PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
EGFR	5	LYN	2	affinity chromatography technology, affinity chromatography technology, two hybrid, protein complementation assay, affinity chromatography technology	Wu SL (2006), Wu SL (2006), Kotlyar M (2015), Petschnigg J (2014), Petschnigg J (2014)	5
TNK2	7	LYN	2	pull down, affinity chromatography technology	Chan W (2011), Chan W (2011)	2
ELAVL1	0	PTK2	2	affinity chromatography technology	Abdelmohsen K (2009)	1
SH2D1A	0	LY9	1	affinity chromatography technology, two hybrid, affinity chromatography technology	Sayos J (2001), Sayos J (2001), Morra M (2001)	3
NCK1	0	SH2D1A	0	two hybrid	Grossmann A (2015)	1
EGFR	5	DOK1	2	two hybrid, protein complementation assay, affinity chromatography technology	Kotlyar M (2015), Petschnigg J (2014), Petschnigg J (2014)	3
SH2D1A	0	ZNHIT1	0	two hybrid	Grossmann A (2015)	1
SH2D1A	0	LHX4	1	two hybrid	Rolland T (2014)	1
CD244	1	FYN	1	affinity chromatography technology	Chen R (2004)	1
MAPK11	1	SH2D1A	0	enzymatic study	Stein B (1997)	1
LYN	2	DOK1	2	enzymatic study, pull down, enzymatic study	van Dijk TB (2000), van Dijk TB (2000), Liang X (2002)	3
SH2D1A	0	CD84	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Tangye SG (2003), Sayos J (2001), Tangye SG (2002), Morra M (2001)	4
MAPK11	1	MAPK14	0	two hybrid, affinity chromatography technology	Vinayagam A (2011), Varjosalo M (2013)	2
NCK1	0	PTK2	2	pull down, affinity chromatography technology, pull down	Minegishi M (1996), Goicoechea SM (2002), Goicoechea SM (2002)	3
ELAVL1	0	SH2D1A	0	affinity chromatography technology	Abdelmohsen K (2009)	1
PTK2	2	FYN	1	affinity chromatography technology, x-ray crystallography	Messina S (2003), Arold ST (2001)	2
SH2D1A	0	ATF3	0	two hybrid	Grossmann A (2015)	1
SH2D1A	0	CCDC74A	1	two hybrid	Grossmann A (2015)	1
SH2D1A	0	TNK2	7	two hybrid	Rolland T (2014)	1
SH2D1A	0	ERBB3	3	unspecified method	Jones RB (2006)	1
EGFR	5	TNK2	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology	Lin Q (2010), Pao-Chun L (2009), Shen F (2007), Howlin J (2008), Howlin J (2008), Tong J (2008), Jones S (2014), Jones S (2014), Chua BT (2010)	9
SH2D1A	0	OLIG1	0	two hybrid	Grossmann A (2015)	1
MAPK14	0	EGFR	5	enzymatic study	Raingeaud J (1995)	1
LYN	2	SH2D1A	0	affinity chromatography technology, affinity chromatography technology	Zhu J (2013), Zhu J (2013)	2
ELAVL1	0	LYN	2	affinity chromatography technology	Abdelmohsen K (2009)	1
NCK1	0	OLIG1	0	two hybrid	Grossmann A (2015)	1
MAPK14	0	ZNHIT1	0	enzymatic study, two hybrid	Cuadrado A (2007), Wang J (2008)	2
ELAVL1	0	VCP	6	affinity chromatography technology, pull down	Zhou HL (2013), Zhou HL (2013)	2
SLAMF6	2	SH2D1A	0	affinity chromatography technology	Bottino C (2001)	1
SH2D1A	0	SLAMF1	2	two hybrid, affinity chromatography technology, affinity chromatography technology, pull down	Howie D (2002), Howie D (2002), Morra M (2001), Morra M (2001)	4
SH2D1A	0	DOK1	2	pull down, affinity chromatography technology	Sylla BS (2000), Sylla BS (2000)	2
DOK1	2	NCK1	0	unspecified method, affinity chromatography technology	Liu BA (2012), Wick MJ (2001)	2
SH2D1A	0	FYN	1	pull down, affinity chromatography technology, pull down	Li C (2003), Li C (2003), Chan B (2003)	3
FYN	1	SLAMF1	2	pull down	Chan B (2003)	1
PTK2	2	LYN	2	affinity chromatography technology, two hybrid	Chung J (1997), Grossmann A (2015)	2
SH2D1A	0	CD244	1	affinity chromatography technology, affinity chromatography technology	Morra M (2001), Chen R (2004)	2
PTK2	2	EGFR	5	affinity chromatography technology, two hybrid, protein complementation assay	Sieg DJ (2000), Kotlyar M (2015), Petschnigg J (2014)	3
FYN	1	TNK2	7	affinity chromatography technology, pull down	Linseman DA (2001), Linseman DA (2001)	2
NCK1	0	ERBB3	3	unspecified method	Jones RB (2006)	1
SH2D1A	0	NGEF	1	two hybrid	Grossmann A (2015)	1
MAPK14	0	SH2D1A	0	enzymatic study	Stein B (1997)	1
SH2D1A	0	PTK2	2	two hybrid	Grossmann A (2015)	1
SH2D1A	0	VCP	6	affinity chromatography technology	Nagy N (2009)	1
SH2D1A	0	EGFR	5	unspecified method	Jones RB (2006)	1
NCK1	0	EGFR	5	pull down, affinity chromatography technology, affinity chromatography technology, unspecified method, two hybrid, protein complementation assay	Tang J (1997), Li W (1992), Braverman LE (1999), Jones RB (2006), Kotlyar M (2015), Petschnigg J (2014)	6
TNK2	7	NCK1	0	pull down, affinity chromatography technology	Chan W (2011), Hein MY (2015)	2
SH2D1A	0	LETMD1	1	two hybrid	Grossmann A (2015)	1
EGFR	5	ERBB3	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Marques MM (1999), Li J (2013), Li J (2013), Sharif A (2009)	4