PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
CUL3	17	CUL1	7	affinity chromatography technology, affinity chromatography technology, biochemical	Bennett EJ (2010), Bennett EJ (2010), Wan C (2015)	3
MCM2	3	EWSR1	2	affinity chromatography technology	Drissi R (2015)	1
MAPK6	1	UCHL5	1	affinity chromatography technology	Rodriguez J (2016)	1
CAND1	2	EWSR1	2	affinity chromatography technology	Bennett EJ (2010)	1
GOLGA2	2	KIFC3	3	two hybrid	Rolland T (2014)	1
CUL3	17	SMARCB1	1	affinity chromatography technology	Bennett EJ (2010)	1
GAN	4	KIFC3	3	affinity chromatography technology	Johnson-Kerner BL (2015)	1
UBE2A	0	KRT19	0	affinity chromatography technology	An H (2017)	1
CUL5	1	KRT6B	1	affinity chromatography technology	Bennett EJ (2010)	1
COPS5	0	KRT13	2	affinity chromatography technology	Bennett EJ (2010)	1
COPS5	0	EWSR1	2	affinity chromatography technology	Bennett EJ (2010)	1
CUL5	1	COPS5	0	affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Bennett EJ (2010)	2
MAPK6	1	ALB	1	affinity chromatography technology	Huttlin EL (2017)	1
GOLGA2	2	CUL5	1	two hybrid, two hybrid	Rolland T (2014), Yu H (2011)	2
GAN	4	HNRNPA1	1	affinity chromatography technology	Johnson-Kerner BL (2015)	1
MAPK6	1	KRT6B	1	affinity chromatography technology	Rodriguez J (2016)	1
SMARCB1	1	GOLGA2	2	two hybrid	Daakour S (2016)	1
GAN	4	KRT6B	1	affinity chromatography technology	Johnson-Kerner BL (2015)	1
UBE3A	4	MAPK6	1	affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Martinez-Noel G (2012), Martinez-Noel G (2012), Rodriguez J (2016), Rodriguez J (2016)	4
UCHL5	1	KRT6B	1	affinity chromatography technology	Fang Y (2011)	1
COPS5	0	CUL1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Min KW (2005), Min KW (2005), Chua YS (2011), Boh BK (2011), Emberley ED (2012), Emberley ED (2012), Choo YY (2011), Choo YY (2011), Bennett EJ (2010), Bennett EJ (2010), Bennett EJ (2010), Gastaldello S (2012), Enchev RI (2012), Birol M (2014), Pick E (2012), Sharon M (2009), Enchev RI (2012), Bornstein G (2015), Rockel B (2014), Schlierf A (2016), Reitsma JM (2017), Reitsma JM (2017)	23
COPS5	0	CAND1	2	biochemical, affinity chromatography technology	Bornstein G (2006), Bennett EJ (2010)	2
ALB	1	KRT6B	1	affinity chromatography technology	Zhou M (2004)	1
KRT19	0	KDM1A	2	two hybrid	Weimann M (2013)	1
KRT15	2	KRT19	0	two hybrid	Rual JF (2005)	1
IQCB1	3	KRT6B	1	affinity chromatography technology	Sang L (2011)	1
CYLD	2	ALB	1	affinity chromatography technology	Elliott PR (2016)	1
HNRNPA1	1	KRT15	2	affinity chromatography technology	Roy R (2014)	1
UBE3A	4	KRT6B	1	pull down	Kapoor I (2015)	1
SMARCB1	1	TFIP11	5	two hybrid	Daakour S (2016)	1
CUL3	17	CUL5	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Bennett EJ (2010), Schenkova K (2012)	3
CUL1	7	KRT13	2	affinity chromatography technology	Bennett EJ (2010)	1
MCM2	3	KRT6B	1	affinity chromatography technology	Drissi R (2015)	1
IQCB1	3	ALB	1	affinity chromatography technology	Sang L (2011)	1
CUL5	1	EWSR1	2	affinity chromatography technology	Bennett EJ (2010)	1
CUL5	1	KRT13	2	affinity chromatography technology	Bennett EJ (2010)	1
ALB	1	KRT13	2	affinity chromatography technology	Zhou M (2004)	1
SMARCB1	1	KRT6B	1	two hybrid	Daakour S (2016)	1
KRT38	4	KDM1A	2	two hybrid	Rolland T (2014)	1
CUL3	17	HNRNPA1	1	affinity chromatography technology	Bennett EJ (2010)	1
PAPD5	3	KRT6B	1	affinity chromatography technology	Hein MY (2015)	1
GAN	4	CUL3	17	affinity chromatography technology, affinity chromatography technology	Zhang DD (2005), Bennett EJ (2010)	2
UBASH3B	4	INPPL1	6	affinity chromatography technology	Brehme M (2009)	1
