (2001), Sangadala S (2007), Lee YS (2011), Lee YS (2011)	5
SMAD1	0	USP15	4	affinity chromatography technology, affinity chromatography technology	Inui M (2011), Eichhorn PJ (2012)	2
EP300	36	ZEB1	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study	Mizuguchi Y (2012), Postigo AA (2003), Postigo AA (2003), Postigo AA (2003)	4
WWP1	3	SMAD4	9	affinity chromatography technology	Seo SR (2004)	1
EP300	36	SMAD2	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology	Wotton D (1999), Pessah M (2001), Furumatsu T (2005), Wang J (2011), Suganuma T (2002)	5
UBE2L3	1	NEDD4	2	enzymatic study, pull down, pull down, pull down, pull down, pull down, enzymatic study, pull down, pull down, pull down, pull down, pull down, pull down, pull down	Anan T (1998), Bruce MC (2008), Wiesner S (2007), Vina-Vilaseca A (2010), Anindya R (2007), Lin Q (2010), Chung S (2011), Tofaris GK (2011), Han L (2013), Persaud A (2014), Uchiki T (2009), Miyazaki K (2003), Zhang W (2016), Zhang X (2017)	14
ATM	9	MAPK14	0	affinity chromatography technology	Zhang S (2006)	1
EP300	36	STRAP	2	affinity chromatography technology	Xu D (2008)	1
ACVR1	4	TSC22D1	1	affinity chromatography technology	Yan X (2011)	1
SMAD7	1	PPP1R15A	2	two hybrid, affinity chromatography technology, affinity chromatography technology	Shi W (2004), Shi W (2004), Shi W (2004)	3
NR4A1	4	EP300	36	pull down, enzymatic study	Wansa KD (2002), Kang SA (2010)	2
CDH1	4	HDAC1	4	affinity chromatography technology, biochemical	Yoon YM (2004), Yoon YM (2004)	2
TGFBR1	2	EP300	36	affinity chromatography technology, affinity chromatography technology	Mu Y (2011), Mu Y (2011)	2
MAP2K3	1	MAPK14	0	enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe, affinity chromatography technology, fluorescent resonance energy transfe	Chen Z (2001), Casar B (2007), Deacon K (1997), Mo JS (2010), Varjosalo M (2013), Huttlin EL (2015), Li L (2014), Huttlin EL (2017), Ivanov AA (2017)	9
PIAS4	5	LEF1	3	two hybrid, pull down, affinity chromatography technology	Sachdev S (2001), Sachdev S (2001), Sachdev S (2001)	3
MAP3K7	2	MAP2K6	2	enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study	Ishitani T (2003), Wang C (2001), Ninomiya-Tsuji J (1999), Sakurai H (2000), Wu ZH (2010), Xia ZP (2009), Jiang Z (2003), Singhirunnusorn P (2005), Jiang Z (2002), Hong S (2007), Kojima H (2005), Huangfu WC (2006), Kajino T (2006), Li MG (2003), Wu X (2007), Shambharkar PB (2007), Kishimoto K (2000), Lamb A (2013), Lin J (2015), Liu X (2013), Ninomiya-Tsuji J (2003)	21
SMAD3	1	SMAD2	5	affinity chromatography technology, genetic interference, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology	Nakao A (1997), Lebrun JJ (1999), Dumont E (2003), Brown KA (2008), Brown KA (2008), Wu RY (1997), Wu RY (1997), Tang Y (2003), Tang Y (2003), Wang J (2011), Huttlin EL (2015), Huttlin EL (2017)	12
SMAD3	1	YAP1	0	affinity chromatography technology	Alarcon C (2009)	1
ZEB1	3	SMAD3	1	affinity chromatography technology	Postigo AA (2003)	1
LEF1	3	EP300	36	enzymatic study, affinity chromatography technology, pull down	Hecht A (2003), Hecht A (2003), Hecht A (2003)	3
AXIN1	1	TP53	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, genetic interference, pull down	Li Q (2011), Li Q (2011), He Y (2013), He Y (2013), He Y (2013), He Y (2013)	6
