PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
CRK	0	KRT2	0	affinity chromatography technology	Brehme M (2009)	1
EIF4E2	2	CARD9	3	two hybrid	Rolland T (2014)	1
GRB2	2	KRT15	2	affinity chromatography technology	Brehme M (2009)	1
KRT15	2	HGS	5	two hybrid	Rolland T (2014)	1
KRT15	2	EXOC8	1	two hybrid	Rual JF (2005)	1
EIF4E2	2	PLEKHA5	2	affinity chromatography technology	Boldt K (2016)	1
ITGA4	4	EED	1	two hybrid	Rietzler M (1998)	1
USP32	0	KRT19	0	affinity chromatography technology	Sowa ME (2009)	1
USHBP1	1	EXOC8	1	two hybrid, affinity chromatography technology	Rual JF (2005), Rual JF (2005)	2
KRT19	0	DEPP1	0	two hybrid	Rual JF (2005)	1
UBE2A	0	KRT19	0	affinity chromatography technology	An H (2017)	1
PLEKHA5	2	KRT19	0	two hybrid	Bandyopadhyay S (2010)	1
KRT15	2	USHBP1	1	two hybrid	Rual JF (2005)	1
VCAM1	2	GRB2	2	affinity chromatography technology	Humphries JD (2009)	1
PCM1	5	ABI2	4	two hybrid	Rual JF (2005)	1
GRB2	2	KRT2	0	affinity chromatography technology	Brehme M (2009)	1
PCM1	5	EXOC8	1	two hybrid	Rual JF (2005)	1
KRT15	2	AMOTL2	5	two hybrid, two hybrid	Rual JF (2005), Rolland T (2014)	2
KIFC3	3	ABI2	4	two hybrid	Rolland T (2014)	1
MAGOH	0	KRT2	0	affinity chromatography technology	Singh G (2012)	1
UCHL5	1	KRT6B	1	affinity chromatography technology	Fang Y (2011)	1
EXOC8	1	CEP57L1	3	two hybrid	Rolland T (2014)	1
KRT15	2	DGCR6L	0	two hybrid	Rual JF (2005)	1
KRT19	0	KDM1A	2	two hybrid	Weimann M (2013)	1
KRT19	0	EIF4E2	2	two hybrid	Rolland T (2014)	1
BAG3	4	MCM5	1	affinity chromatography technology	Chen Y (2013)	1
KRT15	2	KRT19	0	two hybrid	Rual JF (2005)	1
ZNF638	8	PLEKHA5	2	affinity chromatography technology	Boldt K (2016)	1
FAM124B	2	USHBP1	1	two hybrid	Rolland T (2014)	1
KRT19	0	HAUS1	0	two hybrid	Rolland T (2014)	1
EIF4E2	2	EIF4ENIF1	1	two hybrid, affinity chromatography technology, two hybrid, affinity chromatography technology	Rual JF (2005), Morita M (2012), Venkatesan K (2009), Huttlin EL (2017)	4
MCM5	1	KRT19	0	affinity chromatography technology	Drissi R (2015)	1
ITGA4	4	GRB2	2	affinity chromatography technology	Byron A (2012)	1
EIF4E2	2	USHBP1	1	two hybrid	Rolland T (2014)	1
KRT2	0	KRT19	0	two hybrid	Rolland T (2014)	1
IKZF3	1	C1orf109	1	two hybrid	Rolland T (2014)	1
MCM5	1	KRT2	0	affinity chromatography technology	Drissi R (2015)	1
VCAM1	2	EIF4A3	1	affinity chromatography technology	Humphries JD (2009)	1
CCDC146	3	USHBP1	1	two hybrid	Rolland T (2014)	1
KRT15	2	PPP1R18	2	two hybrid	Rolland T (2014)	1
SMARCB1	1	KRT6B	1	two hybrid	Daakour S (2016)	1
KRT19	0	PPP1R18	2	two hybrid	Rolland T (2014)	1
CARD9	3	FAM124B	2	two hybrid	Rolland T (2014)	1
KRT19	0	CARD9	3	two hybrid	Rolland T (2014)	1
APC	5	KRT19	0	two hybrid	Bandyopadhyay S (2010)	1
