PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
YWHAZ	1	APP	1	pull down	Olah J (2011)	1
LIMK1	3	NRG1	1	two hybrid, pull down, affinity chromatography technology	Wang JY (1998), Wang JY (1998), Wang JY (1998)	3
ARRB1	2	MAPK14	0	affinity chromatography technology	McLaughlin NJ (2006)	1
MAPK14	0	MBP	0	enzymatic study, enzymatic study, enzymatic study, enzymatic study	Sudo T (2000), Plun-Favreau H (2007), Ge B (2003), Chen G (2000)	4
ARRB2	5	LIMK1	3	pull down, affinity chromatography technology	Zoudilova M (2007), Zoudilova M (2007)	2
LIMK1	3	LIMK2	0	affinity chromatography technology, enzymatic study	Hiraoka J (1996), Smolich B (1997)	2
PAK4	3	APP	1	pull down	Olah J (2011)	1
FBXO7	1	LIMK1	3	enzymatic study	Teixeira FR (2016)	1
LIMK2	0	HIST1H1A	0	enzymatic study	Okano I (1995)	1
LIMK1	3	HIST1H1A	0	enzymatic study	Okano I (1995)	1
MAPK14	0	LIMK1	3	enzymatic study	Kobayashi M (2006)	1
ELAVL1	0	LAMTOR1	0	affinity chromatography technology	Abdelmohsen K (2009)	1
UXT	0	APP	1	pull down	Olah J (2011)	1
LATS1	3	APP	1	pull down	Olah J (2011)	1
LIMK2	0	MBP	0	enzymatic study	Okano I (1995)	1
PRKN	1	FBXO7	1	affinity chromatography technology, pull down, pull down	Burchell VS (2013), Burchell VS (2013), Burchell VS (2013)	3
BRAF	12	BAD	1	enzymatic study	Polzien L (2009)	1
LIMK1	3	LIMK1	3	affinity chromatography technology, pull down	Hiraoka J (1996), Hiraoka J (1996)	2
HSP90AA1	7	BRAF	12	affinity chromatography technology, affinity chromatography technology	Taipale M (2012), Eisenhardt AE (2016)	2
HSP90AA1	7	APP	1	affinity chromatography technology	Kumar P (2007)	1
ARRB1	2	HSP90AA1	7	affinity chromatography technology	Xiao K (2007)	1
ARRB2	5	CFL1	0	affinity chromatography technology, affinity chromatography technology	Xiao K (2007), Zoudilova M (2007)	2
SRPK1	2	MAPK14	0	enzymatic study	Varjosalo M (2013)	1
ELAVL1	0	LIMK1	3	affinity chromatography technology	Abdelmohsen K (2009)	1
PAK1	2	HSP90AA1	7	two hybrid	Bandyopadhyay S (2010)	1
LIMK1	3	RAD54L	2	affinity chromatography technology	Hein MY (2015)	1
MAPK14	0	PAK1	2	affinity chromatography technology	Chan PM (2008)	1
LIMK1	3	BMPR2	1	two hybrid, affinity chromatography technology	Foletta VC (2003), Foletta VC (2003)	2
CDKN1C	0	LIMK1	3	two hybrid, affinity chromatography technology, affinity chromatography technology	Yokoo T (2003), Yokoo T (2003), Yokoo T (2003)	3
YWHAZ	1	MAPKAPK2	1	pull down, pull down, enzymatic study	Powell DW (2003), Powell DW (2003), Powell DW (2003)	3
FBXO7	1	HSP90AA1	7	affinity chromatography technology	Teixeira FR (2016)	1
LIMK1	3	LAMTOR1	0	affinity chromatography technology	Hein MY (2015)	1
PAK1	2	APP	1	pull down	Olah J (2011)	1
HSPA4	3	LIMK1	3	affinity chromatography technology	Lim MK (2007)	1
APP	1	CFL1	0	two hybrid	Soler-Lopez M (2011)	1
ARRB1	2	CFL1	0	affinity chromatography technology, affinity chromatography technology	Xiao K (2007), Zoudilova M (2007)	2
HSP90AA1	7	HSPA4	3	affinity chromatography technology, biochemical, affinity chromatography technology, biochemical	Kim TS (2006), Hidalgo-de-Quintana J (2008), Skarra DV (2011), Wan C (2015)	4
