PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
XPO1	8	BLOC1S5	1	affinity chromatography technology	Kirli K (2015)	1
BLOC1S6	0	SNAPIN	1	biochemical, affinity chromatography technology	Starcevic M (2004), Starcevic M (2004)	2
BLOC1S2	0	BLOC1S1	0	affinity chromatography technology, two hybrid	Starcevic M (2004), Starcevic M (2004)	2
BLOC1S6	0	BLOC1S5	1	affinity chromatography technology, affinity chromatography technology	Starcevic M (2004), Falcon-Perez JM (2002)	2
XPO1	8	BLOC1S3	0	affinity chromatography technology	Kirli K (2015)	1
DNALI1	0	BLOC1S3	0	affinity chromatography technology	Boldt K (2016)	1
BCAS4	0	SNAPIN	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
BLOC1S3	0	BLOC1S5	1	affinity chromatography technology	Starcevic M (2004)	1
BLOC1S2	0	BLOC1S5	1	affinity chromatography technology, two hybrid	Starcevic M (2004), Starcevic M (2004)	2
BLOC1S6	0	BLOC1S1	0	biochemical, two hybrid, two hybrid, affinity chromatography technology	Starcevic M (2004), Starcevic M (2004), Starcevic M (2004), Starcevic M (2004)	4
BCAS4	0	BLOC1S6	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
DTNBP1	1	BLOC1S5	1	affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology	Starcevic M (2004), Starcevic M (2004), Huttlin EL (2015), Huttlin EL (2017)	4
DTNBP1	1	BLOC1S3	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Starcevic M (2004), Huttlin EL (2015), Huttlin EL (2017)	3
SNAPIN	1	BLOC1S1	0	two hybrid, two hybrid	Starcevic M (2004), Starcevic M (2004)	2
DTNBP1	1	BCAS4	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
BCAS4	0	BLOC1S3	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
TRIM25	5	XPO1	8	affinity chromatography technology	Choudhury NR (2017)	1
BLOC1S2	0	SNAPIN	1	affinity chromatography technology, two hybrid, two hybrid, biochemical	Starcevic M (2004), Starcevic M (2004), Starcevic M (2004), Wan C (2015)	4
XPO1	8	DTNBP1	1	affinity chromatography technology	Kirli K (2015)	1
BCAS4	0	BLOC1S2	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
TRIM25	5	BLOC1S3	0	affinity chromatography technology	Choudhury NR (2017)	1
BCAS4	0	BLOC1S1	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
BCAS4	0	BLOC1S5	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
BLOC1S6	0	DTNBP1	1	biochemical, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology	Starcevic M (2004), Starcevic M (2004), Starcevic M (2004), Huttlin EL (2015), Huttlin EL (2017)	5
DTNBP1	1	SNAPIN	1	affinity chromatography technology, two hybrid, affinity chromatography technology, biochemical, affinity chromatography technology	Starcevic M (2004), Starcevic M (2004), Huttlin EL (2015), Wan C (2015), Huttlin EL (2017)	5
BLOC1S6	0	BLOC1S2	0	biochemical, affinity chromatography technology, affinity chromatography technology	Starcevic M (2004), Starcevic M (2004), Starcevic M (2004)	3
TRIM25	5	BLOC1S6	0	affinity chromatography technology	Choudhury NR (2017)	1
MBLAC2	1	BLOC1S3	0	affinity chromatography technology	Huttlin EL (2017)	1
BLOC1S6	0	BLOC1S3	0	biochemical, affinity chromatography technology, affinity chromatography technology	Starcevic M (2004), Starcevic M (2004), Starcevic M (2004)	3
BLOC1S3	0	SNAPIN	1	affinity chromatography technology	Starcevic M (2004)	1
BLOC1S3	0	BLOC1S1	0	affinity chromatography technology	Starcevic M (2004)	1
DTNBP1	1	BLOC1S1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Starcevic M (2004), Huttlin EL (2015), Huttlin EL (2017)	3
DTNBP1	1	BLOC1S2	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Starcevic M (2004), Huttlin EL (2015), Huttlin EL (2017)	3
BLOC1S2	0	BLOC1S3	0	affinity chromatography technology, affinity chromatography technology, two hybrid	Starcevic M (2004), Starcevic M (2004), Starcevic M (2004)	3