PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
CCNH	3	GTF2H4	2	biochemical	Havugimana PC (2012)	1
CDK7	0	GTF2H1	0	affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Rossignol M (1997), Shiekhattar R (1995), Yee A (1995), Kershnar E (1998), Reardon JT (1996), Varjosalo M (2013)	6
GTF2H2	0	GTF2H4	2	affinity chromatography technology, biochemical, biochemical, pull down	Vermeulen W (2000), Havugimana PC (2012), Wan C (2015), Luo J (2015)	4
GTF2H1	0	GTF2H4	2	biochemical, biochemical	Havugimana PC (2012), Wan C (2015)	2
GTF2H5	0	MNAT1	0	affinity chromatography technology	Hein MY (2015)	1
GTF2H3	2	GTF2H1	0	pull down, biochemical, affinity chromatography technology, pull down, biochemical, biochemical, affinity chromatography technology, pull down	Chymkowitch P (2011), Humbert S (1994), Humbert S (1994), Jawhari A (2002), Havugimana PC (2012), Wan C (2015), Huttlin EL (2017), Luo J (2015)	8
730394	0	CDK7	0	affinity chromatography technology	Huttlin EL (2017)	1
GTF2H5	0	PPP1R2	2	affinity chromatography technology	Hein MY (2015)	1
ERCC3	3	CDK7	0	biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Giglia-Mari G (2004), Rossignol M (1997), Yee A (1995), Jeronimo C (2007), Jeronimo C (2007), Reardon JT (1996), Chen D (1999), Varjosalo M (2013), Huttlin EL (2017), Luo J (2015)	10
CDK7	0	CCNH	3	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, pull down, biochemical, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, pull down	Maekelae TP (1994), Maekelae TP (1994), Maekelae TP (1994), Maekelae TP (1994), Yee A (1995), Garber ME (2000), Garber ME (2000), Jeronimo C (2007), Reardon JT (1996), Liu J (1997), Cujec TP (1997), Epie N (2005), Bockstaele L (2006), Tassan JP (1995), Chen D (1999), Havugimana PC (2012), Poterszman A (1997), Nguyen VT (2001), Garrett S (2001), Pinhero R (2004), Varjosalo M (2013), Huttlin EL (2015), Wan C (2015), Huttlin EL (2017), Luo J (2015)	25
GTF2H5	0	HARS2	0	affinity chromatography technology	Hein MY (2015)	1
MNAT1	0	GTF2H3	2	biochemical	Havugimana PC (2012)	1
ERCC3	3	CCNH	3	biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Giglia-Mari G (2004), Jeronimo C (2007), Drapkin R (1996), Drapkin R (1996), Huttlin EL (2015), Huttlin EL (2017), Luo J (2015)	7
GTF2H5	0	CDCA3	0	affinity chromatography technology	Hein MY (2015)	1
GTF2H5	0	CDK7	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Giglia-Mari G (2004), Varjosalo M (2013), Hein MY (2015)	3
ERCC3	3	GTF2H3	2	biochemical, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, biochemical, affinity chromatography technology, affinity chromatography technology	Giglia-Mari G (2004), Marinoni JC (1997), Jeronimo C (2007), Humbert S (1994), Humbert S (1994), Havugimana PC (2012), Wan C (2015), Huttlin EL (2017), Luo J (2015)	9
GTF2H5	0	RNF40	11	affinity chromatography technology	Hein MY (2015)	1
GTF2H1	0	MNAT1	0	biochemical, biochemical, pull down	Kershnar E (1998), Havugimana PC (2012), Luo J (2015)	3
UNK	3	NUP98	5	affinity chromatography technology	Murn J (2015)	1
CCNH	3	MNAT1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, pull down, affinity chromatography technology, biochemical, affinity chromatography technology	Ewing RM (2007), Talukder AH (2003), Bockstaele L (2006), Havugimana PC (2012), Pinhero R (2004), Huttlin EL (2015), Wan C (2015), Huttlin EL (2017)	8