PRKN	1	HSP90AA1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Imai Y (2003), Taipale M (2012), Zanon A (2013)	3
FYN	1	HSP90AA1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Loewenberg M (2006), Taipale M (2012), Taipale M (2012), Huttlin EL (2017)	4
KIF23	0	LIMK1	3	affinity chromatography technology, affinity chromatography technology	Okamoto A (2015), Okamoto A (2015)	2
ARRB2	5	HIST1H1A	0	affinity chromatography technology	Xiao K (2007)	1
ELAVL1	0	MAPKAPK2	1	affinity chromatography technology	Abdelmohsen K (2009)	1
PAK1	2	BAD	1	enzymatic study, enzymatic study, enzymatic study, enzymatic study	Jin S (2005), Polzien L (2009), Yuan ZQ (2005), Schuermann A (2000)	4
MAPKAPK2	1	LIMK1	3	enzymatic study	Kobayashi M (2006)	1
LIMK1	3	ITGA1	1	affinity chromatography technology	Hein MY (2015)	1
LIMK1	3	POLR2D	0	affinity chromatography technology	Hein MY (2015)	1
ELAVL1	0	SRPK1	2	affinity chromatography technology	Abdelmohsen K (2009)	1
ARRB2	5	ARRB1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ewing RM (2007), Xiao K (2007), Xiao K (2007), Huttlin EL (2017)	4
PAK1	2	YWHAZ	1	two hybrid	Bandyopadhyay S (2010)	1
HSP90AA1	7	SRPK1	2	affinity chromatography technology	Taipale M (2012)	1
YWHAZ	1	BRAF	12	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe	Ewing RM (2007), Jin J (2004), Gloeckner CJ (2007), Hein MY (2015), Huttlin EL (2017), Eisenhardt AE (2016), Ivanov AA (2017)	7
SRPK1	2	LIMK1	3	enzymatic study	Varjosalo M (2013)	1
BRAF	12	HSPA4	3	affinity chromatography technology	Eisenhardt AE (2016)	1
LIMK1	3	FYN	1	affinity chromatography technology	Hein MY (2015)	1
YWHAZ	1	BAD	1	pull down, two hybrid, two hybrid, affinity chromatography technology, pull down, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Yang H (2001), Yang H (2001), Bandyopadhyay S (2010), Liang X (2010), Subramanian RR (2001), Polzien L (2009), Wang J (2011), Jin L (2009), Mortenson JB (2015), Dong S (2007)	10
LIMK1	3	RRAS	2	affinity chromatography technology	Hein MY (2015)	1
SRPK1	2	PAK4	3	enzymatic study	Varjosalo M (2013)	1
LIMK1	3	CFL1	0	enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study	Foletta VC (2003), Maekawa M (1999), Yang X (2004), Talukder AH (2006), Zoudilova M (2007)	5
LIMK1	3	UXT	0	affinity chromatography technology	Hein MY (2015)	1
PRKN	1	APP	1	affinity chromatography technology, imaging technique	Rosen KM (2010), Lonskaya I (2012)	2
PAK1	2	LIMK1	3	affinity chromatography technology, pull down	Edwards DC (1999), Edwards DC (1999)	2
LIMK1	3	OSBPL5	5	affinity chromatography technology	Hein MY (2015)	1
LIMK1	3	PRKN	1	affinity chromatography technology, affinity chromatography technology	Lim MK (2007), Lim MK (2007)	2
CFL1	0	LIMK2	0	affinity chromatography technology	Maekawa M (1999)	1
LIMK1	3	TADA3	0	affinity chromatography technology	Hein MY (2015)	1
LIMK1	3	PAK4	3	pull down, enzymatic study	Dan C (2001), Dan C (2001)	2