SMURF1	4	TAB1	1	enzymatic study	Andrews PS (2010)	1
SMAD6	9	USP15	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Herhaus L (2014), Herhaus L (2014), Herhaus L (2014)	3
BMPR2	1	ACVR1	4	two hybrid, affinity chromatography technology, two hybrid, affinity chromatography technology, two hybrid, affinity chromatography technology	Liu F (1995), Liu F (1995), Liu F (1995), Liu F (1995), Kawabata M (1995), Huttlin EL (2017)	6
SMAD7	1	BMPR1A	5	affinity chromatography technology, affinity chromatography technology	Mochizuki T (2004), Kamiya Y (2010)	2
COPS5	0	SKP2	2	affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Bennett EJ (2010)	2
HDAC5	4	HDAC3	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Grozinger CM (1999), Fischle W (2002), Zhang J (2002), Grozinger CM (2000), Greco TM (2011), Greco TM (2011)	6
MAPK14	0	COPS5	0	two hybrid	Wang J (2008)	1
SMAD2	5	HDAC1	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Wotton D (1999), Wotton D (1999), Takeda M (2004), Lo RS (2001)	4
EP300	36	SIRT1	3	affinity chromatography technology, affinity chromatography technology	Bouras T (2005), Bourguignon LY (2009)	2
SMAD1	0	ERBIN	5	pull down	Warner DR (2003)	1
AXIN2	1	SMAD7	1	affinity chromatography technology, pull down	Zhou F (2014), Elkouris M (2016)	2
SMURF1	4	TGFBR2	0	affinity chromatography technology, affinity chromatography technology	Ebisawa T (2001), Johansson E (2016)	2
SMAD6	9	ITCH	1	affinity chromatography technology	Herhaus L (2014)	1
YAP1	0	HDAC1	4	affinity chromatography technology	Enzo E (2015)	1
SMAD6	9	WWP1	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Komuro A (2004), Seo SR (2004), Herhaus L (2014)	3
HDAC3	5	SMAD7	1	affinity chromatography technology, affinity chromatography technology	Simonsson M (2005), Laganiere J (2005)	2
SMAD2	5	ERBIN	5	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Warner DR (2003), Xi Q (2008), Brown KA (2008), Dai F (2007), Dai F (2007), Dai F (2007)	6
SMAD4	9	PARD3	5	pull down	Warner DR (2003)	1
TAB2	5	HDAC1	4	pull down	Baek SH (2002)	1
EP300	36	XRCC6	3	enzymatic study	Cohen HY (2004)	1
SMAD7	1	ZBTB11	4	two hybrid	Colland F (2004)	1
CTNNB1	30	USP15	4	affinity chromatography technology, affinity chromatography technology	Greenblatt MB (2016), Greenblatt MB (2016)	2
DVL1	5	NEDD4	2	pull down	Nethe M (2012)	1
MAP3K7	2	TAB3	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Cheung PC (2004), Cheung PC (2004), Ishitani T (2003), Ishitani T (2003), Li S (2011), Li S (2011), Mendoza H (2008), Criollo A (2011), Hong S (2007), Minoda Y (2009), Liu R (2014), Shinohara H (2016), Zhang J (2017)	13
SMAD6	9	NEDD4	2	affinity chromatography technology	Kuratomi G (2005)	1
SMAD2	5	PARD3	5	pull down	Warner DR (2003)	1
STAMBP	2	SMAD7	1	affinity chromatography technology, two hybrid	Itoh F (2001), Itoh F (2001)	2
HDAC1	4	MYC	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Matsuoka Y (2008), Matsuoka Y (2008), Liu T (2007), Liu T (2007), Liu T (2007), Koch HB (2007), Hwang IY (2012), Hein MY (2015)	8
ATM	9	HDAC1	4	pull down, affinity chromatography technology	Kim GD (1999), Kim GD (1999)	2
AXIN2	1	CTNNB1	30	affinity chromatography technology	von Kries JP (2000)	1
