PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
HNRNPU	12	HNRNPC	0	affinity chromatography technology	Hein MY (2015)	1
OBSL1	9	HNRNPC	0	affinity chromatography technology	Hanson D (2014)	1
CUL3	17	CUL1	7	affinity chromatography technology, affinity chromatography technology, biochemical	Bennett EJ (2010), Bennett EJ (2010), Wan C (2015)	3
CBL	7	HSPA5	0	affinity chromatography technology, affinity chromatography technology	Valiya Veettil M (2011), Brehme M (2009)	2
CUL2	3	KRT14	2	affinity chromatography technology	Bennett EJ (2010)	1
EIF4A3	1	KRT14	2	affinity chromatography technology	Singh G (2012)	1
GRB2	2	AP2M1	5	affinity chromatography technology	Blagoev B (2003)	1
CUL4B	8	KRT5	1	affinity chromatography technology	Bennett EJ (2010)	1
SHC1	0	AP2M1	5	affinity chromatography technology, affinity chromatography technology	Brehme M (2009), Li J (2013)	2
CUL5	1	HNRNPU	12	affinity chromatography technology	Bennett EJ (2010)	1
OBSL1	9	HNRNPA1	1	affinity chromatography technology	Hanson D (2014)	1
CBL	7	KRT3	0	affinity chromatography technology	Brehme M (2009)	1
CUL3	17	HSPA5	0	affinity chromatography technology	Bennett EJ (2010)	1
CUL5	1	KRT3	0	affinity chromatography technology	Bennett EJ (2010)	1
CUL1	7	HNRNPU	12	affinity chromatography technology	Bennett EJ (2010)	1
AP2M1	5	KRT5	1	affinity chromatography technology	Brehme M (2009)	1
CAND1	2	HNRNPU	12	affinity chromatography technology	Bennett EJ (2010)	1
EPS15	1	GRB2	2	far western blotting, affinity chromatography technology, affinity chromatography technology, pull down	Schumacher C (1995), Parachoniak CA (2009), Parachoniak CA (2009), Parachoniak CA (2009)	4
CUL5	1	NEDD8	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Huttlin EL (2017), Zhu Z (2017)	3
CYLD	2	HNRNPU	12	affinity chromatography technology	Elliott PR (2016)	1
CBL	7	PIK3R2	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid	Lin H (2001), Hartley D (1995), Feshchenko EA (2004), Alcazar I (2009), Brehme M (2009), Brehme M (2009), Grossmann A (2015)	7
INPPL1	6	HSPA5	0	affinity chromatography technology	Brehme M (2009)	1
CYLD	2	HNRNPC	0	affinity chromatography technology	Elliott PR (2016)	1
CUL5	1	COPS5	0	affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Bennett EJ (2010)	2
HSPA5	0	HNRNPU	12	affinity chromatography technology, biochemical	Li J (2013), Wan C (2015)	2
MDM2	2	KRT14	2	affinity chromatography technology	Frum R (2007)	1
ALB	1	KRT5	1	affinity chromatography technology	Zhou M (2004)	1
CAND1	2	HNRNPC	0	affinity chromatography technology	Bennett EJ (2010)	1
GRB2	2	KRT14	2	affinity chromatography technology	Brehme M (2009)	1
PIK3R2	3	SHC1	0	affinity chromatography technology, affinity chromatography technology	Brehme M (2009), Brehme M (2009)	2
CUL2	3	HNRNPU	12	affinity chromatography technology	Bennett EJ (2010)	1
CUL3	17	PIK3R2	3	affinity chromatography technology	Bennett EJ (2010)	1
HNRNPC	0	KRT14	2	biochemical	Havugimana PC (2012)	1
UBE2A	0	KRT14	2	affinity chromatography technology	An H (2017)	1
HNRNPU	12	HNRNPA1	1	biochemical, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Havugimana PC (2012), Kristensen AR (2012), Roy R (2014), Hein MY (2015), Hein MY (2015)	5
