PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
SFPQ	2	U2AF2	7	affinity chromatography technology, biochemical, affinity chromatography technology	Liu L (2011), Havugimana PC (2012), Whisenant TC (2015)	3
SMAD5	2	SKI	3	affinity chromatography technology	Takeda M (2004)	1
SMAD2	5	RUNX3	1	affinity chromatography technology	Hanai J (1999)	1
EP300	36	SMAD3	1	affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Qiu P (2006), Furumatsu T (2005), Itoh S (2000), Akiyoshi S (1999), Abecassis L (2004), Kaimori A (2010), Janknecht R (1998), Janknecht R (1998), Nishihara A (1999), Nishihara A (1999), Furumatsu T (2005), Ghosh AK (2004), Shen X (1998), Shen X (1998), Ghosh AK (2001), Postigo AA (2003), Postigo AA (2003), Yang WS (2005), Lim JY (2012), Lim JY (2012), Jinnin M (2007), Wang G (2005)	22
SMAD5	2	RUNX3	1	affinity chromatography technology	Hanai J (1999)	1
SMAD5	2	YAP1	0	affinity chromatography technology, affinity chromatography technology	Alarcon C (2009), Alarcon C (2009)	2
SMURF2	3	SNRNP70	2	two hybrid	Colland F (2004)	1
COPS5	0	UBA1	1	affinity chromatography technology	Bennett EJ (2010)	1
STUB1	4	RUNX2	2	affinity chromatography technology, two hybrid	Li X (2008), Li X (2008)	2
SMAD5	2	HDAC1	4	affinity chromatography technology	Takeda M (2004)	1
PTPN12	2	EPN1	4	biochemical	Kristensen AR (2012)	1
EP300	36	SMAD4	9	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, unspecified method, affinity chromatography technology	Kim RH (2000), Luciakova K (2008), Janknecht R (1998), Chung CL (2011), Shen X (1998), Dornan D (2003), Yang Y (2015)	7
SMURF1	4	ANKRD13A	1	enzymatic study	Andrews PS (2010)	1
ACVR1	4	SMURF1	4	affinity chromatography technology	Murakami G (2003)	1
NAA20	2	SMAD5	2	biochemical	Havugimana PC (2012)	1
RUNX3	1	EP300	36	affinity chromatography technology, affinity chromatography technology	Jin YH (2004), Jin YH (2004)	2
SMURF2	3	SMURF1	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Fukunaga E (2008), Fukunaga E (2008), Lee YS (2011), Huttlin EL (2017)	4
SMAD5	2	PTPN12	2	two hybrid	Colland F (2004)	1
SMURF1	4	XPO1	8	affinity chromatography technology	Tajima Y (2003)	1
SMAD3	1	SUV39H1	0	affinity chromatography technology	Wakabayashi Y (2011)	1
SMURF1	4	EPN1	4	enzymatic study	Andrews PS (2010)	1
SMAD2	5	KAT2A	1	affinity chromatography technology	Kahata K (2004)	1
HDAC1	4	RUNX1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Reed-Inderbitzin E (2006), Guo H (2011), Guo H (2011), Guo H (2011), Shia WJ (2012), Leong WY (2016)	6
SMAD5	2	CHMP3	0	two hybrid	Colland F (2004)	1
SMAD5	2	SMAD6	9	affinity chromatography technology	Murakami G (2003)	1
U2AF2	7	RBM4	1	two hybrid, two hybrid	Hegele A (2012), Hegele A (2012)	2
NEDD4	2	HGS	5	enzymatic study, affinity chromatography technology, affinity chromatography technology	Katz M (2002), Sun Y (2013), Tan X (2015)	3
NEDD4	2	SMURF2	3	affinity chromatography technology, affinity chromatography technology	Kuratomi G (2005), Huttlin EL (2017)	2
YAP1	0	RUNX2	2	pull down	Yagi R (1999)	1
YAP1	0	SMAD2	5	affinity chromatography technology	Pefani DE (2016)	1