NR4A1	4	HDAC6	0	affinity chromatography technology	Rambaud J (2009)	1
SMAD2	5	CTNNB1	30	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Tian YC (2002), Dahle O (2010), Xi Y (2013)	3
SMAD3	1	XRCC6	3	two hybrid	Colland F (2004)	1
SMAD4	9	CTNNB1	30	affinity chromatography technology	Tian YC (2002)	1
SMAD7	1	SRF	1	affinity chromatography technology, affinity chromatography technology	Camoretti-Mercado B (2006), Camoretti-Mercado B (2006)	2
CTNNB1	30	EP300	36	genetic interference, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, genetic interference, affinity chromatography technology	Kennell JA (2003), Sun Y (2000), Sun Y (2000), Sun Y (2000), Saegusa M (2005), Daniels DL (2002), Levy L (2004), Labalette C (2004), Lee YH (2006), Zhao Y (2016)	10
HDAC5	4	HDAC1	4	affinity chromatography technology	Greco TM (2011)	1
SETD7	2	SMURF2	3	affinity chromatography technology	Elkouris M (2016)	1
LEF1	3	SMAD2	5	pull down, affinity chromatography technology, affinity chromatography technology	Labbe E (2000), Labbe E (2000), Cui Q (2005)	3
SMAD4	9	HDAC1	4	affinity chromatography technology	Takeda M (2004)	1
MAPK14	0	USP11	3	affinity chromatography technology	Varjosalo M (2013)	1
TGFBR1	2	USP15	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Eichhorn PJ (2012), Zhang L (2013), Herhaus L (2014)	3
BMPR2	1	BMPR1A	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique	Liu F (1995), Liu F (1995), Gilboa L (2000), Gilboa L (2000)	4
SMAD1	0	DVL1	5	pull down	Warner DR (2003)	1
MYC	2	TP53	0	affinity chromatography technology, fluorescent resonance energy transfe	Agrawal P (2010), Ivanov AA (2017)	2
COPS5	0	XRCC6	3	affinity chromatography technology	Bennett EJ (2010)	1
SMAD7	1	SOX7	4	two hybrid	Colland F (2004)	1
ITCH	1	HDAC6	0	affinity chromatography technology	OConnor HF (2015)	1
TGFBR1	2	TAB2	5	affinity chromatography technology	Kim SI (2009)	1
PIAS4	5	SMAD2	5	affinity chromatography technology, two hybrid, affinity chromatography technology	Imoto S (2003), Long J (2003), Long J (2003)	3
SMAD2	5	USP15	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Inui M (2011), Eichhorn PJ (2012), Wijnhoven P (2015)	3
WWP2	7	STRAP	2	affinity chromatography technology	Chaudhary N (2014)	1
TP53	0	HDAC1	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, imaging technique, affinity chromatography technology, affinity chromatography technology, imaging technique	Ito A (2002), Wang C (2005), Dohi Y (2008), Jin W (2008), Lei Q (2006), Wu Y (2001), Wu Y (2001), Luo J (2000), Juan LJ (2000), Juan LJ (2000), Juan LJ (2000), Murphy M (1999), Insinga A (2004), Sun JM (2007), Yu XY (2010), Sinha S (2010), Sinha S (2010), Li Y (2012), Di Agostino S (2006), Pavithra L (2009), Pavithra L (2009), Luo J (2000), Chen TC (2014), Park EK (2015), Park EK (2015), Park EK (2015)	26