SHC1	0	KRT14	2	affinity chromatography technology	Brehme M (2009)	1
OBSL1	9	HSPA5	0	affinity chromatography technology	Hanson D (2014)	1
COPS5	0	HNRNPC	0	affinity chromatography technology	Bennett EJ (2010)	1
CCDC8	1	KRT5	1	affinity chromatography technology	Hanson D (2014)	1
KRT14	2	KRT3	0	biochemical	Havugimana PC (2012)	1
POU5F1	0	KRT14	2	affinity chromatography technology	Hawkins PG (2010)	1
CUL7	4	HNRNPU	12	affinity chromatography technology, affinity chromatography technology	Hanson D (2014), Hanson D (2014)	2
COPS5	0	CUL1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Min KW (2005), Min KW (2005), Chua YS (2011), Boh BK (2011), Emberley ED (2012), Emberley ED (2012), Choo YY (2011), Choo YY (2011), Bennett EJ (2010), Bennett EJ (2010), Bennett EJ (2010), Gastaldello S (2012), Enchev RI (2012), Birol M (2014), Pick E (2012), Sharon M (2009), Enchev RI (2012), Bornstein G (2015), Rockel B (2014), Schlierf A (2016), Reitsma JM (2017), Reitsma JM (2017)	23
CUL4B	8	KRT14	2	affinity chromatography technology	Bennett EJ (2010)	1
COPS5	0	KRT3	0	affinity chromatography technology	Bennett EJ (2010)	1
COPS5	0	CAND1	2	biochemical, affinity chromatography technology	Bornstein G (2006), Bennett EJ (2010)	2
CYLD	2	HSPA5	0	affinity chromatography technology	Elliott PR (2016)	1
CUL3	17	HNRNPU	12	affinity chromatography technology	Bennett EJ (2010)	1
AP2M1	5	KRT3	0	affinity chromatography technology	Brehme M (2009)	1
AP2M1	5	KRT14	2	affinity chromatography technology	Brehme M (2009)	1
CBL	7	GRB2	2	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, fluorescent resonance energy transfe, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, far western blotting, affinity chromatography technology, pull down, far western blotting, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, pull down, two hybrid, pull down, pull down, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Jain SK (1997), Liu SK (1998), Ettenberg SA (1999), Wong A (2002), Wong A (2002), Robertson H (1997), Donovan JA (1994), Park RK (1999), Erdreich-Epstein A (1999), Gesbert F (1998), Gesbert F (1998), Gesbert F (1998), Husson H (1997), Saci A (2002), Odai H (1997), Ng C (2008), Khan EM (2008), Bandyopadhyay S (2010), Jiang X (2003), Waterman H (2002), Miraoui H (2010), Ravid T (2004), Ingham RJ (1996), Erdreich-Epstein A (1997), Rellahan BL (2003), Izadi KD (1998), Wang Y (1999), Chu J (1998), Bonita DP (1997), Boussiotis VA (1997), Meisner H (1995), Meisner H (1995), Barber DL (1997), Shishido T (2000), Bartkiewicz M (1999), Buday L (1996), Tarcic G (2009), Belleudi F (2007), Brizzi MF (1996), Brenner B (2001), Donovan JA (1996), Donovan JA (1996), Donovan JA (1996), Gaston I (2004), Gaston I (2004), Tsygankov AY (1996), Tsygankov AY (1996), Hunter S (1997), Jain SK (1997), Levkowitz G (1996), Liu YC (1997), Odai H (1995), Odai H (1995), Meisner H (1995), Huang JY (2000), Panchamoorthy G (1996), Panchamoorthy G (1996), Yokouchi M (1997), Oda A (1996), Fukazawa T (1995), Fukazawa T (1995), Selbach M (2006), Brehme M (2009), Brehme M (2009), Fukazawa T (1995), Cerboni C (1998), Cerboni C (1998), Fixman ED (1997), Anderson SM (1997), Houtman JC (2006), Brizzi MF (1996), Scott RP (2005), Scott RP (2005), Bisson N (2011), Fukazawa T (1996), Fukazawa T (1996), Umehara H (2002), Taipale M (2014), Taipale M (2014), Grossmann A (2015), Grossmann A (2015), Igloi Z (2015), Huttlin EL (2017)	83