SMAD4	9	SMAD2	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, x-ray crystallography, pull down, affinity chromatography technology, two hybrid, two hybrid, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Moren A (2003), Wotton D (1999), Mori N (2001), Wu JW (2002), Wu JW (2002), Nakao A (1997), Wicks SJ (2000), Wu JW (2001), Chen X (1997), Hanai J (1999), Lebrun JJ (1999), Poncelet AC (2001), Razani B (2001), Razani B (2001), Wang B (2008), Moren A (2005), Kurisaki K (2003), Prunier C (2003), Kato Y (2002), Xu J (2000), Wang L (2011), He W (2006), He W (2006), Dupont S (2009), Brown JD (1999), Pardali K (2000), Fu G (2011), Chen W (2007), Gao S (2009), Lin X (2003), Seo SR (2006), Brown KA (2008), Brown KA (2008), Halder SK (2005), Barrios-Rodiles M (2005), Barrios-Rodiles M (2005), Dai F (2007), Chacko BM (2004), Chacko BM (2004), Chacko BM (2004), Wu RY (1997), Wu RY (1997), Tomita M (2004), Colland F (2004), Tang Y (2003), Ding L (2009), Fattet L (2013), Wang J (2011), Ali A (2013), Yamakawa N (2002), Yamakawa N (2002), Li X (2015), Zhou F (2014), Yang Y (2015), Yan X (2016), Zhou F (2017)	56
SMAD5	2	SOX7	4	two hybrid	Colland F (2004)	1
SMAD3	1	HGS	5	affinity chromatography technology	Miura S (2000)	1
YAP1	0	SMAD6	9	affinity chromatography technology	Ferrigno O (2002)	1
COPS5	0	ELAVL1	0	affinity chromatography technology	Bennett EJ (2010)	1
PAX6	3	EP300	36	pull down, affinity chromatography technology, affinity chromatography technology	Hussain MA (1999), Hussain MA (1999), Hussain MA (1999)	3
EP300	36	HDAC1	4	affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology	Han Y (2008), Mayanil CS (2006), Simone C (2004), Simone C (2004), Simone C (2004), Liu Y (2012), Mizuguchi Y (2012)	7
SMAD2	5	NEDD4	2	affinity chromatography technology, affinity chromatography technology	Kuratomi G (2005), Kuratomi G (2005)	2
SMAD3	1	MEN1	1	affinity chromatography technology	Kaji H (2001)	1
SMAD3	1	WWP1	3	affinity chromatography technology, affinity chromatography technology, two hybrid	Komuro A (2004), Seo SR (2004), Rolland T (2014)	3
SMAD1	0	STUB1	4	affinity chromatography technology, x-ray crystallography, enzymatic study, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study	Wang L (2011), Wang L (2011), Wang L (2011), Li L (2004), Li L (2004), Li L (2004), Li L (2004), Shimamoto S (2013), Shimamoto S (2013)	9
SMAD5	2	KAT2A	1	affinity chromatography technology	Kahata K (2004)	1
SMAD1	0	PAX6	3	affinity chromatography technology	Grocott T (2007)	1
SMAD5	2	RYR2	26	two hybrid	Colland F (2004)	1
TOB1	1	SMAD4	9	affinity chromatography technology	Yoshida Y (2000)	1
SMAD5	2	WWP1	3	affinity chromatography technology, two hybrid	Komuro A (2004), Colland F (2004)	2
SMURF2	3	SMAD4	9	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Zhang L (2013), Zhou F (2017), Zhou F (2017)	3
SMAD3	1	RUNX1	0	affinity chromatography technology, affinity chromatography technology	Hanai J (1999), Nitta E (2005)	2
SMAD2	5	SMAD6	9	affinity chromatography technology	Topper JN (1997)	1
SMAD4	9	SMAD5	2	affinity chromatography technology, two hybrid, two hybrid	Hanai J (1999), Haag J (2006), Colland F (2004)	3
XPO1	8	EPN1	4	affinity chromatography technology	Kirli K (2015)	1
TOB1	1	SMAD5	2	affinity chromatography technology	Yoshida Y (2000)	1
SMAD1	0	SKI	3	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Harada J (2003), Harada J (2003), Takeda M (2004), Mizuide M (2003)	4
SFPQ	2	SNRPA	0	affinity chromatography technology, affinity chromatography technology	Liu L (2011), Hall-Pogar T (2007)	2
SF3B1	12	U2AF2	7	biochemical, affinity chromatography technology, affinity chromatography technology	Havugimana PC (2012), Whisenant TC (2015), Huttlin EL (2017)	3