SMAD3	1	SMAD4	9	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, x-ray crystallography, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, pull down, pull down, pull down, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, protein complementation assay, affinity chromatography technology, affinity chromatography technology	Seoane J (2004), Moren A (2003), Wu JW (2002), Nakao A (1997), Hanai J (1999), Lebrun JJ (1999), Poncelet AC (2001), Jablonska E (2010), Prunier C (2003), Kato Y (2002), Kaimori A (2010), Tang LY (2011), Tang LY (2011), Dupont S (2009), Dupont S (2009), Pardali K (2000), Kardassis D (2000), Xu L (2003), Fu G (2011), Chen W (2007), Kang JM (2012), Gao S (2009), Li H (2009), Li H (2009), Brown KA (2008), Brown KA (2008), Halder SK (2005), Barrios-Rodiles M (2005), Dai F (2007), Dai F (2007), Chacko BM (2004), Chacko BM (2004), Chacko BM (2004), Stroschein SL (1999), Stroschein SL (1999), Stroschein SL (1999), Wu RY (1997), Wu RY (1997), Wu RY (1997), Wu RY (1997), Tomita M (2004), Colland F (2004), Colland F (2004), Tang Y (2003), Ding L (2009), Fattet L (2013), Wang J (2011), Xue J (2014), Ali A (2013), Gao S (2009), Yamakawa N (2002), Yamakawa N (2002), Wang G (2005), Li X (2015), Zhou F (2014), Yang Y (2015), Yan X (2016), Yan X (2016), Wu Y (2017), Wu Y (2017)	60
MYC	2	UBE2O	5	genetic interference	Kessler JD (2012)	1
SMAD7	1	BMPR2	1	affinity chromatography technology	Kamiya Y (2010)	1
WWP2	7	ITCH	1	affinity chromatography technology	Chaudhary N (2014)	1
TTF1	3	KAT2B	2	pull down	Muth V (2001)	1
SMAD7	1	MAP2K6	2	affinity chromatography technology	Edlund S (2003)	1
WWP2	7	MYC	2	affinity chromatography technology, affinity chromatography technology	Yu Z (2016), Yu Z (2016)	2
DVL1	5	AXIN1	1	affinity chromatography technology, affinity chromatography technology	Li L (1999), Kim MJ (2008)	2
MYC	2	MAP2K3	1	genetic interference, fluorescent resonance energy transfe, affinity chromatography technology, affinity chromatography technology	Toyoshima M (2012), Ivanov AA (2017), Ivanov AA (2017), Ivanov AA (2017)	4
TGFBR1	2	TOLLIP	3	affinity chromatography technology, affinity chromatography technology	Zhu L (2012), Zhu L (2012)	2
SMURF1	4	UBE2L3	1	pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down	Cao Y (2014), Xie P (2014), Anindya R (2007), Kristariyanto YA (2015), Zhang W (2016), Andrews PS (2010), He S (2017), Zhang Y (2017)	8
KAT2B	2	SMAD2	5	pull down, affinity chromatography technology, affinity chromatography technology	Itoh S (2000), Kahata K (2004), Dai M (2012)	3
CTNNB1	30	CBL	7	affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology	Chitalia V (2013), Chitalia V (2013), Chitalia V (2013), Shivanna S (2015)	4
SMAD4	9	SKP2	2	affinity chromatography technology, affinity chromatography technology, pull down	Yang L (2006), Liang M (2004), Liang M (2004)	3
SETD7	2	SMAD7	1	enzymatic study	Elkouris M (2016)	1
FKBP1A	0	SMAD7	1	affinity chromatography technology, affinity chromatography technology	Yamaguchi T (2006), Yamaguchi T (2006)	2
TP53	0	SMAD1	0	affinity chromatography technology, affinity chromatography technology	Chau JF (2012), Chau JF (2012)	2
COPS5	0	PPP1R15A	2	affinity chromatography technology	Bennett EJ (2010)	1
ITCH	1	TAB1	1	affinity chromatography technology, affinity chromatography technology, pull down	Theivanthiran B (2015), Theivanthiran B (2015), Theivanthiran B (2015)	3
SMAD6	9	ACVR1	4	affinity chromatography technology, affinity chromatography technology	Kamiya Y (2010), Zhang X (2013)	2
CBL	7	SMAD3	1	affinity chromatography technology, affinity chromatography technology	Kang JM (2012), Kang JM (2012)	2
