PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
RBPMS	0	FAM103A1	0	two hybrid	Rual JF (2005)	1
TRIP6	2	INCA1	1	two hybrid	Rolland T (2014)	1
CDK2	0	INCA1	1	enzymatic study	Diederichs S (2004)	1
CCNA1	3	CDK2	0	affinity chromatography technology, two hybrid, affinity chromatography technology, pull down, x-ray crystallography, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, biochemical, x-ray crystallography, affinity chromatography technology, pull down, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, imaging technique	Sweeney C (1996), Yang R (1997), Yang R (1997), Mueller-Tidow C (2001), Brown NR (1999), Niida H (2005), Yam CH (2000), Wang H (2009), Narayanan R (2005), Harwell RM (2004), Shen WH (2004), He W (2003), Peiretti A (2003), Peiretti A (2003), Pan ZQ (1993), Kim KS (2002), Lyapina SA (1998), Desai D (1995), Thomas DM (2004), Johnson LN (2002), Rohaly G (2005), Chen TC (2014)	22
UBXN2B	2	INCA1	1	two hybrid	Rolland T (2014)	1
PTGER3	2	INCA1	1	two hybrid	Rolland T (2014)	1
PATE1	0	INCA1	1	two hybrid	Rolland T (2014)	1
FMR1	1	INCA1	1	two hybrid	Corominas R (2014)	1
EPHB6	4	INCA1	1	two hybrid	Rolland T (2014)	1
CDKN2D	0	INCA1	1	two hybrid	Rolland T (2014)	1
STAMBPL1	2	INCA1	1	two hybrid	Rolland T (2014)	1
SAP18	1	INCA1	1	two hybrid	Rolland T (2014)	1
CDK2	0	SAP18	1	affinity chromatography technology	Neganova I (2011)	1
FHL2	0	INCA1	1	two hybrid	Rolland T (2014)	1
CCNA1	3	INCA1	1	two hybrid, affinity chromatography technology, pull down, pull down	Diederichs S (2004), Diederichs S (2004), Diederichs S (2004), Diederichs S (2004)	4
SCNM1	0	INCA1	1	two hybrid	Rolland T (2014)	1
GRB2	2	INCA1	1	two hybrid	Rolland T (2014)	1
VPS28	2	INCA1	1	two hybrid	Rolland T (2014)	1
SPG21	0	INCA1	1	two hybrid	Rolland T (2014)	1
SEC14L4	0	INCA1	1	two hybrid	Rolland T (2014)	1
COL8A1	3	INCA1	1	two hybrid	Rolland T (2014)	1
CTNNBIP1	1	INCA1	1	two hybrid	Rolland T (2014)	1
RBPMS	0	DMRT3	2	two hybrid	Rolland T (2014)	1
HAUS1	0	INCA1	1	two hybrid	Rolland T (2014)	1
CDC23	3	RBPMS	0	two hybrid, two hybrid	Rual JF (2005), Rolland T (2014)	2
STK16	1	INCA1	1	two hybrid	Rolland T (2014)	1
CDC23	3	INCA1	1	two hybrid	Rolland T (2014)	1
OSGIN1	1	INCA1	1	two hybrid	Rolland T (2014)	1
FAM103A1	0	INCA1	1	two hybrid	Rolland T (2014)	1
81854	0	INCA1	1	two hybrid	Rolland T (2014)	1
UBE2D4	0	INCA1	1	two hybrid	Rolland T (2014)	1
DMRT3	2	INCA1	1	two hybrid	Rolland T (2014)	1
GRB2	2	VPS28	2	affinity chromatography technology	Huttlin EL (2017)	1
NEK6	2	INCA1	1	two hybrid	Rolland T (2014)	1
TRIP6	2	STK16	1	two hybrid	Rolland T (2014)	1
ZMYND19	1	INCA1	1	two hybrid	Rolland T (2014)	1
CABP5	1	INCA1	1	two hybrid	Rolland T (2014)	1
RBPMS	0	INCA1	1	two hybrid	Rolland T (2014)	1
ARMC7	1	INCA1	1	two hybrid	Rolland T (2014)	1
CHCHD2	0	INCA1	1	two hybrid	Rolland T (2014)	1
TRIP6	2	DMRT3	2	two hybrid	Rolland T (2014)	1