CYLD	2	ALB	1	affinity chromatography technology	Elliott PR (2016)	1
COPS5	0	APC	5	affinity chromatography technology	Huang X (2009)	1
CCDC8	1	HNRNPU	12	affinity chromatography technology, affinity chromatography technology	Hanson D (2014), Hanson D (2014)	2
RPS6KB2	3	HNRNPU	12	affinity chromatography technology	Roy R (2014)	1
RPS6KB2	3	HNRNPA1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study	Roy R (2014), Roy R (2014), Roy R (2014), Roy R (2014)	4
IQCB1	3	KRT14	2	affinity chromatography technology	Sang L (2011)	1
KRT14	2	KRT5	1	biochemical	Havugimana PC (2012)	1
CYLD	2	KRT5	1	affinity chromatography technology	Elliott PR (2016)	1
CUL3	17	CUL5	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Bennett EJ (2010), Schenkova K (2012)	3
NEDD8	0	HNRNPC	0	affinity chromatography technology	Bennett EJ (2010)	1
CCDC8	1	HSPA5	0	affinity chromatography technology	Hanson D (2014)	1
GRB2	2	KRT5	1	affinity chromatography technology	Brehme M (2009)	1
CYLD	2	PKP1	2	affinity chromatography technology	Elliott PR (2016)	1
COPS5	0	MDM2	2	affinity chromatography technology, pull down	Zhang XC (2008), Zhang XC (2008)	2
MDM2	2	CUL4B	8	affinity chromatography technology	Latini P (2011)	1
IQCB1	3	ALB	1	affinity chromatography technology	Sang L (2011)	1
INPPL1	6	KRT14	2	affinity chromatography technology	Brehme M (2009)	1
NEDD8	0	HNRNPU	12	affinity chromatography technology	Bennett EJ (2010)	1
CUL7	4	KRT14	2	affinity chromatography technology	Hanson D (2014)	1
CBL	7	KRT5	1	affinity chromatography technology	Brehme M (2009)	1
EPS15	1	AP2M1	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Brehme M (2009), Brehme M (2009), Li J (2013), Huttlin EL (2015), Huttlin EL (2017)	5
HNRNPA1	1	PKP1	2	affinity chromatography technology	Roy R (2014)	1
AP2M1	5	APC	5	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
COPS5	0	HSPA5	0	affinity chromatography technology	Bennett EJ (2010)	1
SHC1	0	HNRNPU	12	affinity chromatography technology	Li J (2013)	1
CUL3	17	HNRNPA1	1	affinity chromatography technology	Bennett EJ (2010)	1
CUL3	17	HNRNPC	0	affinity chromatography technology	Bennett EJ (2010)	1
EIF4A3	1	KRT5	1	affinity chromatography technology	Singh G (2012)	1
INPPL1	6	KRT3	0	affinity chromatography technology	Brehme M (2009)	1
UBASH3B	4	INPPL1	6	affinity chromatography technology	Brehme M (2009)	1
CAND1	2	KRT14	2	affinity chromatography technology	Bennett EJ (2010)	1
CUL5	1	HNRNPA1	1	affinity chromatography technology	Bennett EJ (2010)	1
COPS5	0	CUL3	17	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Choo YY (2011), Bennett EJ (2010), Bennett EJ (2010), Bennett EJ (2010), Olma MH (2009), Olma MH (2009), Huttlin EL (2017)	8
CRK	0	INPPL1	6	affinity chromatography technology	Brehme M (2009)	1
CUL3	17	CUL2	3	biochemical	Wan C (2015)	1
EPS15	1	CRK	0	far western blotting, pull down, affinity chromatography technology, affinity chromatography technology	Schumacher C (1995), Schumacher C (1995), Brehme M (2009), Brehme M (2009)	4