COPS5	0	SNRNP70	2	affinity chromatography technology	Bennett EJ (2010)	1
COPS5	0	RBM4	1	affinity chromatography technology	Bennett EJ (2010)	1
ELAVL1	0	YAP1	0	affinity chromatography technology	Abdelmohsen K (2009)	1
SMAD2	5	WWP1	3	affinity chromatography technology, affinity chromatography technology	Komuro A (2004), Seo SR (2004)	2
CDK8	1	RBM4	1	affinity chromatography technology	Hein MY (2015)	1
XPO1	8	SNRNP70	2	affinity chromatography technology	Kirli K (2015)	1
SNRPA	0	U2AF2	7	two hybrid, two hybrid, affinity chromatography technology, two hybrid, two hybrid	Hegele A (2012), Hegele A (2012), Hegele A (2012), Rolland T (2014), Yu H (2011)	5
SMAD1	0	PSMD11	0	two hybrid	Colland F (2004)	1
SMAD2	5	SMURF2	3	two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Lin X (2000), Lin X (2000), Bonni S (2001), Nakano A (2009), Komuro A (2004), Zhang Y (2001), Zhang Y (2001), Runyan CE (2009), Runyan CE (2009), Chong PA (2010), Brown KA (2008), Colland F (2004), Colland F (2004), Zhang Y (2017), Zhou F (2017), Zhou F (2017)	16
SMAD2	5	SMAD5	2	affinity chromatography technology	Brown KA (2008)	1
ACVR1	4	SMAD1	0	affinity chromatography technology, affinity chromatography technology	Pardali E (2000), Macias-Silva M (1998)	2
SMURF1	4	SF3B1	12	affinity chromatography technology	Xie Y (2013)	1
SMAD3	1	PSMD11	0	two hybrid	Colland F (2004)	1
XPO1	8	PPIL4	0	affinity chromatography technology	Kirli K (2015)	1
COPS5	0	SF3B3	4	affinity chromatography technology	Bennett EJ (2010)	1
SMAD4	9	SKI	3	pull down, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Harada J (2003), Ueki N (2003), Wu JW (2002), Stroschein SL (1999), Tabata T (2009), Prunier C (2003), Prunier C (2003), Takeda M (2004), Takeda M (2004), Ferrand N (2010), Wu K (2003), Wu K (2003), Barrios-Rodiles M (2005), Colland F (2004), He J (2003), He J (2003), Jinnin M (2007), Li X (2015), Rashidian J (2015), Rashidian J (2015), Zhou F (2017)	21
SMAD5	2	ANKRD13A	1	two hybrid	Colland F (2004)	1
CDK8	1	WWP1	3	affinity chromatography technology	Hein MY (2015)	1
ELAVL1	0	ANKRD13A	1	affinity chromatography technology	Abdelmohsen K (2009)	1
SMAD1	0	MEN1	1	affinity chromatography technology	Sowa H (2003)	1
ELAVL1	0	SFPQ	2	affinity chromatography technology	Abdelmohsen K (2009)	1
U2AF2	7	ELAVL1	0	affinity chromatography technology	Whisenant TC (2015)	1
CDK8	1	SMAD1	0	enzymatic study, affinity chromatography technology, affinity chromatography technology	Alarcon C (2009), Alarcon C (2009), Alarcon C (2009)	3
ELAVL1	0	XPO1	8	affinity chromatography technology	Abdelmohsen K (2009)	1
HECW2	13	ELAVL1	0	affinity chromatography technology	Lu L (2013)	1
SMAD5	2	MEN1	1	affinity chromatography technology	Sowa H (2003)	1
RUNX2	2	WWP1	3	affinity chromatography technology, affinity chromatography technology	Jones DC (2006), Jones DC (2006)	2
SMAD5	2	SF3B3	4	two hybrid	Vinayagam A (2011)	1
HECW2	13	KAT2A	1	affinity chromatography technology	Lu L (2013)	1
SMAD3	1	SMURF2	3	two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Lin X (2000), Lin X (2000), Bonni S (2001), Nakano A (2009), Komuro A (2004), Zhang Y (2001), Zhang Y (2001), Tang LY (2011), Brown KA (2008), Zhang L (2013), Li Y (2017), Zhang Y (2017)	12
XPO1	8	SMAD1	0	affinity chromatography technology	Kirli K (2015)	1
SMAD3	1	HDAC1	4	two hybrid, pull down	Liberati NT (2001), Akiyoshi S (1999)	2