SMAD1	0	YAP1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, x-ray crystallography	Alarcon C (2009), Alarcon C (2009), Aragon E (2011), Aragon E (2011), Aragon E (2011)	5
TP53	0	ITCH	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Abedini MR (2008), Saha A (2011), Saha A (2011)	3
KAT2B	2	HDAC3	5	pull down, affinity chromatography technology	Gregoire S (2007), Gregoire S (2007)	2
NEDD4L	3	TGFB1I1	2	pull down	Persaud A (2009)	1
MYC	2	SMAD3	1	affinity chromatography technology, pull down, two hybrid	Feng XH (2002), Feng XH (2002), Feng XH (2002)	3
SMAD7	1	NEDD4	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kuratomi G (2005), Kuratomi G (2005), Al-Salihi MA (2012)	3
SMAD1	0	MAP2K3	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
TP53	0	HDAC2	1	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Li P (2010), Insinga A (2004), Sun JM (2007), Tian B (2011), Adenuga D (2010), Brandl A (2012)	6
SKP2	2	ATM	9	affinity chromatography technology	Wu J (2012)	1
MAP3K7	2	TAB1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, genetic interference, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, biochemical, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Cheung PC (2004), Cheung PC (2004), Channavajhala PL (2003), Ninomiya-Tsuji J (1999), Sakurai H (2000), Liu XY (2008), Li S (2011), Li S (2011), Ear T (2010), Singhirunnusorn P (2005), Prickett TD (2008), Kim SY (2012), Jiang Z (2002), Shibuya H (1996), Shibuya H (1996), Minoda Y (2009), Minoda Y (2009), Scholz R (2010), Scholz R (2010), Scholz R (2010), Kim SI (2009), Ge B (2003), Blonska M (2005), Kishimoto K (2000), Kishimoto K (2000), Zhu Y (2013), Liu R (2014), Chen TC (2014), Moon G (2015), Ninomiya-Tsuji J (2003), Min Y (2016), St-Denis N (2016), Zhang J (2017)	33
AXIN1	1	MYC	2	affinity chromatography technology, affinity chromatography technology, pull down	Arnold HK (2009), Arnold HK (2009), Arnold HK (2009)	3
EP300	36	SMAD1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Pearson KL (1999), Nakashima K (1999), Nakashima K (1999), Jeon EJ (2006), Jun JH (2010), Weng Q (2012)	6
ITCH	1	SMAD2	5	enzymatic study, affinity chromatography technology	Bai Y (2004), Bai Y (2004)	2
SIRT1	3	KAT2B	2	enzymatic study, affinity chromatography technology, affinity chromatography technology	Pediconi N (2009), Pediconi N (2009), Pediconi N (2009)	3
SIRT1	3	HDAC2	1	affinity chromatography technology	Law IK (2009)	1
SMAD1	0	SMAD6	9	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid	Topper JN (1997), Murakami G (2003), Itoh F (2001), Hata A (1998), Hata A (1998)	5
STAMBP	2	TP53	0	enzymatic study	Fernandez-Majada V (2016)	1
CTNNB1	30	AXIN1	1	pull down, two hybrid, affinity chromatography technology, two hybrid, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Nakamura T (1998), Nakamura T (1998), Nakamura T (1998), Nakamura T (1998), Nakamura T (1998), Nakamura T (1998), Hocevar BA (2003), Hino S (2005), Stoothoff WH (2002), Kim MJ (2008), Kitagawa M (1999), Kitagawa M (1999), Arnold HK (2009), Zhang YG (2012), Godin JD (2010), Godin JD (2010), Sue Ng S (2010), Sue Ng S (2010), Tang Y (2008), Li VS (2012), Yamamoto H (2006), Fei C (2013), Hein MY (2015), Kuslansky Y (2016), Novellasdemunt L (2017)	25
