PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
ATXN3	2	RHOG	4	affinity chromatography technology	Kristensen LV (2018)	1
RHOG	4	ELMOD2	0	pull down, affinity chromatography technology	Katoh H (2003), Katoh H (2003)	2
ARHGDIA	3	RHOG	4	two hybrid	Faure J (2001)	1
FBXO6	0	RHOG	4	affinity chromatography technology	Liu B (2012)	1
RAB7A	0	KTN1	1	affinity chromatography technology	Hein MY (2015)	1
TRIM25	5	RAB7A	0	affinity chromatography technology	Choudhury NR (2017)	1
RHOG	4	KTN1	1	two hybrid, pull down, two hybrid, affinity chromatography technology	Neudauer CL (2001), Vignal E (2001), Vignal E (2001), Vignal E (2001)	4
TRIM25	5	RHOG	4	affinity chromatography technology	Choudhury NR (2017)	1
ATP6AP2	2	KTN1	1	affinity chromatography technology	Hein MY (2015)	1
ATXN3	2	ARHGDIA	3	two hybrid	Shen L (2005)	1
RHOG	4	VAV3	4	pull down	Movilla N (1999)	1
RAB7A	0	RHOG	4	affinity chromatography technology	Hein MY (2015)	1
ATP6AP2	2	RHOG	4	affinity chromatography technology	Hein MY (2015)	1
RHOG	4	MAP3K11	7	pull down	Wennerberg K (2002)	1
ATP6AP2	2	RAB7A	0	affinity chromatography technology	Hein MY (2015)	1
TRIM25	5	TRIO	31	affinity chromatography technology	Choudhury NR (2017)	1
RHOG	4	DOCK1	14	affinity chromatography technology	Katoh H (2003)	1
ELMO1	2	RHOG	4	two hybrid	Patel M (2011)	1
RHOG	4	IQGAP2	6	pull down	Wennerberg K (2002)	1
ELMO1	2	DOCK1	14	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology	Gumienny TL (2001), Brugnera E (2002), Makino Y (2006), Yang C (2011), Huttlin EL (2015), Patel M (2011), Lee J (2016), Huttlin EL (2017)	8
ARHGDIG	1	RHOG	4	two hybrid	Zalcman G (1996)	1
TRIO	31	RHOG	4	affinity chromatography technology	van Haren J (2014)	1
NT5E	1	RHOG	4	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
TRIM25	5	KTN1	1	affinity chromatography technology	Choudhury NR (2017)	1