PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
NPM1	0	ARHGAP5	3	affinity chromatography technology	Chen R (2013)	1
IQCF1	0	ARHGAP5	3	affinity chromatography technology	Huttlin EL (2017)	1
SMURF2	3	SMURF1	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Fukunaga E (2008), Fukunaga E (2008), Lee YS (2011), Huttlin EL (2017)	4
XRCC6	3	ARHGAP5	3	biochemical	Havugimana PC (2012)	1
ARHGAP5	3	RND3	0	two hybrid, affinity chromatography technology, pull down	Wennerberg K (2003), Wennerberg K (2003), Wennerberg K (2003)	3
UNK	3	ARHGAP5	3	affinity chromatography technology	Murn J (2015)	1
SMURF1	4	ARHGAP5	3	affinity chromatography technology	Xie Y (2013)	1
SMURF1	4	XRCC6	3	affinity chromatography technology	Xie Y (2013)	1
RHOA	0	ARHGAP5	3	affinity chromatography technology, pull down	Wennerberg K (2003), Wennerberg K (2003)	2
RHOA	0	SMURF1	4	pull down, enzymatic study, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Asanuma K (2006), Tian M (2011), Tian M (2011), Tian M (2011), Lee MG (2016), He S (2017)	6
CDH1	4	PXN	1	bioid	Guo Z (2014)	1
ARHGAP5	3	RND2	0	two hybrid, affinity chromatography technology, pull down	Wennerberg K (2003), Wennerberg K (2003), Wennerberg K (2003)	3
PTPRU	7	ARHGAP5	3	bioid	St-Denis N (2016)	1
SMURF2	3	RHOA	0	pull down, enzymatic study, enzymatic study	Ogunjimi AA (2010), Lu K (2011), Wiesner S (2007)	3
ARHGAP5	3	PXN	1	affinity chromatography technology	Shikata Y (1999)	1
ADRB2	0	ARHGAP5	3	protein complementation assay, affinity chromatography technology	Kittanakom S (2014), Kittanakom S (2014)	2
ARHGAP5	3	RND1	0	two hybrid, affinity chromatography technology, pull down	Wennerberg K (2003), Wennerberg K (2003), Wennerberg K (2003)	3
SMURF2	3	ARHGAP5	3	two hybrid, affinity chromatography technology	Colland F (2004), Huttlin EL (2017)	2
PLK1	0	ARHGAP5	3	affinity chromatography technology	Huttlin EL (2017)	1
CDH1	4	ARHGAP5	3	bioid	Guo Z (2014)	1