PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
RND3	0	RBPJ	1	affinity chromatography technology, affinity chromatography technology	Liu B (2015), Liu B (2015)	2
ARHGAP5	3	RND3	0	two hybrid, affinity chromatography technology, pull down	Wennerberg K (2003), Wennerberg K (2003), Wennerberg K (2003)	3
RND3	0	ROCK1	6	pull down	Riento K (2003)	1
RND3	0	CIT	14	two hybrid	Riento K (2003)	1
RND3	0	RGS14	2	affinity chromatography technology	Goh LL (2012)	1
RND3	0	UBXN11	1	two hybrid, pull down, pull down	Katoh H (2002), Katoh H (2002), Katoh H (2002)	3
FBXW7	2	RND3	0	affinity chromatography technology	Liu B (2015)	1
RND3	0	NOTCH1	25	affinity chromatography technology, affinity chromatography technology	Liu B (2015), Liu B (2015)	2
PLXNB1	12	RND3	0	pull down, affinity chromatography technology	Oinuma I (2003), Goh LL (2012)	2
NOTCH1	25	RBPJ	1	pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Nam Y (2003), Aster JC (1997), Aster JC (1997), Gao J (2010), Gao J (2010), Kim MY (2007), Kim MY (2007), Popko-Scibor AE (2011), Mo JS (2007), Kim MY (2011), Kim MY (2011), Yatim A (2012), Yatim A (2012), Choi YH (2013), Jeffries S (2002), Jeffries S (2002), Jeffries S (2002), Kitagawa M (2001), Cho S (2011), Baek HJ (2015), Baek HJ (2015), Huttlin EL (2015), Hein MY (2015), Li X (2015), Huttlin EL (2017), Tremblay CS (2009), Tremblay CS (2009)	27
RND3	0	MAML1	5	affinity chromatography technology, affinity chromatography technology	Liu B (2015), Liu B (2015)	2
MAML1	5	RBPJ	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Yatim A (2012), Jeffries S (2002), Huttlin EL (2015), Hein MY (2015), Li X (2015), Huttlin EL (2017)	6
RND3	0	SKP2	2	affinity chromatography technology, pull down, enzymatic study	Lonjedo M (2013), Lonjedo M (2013), Lonjedo M (2013)	3
NOTCH1	25	FBXW7	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, enzymatic study, protein complementation assay	Gupta-Rossi N (2001), Thompson BJ (2007), Thompson BJ (2007), ONeil J (2007), ONeil J (2007), Busino L (2012), Mo JS (2007), Kim MY (2011), Yatim A (2012), Yumimoto K (2013), Baek HJ (2015), Liu B (2015), Yeh CH (2016), Ahn JS (2016), Ahn JS (2016), Zhao J (2017), Zhao J (2017), Zhao J (2017), Daakour S (2016)	19
RND3	0	PLEKHG5	5	affinity chromatography technology	Goh LL (2012)	1
SFN	1	RND3	0	affinity chromatography technology	Benzinger A (2005)	1
MAML1	5	NOTCH1	25	pull down, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Wu L (2000), Wu L (2000), Wu L (2002), Popko-Scibor AE (2011), Popko-Scibor AE (2011), Kim MY (2011), Yatim A (2012), Yatim A (2012), Yatim A (2012), Jeffries S (2002), Kitagawa M (2001)	11
NOTCH1	25	ROCK1	6	affinity chromatography technology	Yatim A (2012)	1
RND3	0	ARHGAP35	12	affinity chromatography technology	Goh LL (2012)	1