PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
EP300	36	FOXO3	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Li XN (2009), Li XN (2009), Mahmud DL (2002), Li X (2015)	4
ICK	1	MAPK1	1	affinity chromatography technology, affinity chromatography technology	Fu Z (2006), August A (1996)	2
SMAD2	5	USP9X	15	affinity chromatography technology	Dupont S (2009)	1
MAP2K3	1	KAT2A	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
SMAD2	5	MED24	4	affinity chromatography technology	Kato Y (2002)	1
ZNF521	3	SMAD4	9	affinity chromatography technology	Bond HM (2004)	1
CREBBP	29	NEUROG1	0	pull down, affinity chromatography technology, genetic interference	Sun Y (2001), Sun Y (2001), Sun Y (2001)	3
SMAD5	2	SKI	3	affinity chromatography technology	Takeda M (2004)	1
SMAD2	5	RUNX3	1	affinity chromatography technology	Hanai J (1999)	1
SMAD1	0	SKIL	3	affinity chromatography technology	Mizuide M (2003)	1
EP300	36	SMAD3	1	affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Qiu P (2006), Furumatsu T (2005), Itoh S (2000), Akiyoshi S (1999), Abecassis L (2004), Kaimori A (2010), Janknecht R (1998), Janknecht R (1998), Nishihara A (1999), Nishihara A (1999), Furumatsu T (2005), Ghosh AK (2004), Shen X (1998), Shen X (1998), Ghosh AK (2001), Postigo AA (2003), Postigo AA (2003), Yang WS (2005), Lim JY (2012), Lim JY (2012), Jinnin M (2007), Wang G (2005)	22
SMAD1	0	PIAS4	5	two hybrid, affinity chromatography technology, two hybrid	Long J (2003), Long J (2003), Colland F (2004)	3
PIAS4	5	SMAD7	1	two hybrid, affinity chromatography technology, two hybrid	Imoto S (2003), Imoto S (2003), Colland F (2004)	3
SMAD5	2	RUNX3	1	affinity chromatography technology	Hanai J (1999)	1
GSK3B	1	SNRNP70	2	affinity chromatography technology	Ewing RM (2007)	1
SMAD6	9	SMAD7	1	two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology	Topper JN (1997), Topper JN (1997), Topper JN (1997), Yan X (2016)	4
SMAD5	2	YAP1	0	affinity chromatography technology, affinity chromatography technology	Alarcon C (2009), Alarcon C (2009)	2
WDR77	2	SMAD1	0	two hybrid, affinity chromatography technology	Li Y (2013), Li Y (2013)	2
SMAD2	5	MED6	0	affinity chromatography technology	Kato Y (2002)	1
SMURF2	3	SNRNP70	2	two hybrid	Colland F (2004)	1
SMAD7	1	ERBIN	5	pull down	Warner DR (2003)	1
STUB1	4	RUNX2	2	affinity chromatography technology, two hybrid	Li X (2008), Li X (2008)	2
SF3B1	12	SNIP1	0	two hybrid, two hybrid	Hegele A (2012), Hegele A (2012)	2
STAT3	0	CDK9	3	affinity chromatography technology, affinity chromatography technology, pull down	Giraud S (2004), Giraud S (2004), Giraud S (2004)	3
SMAD5	2	HDAC1	4	affinity chromatography technology	Takeda M (2004)	1
SMAD1	0	ANKRD27	4	two hybrid	Colland F (2004)	1
USP15	4	BMPR1A	5	affinity chromatography technology, imaging technique, enzymatic study	Herhaus L (2014), Herhaus L (2014), Herhaus L (2014)	3
SMAD1	0	INPP4A	5	two hybrid	Colland F (2004)	1
DNMT3L	2	PAX6	3	pull down, imaging technique, affinity chromatography technology	Pacaud R (2014), Pacaud R (2014), Pacaud R (2014)	3
ZNF512B	2	XPC	1	two hybrid	Colland F (2004)	1
KDM6B	16	SMAD2	5	affinity chromatography technology	Dahle O (2010)	1
HBP1	1	EP300	36	affinity chromatography technology, enzymatic study	Wang W (2012), Wang W (2012)	2
EP300	36	SMAD4	9	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, unspecified method, affinity chromatography technology	Kim RH (2000), Luciakova K (2008), Janknecht R (1998), Chung CL (2011), Shen X (1998), Dornan D (2003), Yang Y (2015)	7
ACVR1	4	SMURF1	4	affinity chromatography technology	Murakami G (2003)	1
TP53	0	MAP2K3	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
RUNX3	1	EP300	36	affinity chromatography technology, affinity chromatography technology	Jin YH (2004), Jin YH (2004)	2
EP300	36	PIAS1	4	pull down, affinity chromatography technology	Ledsaak M (2016), Ledsaak M (2016)	2
SMURF2	3	SMURF1	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Fukunaga E (2008), Fukunaga E (2008), Lee YS (2011), Huttlin EL (2017)	4
DNMT3L	2	GMEB1	4	pull down	Pacaud R (2014)	1
PIAS4	5	SMAD3	1	affinity chromatography technology, two hybrid, affinity chromatography technology, pull down, affinity chromatography technology, pull down	Imoto S (2003), Long J (2003), Long J (2003), Long J (2003), Long J (2003), Long J (2003)	6
SMURF1	4	XPO1	8	affinity chromatography technology	Tajima Y (2003)	1
DACH1	3	STK11	2	fluorescent resonance energy transfe	Ivanov AA (2017)	1
MED15	6	MED24	4	biochemical	Wan C (2015)	1
SMAD7	1	PIAS1	4	two hybrid	Colland F (2004)	1
SMAD2	5	KAT2A	1	affinity chromatography technology	Kahata K (2004)	1
APP	1	GSK3B	1	affinity chromatography technology, affinity chromatography technology, pull down	Zhou F (2012), Zhou F (2012), Olah J (2011)	3
AR	3	FOXG1	26	two hybrid, pull down	Obendorf M (2007), Obendorf M (2007)	2
TOB1	1	APP	1	pull down	Olah J (2011)	1
SMAD2	5	DVL1	5	pull down	Warner DR (2003)	1
HDAC1	4	RUNX1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Reed-Inderbitzin E (2006), Guo H (2011), Guo H (2011), Guo H (2011), Shia WJ (2012), Leong WY (2016)	6
BMPR1A	5	SMURF1	4	affinity chromatography technology	Murakami G (2003)	1
LEF1	3	SMAD3	1	pull down, affinity chromatography technology, unspecified method, pull down, affinity chromatography technology	Labbe E (2000), Labbe E (2000), Cui Q (2005), Cui Q (2005), Cui Q (2005)	5
SMAD3	1	PARD3	5	pull down	Warner DR (2003)	1
SMAD5	2	CHMP3	0	two hybrid	Colland F (2004)	1
SMAD5	2	SMAD6	9	affinity chromatography technology	Murakami G (2003)	1
ERBIN	5	FOXO3	1	unspecified method	Boisguerin P (2004)	1
SMAD1	0	XPC	1	two hybrid	Colland F (2004)	1
SMAD1	0	FOXO3	1	affinity chromatography technology	Sapkota G (2007)	1
TP53	0	WDR77	2	affinity chromatography technology	Horikawa I (2014)	1
SMAD1	0	SS18L1	2	two hybrid	Ravasi T (2010)	1
NEDD4	2	HGS	5	enzymatic study, affinity chromatography technology, affinity chromatography technology	Katz M (2002), Sun Y (2013), Tan X (2015)	3
SMAD4	9	YY1	7	imaging technique, pull down, affinity chromatography technology	Kurisaki K (2003), Kurisaki K (2003), Kurisaki K (2003)	3
STK11	2	STUB1	4	affinity chromatography technology	Gaude H (2012)	1
AR	3	HDAC1	4	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Gaughan L (2002), Gaughan L (2002), Gaughan L (2005), Gaughan L (2005), Gobinet J (2005), Peche LY (2015)	6
ZNF512B	2	PIAS4	5	two hybrid	Colland F (2004)	1
ZNF423	14	SMAD1	0	affinity chromatography technology, affinity chromatography technology	Hata A (2000), Bond HM (2004)	2
AR	3	SMAD3	1	affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, pull down, pull down	Chipuk JE (2002), Hayes SA (2001), Hayes SA (2001), Hayes SA (2001), Chipuk JE (2002), Hayes SA (2001), Hayes SA (2001), Kang HY (2002), Kang HY (2002), Kang HY (2002), Kang HY (2002), Chipuk JE (2002)	12
SMURF1	4	UBC	7	affinity chromatography technology, enzymatic study, pull down	Xie Y (2013), Kristariyanto YA (2015), Zhang Y (2017)	3
SMAD7	1	SMURF2	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, unspecified method, affinity chromatography technology, affinity chromatography technology, pull down, x-ray crystallography, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Asano Y (2004), Kavsak P (2000), Lee YS (2008), Komuro A (2004), Chong PA (2010), Chong PA (2010), Chong PA (2010), Cai Y (2012), Cai Y (2012), Chong PA (2006), Al-Salihi MA (2012), Ogunjimi AA (2005), Aragon E (2012), Aragon E (2012), Colland F (2004), Zhang L (2013), Chandhoke AS (2015), Iyengar PV (2015), Elkouris M (2016)	19
MAPK1	1	AR	3	pull down	Yeh S (1999)	1
CREBBP	29	GLI3	10	pull down, affinity chromatography technology, affinity chromatography technology	Dai P (1999), Dai P (1999), Zhou H (2006)	3
NEDD4	2	SMURF2	3	affinity chromatography technology, affinity chromatography technology	Kuratomi G (2005), Huttlin EL (2017)	2
YAP1	0	RUNX2	2	pull down	Yagi R (1999)	1
SMAD3	1	SS18L1	2	two hybrid	Ravasi T (2010)	1
YAP1	0	SMAD2	5	affinity chromatography technology	Pefani DE (2016)	1
SMAD4	9	SMAD2	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, x-ray crystallography, pull down, affinity chromatography technology, two hybrid, two hybrid, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Moren A (2003), Wotton D (1999), Mori N (2001), Wu JW (2002), Wu JW (2002), Nakao A (1997), Wicks SJ (2000), Wu JW (2001), Chen X (1997), Hanai J (1999), Lebrun JJ (1999), Poncelet AC (2001), Razani B (2001), Razani B (2001), Wang B (2008), Moren A (2005), Kurisaki K (2003), Prunier C (2003), Kato Y (2002), Xu J (2000), Wang L (2011), He W (2006), He W (2006), Dupont S (2009), Brown JD (1999), Pardali K (2000), Fu G (2011), Chen W (2007), Gao S (2009), Lin X (2003), Seo SR (2006), Brown KA (2008), Brown KA (2008), Halder SK (2005), Barrios-Rodiles M (2005), Barrios-Rodiles M (2005), Dai F (2007), Chacko BM (2004), Chacko BM (2004), Chacko BM (2004), Wu RY (1997), Wu RY (1997), Tomita M (2004), Colland F (2004), Tang Y (2003), Ding L (2009), Fattet L (2013), Wang J (2011), Ali A (2013), Yamakawa N (2002), Yamakawa N (2002), Li X (2015), Zhou F (2014), Yang Y (2015), Yan X (2016), Zhou F (2017)	56