SMAD3	1	CXXC5	1	two hybrid	Colland F (2004)	1
SMAD4	9	SMAD6	9	affinity chromatography technology, affinity chromatography technology	Topper JN (1997), Moren A (2005)	2
LSR	0	SMAD5	2	affinity chromatography technology	Huttlin EL (2017)	1
SMAD1	0	SOX5	11	two hybrid	Colland F (2004)	1
SMAD4	9	STUB1	4	pull down, affinity chromatography technology	Li L (2004), Li L (2004)	2
SMAD5	2	RBM4	1	two hybrid	Colland F (2004)	1
STUB1	4	RUNX1	0	affinity chromatography technology, pull down, affinity chromatography technology	Shang Y (2009), Shang Y (2009), Shang Y (2009)	3
IPPK	1	SMAD5	2	affinity chromatography technology	Huttlin EL (2017)	1
SMAD2	5	SMURF1	4	affinity chromatography technology, affinity chromatography technology, two hybrid	Komuro A (2004), Ito I (2010), Colland F (2004)	3
SMAD5	2	CXXC5	1	two hybrid	Colland F (2004)	1
CDK8	1	SMAD3	1	enzymatic study	Alarcon C (2009)	1
HMGA2	1	SMAD1	0	affinity chromatography technology	Monzen K (2008)	1
SMAD2	5	SKI	3	pull down, affinity chromatography technology, affinity chromatography technology, pull down, pull down, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Harada J (2003), Luo K (1999), Tabata T (2009), Prunier C (2003), Prunier C (2003), Akiyoshi S (1999), Akiyoshi S (1999), Takeda M (2004), Inoue Y (2011), Ferrand N (2010), Chen W (2007), Brown KA (2008), He J (2003), Rashidian J (2015), Zhou F (2017)	15
ELAVL1	0	SMAD5	2	affinity chromatography technology	Abdelmohsen K (2009)	1
SMAD1	0	SMAD4	9	affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Harada J (2003), Hanai J (1999), Lopez-Rovira T (2002), Kato Y (2002), Wang L (2011), Li L (2004), Hata A (1998), Barrios-Rodiles M (2005), Wu RY (1997), Wu RY (1997), Colland F (2004), Qiu T (2007), Yan X (2016), Zhou F (2017)	14
SMAD2	5	COPS5	0	two hybrid	Colland F (2004)	1
SMAD5	2	PSMD11	0	two hybrid	Colland F (2004)	1
EP300	36	RUNX2	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Lee HW (2006), Jeon EJ (2006), Jeon EJ (2006), Jun JH (2010)	4
SMAD1	0	RUNX3	1	affinity chromatography technology	Hanai J (1999)	1
SMAD4	9	HGS	5	affinity chromatography technology, affinity chromatography technology	Miura S (2000), Haag J (2006)	2
SMAD1	0	WWP1	3	affinity chromatography technology, affinity chromatography technology	Komuro A (2004), Seo SR (2004)	2
SMAD3	1	SNRNP70	2	two hybrid	Colland F (2004)	1
SMAD5	2	NEDD4	2	two hybrid	Colland F (2004)	1
RUNX3	1	SMURF2	3	affinity chromatography technology	Jin YH (2004)	1
SMAD3	1	SMAD1	0	affinity chromatography technology, two hybrid, two hybrid	Brown KA (2008), Wu RY (1997), Wu RY (1997)	3
SMAD2	5	STUB1	4	pull down	Li L (2004)	1
YAP1	0	EP300	36	imaging technique	Strano S (2005)	1
SNRNP70	2	SNRPA	0	affinity chromatography technology	Huttlin EL (2017)	1
U2AF2	7	UBA1	1	affinity chromatography technology	Whisenant TC (2015)	1
SSMEM1	0	SMAD5	2	affinity chromatography technology	Huttlin EL (2017)	1
ELAVL1	0	SMAD2	5	affinity chromatography technology	Abdelmohsen K (2009)	1
COPS5	0	SF3B1	12	affinity chromatography technology	Bennett EJ (2010)	1
SMAD3	1	STUB1	4	pull down	Li L (2004)	1
MEN1	1	HDAC1	4	pull down	Kim H (2003)	1
YAP1	0	STUB1	4	affinity chromatography technology	Hauri S (2013)	1
XPO1	8	YAP1	0	affinity chromatography technology	Kirli K (2015)	1
SMAD2	5	RUNX2	2	affinity chromatography technology	Hanai J (1999)	1
RUNX3	1	HDAC1	4	affinity chromatography technology	Jin YH (2004)	1