GTF2H5	0	GTF2H1	0	affinity chromatography technology, affinity chromatography technology	Hein MY (2015), Huttlin EL (2017)	2
730394	0	GTF2H4	2	affinity chromatography technology, biochemical, affinity chromatography technology	Huttlin EL (2015), Wan C (2015), Huttlin EL (2017)	3
UNK	3	GTF2H5	0	affinity chromatography technology	Murn J (2015)	1
ERCC5	0	ERCC2	4	affinity chromatography technology, pull down	Iyer N (1996), Iyer N (1996)	2
GTF2H1	0	CCNH	3	biochemical, biochemical, affinity chromatography technology	Shiekhattar R (1995), Kershnar E (1998), Araujo SJ (2001)	3
GTF2H3	2	730394	0	two hybrid, affinity chromatography technology, biochemical, affinity chromatography technology	Rolland T (2014), Huttlin EL (2015), Wan C (2015), Huttlin EL (2017)	4
MNAT1	0	GTF2H2	0	affinity chromatography technology, pull down	Drapkin R (1996), Luo J (2015)	2
CDK7	0	MNAT1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, pull down	Talukder AH (2003), Yee A (1995), Jeronimo C (2007), Busso D (2000), Cujec TP (1997), Tassan JP (1995), Chen D (1999), Havugimana PC (2012), Varjosalo M (2013), Huttlin EL (2015), Wan C (2015), Huttlin EL (2017), Luo J (2015)	13
CDK7	0	GTF2H3	2	affinity chromatography technology, pull down, affinity chromatography technology	Jeronimo C (2007), Chymkowitch P (2011), Varjosalo M (2013)	3
ERCC3	3	ERCC2	4	biochemical, affinity chromatography technology, pull down, affinity chromatography technology, pull down, biochemical, affinity chromatography technology, affinity chromatography technology, pull down	Giglia-Mari G (2004), Marinoni JC (1997), Drapkin R (1994), Iyer N (1996), Iyer N (1996), Havugimana PC (2012), Stehling O (2012), Luo J (2015), Luo J (2015)	9
ERCC2	4	GTF2H1	0	pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Drapkin R (1994), Rossignol M (1997), Seroz T (2000), Luo J (2015), Luo J (2015)	5
GTF2H5	0	ERCC2	4	affinity chromatography technology	Hein MY (2015)	1
ERCC2	4	MNAT1	0	affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, pull down	Busso D (2000), Havugimana PC (2012), Huttlin EL (2015), Huttlin EL (2017), Luo J (2015)	5
730394	0	ERCC3	3	affinity chromatography technology, biochemical, affinity chromatography technology	Huttlin EL (2015), Wan C (2015), Huttlin EL (2017)	3
ERCC3	3	GTF2H1	0	biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Giglia-Mari G (2004), Marinoni JC (1997), Rossignol M (1997), Jeronimo C (2007), Drapkin R (1996), Araujo SJ (2001), Havugimana PC (2012), Maru Y (1999), Wan C (2015), Huttlin EL (2017), Luo J (2015), Luo J (2015)	12
GTF2H3	2	GTF2H2	0	pull down, affinity chromatography technology, pull down, biochemical, biochemical, affinity chromatography technology, pull down	Chymkowitch P (2011), Kellenberger E (2005), Jawhari A (2002), Havugimana PC (2012), Wan C (2015), Huttlin EL (2017), Luo J (2015)	7
MNAT1	0	GTF2H4	2	biochemical	Havugimana PC (2012)	1
CDK7	0	ERCC2	4	affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Reardon JT (1996), Havugimana PC (2012), Varjosalo M (2013), Huttlin EL (2015), Huttlin EL (2017)	5
GTF2H2	0	GTF2H5	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Giglia-Mari G (2004), Vermeulen W (2000), Giglia-Mari G (2006), Hein MY (2015), Huttlin EL (2017)	5