INPPL1	6	HNRNPU	12	affinity chromatography technology	Brehme M (2009)	1
NEDD8	0	HNRNPA1	1	affinity chromatography technology	Bennett EJ (2010)	1
OBSL1	9	HNRNPU	12	affinity chromatography technology, affinity chromatography technology	Hanson D (2014), Hanson D (2014)	2
HNRNPA1	1	EIF4A3	1	affinity chromatography technology	Roy R (2014)	1
CUL5	1	HNRNPC	0	affinity chromatography technology	Bennett EJ (2010)	1
CUL4B	8	CUL5	1	affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Bennett EJ (2010)	2
PTEN	24	PIK3R2	3	enzymatic study, affinity chromatography technology	He J (2010), He J (2010)	2
RPS6KB2	3	KRT14	2	affinity chromatography technology	Roy R (2014)	1
CUL3	17	AP2M1	5	affinity chromatography technology	Bennett EJ (2010)	1
SHC1	0	KRT3	0	affinity chromatography technology	Brehme M (2009)	1
HNRNPA1	1	KRT14	2	affinity chromatography technology	Roy R (2014)	1
PKP1	2	KRT14	2	pull down	Hofmann I (2000)	1
HSPA5	0	KRT14	2	two hybrid	Wang J (2011)	1
CUL2	3	CUL4B	8	affinity chromatography technology	Bennett EJ (2010)	1
PTEN	24	HNRNPU	12	affinity chromatography technology	Maddika S (2011)	1
GRB2	2	HNRNPU	12	affinity chromatography technology	Brehme M (2009)	1
GRB2	2	SHC1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, biochemical, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, unspecified method, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Blagoev B (2003), Skolnik EY (1993), Skolnik EY (1993), Puil L (1994), Satoh T (1996), Fixman ED (1996), Fixman ED (1996), Fixman ED (1996), Ishihara H (1997), Fournier E (1999), Ravichandran KS (1994), Lamprecht R (2002), Park RK (1999), Sakaguchi K (2001), Park RK (1999), Park RK (1999), Hallak H (2001), Yokote K (1994), Saci A (2002), Zhang S (1999), Lazar DF (1994), VanderKuur J (1995), Kanai M (1997), Spivak-Kroizman T (1994), Giordano V (1997), Drobot L (2005), Erdreich-Epstein A (1997), Takahashi Y (1999), Barber DL (1997), Ahn SC (2003), Odai H (1995), Panchamoorthy G (1996), Panchamoorthy G (1996), Brehme M (2009), Brehme M (2009), Brehme M (2009), Cerboni C (1998), Zhang L (1999), Brizzi MF (1996), Brizzi MF (1996), Liu BA (2012), Bisson N (2011), Fukazawa T (1996), Bisson N (2011), Umehara H (2002), Oksvold MP (2001), Oksvold MP (2001), Li J (2013), Li J (2013), Ueno H (1995), Prigent SA (1996), Wills MK (2014), Rausch O (1997), Ho JM (2002), Ho JM (2002), Yu WM (2006), Klint P (1995)	57
ALB	1	KRT14	2	affinity chromatography technology	Zhou M (2004)	1
CUL1	7	MDM2	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Inuzuka H (2010), Inuzuka H (2010), He Y (2014)	3
UBASH3B	4	CRK	0	affinity chromatography technology, affinity chromatography technology	Brehme M (2009), Brehme M (2009)	2
EPS15	1	KRT3	0	affinity chromatography technology	Brehme M (2009)	1
CUL5	1	CUL1	7	affinity chromatography technology	Bennett EJ (2010)	1
ALB	1	OBSL1	9	affinity chromatography technology	Zhou M (2004)	1
UBE2A	0	HNRNPC	0	affinity chromatography technology	An H (2017)	1
COPS5	0	HNRNPA1	1	affinity chromatography technology	Bennett EJ (2010)	1
AP2M1	5	CRK	0	affinity chromatography technology	Brehme M (2009)	1
HNRNPU	12	KRT3	0	biochemical	Havugimana PC (2012)	1