SMAD1	0	PIGQ	1	two hybrid	Colland F (2004)	1
SMAD1	0	NEDD9	3	affinity chromatography technology, two hybrid	Liu X (2000), Colland F (2004)	2
HDAC1	4	NKX3-2	1	pull down, pull down, affinity chromatography technology	Kim DW (2003), Kim DW (2003), Kim DW (2003)	3
HDAC1	4	ZNF521	3	affinity chromatography technology, affinity chromatography technology	Joshi P (2013), Huttlin EL (2017)	2
UBC	7	STUB1	4	affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study	Connell P (2001), Connell P (2001), Windheim M (2008), Zhang M (2005)	4
ZEB1	3	SMAD1	0	affinity chromatography technology	Postigo AA (2003)	1
SMURF2	3	UBC	7	enzymatic study, affinity chromatography technology, enzymatic study, pull down, pull down	Maspero E (2013), Zhang L (2013), Kristariyanto YA (2015), Mari S (2014), Zhang Y (2017)	5
EP300	36	UBC	7	enzymatic study, affinity chromatography technology	Delvecchio M (2013), Kirilyuk A (2012)	2
SMURF1	4	LMNA	2	enzymatic study	Andrews PS (2010)	1
TP53	0	UBC	7	affinity chromatography technology, affinity chromatography technology	Ayroldi E (2014), Ke JY (2014)	2
SMAD3	1	HGS	5	affinity chromatography technology	Miura S (2000)	1
MAPK1	1	CREBBP	29	enzymatic study	Janknecht R (1996)	1
YAP1	0	SMAD6	9	affinity chromatography technology	Ferrigno O (2002)	1
DACH1	3	SMAD4	9	affinity chromatography technology, affinity chromatography technology, pull down	Wu K (2003), Wu K (2003), Wu K (2003)	3
SMAD3	1	USP15	4	affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology	Inui M (2011), Inui M (2011), Inui M (2011), Eichhorn PJ (2012), Wijnhoven P (2015)	5
PAX6	3	EP300	36	pull down, affinity chromatography technology, affinity chromatography technology	Hussain MA (1999), Hussain MA (1999), Hussain MA (1999)	3
STAT3	0	SMAD1	0	affinity chromatography technology	Nakashima K (1999)	1
BMP7	3	ICK	1	affinity chromatography technology	Huttlin EL (2015)	1
NUP214	3	SMAD4	9	affinity chromatography technology, pull down	Xu L (2003), Xu L (2003)	2
NUP214	3	SMAD3	1	affinity chromatography technology, pull down	Xu L (2003), Xu L (2003)	2
EP300	36	HDAC1	4	affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology	Han Y (2008), Mayanil CS (2006), Simone C (2004), Simone C (2004), Simone C (2004), Liu Y (2012), Mizuguchi Y (2012)	7
PIAS4	5	SMAD6	9	two hybrid, affinity chromatography technology	Imoto S (2003), Imoto S (2003)	2
UCHL3	1	USP9X	15	biochemical	Havugimana PC (2012)	1
HGS	5	APP	1	pull down, pull down, pull down	Pridgeon JW (2009), Olah J (2011), Virok DP (2011)	3
SMAD2	5	NEDD4	2	affinity chromatography technology, affinity chromatography technology	Kuratomi G (2005), Kuratomi G (2005)	2
SMAD3	1	MEN1	1	affinity chromatography technology	Kaji H (2001)	1
SMAD1	0	RFX1	3	two hybrid	Colland F (2004)	1
HOXC8	0	SMAD4	9	affinity chromatography technology	Shi X (1999)	1
FRZB	2	SMAD1	0	two hybrid	Vinayagam A (2011)	1
SMAD3	1	WWP1	3	affinity chromatography technology, affinity chromatography technology, two hybrid	Komuro A (2004), Seo SR (2004), Rolland T (2014)	3
UBC	7	XPC	1	affinity chromatography technology	Bish RA (2007)	1
HDAC1	4	SMAD7	1	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Simonsson M (2005), Simonsson M (2005), Simonsson M (2005), Laganiere J (2005)	4
SMAD1	0	STUB1	4	affinity chromatography technology, x-ray crystallography, enzymatic study, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study	Wang L (2011), Wang L (2011), Wang L (2011), Li L (2004), Li L (2004), Li L (2004), Li L (2004), Shimamoto S (2013), Shimamoto S (2013)	9
SMAD5	2	KAT2A	1	affinity chromatography technology	Kahata K (2004)	1
SMAD1	0	PAX6	3	affinity chromatography technology	Grocott T (2007)	1
TOB1	1	SMAD4	9	affinity chromatography technology	Yoshida Y (2000)	1
SMAD5	2	WWP1	3	affinity chromatography technology, two hybrid	Komuro A (2004), Colland F (2004)	2
SMURF2	3	SMAD4	9	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Zhang L (2013), Zhou F (2017), Zhou F (2017)	3
SMAD3	1	RUNX1	0	affinity chromatography technology, affinity chromatography technology	Hanai J (1999), Nitta E (2005)	2
STUB1	4	RFX1	3	affinity chromatography technology, affinity chromatography technology	Guo Y (2016), Guo Y (2016)	2
SMAD2	5	SMAD6	9	affinity chromatography technology	Topper JN (1997)	1
SMAD4	9	SMAD5	2	affinity chromatography technology, two hybrid, two hybrid	Hanai J (1999), Haag J (2006), Colland F (2004)	3
NEDD4	2	UBC	7	x-ray crystallography, pull down, unspecified method, enzymatic study, x-ray crystallography, enzymatic study, pull down, pull down	Maspero E (2011), Maspero E (2011), Ernst A (2013), Maspero E (2013), Mari S (2014), Mari S (2014), Mari S (2014), Kathman SG (2015)	8
CREBBP	29	MECOM	4	affinity chromatography technology, enzymatic study	Chakraborty S (2001), Chakraborty S (2001)	2
SKI	3	SKIL	3	pull down, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology	Cohen SB (1999), Cohen SB (1999), Tan R (2006), He J (2003), Ikeuchi Y (2014)	5
ZCCHC12	1	SMAD1	0	pull down, affinity chromatography technology, affinity chromatography technology	Cho G (2008), Cho G (2008), Cho G (2009)	3
TOB1	1	SMAD5	2	affinity chromatography technology	Yoshida Y (2000)	1
SMAD1	0	SKI	3	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Harada J (2003), Harada J (2003), Takeda M (2004), Mizuide M (2003)	4
SMAD3	1	USP9X	15	affinity chromatography technology	Dupont S (2009)	1
SMAD1	0	OAZ1	2	two hybrid	Gruendler C (2001)	1
CREBBP	29	ZCCHC12	1	affinity chromatography technology	Cho G (2009)	1
LMNA	2	USP15	4	bioid	Roux KJ (2012)	1
XPO1	8	NUP214	3	affinity chromatography technology, affinity chromatography technology	Lindsay ME (2001), Saito S (2004)	2
TP53	0	YY1	7	pull down, affinity chromatography technology, affinity chromatography technology, pull down, pull down, pull down, pull down, pull down	Groenroos E (2004), Groenroos E (2004), Sui G (2004), Sui G (2004), Sui G (2004), Wu S (2007), Wan M (2012), Kotlyar M (2015)	8
SMAD7	1	SMURF1	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down	Asano Y (2004), Yamaguchi T (2006), Komuro A (2004), Ebisawa T (2001), Ebisawa T (2001), Al-Salihi MA (2012), Suzuki C (2002), Aragon E (2012), Aragon E (2012), Tajima Y (2003), Fei C (2013), Fei C (2014), Wan L (2011), Elkouris M (2016)	14
SMAD1	0	SMAD7	1	affinity chromatography technology	Yan X (2016)	1
SMAD7	1	WWP1	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Komuro A (2004), Seo SR (2004), Seo SR (2004), Al-Salihi MA (2012)	4
SMAD2	5	SMAD7	1	genetic interference, pull down, affinity chromatography technology	Lebrun JJ (1999), Zhang S (2007), Yan X (2016)	3
STK11	2	MAP2K3	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
SMAD7	1	TP53	0	affinity chromatography technology	Zhang S (2006)	1
CDK9	3	SMAD3	1	enzymatic study	Alarcon C (2009)	1
SMAD2	5	WWP1	3	affinity chromatography technology, affinity chromatography technology	Komuro A (2004), Seo SR (2004)	2
SMAD7	1	SMAD3	1	genetic interference, genetic interference, affinity chromatography technology, protein complementation assay	Datta PK (2000), Lebrun JJ (1999), Yan X (2016), Yan X (2016)	4
SMAD1	0	STARD13	4	two hybrid	Colland F (2004)	1
MAPK1	1	SMAD1	0	enzymatic study, enzymatic study, enzymatic study	Sapkota G (2007), Alarcon C (2009), Fuentealba LC (2007)	3
SMAD1	0	PUM1	4	two hybrid	Colland F (2004)	1
XPO1	8	SNRNP70	2	affinity chromatography technology	Kirli K (2015)	1
HIPK2	0	EP300	36	enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down	Aikawa Y (2006), Aikawa Y (2006), Aikawa Y (2006), Aikawa Y (2006)	4
SMAD1	0	PSMD11	0	two hybrid	Colland F (2004)	1
SMAD1	0	FOXG1	26	pull down	Rodriguez C (2001)	1
SMAD7	1	TTF2	4	two hybrid	Colland F (2004)	1
DNMT3L	2	HOXA5	0	pull down	Pacaud R (2014)	1
SMAD2	5	SMURF2	3	two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Lin X (2000), Lin X (2000), Bonni S (2001), Nakano A (2009), Komuro A (2004), Zhang Y (2001), Zhang Y (2001), Runyan CE (2009), Runyan CE (2009), Chong PA (2010), Brown KA (2008), Colland F (2004), Colland F (2004), Zhang Y (2017), Zhou F (2017), Zhou F (2017)	16
SMAD2	5	SMAD5	2	affinity chromatography technology	Brown KA (2008)	1
ACVR1	4	SMAD1	0	affinity chromatography technology, affinity chromatography technology	Pardali E (2000), Macias-Silva M (1998)	2