SF3B1	12	SFPQ	2	biochemical	Havugimana PC (2012)	1
SMAD5	2	SMURF1	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, unspecified method, two hybrid, two hybrid, enzymatic study	Lu K (2008), Komuro A (2004), Ebisawa T (2001), Nie J (2010), Alarcon C (2009), Murakami G (2003), Sangadala S (2007), Sangadala S (2007), Sangadala S (2007), Haag J (2006), Colland F (2004), Lu K (2008)	12
SMAD5	2	SFPQ	2	two hybrid	Colland F (2004)	1
SMAD3	1	SMURF1	4	affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology	Komuro A (2004), Colland F (2004), Li Y (2017), Li Y (2017)	4
SMAD5	2	BCAT1	6	two hybrid	Colland F (2004)	1
RUNX2	2	SMAD1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique	Zhang YW (2000), Zhang YW (2000), Hanai J (1999), Jun JH (2010), Wang Q (2007)	5
SMAD3	1	U2AF2	7	affinity chromatography technology	Brown KA (2008)	1
SMAD5	2	SF3B1	12	two hybrid	Colland F (2004)	1
SMURF1	4	SNRPA	0	affinity chromatography technology	Xie Y (2013)	1
SMAD5	2	UBA1	1	two hybrid	Vinayagam A (2011)	1
ACVR1	4	SMAD5	2	affinity chromatography technology, affinity chromatography technology	Pardali E (2000), Macias-Silva M (1998)	2
HGS	5	UBA1	1	pull down	Pridgeon JW (2009)	1
SMAD5	2	HGS	5	affinity chromatography technology, two hybrid	Haag J (2006), Haag J (2006)	2
XPO1	8	SMAD5	2	affinity chromatography technology	Kirli K (2015)	1
COPS5	0	SNRPA	0	affinity chromatography technology	Bennett EJ (2010)	1
SKI	3	SMURF2	3	affinity chromatography technology	Zhou F (2017)	1
SMAD3	1	PAX6	3	affinity chromatography technology	Grocott T (2007)	1
SMAD1	0	HDAC1	4	affinity chromatography technology	Takeda M (2004)	1
RUNX3	1	SMURF1	4	affinity chromatography technology	Jin YH (2004)	1
SMAD5	2	RUNX2	2	affinity chromatography technology	Hanai J (1999)	1
SMAD3	1	RUNX3	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Hanai J (1999), Jin YH (2004), Kong Y (2016)	3
EP300	36	SMAD5	2	affinity chromatography technology, two hybrid	Jeon EJ (2006), Haag J (2006)	2
SMAD6	9	SMURF1	4	affinity chromatography technology, affinity chromatography technology, unspecified method, affinity chromatography technology, affinity chromatography technology	Komuro A (2004), Ebisawa T (2001), Sangadala S (2007), Lee YS (2011), Lee YS (2011)	5
SMAD5	2	SNRPA	0	two hybrid	Colland F (2004)	1
WWP1	3	SMAD4	9	affinity chromatography technology	Seo SR (2004)	1
EP300	36	SMAD2	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology	Wotton D (1999), Pessah M (2001), Furumatsu T (2005), Wang J (2011), Suganuma T (2002)	5
ELAVL1	0	RUNX1	0	affinity chromatography technology	Abdelmohsen K (2009)	1
SMURF2	3	RUNX2	2	enzymatic study	Lu K (2011)	1
SMAD2	5	RUNX1	0	affinity chromatography technology	Hanai J (1999)	1
SMAD5	2	STUB1	4	affinity chromatography technology	Wang L (2011)	1
CDK8	1	SMAD5	2	affinity chromatography technology	Alarcon C (2009)	1
SMAD3	1	SMAD2	5	affinity chromatography technology, genetic interference, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology	Nakao A (1997), Lebrun JJ (1999), Dumont E (2003), Brown KA (2008), Brown KA (2008), Wu RY (1997), Wu RY (1997), Tang Y (2003), Tang Y (2003), Wang J (2011), Huttlin EL (2015), Huttlin EL (2017)	12
SMAD3	1	YAP1	0	affinity chromatography technology	Alarcon C (2009)	1
COPS5	0	U2AF2	7	affinity chromatography technology	Bennett EJ (2010)	1
SMAD1	0	SNRNP70	2	two hybrid	Colland F (2004)	1
SF3B3	4	SFPQ	2	biochemical	Havugimana PC (2012)	1