CUL5	1	KRT5	1	affinity chromatography technology	Bennett EJ (2010)	1
CRK	0	GRB2	2	pull down, far western blotting, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Riordan SM (2000), Matsuda M (1996), Okada S (1996), Okada S (1996), Garcia-Guzman M (2000), Brehme M (2009)	6
CUL1	7	KRT14	2	affinity chromatography technology	Bennett EJ (2010)	1
CRK	0	KRT14	2	affinity chromatography technology	Brehme M (2009)	1
UBE2A	0	EIF4A3	1	affinity chromatography technology	An H (2017)	1
NEDD8	0	HSPA5	0	affinity chromatography technology	Bennett EJ (2010)	1
EPS15	1	HSPA5	0	affinity chromatography technology	Brehme M (2009)	1
UBE2A	0	KRT5	1	affinity chromatography technology	An H (2017)	1
CRK	0	KRT3	0	affinity chromatography technology	Brehme M (2009)	1
CUL3	17	KRT14	2	affinity chromatography technology	Bennett EJ (2010)	1
IQCB1	3	HSPA5	0	affinity chromatography technology	Sang L (2011)	1
CBL	7	KRT14	2	affinity chromatography technology	Brehme M (2009)	1
NEDD8	0	CUL1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Norman JA (2006), Bennett EJ (2010), Bennett EJ (2010), Gastaldello S (2012)	4
PIK3R2	3	KRT5	1	affinity chromatography technology	Brehme M (2009)	1
CAND1	2	CUL5	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Chua YS (2011), Chua YS (2011), Tron AE (2012), Bennett EJ (2010), Bennett EJ (2010), Bennett EJ (2010), Liu J (2002), Huttlin EL (2017)	8
RPS6KB2	3	KRT5	1	affinity chromatography technology	Roy R (2014)	1
CUL4B	8	CAND1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Min KW (2003), Min KW (2003), Min KW (2003), Bennett EJ (2010), Bennett EJ (2010), Hein MY (2015)	6
CBL	7	SHC1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Park RK (1999), Gesbert F (1998), Erdreich-Epstein A (1997), Wang Y (1999), Brehme M (2009), Brehme M (2009), Cerboni C (1998), Brizzi MF (1996), Fukazawa T (1996)	9
NEDD8	0	CUL2	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Norman JA (2006), Bennett EJ (2010), Bennett EJ (2010)	3
CUL2	3	HNRNPA1	1	affinity chromatography technology	Bennett EJ (2010)	1
CCDC8	1	KRT14	2	affinity chromatography technology	Hanson D (2014)	1
SHC1	0	KRT5	1	affinity chromatography technology	Brehme M (2009)	1
CBL	7	PTEN	24	affinity chromatography technology, affinity chromatography technology	Rodriguez S (2013), Rodriguez S (2013)	2
GRB2	2	HSPA5	0	two hybrid, affinity chromatography technology	Bandyopadhyay S (2010), Brehme M (2009)	2
MAGOH	0	HNRNPC	0	affinity chromatography technology	Singh G (2012)	1
CCDC8	1	HNRNPA1	1	affinity chromatography technology	Hanson D (2014)	1
APC	5	KRT14	2	two hybrid	Bandyopadhyay S (2010)	1
CUL4B	8	HNRNPA1	1	affinity chromatography technology	Bennett EJ (2010)	1
HNRNPA1	1	KRT5	1	affinity chromatography technology	Roy R (2014)	1
INPPL1	6	KRT5	1	affinity chromatography technology	Brehme M (2009)	1
UBASH3B	4	HNRNPU	12	affinity chromatography technology	Li J (2013)	1
MAGOH	0	HNRNPU	12	affinity chromatography technology	Singh G (2012)	1
MDM2	2	HNRNPU	12	affinity chromatography technology, affinity chromatography technology	Okoro DR (2013), Jacob AG (2014)	2
CUL1	7	HNRNPC	0	affinity chromatography technology	Bennett EJ (2010)	1
CUL7	4	EIF4A3	1	affinity chromatography technology	Hanson D (2014)	1