CDH1	4	CBL	7	bioid	Guo Z (2014)	1
MAPK14	0	EP300	36	pull down, enzymatic study, affinity chromatography technology	Pillai VB (2011), Pillai VB (2011), Saha RN (2007)	3
HDAC1	4	MYOD1	0	pull down, affinity chromatography technology, pull down, affinity chromatography technology	Puri PL (2001), Puri PL (2001), Mal A (2001), Bruscoli S (2010)	4
UBE2L3	1	YAP1	0	biochemical	Havugimana PC (2012)	1
TAB1	1	TAB3	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Cheung PC (2004), Cheung PC (2004), Li S (2011), Li S (2011), Mendoza H (2008), St-Denis N (2016)	6
SMAD1	0	NEDD4	2	affinity chromatography technology, two hybrid	Kim BG (2011), Colland F (2004)	2
SMAD7	1	TAB1	1	affinity chromatography technology, affinity chromatography technology	Edlund S (2003), Yanagisawa M (2001)	2
BMPR1A	5	SMAD1	0	enzymatic study	Kretzschmar M (1997)	1
SMAD3	1	SMAD9	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
SMAD6	9	NEDD4L	3	affinity chromatography technology	Herhaus L (2014)	1
USP15	4	USP11	3	affinity chromatography technology	Sowa ME (2009)	1
SMAD4	9	PIAS1	4	two hybrid, two hybrid	Colland F (2004), Wang J (2011)	2
SMAD7	1	TCF7L2	12	affinity chromatography technology	Edlund S (2005)	1
SMAD3	1	ERBIN	5	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Warner DR (2003), Xi Q (2008), Brown KA (2008), Dai F (2007), Dai F (2007), Dai F (2007)	6
TGFBR1	2	SMAD4	9	biochemical, affinity chromatography technology	Razani B (2001), Barrios-Rodiles M (2005)	2
SMURF1	4	SMAD1	0	enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study, pull down, unspecified method, two hybrid, affinity chromatography technology, pull down, enzymatic study, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down	Sangadala S (2006), Komuro A (2004), Tian M (2011), Tian M (2011), Tian M (2011), Sapkota G (2007), Sapkota G (2007), Li L (2004), Alarcon C (2009), Aragon E (2011), Aragon E (2011), Aragon E (2011), Aragon E (2011), Gao S (2009), Sangadala S (2007), Sangadala S (2007), Sangadala S (2007), Sangadala S (2007), Sangadala S (2007), Colland F (2004), Cao Y (2014), Cao Y (2014), Sangadala S (2007), Gao S (2009), Wan L (2011), Wan L (2011), Zhang Y (2017), Zhang Y (2017)	28
ACVR1	4	BAMBI	3	pull down	Yan X (2009)	1
SMAD7	1	ZEB1	3	affinity chromatography technology, affinity chromatography technology, pull down	Nakahata S (2010), Nakahata S (2010), Nakahata S (2010)	3
ACVR1B	1	BAMBI	3	pull down	Yan X (2009)	1
ATM	9	TP53	0	pull down, pull down, pull down, genetic interference, unspecified method, enzymatic study, enzymatic study, pull down, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, imaging technique	Kang J (2005), Fabbro M (2004), Khanna KK (1998), Westphal CH (1997), Kim ST (1999), Khanna KK (1998), Lee JH (2004), Lee JH (2004), Hunt CR (2007), Lin WC (2001), Ling S (2011), Taira N (2010), Lee JH (2005), Zhou BB (2000), Chan DW (2000), Yoshiyama KO (2013), Kim ST (1999), Zhang P (2014), Wang L (2014), Golding SE (2004), Ochodnicka-Mackovicova K (2016)	21
NR4A1	4	KAT2B	2	pull down	Wansa KD (2002)	1
SETD7	2	SMURF1	4	affinity chromatography technology	Elkouris M (2016)	1
BMPR2	1	ACVR1B	1	two hybrid	Liu F (1995)	1