ELAVL1	0	TOB1	1	affinity chromatography technology	Abdelmohsen K (2009)	1
SMAD2	5	HDAC1	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Wotton D (1999), Wotton D (1999), Takeda M (2004), Lo RS (2001)	4
YAP1	0	HDAC1	4	affinity chromatography technology	Enzo E (2015)	1
SMAD6	9	WWP1	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Komuro A (2004), Seo SR (2004), Herhaus L (2014)	3
SMURF1	4	PLEKHO1	1	affinity chromatography technology, pull down, pull down, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Lu K (2008), Lu K (2008), Nie J (2010), Nie J (2010), Wang Y (2012), Wang Y (2012), Wang Y (2012), Wan L (2011)	8
SMAD5	2	RUNX1	0	affinity chromatography technology	Hanai J (1999)	1
SMAD5	2	PLEKHO1	1	affinity chromatography technology, pull down	Lu K (2008), Lu K (2008)	2
SMAD6	9	NEDD4	2	affinity chromatography technology	Kuratomi G (2005)	1
SMAD1	0	HGS	5	affinity chromatography technology	Miura S (2000)	1
PAX6	3	RBM4	1	affinity chromatography technology	Hein MY (2015)	1
SUV39H1	0	SMAD5	2	affinity chromatography technology	Frontelo P (2004)	1
SF3B1	12	SNRPA	0	biochemical, biochemical	Havugimana PC (2012), Wan C (2015)	2
RUNX2	2	SMURF1	4	imaging technique	Wang Q (2007)	1
SMAD4	9	HDAC1	4	affinity chromatography technology	Takeda M (2004)	1
SMAD3	1	KAT2A	1	affinity chromatography technology	Kahata K (2004)	1
SF3B1	12	SF3B3	4	affinity chromatography technology, affinity chromatography technology, biochemical, biochemical	Das BK (1999), Will CL (2002), Havugimana PC (2012), Wan C (2015)	4
SMURF2	3	XPO1	8	affinity chromatography technology, affinity chromatography technology, pull down	Kim DG (2016), Kim DG (2016), Kim DG (2016)	3
YAP1	0	RUNX3	1	pull down	Yagi R (1999)	1
SMAD5	2	MTMR10	0	two hybrid	Colland F (2004)	1
SMAD5	2	SOX5	11	two hybrid	Colland F (2004)	1
SMAD5	2	PAX6	3	affinity chromatography technology	Grocott T (2007)	1
EPN1	4	SMAD5	2	biochemical	Havugimana PC (2012)	1
SMAD3	1	SMAD4	9	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, x-ray crystallography, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, pull down, pull down, pull down, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, protein complementation assay, affinity chromatography technology, affinity chromatography technology	Seoane J (2004), Moren A (2003), Wu JW (2002), Nakao A (1997), Hanai J (1999), Lebrun JJ (1999), Poncelet AC (2001), Jablonska E (2010), Prunier C (2003), Kato Y (2002), Kaimori A (2010), Tang LY (2011), Tang LY (2011), Dupont S (2009), Dupont S (2009), Pardali K (2000), Kardassis D (2000), Xu L (2003), Fu G (2011), Chen W (2007), Kang JM (2012), Gao S (2009), Li H (2009), Li H (2009), Brown KA (2008), Brown KA (2008), Halder SK (2005), Barrios-Rodiles M (2005), Dai F (2007), Dai F (2007), Chacko BM (2004), Chacko BM (2004), Chacko BM (2004), Stroschein SL (1999), Stroschein SL (1999), Stroschein SL (1999), Wu RY (1997), Wu RY (1997), Wu RY (1997), Wu RY (1997), Tomita M (2004), Colland F (2004), Colland F (2004), Tang Y (2003), Ding L (2009), Fattet L (2013), Wang J (2011), Xue J (2014), Ali A (2013), Gao S (2009), Yamakawa N (2002), Yamakawa N (2002), Wang G (2005), Li X (2015), Zhou F (2014), Yang Y (2015), Yan X (2016), Yan X (2016), Wu Y (2017), Wu Y (2017)	60
SF3B3	4	U2AF2	7	biochemical, affinity chromatography technology	Havugimana PC (2012), Whisenant TC (2015)	2
