Gene Name	Entrez ID	Drug Name	Chembl ID	Interaction Types	Sources	publications
LPA	4018	AMINOCAPROIC ACID	CHEMBL1046	other	DrugBank	15287725, 17139284, 17016423

Gene Name	Variant	Alleles	Chemical	Phenotype Category	Significance	Notes	Sentence	Publications	Annotation ID
LPA	rs10455872	G	hmg coa reductase inhibitors	efficacy	yes	Carriers of this variant respond to statins with a 5.9% smaller LDL-C lowering per minor allele compared with non-carriers.	Allele G is associated with decreased response to hmg coa reductase inhibitors as compared to allele A.	25350695	1184997420
LPA	rs10455872	AG + GG	rosuvastatin	efficacy	yes	The minor allele of this SNP is associated with decreased LDL-C reduction on rosuvastatin. The mean per allele effect was 6.2 mg/dL, corresponding to observed median LDL-C reductions of -55, -48, and -46 mg/dL for individuals with 0, 1, or 2 copies of the minor allele, respectively.	Genotypes AG + GG are associated with decreased response to rosuvastatin as compared to genotype AA.	22331829	1447951965
LPA	rs10455872	G	hmg coa reductase inhibitors	efficacy	yes	as part of a three SNP genetic risk score with rs2231142 in ABCG2 and rs2075650 in APOE. Associated allele not explicitly stated but methods reference Chasman et al., so used the associated allele from there [PMID:22331829].	Allele G is associated with decreased response to hmg coa reductase inhibitors as compared to allele A.	27045730	1447986186