ERCC3	3	ERCC5	0	affinity chromatography technology, affinity chromatography technology	Jeronimo C (2007), Huttlin EL (2017)	2
ERCC3	3	GTF2H2	0	biochemical, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, pull down	Giglia-Mari G (2004), Marinoni JC (1997), Jeronimo C (2007), Humbert S (1994), Humbert S (1994), Wan C (2015), Huttlin EL (2017), Luo J (2015), Luo J (2015)	9
ERCC3	3	GTF2H4	2	biochemical, affinity chromatography technology, biochemical, biochemical, affinity chromatography technology, affinity chromatography technology, pull down	Giglia-Mari G (2004), Marinoni JC (1997), Havugimana PC (2012), Wan C (2015), Huttlin EL (2017), Luo J (2015), Luo J (2015)	7
GTF2H5	0	ERCC3	3	affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Giglia-Mari G (2004), Giglia-Mari G (2004), Giglia-Mari G (2006), Hein MY (2015), Huttlin EL (2017), Luo J (2015)	6
GTF2H1	0	ERCC5	0	affinity chromatography technology, pull down	Araujo SJ (2001), Gervais V (2004)	2
CDK7	0	GTF2H4	2	affinity chromatography technology, affinity chromatography technology	Jeronimo C (2007), Varjosalo M (2013)	2
GTF2H5	0	CCNH	3	affinity chromatography technology	Hein MY (2015)	1
GTF2H5	0	ERCC5	0	affinity chromatography technology	Hein MY (2015)	1
GTF2H2	0	CDK7	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Vermeulen W (2000), Jeronimo C (2007), Varjosalo M (2013)	3
CDK7	0	ERCC5	0	affinity chromatography technology, affinity chromatography technology	Jeronimo C (2007), Varjosalo M (2013)	2
GTF2H5	0	NUP98	5	affinity chromatography technology	Hein MY (2015)	1
GTF2H5	0	ITPR1	25	affinity chromatography technology	Hein MY (2015)	1
GTF2H5	0	GTF2H4	2	affinity chromatography technology, affinity chromatography technology, pull down	Hein MY (2015), Huttlin EL (2017), Luo J (2015)	3
ERCC2	4	GTF2H2	0	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down	Coin F (1998), Coin F (1998), Vermeulen W (2000), Dubaele S (2003), Luo J (2015)	5
ERCC3	3	MNAT1	0	biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Giglia-Mari G (2004), Jeronimo C (2007), Drapkin R (1996), Drapkin R (1996), Huttlin EL (2017), Luo J (2015), Luo J (2015)	7
GTF2H5	0	GTF2H3	2	affinity chromatography technology, affinity chromatography technology	Hein MY (2015), Huttlin EL (2017)	2
CCNH	3	ERCC2	4	affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Drapkin R (1996), Havugimana PC (2012), Huttlin EL (2015), Huttlin EL (2017)	4
CCNH	3	ERCC5	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
ERCC2	4	730394	0	two hybrid	Rolland T (2014)	1
GTF2H3	2	GTF2H4	2	pull down, biochemical, biochemical, affinity chromatography technology, pull down	Jawhari A (2002), Havugimana PC (2012), Wan C (2015), Huttlin EL (2017), Luo J (2015)	5
GTF2H2	0	GTF2H1	0	affinity chromatography technology, biochemical, affinity chromatography technology, two hybrid, biochemical, pull down	Vermeulen W (2000), Humbert S (1994), Humbert S (1994), Wang J (2011), Wan C (2015), Luo J (2015)	6
730394	0	GTF2H5	0	affinity chromatography technology	Huttlin EL (2017)	1
730394	0	GTF2H1	0	affinity chromatography technology, biochemical, affinity chromatography technology	Huttlin EL (2015), Wan C (2015), Huttlin EL (2017)	3
GTF2H2	0	CCNH	3	affinity chromatography technology	Vermeulen W (2000)	1
GTF2H3	2	ERCC2	4	pull down	Chymkowitch P (2011)	1