UBASH3B	4	CBL	7	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kowanetz K (2004), Kowanetz K (2004), Raguz J (2007), Hoeller D (2006), Peruzzi G (2007), Brehme M (2009)	6
SHC1	0	HSPA5	0	affinity chromatography technology	Brehme M (2009)	1
APC	5	KRT5	1	two hybrid	Bandyopadhyay S (2010)	1
CYLD	2	KRT14	2	affinity chromatography technology	Elliott PR (2016)	1
HNRNPU	12	KRT14	2	biochemical	Havugimana PC (2012)	1
EVPL	6	KRT14	2	biochemical	Havugimana PC (2012)	1
CAND1	2	KRT5	1	affinity chromatography technology	Bennett EJ (2010)	1
EPS15	1	KRT5	1	affinity chromatography technology	Brehme M (2009)	1
CUL1	7	KRT5	1	affinity chromatography technology	Bennett EJ (2010)	1
CUL2	3	KRT5	1	affinity chromatography technology	Bennett EJ (2010)	1
HNRNPA1	1	HNRNPC	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Jeronimo C (2007), Zhang S (2004), Roy R (2014), Hein MY (2015)	4
CBL	7	INPPL1	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Vandenbroere I (2003), Prasad NK (2005), De Schutter J (2009), De Schutter J (2009), Brehme M (2009)	5
CUL3	17	CUL4B	8	affinity chromatography technology	Bennett EJ (2010)	1
PIK3R2	3	KRT14	2	affinity chromatography technology	Brehme M (2009)	1
CAND1	2	HNRNPA1	1	affinity chromatography technology	Bennett EJ (2010)	1
CUL3	17	GRB2	2	affinity chromatography technology	Bennett EJ (2010)	1
CAND1	2	EIF4A3	1	affinity chromatography technology	Bennett EJ (2010)	1
CUL2	3	CAND1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Min KW (2003), Min KW (2003), Menon S (2008), Mao X (2011), Chua YS (2011), Chua YS (2011), Tron AE (2012)	7
CUL1	7	HNRNPA1	1	affinity chromatography technology	Bennett EJ (2010)	1
SHC1	0	INPPL1	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Wisniewski D (1999), Wisniewski D (1999), Pesesse X (2001), Habib T (1998), Brehme M (2009), Brehme M (2009)	6
PTEN	24	KRT14	2	affinity chromatography technology	Crockett DK (2005)	1
CRK	0	KRT5	1	affinity chromatography technology	Brehme M (2009)	1
CUL7	4	HNRNPA1	1	affinity chromatography technology	Hanson D (2014)	1
CYLD	2	HNRNPA1	1	affinity chromatography technology	Elliott PR (2016)	1
OBSL1	9	KRT14	2	affinity chromatography technology	Hanson D (2014)	1
SHC1	0	CRK	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Brehme M (2009), Brehme M (2009), Ota S (1998), Larsson H (1999)	4
CCDC8	1	PKP1	2	affinity chromatography technology	Hanson D (2014)	1
CCDC8	1	ALB	1	affinity chromatography technology	Hanson D (2014)	1
EPS15	1	KRT14	2	affinity chromatography technology	Brehme M (2009)	1
UBASH3B	4	CUL3	17	pull down	Krupina K (2016)	1
PTPRN2	8	HSPA5	0	bioid	St-Denis N (2016)	1
COPS5	0	KRT14	2	affinity chromatography technology	Bennett EJ (2010)	1
HNRNPU	12	EIF4A3	1	biochemical, affinity chromatography technology	Havugimana PC (2012), Singh G (2012)	2
COPS5	0	HNRNPU	12	affinity chromatography technology	Bennett EJ (2010)	1
IQCB1	3	KRT5	1	affinity chromatography technology	Sang L (2011)	1
EIF4A3	1	HNRNPC	0	affinity chromatography technology	Singh G (2012)	1
CUL7	4	HNRNPC	0	affinity chromatography technology	Hanson D (2014)	1
CAND1	2	HSPA5	0	affinity chromatography technology	Bennett EJ (2010)	1
