PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
TRIM25	5	LRP8	4	affinity chromatography technology	Choudhury NR (2017)	1
LRPAP1	2	RAF1	3	two hybrid	Li W (2000)	1
LRPAP1	2	VLDLR	3	pull down, pull down, affinity chromatography technology	Andersen OM (2003), Hiesberger T (1999), Huttlin EL (2017)	3
TCTN3	2	LRPAP1	2	bioid	Gupta GD (2015)	1
LCOR	4	LRP1	25	affinity chromatography technology	Huttlin EL (2017)	1
MTOR	14	EIF4EBP1	1	pull down, affinity chromatography technology, pull down, pull down, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study	Schalm SS (2003), Kim DH (2002), Long X (2005), Hara K (2002), Takahashi T (2000), Burnett PE (1998), Hara K (2002), Wang L (2006), Wang X (2005), Oshiro N (2004), Wang L (2006), McMahon LP (2005), Dunlop EA (2011), Eguchi S (2006), Lee DF (2007), Wang X (2005), Carriere A (2008), Choi KM (2003), Nojima H (2003), Smith EM (2008), Bai X (2007), Thedieck K (2007), Choo AY (2008), Evdokimova V (2006), Koren I (2010), Sancak Y (2007), Rui YN (2015)	27
TCTN3	2	TCTN1	2	affinity chromatography technology	Boldt K (2016)	1
LRPAP1	2	POLA2	2	two hybrid	Stelzl U (2005)	1
ETV7	2	LRPAP1	2	two hybrid	Wang J (2011)	1
SORT1	1	LRPAP1	2	pull down	Petersen CM (1997)	1
TCTN1	2	LRPAP1	2	bioid	Gupta GD (2015)	1
LRPAP1	2	EIF4EBP1	1	affinity chromatography technology	Wang L (2006)	1
TRIM25	5	EIF4EBP1	1	affinity chromatography technology	Choudhury NR (2017)	1
LRPAP1	2	RALGDS	4	two hybrid	Li W (2000)	1
TRIM25	5	RAF1	3	affinity chromatography technology	Choudhury NR (2017)	1
LRP1	25	LRPAP1	2	pull down, affinity chromatography technology	Williams SE (1992), Huttlin EL (2017)	2
TRIM25	5	MTOR	14	affinity chromatography technology	Choudhury NR (2017)	1
LDLR	4	LRPAP1	2	pull down, affinity chromatography technology	Medh JD (1995), Huttlin EL (2017)	2
TRIM25	5	LRP1B	22	affinity chromatography technology	Choudhury NR (2017)	1
LRP2	13	LRPAP1	2	pull down, pull down, affinity chromatography technology	Lou X (2002), Orlando RA (1994), Huttlin EL (2017)	3
LRPAP1	2	ROCK2	2	affinity chromatography technology	Huttlin EL (2017)	1
TRIM25	5	RALGDS	4	affinity chromatography technology	Choudhury NR (2017)	1
LRPAP1	2	SORL1	9	biochemical, pull down, affinity chromatography technology	Jacobsen L (1996), Taira K (2001), Huttlin EL (2017)	3
LCOR	4	LRPAP1	2	affinity chromatography technology	Huttlin EL (2017)	1
RANBP2	9	LRPAP1	2	two hybrid	Bandyopadhyay S (2010)	1
TRIM25	5	RTN4	4	affinity chromatography technology	Choudhury NR (2017)	1
LRPAP1	2	RTN4	4	two hybrid	Stelzl U (2005)	1
LRPAP1	2	MTOR	14	affinity chromatography technology	Wang L (2006)	1
TRIM25	5	LRPAP1	2	affinity chromatography technology	Choudhury NR (2017)	1
LRPAP1	2	LRP4	10	affinity chromatography technology	Huttlin EL (2017)	1
LRPAP1	2	LRP1B	22	affinity chromatography technology	Huttlin EL (2017)	1
LRPAP1	2	LRP8	4	pull down, pull down, affinity chromatography technology	Andersen OM (2003), Sun XM (1999), Huttlin EL (2017)	3