EIF4A3	1	KRT19	0	affinity chromatography technology	Singh G (2012)	1
HGS	5	CEP57L1	3	two hybrid	Rolland T (2014)	1
KRT15	2	HAUS1	0	two hybrid	Rolland T (2014)	1
GRB2	2	FN1	17	two hybrid, affinity chromatography technology	Wang J (2008), Humphries JD (2009)	2
KIFC3	3	KDM1A	2	two hybrid	Weimann M (2013)	1
HAUS1	0	KDM1A	2	affinity chromatography technology, two hybrid	Weimann M (2013), Weimann M (2013)	2
FN1	17	EIF4A3	1	affinity chromatography technology	Humphries JD (2009)	1
KRT6B	1	KRT15	2	two hybrid, two hybrid	Rual JF (2005), Rolland T (2014)	2
DEPP1	0	USHBP1	1	two hybrid	Rual JF (2005)	1
KRT6B	1	KRT19	0	two hybrid	Rual JF (2005)	1
KIFC3	3	KRT19	0	two hybrid	Rolland T (2014)	1
ESR1	0	EIF4A3	1	pull down	Nalvarte I (2010)	1
EIF4A3	1	KRT6B	1	affinity chromatography technology	Singh G (2012)	1
KRT15	2	FAM107A	0	two hybrid	Rual JF (2005)	1
FN1	17	KRT2	0	affinity chromatography technology	Humphries JD (2009)	1
HAUS1	0	CEP57L1	3	two hybrid	Rolland T (2014)	1
KRT19	0	TFPT	0	two hybrid	Rolland T (2014)	1
PNN	2	KRT19	0	two hybrid, pull down	Shi J (2000), Shi J (2000)	2
FN1	17	POLR1C	2	affinity chromatography technology	Humphries JD (2009)	1
BAG3	4	KRT19	0	affinity chromatography technology	Chen Y (2013)	1
AMOTL2	5	CARD9	3	two hybrid	Rolland T (2014)	1
UCHL5	1	TFPT	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Cai Y (2007), Yao T (2008), Huttlin EL (2015), Huttlin EL (2017)	5
FANCG	3	KRT19	0	two hybrid	Rual JF (2005)	1
APC	5	KRT15	2	two hybrid	Bandyopadhyay S (2010)	1
CRK	0	GRB2	2	pull down, far western blotting, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Riordan SM (2000), Matsuda M (1996), Okada S (1996), Okada S (1996), Garcia-Guzman M (2000), Brehme M (2009)	6
APC	5	SMARCB1	1	genetic interference	Shen JP (2017)	1
UCHL5	1	KDM1A	2	two hybrid	Weimann M (2013)	1
UBE2A	0	EIF4A3	1	affinity chromatography technology	An H (2017)	1
FN1	17	ITGA4	4	affinity chromatography technology	Humphries JD (2009)	1
KRT19	0	TBC1D7	1	two hybrid	Rolland T (2014)	1
FANCG	3	USHBP1	1	two hybrid, two hybrid	Rual JF (2005), Xin X (2009)	2
KIFC3	3	CEP57L1	3	two hybrid	Rolland T (2014)	1
PAN2	3	PCM1	5	affinity chromatography technology	Bett JS (2013)	1
KRT19	0	POLR1C	2	two hybrid	Rolland T (2014)	1
KRT19	0	FAM124B	2	two hybrid	Rolland T (2014)	1
KRT19	0	CCDC146	3	two hybrid	Rolland T (2014)	1
CRK	0	KRT15	2	affinity chromatography technology	Brehme M (2009)	1
KIFC3	3	KRT6B	1	two hybrid	Rolland T (2014)	1
BAG3	4	GRB2	2	affinity chromatography technology, affinity chromatography technology	Chen Y (2013), Chen Y (2013)	2
KRT19	0	DGCR6L	0	two hybrid	Rual JF (2005)	1
CARD9	3	CEP57L1	3	two hybrid	Rolland T (2014)	1
EIF4ENIF1	1	PAN2	3	affinity chromatography technology	Boldt K (2016)	1