GRB2	2	CYLD	2	affinity chromatography technology	Huttlin EL (2017)	1
GRB2	2	HNRNPC	0	two hybrid, pull down, affinity chromatography technology	Romero F (1998), Romero F (1998), Romero F (1998)	3
KRT3	0	KRT5	1	biochemical	Havugimana PC (2012)	1
CCDC8	1	CAND1	2	affinity chromatography technology	Hanson D (2014)	1
OBSL1	9	CCDC8	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Hanson D (2011), Hanson D (2011), Hanson D (2014), Nie J (2015)	4
UBASH3B	4	KRT14	2	affinity chromatography technology	Brehme M (2009)	1
UBASH3B	4	HSPA5	0	affinity chromatography technology	Brehme M (2009)	1
RPS6KB2	3	ALB	1	affinity chromatography technology	Roy R (2014)	1
CUL3	17	KRT5	1	affinity chromatography technology	Bennett EJ (2010)	1
OBSL1	9	KRT5	1	affinity chromatography technology	Hanson D (2014)	1
NEDD8	0	CUL4B	8	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Norman JA (2006), Bennett EJ (2010), Bennett EJ (2010)	3
CUL2	3	HNRNPC	0	affinity chromatography technology	Bennett EJ (2010)	1
NEDD8	0	KRT14	2	affinity chromatography technology	Bennett EJ (2010)	1
CUL1	7	EIF4A3	1	affinity chromatography technology	Bennett EJ (2010)	1
SHC1	0	UBASH3B	4	affinity chromatography technology, affinity chromatography technology	Brehme M (2009), Li J (2013)	2
CUL7	4	KRT5	1	affinity chromatography technology	Hanson D (2014)	1
GRB2	2	PIK3R2	3	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bandyopadhyay S (2010), Brehme M (2009), Brehme M (2009), Bisson N (2011)	4
CUL5	1	HSPA5	0	affinity chromatography technology	Bennett EJ (2010)	1
APC	5	HSPA5	0	two hybrid	Bandyopadhyay S (2010)	1
PTPRN2	8	KRT14	2	bioid	St-Denis N (2016)	1
CUL5	1	KRT14	2	affinity chromatography technology	Bennett EJ (2010)	1
OBSL1	9	EIF4A3	1	affinity chromatography technology	Hanson D (2014)	1
CRK	0	HSPA5	0	affinity chromatography technology	Brehme M (2009)	1
COPS5	0	CUL4B	8	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Bennett EJ (2010), Bennett EJ (2010), Bennett EJ (2010), Olma MH (2009), He F (2013), Huttlin EL (2015), Hein MY (2015), Huttlin EL (2017)	9
HSPA5	0	HNRNPA1	1	affinity chromatography technology, affinity chromatography technology	Li J (2013), Roy R (2014)	2
NEDD8	0	KRT5	1	affinity chromatography technology	Bennett EJ (2010)	1
CRK	0	CBL	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, affinity chromatography technology, pull down, two hybrid	Gesbert F (1998), Husson H (1997), Ingham RJ (1996), Ingham RJ (1996), Delehanty LL (2003), Garcia-Guzman M (2000), Garcia-Guzman M (2000), Barber DL (1997), Buday L (1996), Sawasdikosol S (1996), Sawasdikosol S (1996), Thien CB (1997), van Leeuwen JE (1999), Ribon V (1996), Lottin-Divoux S (2006), Reedquist KA (1996), Brehme M (2009), Brehme M (2009), Ota S (1998), Peterson ME (2008), Liu BA (2012), Fukazawa T (1996), Umehara H (2002), Grossmann A (2015)	24
INPPL1	6	PIK3R2	3	affinity chromatography technology, affinity chromatography technology	Brehme M (2009), Brehme M (2009)	2
UBE2A	0	MDM2	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Lyakhovich A (2003), Chen S (2012), Chen S (2012)	3
CUL2	3	HSPA5	0	affinity chromatography technology	Bennett EJ (2010)	1
CUL5	1	CUL2	3	affinity chromatography technology	Bennett EJ (2010)	1