CUL5	1	HNRNPA1	1	affinity chromatography technology	Bennett EJ (2010)	1
EIF4A3	1	KRT19	0	affinity chromatography technology	Singh G (2012)	1
COPS5	0	CUL3	17	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Choo YY (2011), Bennett EJ (2010), Bennett EJ (2010), Bennett EJ (2010), Olma MH (2009), Olma MH (2009), Huttlin EL (2017)	8
CRK	0	INPPL1	6	affinity chromatography technology	Brehme M (2009)	1
UBASH3B	4	EWSR1	2	affinity chromatography technology	Li J (2013)	1
KRT6B	1	TFIP11	5	two hybrid	Rolland T (2014)	1
KIFC3	3	KDM1A	2	two hybrid	Weimann M (2013)	1
KRT6B	1	KRT15	2	two hybrid, two hybrid	Rual JF (2005), Rolland T (2014)	2
COPS5	0	KRT6B	1	affinity chromatography technology	Bennett EJ (2010)	1
KRT6B	1	KRT19	0	two hybrid	Rual JF (2005)	1
HNRNPA1	1	EIF4A3	1	affinity chromatography technology	Roy R (2014)	1
KIFC3	3	KRT19	0	two hybrid	Rolland T (2014)	1
EIF4A3	1	KRT6B	1	affinity chromatography technology	Singh G (2012)	1
EWSR1	2	KRT6B	1	affinity chromatography technology	Elzi DJ (2014)	1
CUL3	17	KRT31	0	affinity chromatography technology	Bennett EJ (2010)	1
CUL3	17	AP2M1	5	affinity chromatography technology	Bennett EJ (2010)	1
HNRNPA1	1	EWSR1	2	affinity chromatography technology, affinity chromatography technology	Close P (2012), Roy R (2014)	2
GOLGA2	2	KDM1A	2	two hybrid	Rolland T (2014)	1
UBASH3B	4	CRK	0	affinity chromatography technology, affinity chromatography technology	Brehme M (2009), Brehme M (2009)	2
UBE3A	4	UCHL5	1	enzymatic study, affinity chromatography technology, affinity chromatography technology	Jacobson AD (2014), Huttlin EL (2015), Huttlin EL (2017)	3
CUL5	1	CUL1	7	affinity chromatography technology	Bennett EJ (2010)	1
MCM2	3	HNRNPA1	1	affinity chromatography technology	Drissi R (2015)	1
COPS5	0	HNRNPA1	1	affinity chromatography technology	Bennett EJ (2010)	1
CBL	7	KRT6B	1	affinity chromatography technology	Brehme M (2009)	1
AP2M1	5	CRK	0	affinity chromatography technology	Brehme M (2009)	1
UCHL5	1	KDM1A	2	two hybrid	Weimann M (2013)	1
UBE2A	0	EIF4A3	1	affinity chromatography technology	An H (2017)	1
COPS5	0	SMARCB1	1	affinity chromatography technology	Bennett EJ (2010)	1
KIFC3	3	TRIM54	1	two hybrid	Rolland T (2014)	1
CAND1	2	CUL5	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Chua YS (2011), Chua YS (2011), Tron AE (2012), Bennett EJ (2010), Bennett EJ (2010), Bennett EJ (2010), Liu J (2002), Huttlin EL (2017)	8
KRT6B	1	KRT13	2	two hybrid	Rolland T (2014)	1
CUL3	17	KRT6B	1	affinity chromatography technology	Bennett EJ (2010)	1
CAND1	2	KRT13	2	affinity chromatography technology	Bennett EJ (2010)	1
CRK	0	KRT15	2	affinity chromatography technology	Brehme M (2009)	1
KIFC3	3	KRT6B	1	two hybrid	Rolland T (2014)	1
CYLD	2	KRT13	2	affinity chromatography technology	Elliott PR (2016)	1
AP2M1	5	KRT6B	1	affinity chromatography technology	Brehme M (2009)	1
TRIM54	1	UCHL5	1	enzymatic study	Loch CM (2012)	1
UBASH3B	4	CBL	7	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kowanetz K (2004), Kowanetz K (2004), Raguz J (2007), Hoeller D (2006), Peruzzi G (2007), Brehme M (2009)	6
NDC80	4	TFIP11	5	two hybrid	Rolland T (2014)	1
CBL	7	INPPL1	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Vandenbroere I (2003), Prasad NK (2005), De Schutter J (2009), De Schutter J (2009), Brehme M (2009)	5
CAND1	2	HNRNPA1	1	affinity chromatography technology	Bennett EJ (2010)	1
CAND1	2	EIF4A3	1	affinity chromatography technology	Bennett EJ (2010)	1
CUL1	7	HNRNPA1	1	affinity chromatography technology	Bennett EJ (2010)	1
CYLD	2	HNRNPA1	1	affinity chromatography technology	Elliott PR (2016)	1