POLR1C	2	IKZF3	1	two hybrid	Rolland T (2014)	1
KIFC3	3	HAUS1	0	two hybrid	Rolland T (2014)	1
UBE2I	0	HGS	5	two hybrid	Rual JF (2005)	1
KRT19	0	EIF4ENIF1	1	two hybrid	Rolland T (2014)	1
PCM1	5	HAUS1	0	affinity chromatography technology, bioid	Gupta GD (2015), Gupta GD (2015)	2
MAGOH	0	PNN	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Singh G (2012), Huttlin EL (2015), Huttlin EL (2017)	3
HGS	5	EXOC8	1	two hybrid	Rual JF (2005)	1
POU5F1	0	KRT19	0	affinity chromatography technology	Hawkins PG (2010)	1
KRT15	2	ZNF638	8	two hybrid	Rual JF (2005)	1
IKZF3	1	EXOC8	1	two hybrid	Rolland T (2014)	1
ITGA4	4	KRT19	0	affinity chromatography technology	Byron A (2012)	1
KIFC3	3	C1orf109	1	two hybrid, two hybrid	Rolland T (2014), Yu H (2011)	2
TFPT	0	HAUS1	0	two hybrid	Rolland T (2014)	1
EED	1	ZNF638	8	affinity chromatography technology	Cao Q (2014)	1
USHBP1	1	HAUS1	0	two hybrid	Rolland T (2014)	1
PAN2	3	KRT19	0	affinity chromatography technology	Bett JS (2013)	1
CYLD	2	KRT2	0	affinity chromatography technology	Elliott PR (2016)	1
EIF4E2	2	AMOTL2	5	two hybrid	Rolland T (2014)	1
ESR1	0	UBE2I	0	two hybrid, enzymatic study	Kobayashi S (2004), Sentis S (2005)	2
CYLD	2	MCM5	1	affinity chromatography technology	Elliott PR (2016)	1
KRT19	0	ABI2	4	two hybrid	Rual JF (2005)	1
VCAM1	2	MCM5	1	affinity chromatography technology	Humphries JD (2009)	1
EED	1	KDM1A	2	affinity chromatography technology	Cao Q (2014)	1
HGS	5	ABI2	4	two hybrid	Rolland T (2014)	1
GRB2	2	IKZF3	1	two hybrid	Rolland T (2014)	1
POU5F1	0	KRT2	0	affinity chromatography technology	Hawkins PG (2010)	1
APC	5	HGS	5	two hybrid	Bandyopadhyay S (2010)	1
EED	1	EIF4A3	1	affinity chromatography technology	Cao Q (2014)	1
KRT19	0	HGS	5	two hybrid	Rual JF (2005)	1
VCAM1	2	ITGA4	4	affinity chromatography technology, affinity chromatography technology	Humphries JD (2009), Byron A (2012)	2
FN1	17	MCM5	1	affinity chromatography technology	Humphries JD (2009)	1
SMARCB1	1	IKZF3	1	two hybrid	Daakour S (2016)	1
MAGOH	0	KRT19	0	affinity chromatography technology	Singh G (2012)	1
UBE2I	0	IKZF3	1	two hybrid, two hybrid	Rual JF (2005), Yu H (2011)	2
CRK	0	KRT19	0	affinity chromatography technology	Brehme M (2009)	1
KRT19	0	UBE2I	0	two hybrid	Rolland T (2014)	1
EIF4A3	1	KRT2	0	affinity chromatography technology	Singh G (2012)	1
VCAM1	2	KRT19	0	affinity chromatography technology	Humphries JD (2009)	1
KRT19	0	PCM1	5	two hybrid	Rual JF (2005)	1
FAM107A	0	USHBP1	1	two hybrid, two hybrid	Rual JF (2005), Rolland T (2014)	2
HAUS1	0	EIF4A3	1	affinity chromatography technology	Fogeron ML (2013)	1
EED	1	KRT2	0	affinity chromatography technology	Cao Q (2014)	1
EIF4E2	2	ZNF638	8	affinity chromatography technology	Boldt K (2016)	1