MECOM	4	SMAD3	1	affinity chromatography technology, pull down, affinity chromatography technology, pull down	Kurokawa M (1998), Kurokawa M (1998), Alliston T (2005), Alliston T (2005)	4
SMAD7	1	LEF1	3	affinity chromatography technology, affinity chromatography technology	Edlund S (2005), Cui Q (2005)	2
SMAD4	9	USP9X	15	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Dupont S (2009), Wu Y (2017), Wu Y (2017)	3
SMURF1	4	SF3B1	12	affinity chromatography technology	Xie Y (2013)	1
SMAD3	1	PSMD11	0	two hybrid	Colland F (2004)	1
PAX6	3	AR	3	two hybrid, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe, pull down, affinity chromatography technology, affinity chromatography technology	Shyr CR (2010), Shyr CR (2010), Shyr CR (2010), Elvenes J (2011), Elvenes J (2011), Elvenes J (2011), Elvenes J (2011)	7
SMAD4	9	SKI	3	pull down, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Harada J (2003), Ueki N (2003), Wu JW (2002), Stroschein SL (1999), Tabata T (2009), Prunier C (2003), Prunier C (2003), Takeda M (2004), Takeda M (2004), Ferrand N (2010), Wu K (2003), Wu K (2003), Barrios-Rodiles M (2005), Colland F (2004), He J (2003), He J (2003), Jinnin M (2007), Li X (2015), Rashidian J (2015), Rashidian J (2015), Zhou F (2017)	21
USP15	4	SMURF2	3	affinity chromatography technology, affinity chromatography technology, enzymatic study	Eichhorn PJ (2012), Iyengar PV (2015), Iyengar PV (2015)	3
SMAD3	1	BMP7	3	imaging technique	Luo DD (2010)	1
STAT3	0	MAPK1	1	affinity chromatography technology	Lo RK (2006)	1
UCHL3	1	YAP1	0	biochemical	Havugimana PC (2012)	1
TP53	0	STUB1	4	affinity chromatography technology, enzymatic study, pull down, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Muller P (2008), Stankiewicz M (2010), Tripathi V (2007), Tripathi V (2007), Esser C (2005), Lim JH (2011), Wang J (2011), Burch L (2004), Landre V (2013), Horikawa I (2014), Horikawa I (2014), Horikawa I (2014), Fraser JA (2015), Narayan V (2015), Yue X (2016), Parrales A (2016), Parrales A (2016)	17
LMNA	2	NUP214	3	bioid	Roux KJ (2012)	1
CDK8	1	WWP1	3	affinity chromatography technology	Hein MY (2015)	1
SMAD1	0	SMARCE1	1	two hybrid	Colland F (2004)	1
TP53	0	SMAD2	5	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, imaging technique	Cordenonsi M (2003), Cordenonsi M (2003), Tateossian H (2009), Lu D (2013), Chen TC (2014)	5
CDK7	0	CDK9	3	enzymatic study, biochemical, enzymatic study	Kim JB (2001), Garcia-Martinez LF (1997), Larochelle S (2012)	3
SMAD1	0	MEN1	1	affinity chromatography technology	Sowa H (2003)	1
SMAD1	0	PPM1A	1	affinity chromatography technology	Chau JF (2012)	1
DNMT3L	2	SMAD1	0	pull down	Pacaud R (2014)	1
NEUROG1	0	EP300	36	genetic interference	Sun Y (2001)	1
SMAD7	1	MKL2	5	two hybrid	Colland F (2004)	1
SMAD7	1	MAP2K3	1	affinity chromatography technology	Edlund S (2003)	1
SMAD3	1	LEMD3	4	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Brown KA (2008), Gao S (2009), Huttlin EL (2015), Huttlin EL (2017)	4
YAP1	0	USP15	4	affinity chromatography technology	Enzo E (2015)	1
TP53	0	PIAS4	5	two hybrid	Goehler H (2004)	1
LEF1	3	HDAC1	4	affinity chromatography technology	Billin AN (2000)	1
MECOM	4	HDAC1	4	affinity chromatography technology, pull down, affinity chromatography technology	Vinatzer U (2001), Vinatzer U (2001), Chakraborty S (2001)	3
TP53	0	DACH1	3	affinity chromatography technology, affinity chromatography technology	Chen K (2013), Chen K (2013)	2
SMAD1	0	ICK	1	two hybrid	Colland F (2004)	1
SMAD4	9	MECOM	4	pull down	Alliston T (2005)	1
TP53	0	SMAD3	1	affinity chromatography technology, pull down, affinity chromatography technology, imaging technique	Cordenonsi M (2003), Cordenonsi M (2003), Lu D (2013), Ali A (2013)	4
ACVRL1	1	SMAD1	0	enzymatic study	Lee NY (2009)	1
CDK8	1	SMAD1	0	enzymatic study, affinity chromatography technology, affinity chromatography technology	Alarcon C (2009), Alarcon C (2009), Alarcon C (2009)	3
NEDD4	2	BMPR1A	5	pull down	Persaud A (2009)	1
SMAD2	5	TGIF1	1	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Wotton D (1999), Wotton D (1999), Wotton D (1999), Pessah M (2001)	4
XPO1	8	SMARCE1	1	affinity chromatography technology	Kirli K (2015)	1
SMAD5	2	MEN1	1	affinity chromatography technology	Sowa H (2003)	1
HDAC1	4	GLI3	10	affinity chromatography technology	Dai P (2002)	1
SMAD7	1	PARD3	5	pull down	Warner DR (2003)	1
RUNX2	2	WWP1	3	affinity chromatography technology, affinity chromatography technology	Jones DC (2006), Jones DC (2006)	2
SMAD3	1	MED24	4	affinity chromatography technology	Kato Y (2002)	1
DACH1	3	HDAC1	4	affinity chromatography technology	Wu K (2007)	1
SMAD3	1	SMURF2	3	two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Lin X (2000), Lin X (2000), Bonni S (2001), Nakano A (2009), Komuro A (2004), Zhang Y (2001), Zhang Y (2001), Tang LY (2011), Brown KA (2008), Zhang L (2013), Li Y (2017), Zhang Y (2017)	12
GSK3B	1	MED24	4	two hybrid	Vinayagam A (2011)	1
SMAD4	9	SMAD7	1	genetic interference, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology	Lebrun JJ (1999), Moren A (2005), Moren A (2005), Moren A (2005), Zhang S (2007), Yan X (2016)	6
UBC	7	AP2A2	3	pull down	Zhang X (2017)	1
HDAC1	4	TGIF1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Melhuish TA (2000), Melhuish TA (2001), Lo RS (2001)	3
CREBBP	29	CDK8	1	biochemical, affinity chromatography technology	Cho H (1998), Cho H (1998)	2
XPO1	8	SMAD1	0	affinity chromatography technology	Kirli K (2015)	1
SMURF2	3	YY1	7	affinity chromatography technology, affinity chromatography technology, pull down, pull down	Jeong HM (2014), Jeong HM (2014), Jeong HM (2014), Jeong HM (2014)	4
SMAD3	1	HDAC1	4	two hybrid, pull down	Liberati NT (2001), Akiyoshi S (1999)	2
AR	3	SMARCE1	1	pull down, pull down, bioid	Link KA (2008), Link KA (2005), Lempiaeinen JK (2017)	3
SMAD4	9	SMAD6	9	affinity chromatography technology, affinity chromatography technology	Topper JN (1997), Moren A (2005)	2
GSK3B	1	AR	3	pull down, affinity chromatography technology	Wang L (2004), Wang L (2004)	2
NEDD4	2	YY1	7	enzymatic study, affinity chromatography technology	Persaud A (2009), Persaud A (2009)	2
APP	1	STUB1	4	affinity chromatography technology, affinity chromatography technology	Kumar P (2007), Kumar P (2007)	2
SMAD1	0	PARD3	5	pull down	Warner DR (2003)	1
SMAD1	0	SOX5	11	two hybrid	Colland F (2004)	1
USP15	4	ACVR1	4	affinity chromatography technology	Herhaus L (2014)	1
SMAD3	1	MED15	6	affinity chromatography technology	Kato Y (2002)	1
SMAD4	9	STUB1	4	pull down, affinity chromatography technology	Li L (2004), Li L (2004)	2
NUP214	3	SMAD2	5	affinity chromatography technology, pull down	Xu L (2003), Xu L (2003)	2
XPO1	8	TTF2	4	affinity chromatography technology	Kirli K (2015)	1
KDM6B	16	SMAD1	0	affinity chromatography technology	Akizu N (2010)	1
MAP2K3	1	APP	1	pull down	Olah J (2011)	1
SMAD1	0	CAMSAP1	5	two hybrid	Colland F (2004)	1
STUB1	4	RUNX1	0	affinity chromatography technology, pull down, affinity chromatography technology	Shang Y (2009), Shang Y (2009), Shang Y (2009)	3
SMAD2	5	ZEB2	7	two hybrid	Colland F (2004)	1
DNMT3L	2	TP53	0	pull down	Pacaud R (2014)	1
CREBBP	29	ZEB1	3	affinity chromatography technology	Postigo AA (2003)	1
SNRNP70	2	APP	1	pull down, pull down	Olah J (2011), Virok DP (2011)	2
SMAD2	5	SMURF1	4	affinity chromatography technology, affinity chromatography technology, two hybrid	Komuro A (2004), Ito I (2010), Colland F (2004)	3
XPO1	8	DVL1	5	affinity chromatography technology	Kirli K (2015)	1
GSK3B	1	SMAD1	0	enzymatic study, imaging technique	Fuentealba LC (2007), Chen TC (2014)	2
CDK8	1	SMAD3	1	enzymatic study	Alarcon C (2009)	1
USP9X	15	YAP1	0	biochemical, affinity chromatography technology, affinity chromatography technology	Havugimana PC (2012), Kim M (2016), Kim M (2016)	3
HMGA2	1	SMAD1	0	affinity chromatography technology	Monzen K (2008)	1
TP53	0	MEN1	1	pull down	Dou Y (2005)	1
SMAD2	5	SKI	3	pull down, affinity chromatography technology, affinity chromatography technology, pull down, pull down, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Harada J (2003), Luo K (1999), Tabata T (2009), Prunier C (2003), Prunier C (2003), Akiyoshi S (1999), Akiyoshi S (1999), Takeda M (2004), Inoue Y (2011), Ferrand N (2010), Chen W (2007), Brown KA (2008), He J (2003), Rashidian J (2015), Zhou F (2017)	15
CDK8	1	MED24	4	affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Ito M (1999), Kang YK (2002), Gu W (1999), Gu W (1999), Malik S (2000), Davis MA (2013), Varjosalo M (2013), Huttlin EL (2015), Wan C (2015), Hein MY (2015), Huttlin EL (2017)	11
SMAD1	0	SMAD4	9	affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Harada J (2003), Hanai J (1999), Lopez-Rovira T (2002), Kato Y (2002), Wang L (2011), Li L (2004), Hata A (1998), Barrios-Rodiles M (2005), Wu RY (1997), Wu RY (1997), Colland F (2004), Qiu T (2007), Yan X (2016), Zhou F (2017)	14