SRF	1	HDAC3	5	affinity chromatography technology	Gregoire S (2007)	1
SIRT1	3	AKT1	1	affinity chromatography technology, affinity chromatography technology, enzymatic study	Sundaresan NR (2011), Sundaresan NR (2011), Sundaresan NR (2011)	3
TP53	0	AKT1	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
PIAS4	5	HDAC1	4	pull down	Gross M (2004)	1
SMAD3	1	KDM2A	4	two hybrid	Colland F (2004)	1
PARD3	5	CTNNB1	30	imaging technique	Chen TC (2014)	1
USP15	4	AXIN1	1	affinity chromatography technology	Greenblatt MB (2016)	1
SMAD7	1	BAMBI	3	affinity chromatography technology, affinity chromatography technology	Yan X (2009), Yan X (2009)	2
ZEB1	3	SMAD2	5	affinity chromatography technology	Postigo AA (2003)	1
SMAD7	1	DVL1	5	pull down	Warner DR (2003)	1
SMAD2	5	HDAC2	1	pull down	Miyamoto-Sato E (2010)	1
TP53	0	PIAS1	4	two hybrid, pull down, enzymatic study, pull down, enzymatic study, enzymatic study, imaging technique, pull down	Gallagher WM (1999), Kahyo T (2001), Kahyo T (2001), Schmidt D (2002), Pelisch F (2010), Schmidt D (2002), Chen TC (2014), Okubo S (2004)	8
SMAD7	1	COPS5	0	two hybrid, affinity chromatography technology, imaging technique, affinity chromatography technology	Kim BC (2004), Kim BC (2004), Kim BC (2004), Kim BC (2004)	4
SMAD7	1	SKP2	2	affinity chromatography technology	Kim TA (2013)	1
SMAD1	0	SMURF2	3	two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology	Lin X (2000), Lin X (2000), Komuro A (2004), Zhang Y (2001), Zhang Y (2001), Li L (2004), Chong PA (2010), Colland F (2004), Huttlin EL (2017), Zhou F (2017)	10
NEDD4	2	AKT1	1	enzymatic study, enzymatic study, affinity chromatography technology	Persaud A (2009), Fan CD (2013), Fan CD (2013)	3
SMAD6	9	BAMBI	3	affinity chromatography technology	Yan X (2009)	1
MYC	2	AKT1	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
SMAD7	1	ACVR1	4	affinity chromatography technology	Kamiya Y (2010)	1
BMPR1A	5	BAMBI	3	pull down	Yan X (2009)	1
COPS5	0	USP15	4	affinity chromatography technology	Bennett EJ (2010)	1
SMAD3	1	DVL1	5	pull down	Warner DR (2003)	1
ATM	9	COPS5	0	enzymatic study	Nagarajan A (2014)	1
SMAD6	9	SMURF2	3	affinity chromatography technology, two hybrid, affinity chromatography technology	Komuro A (2004), Colland F (2004), Herhaus L (2014)	3
HDAC5	4	STRAP	2	affinity chromatography technology	Greco TM (2011)	1
PIAS4	5	SMAD4	9	affinity chromatography technology, two hybrid, affinity chromatography technology, pull down, affinity chromatography technology	Imoto S (2003), Long J (2003), Long J (2003), Long J (2003), Lee PS (2003)	5
FKBP1A	0	TGFBR1	2	two hybrid, two hybrid, affinity chromatography technology	Wang T (1994), Liu F (1995), Wang T (1994)	3
TGFBR1	2	MAP3K7	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sorrentino A (2008), Kim SI (2009), Kim SI (2009), Zhang L (2013)	4
HDAC5	4	SMAD7	1	affinity chromatography technology, affinity chromatography technology	Simonsson M (2005), Laganiere J (2005)	2
SMAD7	1	TGFB1I1	2	affinity chromatography technology, pull down	Wang H (2008), Wang H (2008)	2
UBE2O	5	SMAD6	9	affinity chromatography technology, affinity chromatography technology	Zhang X (2013), Zhang X (2013)	2
ITCH	1	SMAD3	1	pull down	Feng L (2004)	1