KRT19	0	AMOTL2	5	two hybrid	Rolland T (2014)	1
EIF4A3	1	SMARCB1	1	biochemical	Havugimana PC (2012)	1
GRB2	2	CYLD	2	affinity chromatography technology	Huttlin EL (2017)	1
SMARCB1	1	KRT15	2	two hybrid	Daakour S (2016)	1
KRT15	2	PCM1	5	two hybrid	Rual JF (2005)	1
SMARCB1	1	ABI2	4	two hybrid	Daakour S (2016)	1
EED	1	KRT19	0	affinity chromatography technology	Cao Q (2014)	1
KRT19	0	CEP57L1	3	two hybrid	Rolland T (2014)	1
EIF4A3	1	PNN	2	affinity chromatography technology, affinity chromatography technology	Singh G (2012), Huttlin EL (2017)	2
KRT19	0	IKZF3	1	two hybrid	Rolland T (2014)	1
CYLD	2	KRT19	0	affinity chromatography technology	Elliott PR (2016)	1
ITGA4	4	MCM5	1	affinity chromatography technology	Byron A (2012)	1
KIFC3	3	KRT15	2	two hybrid	Rolland T (2014)	1
KRT19	0	SFI1	3	two hybrid	Rual JF (2005)	1
CARD9	3	PPP1R18	2	two hybrid	Rolland T (2014)	1
FN1	17	KRT19	0	affinity chromatography technology	Humphries JD (2009)	1
ESR1	0	KDM1A	2	affinity chromatography technology, affinity chromatography technology	Garcia-Bassets I (2007), Garcia-Bassets I (2007)	2
PAN2	3	KRT2	0	affinity chromatography technology	Bett JS (2013)	1
KRT19	0	USHBP1	1	two hybrid	Rual JF (2005)	1
KRT15	2	ABI2	4	two hybrid, two hybrid	Rual JF (2005), Rolland T (2014)	2
UCHL5	1	KRT19	0	pull down	Fang Y (2011)	1
KRT15	2	DEPP1	0	two hybrid	Rual JF (2005)	1
PCM1	5	CEP57L1	3	bioid	Gupta GD (2015)	1
VCAM1	2	KRT2	0	affinity chromatography technology	Humphries JD (2009)	1
CYLD	2	KRT6B	1	affinity chromatography technology	Elliott PR (2016)	1
KRT19	0	ZNF638	8	two hybrid	Rual JF (2005)	1
C1orf109	1	USHBP1	1	two hybrid	Rolland T (2014)	1
BAG3	4	CRK	0	affinity chromatography technology, affinity chromatography technology	Chen Y (2013), Chen Y (2013)	2
MAGOH	0	EIF4A3	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology	Chan CC (2004), Chan CC (2004), Singh G (2012), Singh G (2012), Singh G (2012), Singh G (2012), Barbosa I (2012)	7
CRK	0	KRT6B	1	affinity chromatography technology	Brehme M (2009)	1
KRT19	0	FAM107A	0	two hybrid	Rual JF (2005)	1
HGS	5	USHBP1	1	two hybrid	Rual JF (2005)	1
UBE2A	0	KRT6B	1	affinity chromatography technology	An H (2017)	1
UBE2I	0	KDM1A	2	enzymatic study	Gocke CB (2005)	1
KRT19	0	EXOC8	1	two hybrid	Rual JF (2005)	1
GRB2	2	HGS	5	affinity chromatography technology	Bisson N (2011)	1
KRT19	0	C1orf109	1	two hybrid	Rolland T (2014)	1
GRB2	2	KRT19	0	affinity chromatography technology	Brehme M (2009)	1
SMARCB1	1	KRT19	0	two hybrid	Daakour S (2016)	1
ITGA4	4	EIF4A3	1	affinity chromatography technology	Byron A (2012)	1
KRT6B	1	KDM1A	2	two hybrid	Weimann M (2013)	1
KRT19	0	KRT19	0	two hybrid	Rolland T (2014)	1
ESR1	0	KRT19	0	pull down	Nalvarte I (2010)	1