SMAD1	0	AKR1B1	0	two hybrid	Colland F (2004)	1
SMAD1	0	TTF2	4	two hybrid	Colland F (2004)	1
SMAD5	2	PSMD11	0	two hybrid	Colland F (2004)	1
TP53	0	RUNX2	2	affinity chromatography technology, affinity chromatography technology	Ozaki T (2013), Ozaki T (2013)	2
SKIL	3	TTF2	4	two hybrid	Colland F (2004)	1
EP300	36	RUNX2	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Lee HW (2006), Jeon EJ (2006), Jeon EJ (2006), Jun JH (2010)	4
SMAD3	1	MED6	0	affinity chromatography technology	Kato Y (2002)	1
SMAD1	0	RUNX3	1	affinity chromatography technology	Hanai J (1999)	1
SMAD4	9	HGS	5	affinity chromatography technology, affinity chromatography technology	Miura S (2000), Haag J (2006)	2
SMAD1	0	AP2A2	3	two hybrid	Colland F (2004)	1
SMAD4	9	RFX1	3	two hybrid	Colland F (2004)	1
SMAD1	0	WWP1	3	affinity chromatography technology, affinity chromatography technology	Komuro A (2004), Seo SR (2004)	2
TP53	0	LMNA	2	affinity chromatography technology	Horikawa I (2014)	1
SMAD3	1	SNRNP70	2	two hybrid	Colland F (2004)	1
TP53	0	EP300	36	pull down, genetic interference, pull down, enzymatic study, pull down, pull down, affinity chromatography technology, biochemical, enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, unspecified method, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, pull down, imaging technique, affinity chromatography technology, enzymatic study, affinity chromatography technology, x-ray crystallography, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, unspecified method, affinity chromatography technology, enzymatic study, unspecified method, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, pull down, enzymatic study, enzymatic study, x-ray crystallography, pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, unspecified method	An W (2004), Pastorcic M (2000), Livengood JA (2002), Livengood JA (2002), Grossman SR (1998), Grossman SR (1998), Grossman SR (1998), Grossman SR (1998), Tang Y (2008), Wang H (2008), Valbuena A (2008), Shi D (2009), Vega FM (2004), Finlan L (2004), Groenroos E (2004), Zhao Y (2006), Roe JS (2006), Pedeux R (2005), Sekaric P (2007), Pan X (2009), Tang Y (2006), Sen GS (2011), Li Y (2012), Li Y (2012), Gillotin S (2010), Grossman SR (2003), Issaeva N (2004), Kitagawa M (2008), Sabbatini P (2002), Burge S (2009), Zilfou JT (2001), Issaeva N (2004), Issaeva N (2004), Feng H (2009), Feng H (2009), Lill NL (1997), Dornan D (2004), Dornan D (2004), Di Agostino S (2006), Wells M (2008), Fath DM (2006), Kobet E (2000), Costanzo A (2002), Kumazawa T (2011), Borger DR (2006), Cui D (2013), Borger DR (2006), Lee SJ (2013), Tang HY (2006), Lin C (2011), Choi WI (2014), Ding G (2013), Kim MK (2013), Ali A (2013), Wu G (2014), Mizuguchi Y (2012), Sinha S (2012), Sinha S (2012), Her YR (2013), Her YR (2013), Wu SY (2009), Wu SY (2009), Liu L (1999), Sakaguchi K (1998), Harrod R (2003), Gu W (1997), Teufel DP (2007), Mantovani F (2007), Mantovani F (2007), Dornan D (2003), Dornan D (2003), Dornan D (2003), Dornan D (2003), Dornan D (2003), MacPartlin M (2005), Mujtaba S (2004), Wang YH (2003), Chen H (1999), Tang Z (2013), Graczyk A (2013), Graczyk A (2013), Chan HM (2001), Thomas MC (2005), Miller Jenkins LM (2015), Miller Jenkins LM (2015), Koh DI (2014), Koh DI (2014), Koh DI (2014), Li H (2015), Chen LF (2005), Shi D (2016), Wright DG (2016), Zhang X (2016), Procopio MG (2015), Tong Q (2015)	95
ZEB2	7	APP	1	pull down	Olah J (2011)	1
SMAD5	2	NEDD4	2	two hybrid	Colland F (2004)	1
TP53	0	CDK9	3	genetic interference, pull down, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology	De Falco G (2000), Claudio PP (2006), Claudio PP (2006), Claudio PP (2006), Claudio PP (2006), Claudio PP (2006)	6
RUNX3	1	SMURF2	3	affinity chromatography technology	Jin YH (2004)	1
SMAD1	0	NEUROG1	0	pull down, genetic interference, genetic interference	Sun Y (2001), Sun Y (2001), Sun Y (2001)	3
AR	3	PIAS1	4	two hybrid, affinity chromatography technology	Kotaja N (2000), Toropainen S (2015)	2
USP15	4	UCHL3	1	enzymatic study	Loch CM (2012)	1
SMAD3	1	SMAD1	0	affinity chromatography technology, two hybrid, two hybrid	Brown KA (2008), Wu RY (1997), Wu RY (1997)	3
TP53	0	USP15	4	affinity chromatography technology, affinity chromatography technology	Liu WT (2016), Liu WT (2016)	2
SMAD6	9	ZEB1	3	affinity chromatography technology, affinity chromatography technology	Nakahata S (2010), Nakahata S (2010)	2
FOXG1	26	TP53	0	affinity chromatography technology	Li X (2015)	1
SMAD1	0	ZNF510	2	two hybrid	Colland F (2004)	1
SMAD2	5	STUB1	4	pull down	Li L (2004)	1
YAP1	0	EP300	36	imaging technique	Strano S (2005)	1
SMAD1	0	GLI3	10	imaging technique	Chen TC (2014)	1
SMAD1	0	ZNF76	2	two hybrid	Colland F (2004)	1
BMP7	3	SMAD1	0	genetic interference	Guo X (2001)	1
HDAC1	4	HBP1	1	affinity chromatography technology, affinity chromatography technology	Swanson KA (2004), Lampert F (2018)	2
LEF1	3	SMAD4	9	pull down	Labbe E (2000)	1
CDK7	0	APP	1	pull down	Olah J (2011)	1
TGIF1	1	SMAD1	0	affinity chromatography technology	Wotton D (1999)	1
WWP1	3	SKIL	3	affinity chromatography technology	Komuro A (2004)	1
TP53	0	HIPK2	0	pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down	Hofmann TG (2002), Hofmann TG (2002), Hofmann TG (2002), Hofmann TG (2002), Kim EJ (2002), Sung KS (2005), Li Q (2011), Di Stefano V (2005), Rinaldo C (2007), Rinaldo C (2007), Lee MG (2014), Mancini F (2016)	12
GLI3	10	SKI	3	two hybrid, pull down, affinity chromatography technology	Dai P (2002), Dai P (2002), Dai P (2002)	3
SMURF1	4	PPM1A	1	affinity chromatography technology	Xie Y (2013)	1
MAPK1	1	TP53	0	affinity chromatography technology, affinity chromatography technology, protein complementation assay, affinity chromatography technology, imaging technique	Persons DL (2000), How PC (2011), Srivastav RK (2011), Fogeron ML (2013), Chen TC (2014)	5
SMAD3	1	APP	1	pull down	Olah J (2011)	1
SS18L1	2	EP300	36	affinity chromatography technology	Aizawa H (2004)	1
SMAD1	0	PSMB4	2	affinity chromatography technology, two hybrid, two hybrid, two hybrid, two hybrid	Lin Y (2002), Lin Y (2002), Guo X (2001), Gruendler C (2001), Colland F (2004)	5
PIAS4	5	MECOM	4	affinity chromatography technology, affinity chromatography technology	Singh S (2013), Singh S (2013)	2
UBC	7	PSMD11	0	affinity chromatography technology, pull down	Matsumoto M (2005), Zhang X (2017)	2
SMURF2	3	SKIL	3	affinity chromatography technology	Bonni S (2001)	1
ICK	1	TP53	0	affinity chromatography technology	Varjosalo M (2013)	1
UBC	7	TTF2	4	pull down	Zhang X (2017)	1
SMAD1	0	UCHL3	1	affinity chromatography technology, affinity chromatography technology	Kim JY (2011), Kim JY (2011)	2
BMP7	3	BMPR1A	5	pull down	ten Dijke P (1994)	1
ACVR1	4	BMPR1A	5	fluorescent resonance energy transfe, fluorescent resonance energy transfe, affinity chromatography technology, affinity chromatography technology	Lavery K (2008), Lavery K (2008), Huttlin EL (2015), Huttlin EL (2017)	4
TP53	0	STK11	2	affinity chromatography technology, fluorescent resonance energy transfe	Karuman P (2001), Ivanov AA (2017)	2
SNIP1	0	SMAD4	9	pull down	Kim RH (2000)	1
SMAD1	0	MGA	9	two hybrid	Colland F (2004)	1
HDAC1	4	TCF20	18	affinity chromatography technology	Hein MY (2015)	1
SMURF2	3	NEDD9	3	affinity chromatography technology, affinity chromatography technology	Moore FE (2010), Moore FE (2010)	2
SMURF1	4	USP15	4	affinity chromatography technology	Xie Y (2013)	1
SMAD2	5	YY1	7	pull down, affinity chromatography technology	Kurisaki K (2003), Brown KA (2008)	2
DACH1	3	SMAD3	1	affinity chromatography technology	Wu K (2003)	1
ZEB2	7	HDAC1	4	affinity chromatography technology	Verstappen G (2008)	1
CDK9	3	SMAD1	0	enzymatic study	Alarcon C (2009)	1
SMAD3	1	STUB1	4	pull down	Li L (2004)	1
SMAD2	5	MECOM	4	pull down	Alliston T (2005)	1
MEN1	1	HDAC1	4	pull down	Kim H (2003)	1
KDM6B	16	SMAD4	9	affinity chromatography technology	Akizu N (2010)	1
YAP1	0	STUB1	4	affinity chromatography technology	Hauri S (2013)	1
SMAD6	9	BMPR1A	5	affinity chromatography technology	Kamiya Y (2010)	1
SMAD3	1	HIPK2	0	pull down	Harada J (2003)	1
NKX3-2	1	SMAD4	9	pull down, affinity chromatography technology	Kim DW (2003), Kim DW (2003)	2
XPO1	8	YAP1	0	affinity chromatography technology	Kirli K (2015)	1
HDAC1	4	YY1	7	pull down, affinity chromatography technology, imaging technique, affinity chromatography technology	Yang WM (1997), He Y (2007), He G (2002), Sun JM (2007)	4
SMAD2	5	RUNX2	2	affinity chromatography technology	Hanai J (1999)	1
USP9X	15	UBC	7	unspecified method, pull down	Ernst A (2013), Kwasna D (2018)	2
NEDD9	3	SMAD3	1	two hybrid, pull down, affinity chromatography technology, pull down, two hybrid, affinity chromatography technology	Feng L (2004), Nourry C (2004), Feng L (2004), Feng L (2004), Liu X (2000), Liu X (2000)	6