HSPA4	3	APP	1	affinity chromatography technology	Kumar P (2007)	1
LIMK1	3	BLMH	0	affinity chromatography technology	Hein MY (2015)	1
BRAF	12	LIMK1	3	affinity chromatography technology	Gloeckner CJ (2007)	1
MAPKAPK2	1	MAPK14	0	affinity chromatography technology, protein complementation assay, two hybrid, affinity chromatography technology, pull down, x-ray crystallography, x-ray crystallography, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, pull down, affinity chromatography technology	Rane MJ (2001), Srivastav RK (2011), Wang J (2011), Varjosalo M (2013), Rane MJ (2001), White A (2007), ter Haar E (2007), Varjosalo M (2013), Gum RJ (1999), Gum RJ (1999), So J (2015), Huttlin EL (2015), Hein MY (2015), Chen TC (2014), Smith JA (2000), Huttlin EL (2017)	16
ARRB2	5	PRKN	1	affinity chromatography technology, pull down	Ahmed MR (2011), Ahmed MR (2011)	2
ARRB1	2	YWHAZ	1	affinity chromatography technology	Xiao K (2007)	1
FBXO7	1	LIMK2	0	enzymatic study	Teixeira FR (2016)	1
HSP90AA1	7	LIMK2	0	affinity chromatography technology, affinity chromatography technology	Taipale M (2012), Taipale M (2012)	2
LIMK1	3	MIIP	1	affinity chromatography technology	Hein MY (2015)	1
PAK4	3	HIST1H1A	0	enzymatic study	Dart AE (2015)	1
HSPA4	3	PRKN	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Moore DJ (2008), Hampe C (2006), Tsai YC (2003), Morishima Y (2008), Kalia SK (2004), Kalia SK (2004), Imai Y (2003), Imai Y (2003)	8
YWHAZ	1	LIMK1	3	two hybrid, pull down	Birkenfeld J (2003), Birkenfeld J (2003)	2
ARRB1	2	PRKN	1	affinity chromatography technology, affinity chromatography technology, pull down	Ahmed MR (2011), Ahmed MR (2011), Ahmed MR (2011)	3
FBXO7	1	UXT	0	enzymatic study	Teixeira FR (2016)	1
LIMK1	3	ERBIN	5	affinity chromatography technology	Hein MY (2015)	1
YWHAZ	1	KIF23	0	affinity chromatography technology	Brajenovic M (2004)	1
OSBPL5	5	APP	1	pull down	Olah J (2011)	1
LIMK1	3	SARNP	0	affinity chromatography technology	Hein MY (2015)	1
BLMH	0	APP	1	pull down, biochemical	Lefterov IM (2000), Lefterov IM (2000)	2
LIMK1	3	RTEL1	9	affinity chromatography technology	Hein MY (2015)	1
LIMK1	3	APP	1	pull down	Olah J (2011)	1
LIMK1	3	LATS1	3	affinity chromatography technology, affinity chromatography technology	Yang X (2004), Yang X (2004)	2
SRPK1	2	APP	1	pull down	Olah J (2011)	1
LIMK1	3	BAD	1	affinity chromatography technology	Hein MY (2015)	1
ARRB1	2	LIMK1	3	pull down, affinity chromatography technology	Zoudilova M (2007), Zoudilova M (2007)	2
HSP90AA1	7	LIMK1	3	affinity chromatography technology	Taipale M (2012)	1
ELAVL1	0	POLR2D	0	affinity chromatography technology	Abdelmohsen K (2009)	1
FBXO7	1	CFL1	0	affinity chromatography technology	Teixeira FR (2016)	1
LIMK1	3	MBP	0	enzymatic study	Okano I (1995)	1
LIMK1	3	SH3PXD2B	7	affinity chromatography technology	Hein MY (2015)	1
YWHAZ	1	PAK4	3	affinity chromatography technology, affinity chromatography technology	Ewing RM (2007), Jin J (2004)	2
PRKN	1	ELAVL1	0	affinity chromatography technology	Zanon A (2013)	1