SMAD1	0	KAT2A	1	affinity chromatography technology	Kahata K (2004)	1
SMAD2	5	HGS	5	affinity chromatography technology	Miura S (2000)	1
SMAD2	5	U2AF2	7	affinity chromatography technology	Brown KA (2008)	1
SUV39H2	3	SMAD5	2	affinity chromatography technology	Frontelo P (2004)	1
SUV39H1	0	HDAC1	4	affinity chromatography technology, pull down	Vaute O (2002), Vaute O (2002)	2
HGS	5	SF3B3	4	pull down	Pridgeon JW (2009)	1
SMAD6	9	ACVR1	4	affinity chromatography technology, affinity chromatography technology	Kamiya Y (2010), Zhang X (2013)	2
SMAD1	0	YAP1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, x-ray crystallography	Alarcon C (2009), Alarcon C (2009), Aragon E (2011), Aragon E (2011), Aragon E (2011)	5
SMAD5	2	COPS5	0	two hybrid, affinity chromatography technology	Haag J (2006), Haag J (2006)	2
SFPQ	2	HDAC1	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Tyson-Capper AJ (2009), Dong L (2011), Liu L (2011), Zhong N (2006), Zhong N (2006)	5
EP300	36	SMAD1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Pearson KL (1999), Nakashima K (1999), Nakashima K (1999), Jeon EJ (2006), Jun JH (2010), Weng Q (2012)	6
SMAD1	0	SMAD6	9	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid	Topper JN (1997), Murakami G (2003), Itoh F (2001), Hata A (1998), Hata A (1998)	5
SF3B3	4	SNRPA	0	biochemical	Havugimana PC (2012)	1
SMAD1	0	RUNX1	0	affinity chromatography technology	Hanai J (1999)	1
SMAD5	2	U2AF2	7	two hybrid	Colland F (2004)	1
YAP1	0	SF3B3	4	affinity chromatography technology	Enzo E (2015)	1
SUV39H1	0	RUNX1	0	affinity chromatography technology, pull down, affinity chromatography technology, biochemical	Chakraborty S (2003), Chakraborty S (2003), Reed-Inderbitzin E (2006), Reed-Inderbitzin E (2006)	4
TOB1	1	SMAD3	1	affinity chromatography technology	Xiong B (2006)	1
SMAD1	0	NEDD4	2	affinity chromatography technology, two hybrid	Kim BG (2011), Colland F (2004)	2
ELAVL1	0	SMAD6	9	affinity chromatography technology	Abdelmohsen K (2009)	1
SMAD3	1	SMAD5	2	affinity chromatography technology	Brown KA (2008)	1
SMURF1	4	SMAD1	0	enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study, pull down, unspecified method, two hybrid, affinity chromatography technology, pull down, enzymatic study, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down	Sangadala S (2006), Komuro A (2004), Tian M (2011), Tian M (2011), Tian M (2011), Sapkota G (2007), Sapkota G (2007), Li L (2004), Alarcon C (2009), Aragon E (2011), Aragon E (2011), Aragon E (2011), Aragon E (2011), Gao S (2009), Sangadala S (2007), Sangadala S (2007), Sangadala S (2007), Sangadala S (2007), Sangadala S (2007), Colland F (2004), Cao Y (2014), Cao Y (2014), Sangadala S (2007), Gao S (2009), Wan L (2011), Wan L (2011), Zhang Y (2017), Zhang Y (2017)	28
YAP1	0	RUNX1	0	two hybrid, affinity chromatography technology, affinity chromatography technology, pull down	Yagi R (1999), Levy D (2008), Levy D (2008), Schuchardt BJ (2014)	4
SMAD2	5	SNRNP70	2	two hybrid	Colland F (2004)	1
XPO1	8	RBM4	1	affinity chromatography technology	Kirli K (2015)	1
SUV39H1	0	RUNX3	1	affinity chromatography technology	Reed-Inderbitzin E (2006)	1
COPS5	0	SFPQ	2	affinity chromatography technology	Bennett EJ (2010)	1
CDK8	1	SMAD2	5	enzymatic study	Alarcon C (2009)	1
XPO1	8	ANKRD13A	1	affinity chromatography technology	Kirli K (2015)	1
SMAD5	2	PNKP	3	two hybrid	Colland F (2004)	1
SMAD2	5	PSMD11	0	two hybrid	Colland F (2004)	1