RUNX3	1	HDAC1	4	affinity chromatography technology	Jin YH (2004)	1
SMAD1	0	ZDHHC3	0	two hybrid	Colland F (2004)	1
SMURF1	4	TP53	0	affinity chromatography technology	Nie J (2010)	1
HGS	5	WDR77	2	biochemical	Kristensen AR (2012)	1
RUNX1	0	CREBBP	29	affinity chromatography technology	Nguyen LA (2005)	1
AR	3	MED24	4	two hybrid	van de Wijngaart DJ (2009)	1
SMAD7	1	SOX5	11	two hybrid	Colland F (2004)	1
SMAD1	0	SMAD1	0	two hybrid, two hybrid	Wu RY (1997), Colland F (2004)	2
SMAD5	2	SMURF1	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, unspecified method, two hybrid, two hybrid, enzymatic study	Lu K (2008), Komuro A (2004), Ebisawa T (2001), Nie J (2010), Alarcon C (2009), Murakami G (2003), Sangadala S (2007), Sangadala S (2007), Sangadala S (2007), Haag J (2006), Colland F (2004), Lu K (2008)	12
HDAC1	4	ZNF76	2	affinity chromatography technology	Zheng G (2006)	1
SS18L1	2	CREBBP	29	affinity chromatography technology, pull down	Aizawa H (2004), Aizawa H (2004)	2
SMAD4	9	USP15	4	affinity chromatography technology, affinity chromatography technology	Inui M (2011), Eichhorn PJ (2012)	2
SMAD1	0	NOTCH2	10	two hybrid	Colland F (2004)	1
CREBBP	29	TP53	0	enzymatic study, pull down, genetic interference, pull down, enzymatic study, fluorescent resonance energy transfe, enzymatic study, affinity chromatography technology, imaging technique, pull down, pull down, pull down, pull down, pull down, enzymatic study, pull down, affinity chromatography technology, unspecified method, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, pull down, affinity chromatography technology, enzymatic study, enzymatic study, pull down, x-ray crystallography, x-ray crystallography, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down	Ito A (2002), Livengood JA (2002), Livengood JA (2002), Giebler HA (2000), Tang Y (2008), Jenkins LM (2009), Shi D (2009), Zhao Y (2006), Saifudeen Z (2005), Scolnick DM (1997), Scolnick DM (1997), Gu W (1997), Gu W (1997), Matsuda S (2004), Pasqualucci L (2011), Lee SK (1999), Dai C (2011), Lee CW (2010), Ferreon JC (2009), Ruas JL (2010), Ruas JL (2010), Huang WC (2007), Huang WC (2007), Mujtaba S (2004), Mujtaba S (2004), Mujtaba S (2004), Mujtaba S (2004), Col E (2002), Jansma AL (2014), Jansma AL (2014), Krois AS (2016), Hasegawa K (2008), Huang X (2013), Huang X (2013), Piskacek M (2016)	35
PSMD11	0	APP	1	pull down	Olah J (2011)	1
SMAD1	0	MECOM	4	pull down	Alliston T (2005)	1
SMAD3	1	SMURF1	4	affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology	Komuro A (2004), Colland F (2004), Li Y (2017), Li Y (2017)	4
RUNX2	2	SMAD1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique	Zhang YW (2000), Zhang YW (2000), Hanai J (1999), Jun JH (2010), Wang Q (2007)	5
SMURF1	4	WDR77	2	affinity chromatography technology	Xie Y (2013)	1
HOXA5	0	SMAD1	0	two hybrid	Ravasi T (2010)	1
HBP1	1	CREBBP	29	affinity chromatography technology, enzymatic study	Wang W (2012), Wang W (2012)	2
CDK8	1	MED15	6	affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Donner AJ (2010), Mittler G (2003), Kagey MH (2010), Varjosalo M (2013), Huttlin EL (2015), Hein MY (2015), Tsutsui T (2013), Huttlin EL (2017)	8
SMAD5	2	SF3B1	12	two hybrid	Colland F (2004)	1
AR	3	CDK7	0	affinity chromatography technology, pull down, pull down, enzymatic study	Lee DK (2000), Lee DK (2000), Chymkowitch P (2011), Chymkowitch P (2011)	4
UBC	7	WDR77	2	affinity chromatography technology	Matsumoto M (2005)	1
AR	3	TCF20	18	affinity chromatography technology, pull down, bioid	Elvenes J (2011), Elvenes J (2011), Lempiaeinen JK (2017)	3
ACVR1	4	SMAD5	2	affinity chromatography technology, affinity chromatography technology	Pardali E (2000), Macias-Silva M (1998)	2
SMAD7	1	USP15	4	affinity chromatography technology	Eichhorn PJ (2012)	1
TGIF1	1	APP	1	pull down	Olah J (2011)	1
MAPK1	1	FOXO3	1	affinity chromatography technology, affinity chromatography technology, enzymatic study	Yang JY (2008), Yang JY (2008), Yang JY (2008)	3
SMAD4	9	SKIL	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Stroschein SL (1999), Stroschein SL (1999), Barrios-Rodiles M (2005), Colland F (2004), Colland F (2004), He J (2003), He J (2003), Ikeuchi Y (2014), Jinnin M (2007), Li X (2015)	10
EP300	36	ZNF76	2	affinity chromatography technology, enzymatic study	Zheng G (2006), Zheng G (2006)	2
SMAD1	0	MED6	0	affinity chromatography technology	Kato Y (2002)	1
AR	3	STAT3	0	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Matsuda T (2001), Ueda T (2002), Yamamoto T (2003), Yamamoto T (2003)	4
SMAD5	2	HGS	5	affinity chromatography technology, two hybrid	Haag J (2006), Haag J (2006)	2
UBC	7	CDK7	0	imaging technique	Zhang X (2017)	1
SKI	3	HIPK2	0	pull down, pull down, affinity chromatography technology	Harada J (2003), Harada J (2003), Harada J (2003)	3
AR	3	EP300	36	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology	Dai Y (2008), Minges JT (2013), Zhong J (2014), Fu M (2000), McClurg UL (2016), Tan G (2017)	6
EP300	36	SMAD7	1	affinity chromatography technology, pull down, affinity chromatography technology, enzymatic study	Groenroos E (2002), Groenroos E (2002), Groenroos E (2002), Groenroos E (2002)	4
XPO1	8	SMAD5	2	affinity chromatography technology	Kirli K (2015)	1
XPO1	8	ERBIN	5	affinity chromatography technology	Kirli K (2015)	1
SMAD1	0	PSMD1	2	two hybrid	Colland F (2004)	1
SKI	3	SMURF2	3	affinity chromatography technology	Zhou F (2017)	1
CDK9	3	SMAD4	9	genetic interference	Shen JP (2017)	1
SMAD3	1	PAX6	3	affinity chromatography technology	Grocott T (2007)	1
SMAD2	5	LEMD3	4	affinity chromatography technology, two hybrid	Brown KA (2008), Hellemans J (2004)	2
MED6	0	CDK8	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Yang F (2004), Wang G (2001), Ito M (1999), Kang YK (2002), Pavri R (2005), Gu W (1999), Gu W (1999), Malik S (2000), Varjosalo M (2013), Huttlin EL (2015), Wan C (2015), Hein MY (2015), Huttlin EL (2017)	13
SMAD1	0	LEF1	3	affinity chromatography technology	Cui Q (2005)	1
OAZ1	2	PIAS4	5	two hybrid	Wang J (2011)	1
SMAD1	0	HDAC1	4	affinity chromatography technology	Takeda M (2004)	1
GSK3B	1	NOTCH2	10	enzymatic study, pull down, affinity chromatography technology	Espinosa L (2003), Espinosa L (2003), Espinosa L (2003)	3
YAP1	0	PARD3	5	affinity chromatography technology	Couzens AL (2013)	1
RUNX3	1	SMURF1	4	affinity chromatography technology	Jin YH (2004)	1
SMAD5	2	RUNX2	2	affinity chromatography technology	Hanai J (1999)	1
XPO1	8	FOXO3	1	affinity chromatography technology	Kirli K (2015)	1
SMAD1	0	TTF1	3	two hybrid	Colland F (2004)	1
SMAD3	1	RUNX3	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Hanai J (1999), Jin YH (2004), Kong Y (2016)	3
SMAD1	0	PIAS1	4	two hybrid	Colland F (2004)	1
FOXG1	26	PUM1	4	affinity chromatography technology	Li X (2015)	1
SMAD2	5	NEDD9	3	affinity chromatography technology	Liu X (2000)	1
EP300	36	SMAD5	2	affinity chromatography technology, two hybrid	Jeon EJ (2006), Haag J (2006)	2
SMAD1	0	MED15	6	affinity chromatography technology	Kato Y (2002)	1
SMAD6	9	SMURF1	4	affinity chromatography technology, affinity chromatography technology, unspecified method, affinity chromatography technology, affinity chromatography technology	Komuro A (2004), Ebisawa T (2001), Sangadala S (2007), Lee YS (2011), Lee YS (2011)	5
MEN1	1	KMT2D	30	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Hughes CM (2004), Hughes CM (2004), Hughes CM (2004)	3
SMAD1	0	NUP214	3	affinity chromatography technology	Sapkota G (2007)	1
PSMD11	0	PSMD1	2	biochemical, biochemical, biochemical	Havugimana PC (2012), Kristensen AR (2012), Wan C (2015)	3
SMAD1	0	USP15	4	affinity chromatography technology, affinity chromatography technology	Inui M (2011), Eichhorn PJ (2012)	2
SMAD2	5	CREBBP	29	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, affinity chromatography technology	Xi Q (2008), Chan EC (2010), He W (2006), Chen W (2007), Colland F (2004), Cui Q (2005)	6
EP300	36	ZEB1	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study	Mizuguchi Y (2012), Postigo AA (2003), Postigo AA (2003), Postigo AA (2003)	4
CREBBP	29	SMAD3	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, pull down, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kang JS (2005), Alliston T (2005), Xi Q (2008), Cui Q (2005), Cui Q (2005), Chen W (2007), Nishihara A (1999), Tomita M (2004), Oussaief L (2009), Oussaief L (2009), Cui Q (2005)	11
SMAD1	0	STK11	2	fluorescent resonance energy transfe	Ivanov AA (2017)	1
WWP1	3	SMAD4	9	affinity chromatography technology	Seo SR (2004)	1
EP300	36	SMAD2	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology	Wotton D (1999), Pessah M (2001), Furumatsu T (2005), Wang J (2011), Suganuma T (2002)	5