SMAD2	5	NEDD4L	3	affinity chromatography technology, two hybrid, pull down, affinity chromatography technology	Gao S (2009), Colland F (2004), Gao S (2009), Yan X (2016)	4
SMAD4	9	SMURF1	4	affinity chromatography technology, affinity chromatography technology	Moren A (2005), Zhang L (2013)	2
TGFBR1	2	ITCH	1	affinity chromatography technology	Bai Y (2004)	1
SMAD7	1	USP11	3	affinity chromatography technology, biochemical, affinity chromatography technology	Al-Salihi MA (2012), Al-Salihi MA (2012), Herhaus L (2014)	3
TCF7L2	12	XRCC6	3	affinity chromatography technology	Idogawa M (2007)	1
SMAD6	9	TAB1	1	affinity chromatography technology	Yanagisawa M (2001)	1
SMAD4	9	DVL1	5	pull down	Warner DR (2003)	1
SMAD7	1	TTF1	3	two hybrid	Colland F (2004)	1
SMAD7	1	YAP1	0	two hybrid, genetic interference, affinity chromatography technology, pull down, x-ray crystallography, affinity chromatography technology, pull down	Ferrigno O (2002), Ferrigno O (2002), Ferrigno O (2002), Aragon E (2012), Aragon E (2012), Aragon E (2012), Schuchardt BJ (2014)	7
HDAC2	1	SMAD7	1	affinity chromatography technology, affinity chromatography technology	Simonsson M (2005), Laganiere J (2005)	2
SOX5	11	SOX13	4	affinity chromatography technology	Huttlin EL (2017)	1
SMURF2	3	AXIN1	1	enzymatic study, affinity chromatography technology	Kim S (2010), Kim S (2010)	2
SMAD9	0	HEYL	1	two hybrid	Colland F (2004)	1
KAT2B	2	XRCC6	3	enzymatic study	Cohen HY (2004)	1
SMAD3	1	AKT1	1	affinity chromatography technology, imaging technique	Song K (2006), Chen TC (2014)	2
SMAD4	9	ERBIN	5	pull down	Warner DR (2003)	1
SMAD1	0	MKL2	5	two hybrid	Colland F (2004)	1
SMAD7	1	AXIN1	1	affinity chromatography technology	Tang Y (2008)	1
MYC	2	XRCC6	3	affinity chromatography technology, affinity chromatography technology	Koch HB (2007), Koch HB (2007)	2
SMAD2	5	SMAD1	0	affinity chromatography technology, two hybrid, two hybrid, fluorescent resonance energy transfe	Brown KA (2008), Wu RY (1997), Wu RY (1997), Ivanov AA (2017)	4
COPS5	0	SMAD4	9	two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology	Wan M (2002), Wan M (2002), Wan M (2002), Wan M (2002), Kim BC (2004), Huang J (2007), Sangadala S (2013), Lee CC (2016), Lee CC (2016)	9
SMAD7	1	MYC	2	affinity chromatography technology, affinity chromatography technology	Kim TA (2013), Kim TA (2013)	2
MAP2K6	2	AKT1	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
CBL	7	UBE2L3	1	pull down, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography	Yokouchi M (1999), Zheng N (2000), Wong ES (2002), Wong ES (2002), Oved S (2006), Dominguez C (2004)	6
NEDD4L	3	SMAD3	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down, pull down, affinity chromatography technology	Gao S (2009), Gao S (2009), Aragon E (2012), Herhaus L (2013), Gao S (2009), Gao S (2009), Yan X (2016)	7
WWP2	7	USP15	4	affinity chromatography technology	Chaudhary N (2014)	1
SMAD3	1	NEDD4	2	affinity chromatography technology, enzymatic study, unspecified method, affinity chromatography technology, affinity chromatography technology, pull down	Kuratomi G (2005), Persaud A (2009), Aragon E (2011), Aragon E (2011), Aragon E (2011), Aragon E (2011)	6
SMAD7	1	MYOD1	0	two hybrid	Colland F (2004)	1