HNRNPA1	1	ALB	1	affinity chromatography technology	Roy R (2014)	1
UBASH3B	4	KRT5	1	affinity chromatography technology	Brehme M (2009)	1
INPPL1	6	GRB2	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Brehme M (2009), Brehme M (2009), Brehme M (2009), Bisson N (2011)	4
CUL7	4	HSPA5	0	affinity chromatography technology	Hanson D (2014)	1
CUL4B	8	HSPA5	0	affinity chromatography technology	Bennett EJ (2010)	1
CUL1	7	CAND1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, imaging technique, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Min KW (2003), Min KW (2003), Min KW (2003), Menon S (2008), Chew EH (2007), Min KW (2005), Min KW (2005), Min KW (2005), Hwang JW (2003), Hwang JW (2003), Mao X (2011), Chua YS (2011), Chua YS (2011), Tron AE (2012), Zheng J (2002), Zheng J (2002), Bornstein G (2006), Oshikawa K (2003), Oshikawa K (2003), Lee JE (2011), He YJ (2006), Emberley ED (2012), Choo YY (2011), Jonason JH (2007), Bennett EJ (2010), Bennett EJ (2010), Bennett EJ (2010), Bennett EJ (2010), Gastaldello S (2012), Liu J (2002), Liu J (2002), Liu J (2002), Liu J (2002), Korzeniewski N (2012), Pierce NW (2013), Kim AY (2008), Zhang S (2016), Tikhmyanova N (2017), Tikhmyanova N (2017), Reitsma JM (2017), Reitsma JM (2017)	41
MAGOH	0	KRT14	2	affinity chromatography technology	Singh G (2012)	1
CUL1	7	HSPA5	0	affinity chromatography technology	Bennett EJ (2010)	1
MAGOH	0	EIF4A3	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology	Chan CC (2004), Chan CC (2004), Singh G (2012), Singh G (2012), Singh G (2012), Singh G (2012), Barbosa I (2012)	7
CCDC8	1	CUL7	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Hanson D (2014), Nie J (2015), Nie J (2015)	3
COPS5	0	KRT5	1	affinity chromatography technology	Bennett EJ (2010)	1
MAGOH	0	KRT5	1	affinity chromatography technology	Singh G (2012)	1
OBSL1	9	CUL7	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Litterman N (2011), Litterman N (2011), Hanson D (2011), Hanson D (2011), Nie J (2015)	5
CUL3	17	CAND1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Min KW (2003), Min KW (2003), Chua YS (2011), Chua YS (2011), Tron AE (2012), Choo YY (2011), Bennett EJ (2010), Bennett EJ (2010), Schumacher FR (2015), Schumacher FR (2015), Lo SC (2006), Lo SC (2006)	12
COPS5	0	NEDD8	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Sowa ME (2009), Norman JA (2006), Bennett EJ (2010), Bennett EJ (2010), Birol M (2014)	5
NEDD8	0	CUL3	17	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid	Norman JA (2006), Bennett EJ (2010), Bennett EJ (2010), Wimuttisuk W (2007)	4
UBASH3B	4	GRB2	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	de Castro RO (2012), Li J (2013), Li J (2013)	3
COPS5	0	CUL2	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study	Sowa ME (2009), Choo YY (2011), Bennett EJ (2010), Bennett EJ (2010), Bennett EJ (2010), Olma MH (2009), Pick E (2012)	7
CUL3	17	EIF4A3	1	affinity chromatography technology	Bennett EJ (2010)	1
RPS6KB2	3	HSPA5	0	affinity chromatography technology	Roy R (2014)	1
PIK3R2	3	CRK	0	affinity chromatography technology, affinity chromatography technology, two hybrid	Brehme M (2009), Brehme M (2009), Grossmann A (2015)	3