AR	3	TGIF1	1	pull down	Sharma M (2001)	1
SMAD1	0	HOXC8	0	two hybrid, pull down, affinity chromatography technology	Shi X (1999), Shi X (1999), Shi X (1999)	3
PSMB4	2	PSMD11	0	biochemical, affinity chromatography technology, biochemical, affinity chromatography technology	Havugimana PC (2012), Huttlin EL (2015), Wan C (2015), Huttlin EL (2017)	4
SMAD1	0	SNIP1	0	two hybrid	Kim RH (2000)	1
SMURF2	3	RUNX2	2	enzymatic study	Lu K (2011)	1
SMARCE1	1	SS18L1	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
GSK3B	1	TP53	0	affinity chromatography technology, two hybrid	Watcharasit P (2002), Vinayagam A (2011)	2
SMAD1	0	IRF2BP1	4	two hybrid	Colland F (2004)	1
SMAD1	0	LEMD3	4	two hybrid, two hybrid	Colland F (2004), Hellemans J (2004)	2
KAT2A	1	STK11	2	fluorescent resonance energy transfe	Ivanov AA (2017)	1
SMAD2	5	RUNX1	0	affinity chromatography technology	Hanai J (1999)	1
CDK8	1	WDR77	2	affinity chromatography technology, affinity chromatography technology, pull down	Tsutsui T (2013), Tsutsui T (2013), Tsutsui T (2013)	3
RUNX1	0	HIPK2	0	affinity chromatography technology, affinity chromatography technology, enzymatic study	Aikawa Y (2006), Aikawa Y (2006), Aikawa Y (2006)	3
PSMB4	2	USP9X	15	biochemical	Havugimana PC (2012)	1
ZNF521	3	SMAD1	0	affinity chromatography technology	Bond HM (2004)	1
SMAD5	2	STUB1	4	affinity chromatography technology	Wang L (2011)	1
SMURF1	4	APP	1	pull down	Olah J (2011)	1
PIAS4	5	LEF1	3	two hybrid, pull down, affinity chromatography technology	Sachdev S (2001), Sachdev S (2001), Sachdev S (2001)	3
CDK8	1	SMAD5	2	affinity chromatography technology	Alarcon C (2009)	1
YY1	7	APP	1	pull down	Olah J (2011)	1
SMAD3	1	SMAD2	5	affinity chromatography technology, genetic interference, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology	Nakao A (1997), Lebrun JJ (1999), Dumont E (2003), Brown KA (2008), Brown KA (2008), Wu RY (1997), Wu RY (1997), Tang Y (2003), Tang Y (2003), Wang J (2011), Huttlin EL (2015), Huttlin EL (2017)	12
SMAD3	1	YAP1	0	affinity chromatography technology	Alarcon C (2009)	1
ZEB1	3	SMAD3	1	affinity chromatography technology	Postigo AA (2003)	1
LEF1	3	EP300	36	enzymatic study, affinity chromatography technology, pull down	Hecht A (2003), Hecht A (2003), Hecht A (2003)	3
STK11	2	APP	1	pull down	Olah J (2011)	1
USP15	4	PSMD11	0	affinity chromatography technology	Sowa ME (2009)	1
YAP1	0	PSMB4	2	affinity chromatography technology	Enzo E (2015)	1
SMAD1	0	SNRNP70	2	two hybrid	Colland F (2004)	1
SMAD6	9	USP15	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Herhaus L (2014), Herhaus L (2014), Herhaus L (2014)	3
MED24	4	APP	1	pull down	Olah J (2011)	1
SKIL	3	CAMSAP1	5	two hybrid	Colland F (2004)	1
SMAD7	1	BMPR1A	5	affinity chromatography technology, affinity chromatography technology	Mochizuki T (2004), Kamiya Y (2010)	2
PSMD11	0	TP53	0	two hybrid	Stelzl U (2005)	1
SMAD1	0	AR	3	affinity chromatography technology, affinity chromatography technology, protein complementation assay, imaging technique, affinity chromatography technology	Qiu T (2007), Qiu T (2007), Qiu T (2007), Qiu T (2007), Li Y (2013)	5
CREBBP	29	EP300	36	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Crusselle-Davis VJ (2007), Dohda T (2004), Dohda T (2004)	3
MED6	0	MED15	6	affinity chromatography technology, affinity chromatography technology, biochemical	Yang F (2004), Mittler G (2003), Wan C (2015)	3
SMAD2	5	HDAC1	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Wotton D (1999), Wotton D (1999), Takeda M (2004), Lo RS (2001)	4
CDK7	0	TP53	0	enzymatic study, affinity chromatography technology, enzymatic study, pull down	Ko LJ (1997), Schneider E (1998), Lu H (1997), Lu H (1997)	4
SMAD1	0	ERBIN	5	pull down	Warner DR (2003)	1
SMAD1	0	MAST4	6	two hybrid	Colland F (2004)	1
YAP1	0	HDAC1	4	affinity chromatography technology	Enzo E (2015)	1
SMAD6	9	WWP1	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Komuro A (2004), Seo SR (2004), Herhaus L (2014)	3
RUNX2	2	BMPR1A	5	affinity chromatography technology	Jeon EJ (2006)	1
SMAD2	5	ERBIN	5	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Warner DR (2003), Xi Q (2008), Brown KA (2008), Dai F (2007), Dai F (2007), Dai F (2007)	6
SMAD4	9	PARD3	5	pull down	Warner DR (2003)	1
GSK3B	1	DNMT3L	2	two hybrid	Vinayagam A (2011)	1
SMARCE1	1	HDAC1	4	affinity chromatography technology	Battaglioli E (2002)	1
SMAD5	2	RUNX1	0	affinity chromatography technology	Hanai J (1999)	1
WDR77	2	AR	3	pull down, affinity chromatography technology	Hosohata K (2003), Li Y (2013)	2
SMURF1	4	USP9X	15	affinity chromatography technology, affinity chromatography technology, pull down, pull down	Xie Y (2013), Xie Y (2013), Xie Y (2013), Xie Y (2013)	4
DVL1	5	NEDD4	2	pull down	Nethe M (2012)	1
SMAD6	9	NEDD4	2	affinity chromatography technology	Kuratomi G (2005)	1
PAX6	3	HIPK2	0	affinity chromatography technology, enzymatic study	Kim EA (2006), Kim EA (2006)	2
WWP1	3	UBC	7	enzymatic study	Kristariyanto YA (2015)	1
SMAD1	0	HGS	5	affinity chromatography technology	Miura S (2000)	1
SMAD2	5	PARD3	5	pull down	Warner DR (2003)	1
USP15	4	UBC	7	pull down, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, pull down, pull down	Hetfeld BK (2005), Bremm A (2010), Komander D (2009), Loch CM (2012), Herhaus L (2014), Wauer T (2015), Das T (2017), Zhang X (2017), Kwasna D (2018)	9
NEDD9	3	APP	1	pull down	Olah J (2011)	1
HDAC1	4	CREBBP	29	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Mayanil CS (2006), Chuang HC (2006), Chuang HC (2006)	3
RUNX2	2	SMURF1	4	imaging technique	Wang Q (2007)	1
STUB1	4	PSMD1	2	affinity chromatography technology	Arndt V (2005)	1
ICK	1	APP	1	pull down, pull down	Olah J (2011), Virok DP (2011)	2
SMAD1	0	APP	1	pull down	Olah J (2011)	1
LEF1	3	SMAD2	5	pull down, affinity chromatography technology, affinity chromatography technology	Labbe E (2000), Labbe E (2000), Cui Q (2005)	3
SMAD4	9	HDAC1	4	affinity chromatography technology	Takeda M (2004)	1
SNIP1	0	EP300	36	affinity chromatography technology, affinity chromatography technology	Kim RH (2000), Kim RH (2000)	2
SMAD3	1	KAT2A	1	affinity chromatography technology	Kahata K (2004)	1
XPO1	8	GSK3B	1	affinity chromatography technology	Kirli K (2015)	1
SMAD4	9	CREBBP	29	affinity chromatography technology	Yang Y (2015)	1
ZNF423	14	SMAD4	9	affinity chromatography technology, affinity chromatography technology	Hata A (2000), Bond HM (2004)	2
SMURF2	3	XPO1	8	affinity chromatography technology, affinity chromatography technology, pull down	Kim DG (2016), Kim DG (2016), Kim DG (2016)	3
SMAD1	0	ZSCAN4	1	two hybrid	Colland F (2004)	1
TP53	0	XPC	1	affinity chromatography technology	Krzeszinski JY (2013)	1
HOXC8	0	SMAD6	9	two hybrid, affinity chromatography technology, pull down	Bai S (2000), Bai S (2000), Bai S (2000)	3
YAP1	0	RUNX3	1	pull down	Yagi R (1999)	1
SMAD1	0	DVL1	5	pull down	Warner DR (2003)	1
EP300	36	ZEB2	7	affinity chromatography technology	Weng Q (2012)	1
CREBBP	29	AR	3	two hybrid, pull down, pull down, genetic interference, affinity chromatography technology, pull down	Kim J (2005), Fronsdal K (1998), Ishitani K (2003), Aarnisalo P (1998), Andersen RJ (2010), Fronsdal K (1998)	6
PIAS4	5	SMAD2	5	affinity chromatography technology, two hybrid, affinity chromatography technology	Imoto S (2003), Long J (2003), Long J (2003)	3
SMAD5	2	SOX5	11	two hybrid	Colland F (2004)	1
SMAD5	2	PAX6	3	affinity chromatography technology	Grocott T (2007)	1
YY1	7	CREBBP	29	affinity chromatography technology, affinity chromatography technology	de Nigris F (2007), de Nigris F (2007)	2
SMAD2	5	USP15	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Inui M (2011), Eichhorn PJ (2012), Wijnhoven P (2015)	3
TP53	0	HDAC1	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, imaging technique, affinity chromatography technology, affinity chromatography technology, imaging technique	Ito A (2002), Wang C (2005), Dohi Y (2008), Jin W (2008), Lei Q (2006), Wu Y (2001), Wu Y (2001), Luo J (2000), Juan LJ (2000), Juan LJ (2000), Juan LJ (2000), Murphy M (1999), Insinga A (2004), Sun JM (2007), Yu XY (2010), Sinha S (2010), Sinha S (2010), Li Y (2012), Di Agostino S (2006), Pavithra L (2009), Pavithra L (2009), Luo J (2000), Chen TC (2014), Park EK (2015), Park EK (2015), Park EK (2015)	26