CUL1	7	EWSR1	2	affinity chromatography technology	Bennett EJ (2010)	1
CAND1	2	KRT6B	1	affinity chromatography technology	Bennett EJ (2010)	1
CRK	0	KRT19	0	affinity chromatography technology	Brehme M (2009)	1
KRT6B	1	TRIM54	1	two hybrid	Rolland T (2014)	1
UBASH3B	4	CUL3	17	pull down	Krupina K (2016)	1
CUL1	7	KRT6B	1	affinity chromatography technology	Bennett EJ (2010)	1
HNRNPA1	1	KRT6B	1	affinity chromatography technology	Roy R (2014)	1
EIF4A3	1	SMARCB1	1	biochemical	Havugimana PC (2012)	1
SMARCB1	1	KRT15	2	two hybrid	Daakour S (2016)	1
UBASH3B	4	KRT6B	1	affinity chromatography technology	Brehme M (2009)	1
CAND1	2	SMARCB1	1	affinity chromatography technology	Bennett EJ (2010)	1
KRT6B	1	KRT38	4	two hybrid	Rolland T (2014)	1
GOLGA2	2	KRT6B	1	two hybrid	Rolland T (2014)	1
CYLD	2	KRT19	0	affinity chromatography technology	Elliott PR (2016)	1
CUL3	17	KRT13	2	affinity chromatography technology	Bennett EJ (2010)	1
CUL1	7	EIF4A3	1	affinity chromatography technology	Bennett EJ (2010)	1
KRT6B	1	KRT31	0	two hybrid	Rolland T (2014)	1
KIFC3	3	KRT15	2	two hybrid	Rolland T (2014)	1
CAND1	2	MCM2	3	affinity chromatography technology	Bennett EJ (2010)	1
UCHL5	1	KRT19	0	pull down	Fang Y (2011)	1
KDM1A	2	TRIM54	1	two hybrid	Rolland T (2014)	1
CYLD	2	KRT6B	1	affinity chromatography technology	Elliott PR (2016)	1
CUL3	17	EWSR1	2	affinity chromatography technology	Bennett EJ (2010)	1
CRK	0	CBL	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, affinity chromatography technology, pull down, two hybrid	Gesbert F (1998), Husson H (1997), Ingham RJ (1996), Ingham RJ (1996), Delehanty LL (2003), Garcia-Guzman M (2000), Garcia-Guzman M (2000), Barber DL (1997), Buday L (1996), Sawasdikosol S (1996), Sawasdikosol S (1996), Thien CB (1997), van Leeuwen JE (1999), Ribon V (1996), Lottin-Divoux S (2006), Reedquist KA (1996), Brehme M (2009), Brehme M (2009), Ota S (1998), Peterson ME (2008), Liu BA (2012), Fukazawa T (1996), Umehara H (2002), Grossmann A (2015)	24
KRT6B	1	NDC80	4	two hybrid	Rolland T (2014)	1
KIFC3	3	KRT31	0	two hybrid	Rolland T (2014)	1
HNRNPA1	1	ALB	1	affinity chromatography technology	Roy R (2014)	1
CUL1	7	CAND1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, imaging technique, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Min KW (2003), Min KW (2003), Min KW (2003), Menon S (2008), Chew EH (2007), Min KW (2005), Min KW (2005), Min KW (2005), Hwang JW (2003), Hwang JW (2003), Mao X (2011), Chua YS (2011), Chua YS (2011), Tron AE (2012), Zheng J (2002), Zheng J (2002), Bornstein G (2006), Oshikawa K (2003), Oshikawa K (2003), Lee JE (2011), He YJ (2006), Emberley ED (2012), Choo YY (2011), Jonason JH (2007), Bennett EJ (2010), Bennett EJ (2010), Bennett EJ (2010), Bennett EJ (2010), Gastaldello S (2012), Liu J (2002), Liu J (2002), Liu J (2002), Liu J (2002), Korzeniewski N (2012), Pierce NW (2013), Kim AY (2008), Zhang S (2016), Tikhmyanova N (2017), Tikhmyanova N (2017), Reitsma JM (2017), Reitsma JM (2017)	41
CRK	0	KRT6B	1	affinity chromatography technology	Brehme M (2009)	1
UBE2A	0	KRT6B	1	affinity chromatography technology	An H (2017)	1
CUL3	17	CAND1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Min KW (2003), Min KW (2003), Chua YS (2011), Chua YS (2011), Tron AE (2012), Choo YY (2011), Bennett EJ (2010), Bennett EJ (2010), Schumacher FR (2015), Schumacher FR (2015), Lo SC (2006), Lo SC (2006)	12
INPPL1	6	KRT6B	1	affinity chromatography technology	Brehme M (2009)	1
SMARCB1	1	KRT19	0	two hybrid	Daakour S (2016)	1
CUL3	17	EIF4A3	1	affinity chromatography technology	Bennett EJ (2010)	1
KRT6B	1	KDM1A	2	two hybrid	Weimann M (2013)	1