SMAD5	2	HBG2	0	two hybrid	Colland F (2004)	1
SMAD1	0	CHMP3	0	two hybrid	Colland F (2004)	1
SMAD1	0	SMURF2	3	two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology	Lin X (2000), Lin X (2000), Komuro A (2004), Zhang Y (2001), Zhang Y (2001), Li L (2004), Chong PA (2010), Colland F (2004), Huttlin EL (2017), Zhou F (2017)	10
TOB1	1	SMAD1	0	affinity chromatography technology	Yoshida Y (2000)	1
KAT2A	1	SF3B3	4	affinity chromatography technology	Kim J (2010)	1
RUNX2	2	HDAC1	4	affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, genetic interference	Lee HW (2006), Zhang Z (2012), Ali SA (2012), Ali SA (2012), Ali SA (2012)	5
SMAD6	9	SMURF2	3	affinity chromatography technology, two hybrid, affinity chromatography technology	Komuro A (2004), Colland F (2004), Herhaus L (2014)	3
RUNX2	2	SUV39H1	0	affinity chromatography technology, affinity chromatography technology	Tandon M (2012), Tandon M (2012)	2
SMAD3	1	RUNX2	2	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Zhang YW (2000), Zhang YW (2000), Hanai J (1999), Ohyama Y (2011)	4
SMAD5	2	SNRNP70	2	two hybrid	Colland F (2004)	1
PNKP	3	SUV39H1	0	two hybrid	Weimann M (2013)	1
SMAD3	1	SKI	3	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Harada J (2003), Ueki N (2003), Ueki N (2003), Tabata T (2009), Prunier C (2003), Liberati NT (2001), Akiyoshi S (1999), Akiyoshi S (1999), Takeda M (2004), Mizuide M (2003), Wu K (2003), Chen W (2007), Band AM (2009), Qin BY (2002), He J (2003), He J (2003), Jinnin M (2007), Jinnin M (2007), Rashidian J (2015)	19
XPO1	8	SNRPA	0	affinity chromatography technology	Kirli K (2015)	1
SNRNP70	2	U2AF2	7	biochemical, affinity chromatography technology	Havugimana PC (2012), Whisenant TC (2015)	2
HMGA2	1	SMAD5	2	affinity chromatography technology	Monzen K (2008)	1
SMAD4	9	SMURF1	4	affinity chromatography technology, affinity chromatography technology	Moren A (2005), Zhang L (2013)	2
RUNX1	0	EP300	36	affinity chromatography technology, enzymatic study	Aikawa Y (2006), Yamaguchi Y (2004)	2
XPO1	8	SMAD4	9	affinity chromatography technology	Kirli K (2015)	1
SMAD4	9	PAX6	3	affinity chromatography technology	Grocott T (2007)	1
SMAD5	2	SMURF2	3	affinity chromatography technology, enzymatic study, two hybrid, affinity chromatography technology	Komuro A (2004), Nie J (2010), Colland F (2004), Huttlin EL (2017)	4
HECW2	13	SMAD5	2	affinity chromatography technology	Lu L (2013)	1
SMAD5	2	PPIL4	0	two hybrid	Colland F (2004)	1
SMAD2	5	SMAD1	0	affinity chromatography technology, two hybrid, two hybrid, fluorescent resonance energy transfe	Brown KA (2008), Wu RY (1997), Wu RY (1997), Ivanov AA (2017)	4
COPS5	0	SMAD4	9	two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology	Wan M (2002), Wan M (2002), Wan M (2002), Wan M (2002), Kim BC (2004), Huang J (2007), Sangadala S (2013), Lee CC (2016), Lee CC (2016)	9
SMAD4	9	SNRNP70	2	two hybrid	Colland F (2004)	1
SMAD3	1	NEDD4	2	affinity chromatography technology, enzymatic study, unspecified method, affinity chromatography technology, affinity chromatography technology, pull down	Kuratomi G (2005), Persaud A (2009), Aragon E (2011), Aragon E (2011), Aragon E (2011), Aragon E (2011)	6
SMAD1	0	SMAD5	2	two hybrid	Colland F (2004)	1
SMAD4	9	PSMD11	0	two hybrid	Colland F (2004)	1
SMAD1	0	SF3B1	12	two hybrid	Colland F (2004)	1
MEN1	1	STUB1	4	affinity chromatography technology	Yaguchi H (2004)	1