SMAD3	1	SMAD4	9	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, x-ray crystallography, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, pull down, pull down, pull down, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, protein complementation assay, affinity chromatography technology, affinity chromatography technology	Seoane J (2004), Moren A (2003), Wu JW (2002), Nakao A (1997), Hanai J (1999), Lebrun JJ (1999), Poncelet AC (2001), Jablonska E (2010), Prunier C (2003), Kato Y (2002), Kaimori A (2010), Tang LY (2011), Tang LY (2011), Dupont S (2009), Dupont S (2009), Pardali K (2000), Kardassis D (2000), Xu L (2003), Fu G (2011), Chen W (2007), Kang JM (2012), Gao S (2009), Li H (2009), Li H (2009), Brown KA (2008), Brown KA (2008), Halder SK (2005), Barrios-Rodiles M (2005), Dai F (2007), Dai F (2007), Chacko BM (2004), Chacko BM (2004), Chacko BM (2004), Stroschein SL (1999), Stroschein SL (1999), Stroschein SL (1999), Wu RY (1997), Wu RY (1997), Wu RY (1997), Wu RY (1997), Tomita M (2004), Colland F (2004), Colland F (2004), Tang Y (2003), Ding L (2009), Fattet L (2013), Wang J (2011), Xue J (2014), Ali A (2013), Gao S (2009), Yamakawa N (2002), Yamakawa N (2002), Wang G (2005), Li X (2015), Zhou F (2014), Yang Y (2015), Yan X (2016), Yan X (2016), Wu Y (2017), Wu Y (2017)	60
TP53	0	FOXO3	1	imaging technique, affinity chromatography technology, affinity chromatography technology	Chen TC (2014), Du WW (2017), Du WW (2017)	3
AP2A2	3	APP	1	pull down	Olah J (2011)	1
SMAD1	0	YY1	7	pull down	Kurisaki K (2003)	1
AR	3	TP53	0	genetic interference	Shenk JL (2001)	1
SNIP1	0	CREBBP	29	affinity chromatography technology	Kim RH (2000)	1
LMNA	2	LEMD3	4	bioid, bioid	Roux KJ (2012), Kim DI (2014)	2
CDK7	0	SMAD1	0	enzymatic study	Alarcon C (2009)	1
SMAD1	0	KAT2A	1	affinity chromatography technology	Kahata K (2004)	1
CREBBP	29	SMAD1	0	affinity chromatography technology, affinity chromatography technology	Pearson KL (1999), Sun Y (2001)	2
TP53	0	SMAD1	0	affinity chromatography technology, affinity chromatography technology	Chau JF (2012), Chau JF (2012)	2
SMAD2	5	HGS	5	affinity chromatography technology	Miura S (2000)	1
AR	3	STUB1	4	affinity chromatography technology, pull down, enzymatic study, unspecified method, two hybrid, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down, affinity chromatography technology	DaSilva J (2009), Chymkowitch P (2011), Chymkowitch P (2011), Rees I (2006), He B (2004), He B (2004), Schuelke JP (2010), McClurg UL (2016), Wang J (2016), Wang J (2016), Wang J (2016)	11
MAPK1	1	TOB1	1	two hybrid, affinity chromatography technology, pull down, enzymatic study	Maekawa M (2002), Maekawa M (2002), Maekawa M (2002), Maekawa M (2002)	4
AR	3	KMT2D	30	bioid, affinity chromatography technology, affinity chromatography technology	Lempiaeinen JK (2017), Grasso CS (2012), Grasso CS (2012)	3
DNMT3L	2	SMAD4	9	pull down	Pacaud R (2014)	1
SMAD6	9	ACVR1	4	affinity chromatography technology, affinity chromatography technology	Kamiya Y (2010), Zhang X (2013)	2
HGS	5	UBC	7	affinity chromatography technology, affinity chromatography technology, two hybrid, pull down, pull down, affinity chromatography technology, pull down, pull down, pull down, pull down, pull down	Mizuno E (2006), Raiborg C (2002), Raiborg C (2002), Nathan JA (2013), Nathan JA (2013), Bishop N (2002), Stuible M (2010), Oved S (2006), Hoeller D (2006), Kharitidi D (2015), Zhang X (2017)	11
SMAD1	0	YAP1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, x-ray crystallography	Alarcon C (2009), Alarcon C (2009), Aragon E (2011), Aragon E (2011), Aragon E (2011)	5
SMAD7	1	NEDD4	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kuratomi G (2005), Kuratomi G (2005), Al-Salihi MA (2012)	3
SMAD1	0	MAP2K3	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
SKIL	3	SMAD2	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology	Stroschein SL (2001), Stroschein SL (1999), Tan R (2006), Mizuide M (2003), Brown KA (2008), Colland F (2004), Colland F (2004), He J (2003), Ikeuchi Y (2014)	9
NEDD4	2	SKIL	3	affinity chromatography technology	Kuratomi G (2005)	1
SKIL	3	PIAS4	5	two hybrid	Colland F (2004)	1
TP53	0	CDK8	1	pull down	Gu W (1999)	1
EP300	36	SMAD1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Pearson KL (1999), Nakashima K (1999), Nakashima K (1999), Jeon EJ (2006), Jun JH (2010), Weng Q (2012)	6
SMAD1	0	OAZ3	2	two hybrid	Guo X (2001)	1
HIPK2	0	CREBBP	29	affinity chromatography technology, affinity chromatography technology	Hofmann TG (2002), Hofmann TG (2002)	2
SMAD1	0	SMAD6	9	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid	Topper JN (1997), Murakami G (2003), Itoh F (2001), Hata A (1998), Hata A (1998)	5
SMAD1	0	RUNX1	0	affinity chromatography technology	Hanai J (1999)	1
SMAD3	1	SKIL	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Stroschein SL (2001), Stroschein SL (2001), Stroschein SL (1999), Liberati NT (2001), Tan R (2006), Mizuide M (2003), Colland F (2004), He J (2003), Jinnin M (2007), Jinnin M (2007)	10
BMP7	3	ACVR1	4	pull down	ten Dijke P (1994)	1
PSMD1	2	XPO1	8	genetic interference	Horlbeck MA (2018)	1
XPO1	8	USP9X	15	affinity chromatography technology	Kirli K (2015)	1
SMAD3	1	YY1	7	pull down, affinity chromatography technology	Kurisaki K (2003), Brown KA (2008)	2
XPO1	8	PUM1	4	affinity chromatography technology	Kirli K (2015)	1
STAT3	0	SS18L1	2	two hybrid	Ravasi T (2010)	1
ZCCHC12	1	APP	1	pull down	Olah J (2011)	1
PSMB4	2	APP	1	pull down	Olah J (2011)	1
SKIL	3	SNRNP70	2	two hybrid	Colland F (2004)	1
TOB1	1	SMAD3	1	affinity chromatography technology	Xiong B (2006)	1
RUNX2	2	CREBBP	29	affinity chromatography technology	Makita N (2008)	1
SMAD1	0	NEDD4	2	affinity chromatography technology, two hybrid	Kim BG (2011), Colland F (2004)	2
BMPR1A	5	SMAD1	0	enzymatic study	Kretzschmar M (1997)	1
SMAD3	1	SMAD5	2	affinity chromatography technology	Brown KA (2008)	1
PSMD1	2	UBC	7	pull down, pull down	Jacobson AD (2014), Zhang X (2017)	2
SMAD4	9	PIAS1	4	two hybrid, two hybrid	Colland F (2004), Wang J (2011)	2
SMAD3	1	ERBIN	5	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Warner DR (2003), Xi Q (2008), Brown KA (2008), Dai F (2007), Dai F (2007), Dai F (2007)	6
SMURF1	4	SMAD1	0	enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study, pull down, unspecified method, two hybrid, affinity chromatography technology, pull down, enzymatic study, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down	Sangadala S (2006), Komuro A (2004), Tian M (2011), Tian M (2011), Tian M (2011), Sapkota G (2007), Sapkota G (2007), Li L (2004), Alarcon C (2009), Aragon E (2011), Aragon E (2011), Aragon E (2011), Aragon E (2011), Gao S (2009), Sangadala S (2007), Sangadala S (2007), Sangadala S (2007), Sangadala S (2007), Sangadala S (2007), Colland F (2004), Cao Y (2014), Cao Y (2014), Sangadala S (2007), Gao S (2009), Wan L (2011), Wan L (2011), Zhang Y (2017), Zhang Y (2017)	28
SMAD1	0	ZNF251	1	two hybrid	Colland F (2004)	1
SMAD7	1	ZEB1	3	affinity chromatography technology, affinity chromatography technology, pull down	Nakahata S (2010), Nakahata S (2010), Nakahata S (2010)	3
CREBBP	29	STAT3	0	affinity chromatography technology, enzymatic study	Sun Y (2001), Yuan ZL (2005)	2
YAP1	0	RUNX1	0	two hybrid, affinity chromatography technology, affinity chromatography technology, pull down	Yagi R (1999), Levy D (2008), Levy D (2008), Schuchardt BJ (2014)	4
SMAD1	0	ZEB2	7	two hybrid, affinity chromatography technology	Colland F (2004), Weng Q (2012)	2
SMAD2	5	HIPK2	0	pull down	Harada J (2003)	1
LMNA	2	SF3B1	12	affinity chromatography technology	Depreux FF (2015)	1
SMAD2	5	SNRNP70	2	two hybrid	Colland F (2004)	1
SMAD1	0	MED24	4	affinity chromatography technology	Kato Y (2002)	1
EP300	36	YY1	7	enzymatic study, affinity chromatography technology, affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down	Yao YL (2001), Lee JS (1995), Lee JS (1995), Lee JS (1995), Lee JS (1995), Kadeppagari RK (2009), Kadeppagari RK (2009), Kadeppagari RK (2009), Sankar N (2008), Sankar N (2008), Sankar N (2008), Wang CC (2007), Wang CC (2007), Galvin KM (1997)	14
AR	3	PIAS4	5	pull down, pull down	Gross M (2001), Gross M (2004)	2
EP300	36	MAPK1	1	affinity chromatography technology, enzymatic study, enzymatic study	Chen YJ (2007), Chen YJ (2007), Sang N (2003)	3
DNMT3L	2	HDAC1	4	pull down, pull down, pull down, pull down, affinity chromatography technology	Aapola U (2002), Aapola U (2002), Deplus R (2002), Deplus R (2002), Deplus R (2002)	5
MAPK1	1	GSK3B	1	affinity chromatography technology, pull down, enzymatic study	Ding Q (2005), Ding Q (2005), Ding Q (2005)	3
CDK8	1	SMAD2	5	enzymatic study	Alarcon C (2009)	1
RFX1	3	HDAC1	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Xu Y (2006), Wang KR (2007), Boldt K (2016)	3
PIAS4	5	HDAC1	4	pull down	Gross M (2004)	1
ZNF76	2	PIAS1	4	affinity chromatography technology, two hybrid	Zheng G (2004), Zheng G (2004)	2
ZEB1	3	SMAD2	5	affinity chromatography technology	Postigo AA (2003)	1
SOX5	11	APP	1	pull down	Olah J (2011)	1
SMAD7	1	DVL1	5	pull down	Warner DR (2003)	1
HDAC1	4	MGA	9	affinity chromatography technology, affinity chromatography technology	Hein MY (2015), Huttlin EL (2017)	2
SMAD2	5	PSMD11	0	two hybrid	Colland F (2004)	1
SMAD1	0	CHMP3	0	two hybrid	Colland F (2004)	1
TP53	0	PIAS1	4	two hybrid, pull down, enzymatic study, pull down, enzymatic study, enzymatic study, imaging technique, pull down	Gallagher WM (1999), Kahyo T (2001), Kahyo T (2001), Schmidt D (2002), Pelisch F (2010), Schmidt D (2002), Chen TC (2014), Okubo S (2004)	8
TP53	0	KAT2A	1	affinity chromatography technology, fluorescent resonance energy transfe	Gamper AM (2008), Ivanov AA (2017)	2
SMAD1	0	SMURF2	3	two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology	Lin X (2000), Lin X (2000), Komuro A (2004), Zhang Y (2001), Zhang Y (2001), Li L (2004), Chong PA (2010), Colland F (2004), Huttlin EL (2017), Zhou F (2017)	10
PIAS1	4	GSK3B	1	affinity chromatography technology, enzymatic study	Coon TA (2015), Coon TA (2015)	2
TOB1	1	SMAD1	0	affinity chromatography technology	Yoshida Y (2000)	1
GSK3B	1	SMURF2	3	affinity chromatography technology	Wu Q (2009)	1
LMNA	2	SMAD1	0	two hybrid	Dittmer TA (2014)	1
UCHL3	1	ZEB1	3	affinity chromatography technology, affinity chromatography technology	Zhou Z (2017), Zhou Z (2017)	2
STAT3	0	EP300	36	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Nakashima K (1999), Nakashima K (1999), Ray S (2002), Ray S (2002), Yuan ZL (2005), Yuan ZL (2005), Gupta M (2011), Wang R (2005), Gray MJ (2005), Hou T (2008), Kotla S (2015)	11
SMAD7	1	ACVR1	4	affinity chromatography technology	Kamiya Y (2010)	1
SMAD4	9	FOXO3	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Seoane J (2004), Seoane J (2004), Fu G (2011), Fu G (2011)	4
RUNX2	2	HDAC1	4	affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, genetic interference	Lee HW (2006), Zhang Z (2012), Ali SA (2012), Ali SA (2012), Ali SA (2012)	5
UCHL3	1	UBC	7	enzymatic study, enzymatic study, enzymatic study, x-ray crystallography, pull down, x-ray crystallography, pull down, enzymatic study, pull down, pull down, enzymatic study, enzymatic study, pull down, pull down, enzymatic study, pull down, pull down	Bremm A (2010), Boudreaux D (2012), Misaghi S (2005), Misaghi S (2005), Wilkinson KD (1999), Wilkinson KD (1999), Phillips AH (2013), Larsen CN (1998), Wada H (1998), Hemelaar J (2004), Altun M (2015), Flierman D (2016), Zhang X (2017), Kwasna D (2018), Lee YC (2017), Lee YC (2017), Hanpude P (2017)	17
SMAD3	1	DVL1	5	pull down	Warner DR (2003)	1
SMAD6	9	SMURF2	3	affinity chromatography technology, two hybrid, affinity chromatography technology	Komuro A (2004), Colland F (2004), Herhaus L (2014)	3
GSK3B	1	SMAD3	1	affinity chromatography technology, pull down, affinity chromatography technology	Guo X (2008), Guo X (2008), Choi SI (2011)	3
SMAD1	0	NKX3-2	1	pull down, pull down, affinity chromatography technology	Kim DW (2003), Kim DW (2003), Kim DW (2003)	3
MAPK1	1	SMAD3	1	enzymatic study, affinity chromatography technology	Alarcon C (2009), Brown KA (2008)	2
ACVR1	4	ACVRL1	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
SMAD3	1	RUNX2	2	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Zhang YW (2000), Zhang YW (2000), Hanai J (1999), Ohyama Y (2011)	4
SMAD1	0	TCF20	18	two hybrid	Ravasi T (2010)	1
PIAS4	5	SMAD4	9	affinity chromatography technology, two hybrid, affinity chromatography technology, pull down, affinity chromatography technology	Imoto S (2003), Long J (2003), Long J (2003), Long J (2003), Lee PS (2003)	5
SMAD5	2	SNRNP70	2	two hybrid	Colland F (2004)	1
HDAC1	4	ZNF512B	2	affinity chromatography technology, affinity chromatography technology	Joshi P (2013), Huttlin EL (2017)	2
SKIL	3	PIAS1	4	two hybrid	Colland F (2004)	1
KDM6B	16	SMAD3	1	affinity chromatography technology	Dahle O (2010)	1
CDK9	3	AR	3	affinity chromatography technology, pull down	Lee DK (2001), Lee DK (2001)	2
DNMT3L	2	YY1	7	pull down	Pacaud R (2014)	1
SMAD3	1	FOXO3	1	affinity chromatography technology, affinity chromatography technology, imaging technique	Seoane J (2004), Fu G (2011), Bollinger LM (2014)	3
ERBIN	5	STAT3	0	two hybrid	Wang J (2011)	1
SMAD3	1	SKI	3	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Harada J (2003), Ueki N (2003), Ueki N (2003), Tabata T (2009), Prunier C (2003), Liberati NT (2001), Akiyoshi S (1999), Akiyoshi S (1999), Takeda M (2004), Mizuide M (2003), Wu K (2003), Chen W (2007), Band AM (2009), Qin BY (2002), He J (2003), He J (2003), Jinnin M (2007), Jinnin M (2007), Rashidian J (2015)	19
GSK3B	1	SF3B1	12	affinity chromatography technology	Ewing RM (2007)	1
SMAD3	1	GMEB1	4	two hybrid	Colland F (2004)	1
SMAD2	5	SNIP1	0	two hybrid	Kim RH (2000)	1
HMGA2	1	SMAD5	2	affinity chromatography technology	Monzen K (2008)	1
ZNF512B	2	SMAD1	0	two hybrid	Colland F (2004)	1
SMAD4	9	SMURF1	4	affinity chromatography technology, affinity chromatography technology	Moren A (2005), Zhang L (2013)	2
OAZ1	2	PSMB4	2	two hybrid, two hybrid	Gruendler C (2001), Gruendler C (2001)	2
XPO1	8	MKL2	5	affinity chromatography technology	Kirli K (2015)	1
RUNX1	0	EP300	36	affinity chromatography technology, enzymatic study	Aikawa Y (2006), Yamaguchi Y (2004)	2
SMAD4	9	DVL1	5	pull down	Warner DR (2003)	1
SMAD7	1	TTF1	3	two hybrid	Colland F (2004)	1
SMAD1	0	DACH1	3	fluorescent resonance energy transfe	Ivanov AA (2017)	1
CDK9	3	RUNX1	0	genetic interference	Shen JP (2017)	1
SMAD7	1	YAP1	0	two hybrid, genetic interference, affinity chromatography technology, pull down, x-ray crystallography, affinity chromatography technology, pull down	Ferrigno O (2002), Ferrigno O (2002), Ferrigno O (2002), Aragon E (2012), Aragon E (2012), Aragon E (2012), Schuchardt BJ (2014)	7
XPO1	8	SMAD4	9	affinity chromatography technology	Kirli K (2015)	1
SMAD4	9	PAX6	3	affinity chromatography technology	Grocott T (2007)	1
HIPK2	0	STUB1	4	affinity chromatography technology, affinity chromatography technology	Choi JR (2016), Choi JR (2016)	2
SMAD5	2	SMURF2	3	affinity chromatography technology, enzymatic study, two hybrid, affinity chromatography technology	Komuro A (2004), Nie J (2010), Colland F (2004), Huttlin EL (2017)	4
FOXO3	1	CREBBP	29	affinity chromatography technology, unspecified method, x-ray crystallography, affinity chromatography technology	van der Horst A (2004), Wang F (2012), Wang F (2012), Li X (2015)	4
SMAD3	1	ZEB2	7	affinity chromatography technology, affinity chromatography technology, two hybrid	Long J (2005), Long J (2005), Colland F (2004)	3
SKIL	3	HDAC1	4	affinity chromatography technology	Nomura T (1999)	1
SMAD1	0	UBC	7	two hybrid	Guo X (2001)	1
ICK	1	PSMD1	2	affinity chromatography technology	Varjosalo M (2013)	1
SMAD1	0	USP9X	15	affinity chromatography technology	Dupont S (2009)	1
DNMT3L	2	SMAD3	1	pull down	Pacaud R (2014)	1
CDK9	3	SMAD2	5	enzymatic study	Alarcon C (2009)	1
STK11	2	GSK3B	1	affinity chromatography technology	Yan D (2012)	1
PSMB4	2	PSMD1	2	biochemical, biochemical	Havugimana PC (2012), Wan C (2015)	2
SMAD1	0	GMEB1	4	two hybrid	Colland F (2004)	1
SKI	3	TP53	0	affinity chromatography technology	Inoue Y (2011)	1
TGIF1	1	SMAD3	1	affinity chromatography technology, pull down	Melhuish TA (2001), Liberati NT (2001)	2
CHMP3	0	APP	1	pull down	Olah J (2011)	1
SMAD4	9	ERBIN	5	pull down	Warner DR (2003)	1
SMAD1	0	MKL2	5	two hybrid	Colland F (2004)	1
SMAD2	5	SMAD1	0	affinity chromatography technology, two hybrid, two hybrid, fluorescent resonance energy transfe	Brown KA (2008), Wu RY (1997), Wu RY (1997), Ivanov AA (2017)	4
MED6	0	MED24	4	biochemical	Wan C (2015)	1
SMAD4	9	SNRNP70	2	two hybrid	Colland F (2004)	1
SMAD4	9	AR	3	affinity chromatography technology, affinity chromatography technology, pull down, pull down	Kang HY (2002), Kang HY (2002), Kang HY (2002), Kang HY (2002)	4
SMAD1	0	KMT2D	30	two hybrid	Colland F (2004)	1
STAT3	0	RUNX2	2	affinity chromatography technology	Fan D (2007)	1
SMAD1	0	HBP1	1	two hybrid	Colland F (2004)	1
SMAD3	1	NEDD4	2	affinity chromatography technology, enzymatic study, unspecified method, affinity chromatography technology, affinity chromatography technology, pull down	Kuratomi G (2005), Persaud A (2009), Aragon E (2011), Aragon E (2011), Aragon E (2011), Aragon E (2011)	6
STAT3	0	HDAC1	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique	Zhang Q (2005), Yuan ZL (2005), Gupta M (2011), Zhi Y (2012), Zhi Y (2012)	5
SMAD1	0	HIPK2	0	pull down, affinity chromatography technology, affinity chromatography technology	Harada J (2003), Harada J (2003), Harada J (2003)	3
SMAD1	0	SMAD5	2	two hybrid	Colland F (2004)	1
SMAD4	9	PSMD11	0	two hybrid	Colland F (2004)	1
SMAD2	5	MED15	6	affinity chromatography technology	Kato Y (2002)	1
SMAD1	0	SF3B1	12	two hybrid	Colland F (2004)	1
MEN1	1	STUB1	4	affinity chromatography technology	Yaguchi H (2004)	1