PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
RPS6KB2	3	KRT13	2	affinity chromatography technology	Roy R (2014)	1
GRB2	2	AP2M1	5	affinity chromatography technology	Blagoev B (2003)	1
AP2M1	5	KRT17	0	affinity chromatography technology	Brehme M (2009)	1
ITGA4	4	EPS15	1	affinity chromatography technology	Byron A (2012)	1
CUL2	3	KRT6A	1	affinity chromatography technology	Bennett EJ (2010)	1
GRB2	2	KRT15	2	affinity chromatography technology	Brehme M (2009)	1
KRT17	0	CCDC85B	0	two hybrid, affinity chromatography technology	Rual JF (2005), Rual JF (2005)	2
GRB2	2	KRT17	0	affinity chromatography technology, affinity chromatography technology	Blagoev B (2003), Brehme M (2009)	2
SHC1	0	AP2M1	5	affinity chromatography technology, affinity chromatography technology	Brehme M (2009), Li J (2013)	2
KRT15	2	HGS	5	two hybrid	Rolland T (2014)	1
ITGA4	4	EED	1	two hybrid	Rietzler M (1998)	1
GOLGA2	2	KIFC3	3	two hybrid	Rolland T (2014)	1
SHC1	0	KRT6A	1	affinity chromatography technology	Brehme M (2009)	1
EED	1	KRT6A	1	affinity chromatography technology	Cao Q (2014)	1
EPS15	1	GRB2	2	far western blotting, affinity chromatography technology, affinity chromatography technology, pull down	Schumacher C (1995), Parachoniak CA (2009), Parachoniak CA (2009), Parachoniak CA (2009)	4
COPS5	0	KRT13	2	affinity chromatography technology	Bennett EJ (2010)	1
CUL5	1	COPS5	0	affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Bennett EJ (2010)	2
GOLGA2	2	CUL5	1	two hybrid, two hybrid	Rolland T (2014), Yu H (2011)	2
CYLD	2	LMNA	2	affinity chromatography technology	Elliott PR (2016)	1
EED	1	CUL1	7	affinity chromatography technology	Cao Q (2014)	1
HNRNPA1	1	KRT17	0	affinity chromatography technology	Roy R (2014)	1
SMARCB1	1	GOLGA2	2	two hybrid	Daakour S (2016)	1
EPS15	1	KRT17	0	affinity chromatography technology	Brehme M (2009)	1
EPS15	1	KRT6A	1	affinity chromatography technology	Brehme M (2009)	1
KRT6A	1	CCDC85B	0	two hybrid, affinity chromatography technology	Rual JF (2005), Rual JF (2005)	2
COPS5	0	CUL1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Min KW (2005), Min KW (2005), Chua YS (2011), Boh BK (2011), Emberley ED (2012), Emberley ED (2012), Choo YY (2011), Choo YY (2011), Bennett EJ (2010), Bennett EJ (2010), Bennett EJ (2010), Gastaldello S (2012), Enchev RI (2012), Birol M (2014), Pick E (2012), Sharon M (2009), Enchev RI (2012), Bornstein G (2015), Rockel B (2014), Schlierf A (2016), Reitsma JM (2017), Reitsma JM (2017)	23
CCDC8	1	LMNA	2	affinity chromatography technology	Hanson D (2014)	1
UBASH3B	4	KRT17	0	affinity chromatography technology	Brehme M (2009)	1
LGR4	3	KRT6A	1	affinity chromatography technology	Carmon KS (2014)	1
GRB2	2	KRT6A	1	affinity chromatography technology	Brehme M (2009)	1
CBL	7	GRB2	2	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, fluorescent resonance energy transfe, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, far western blotting, affinity chromatography technology, pull down, far western blotting, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, pull down, two hybrid, pull down, pull down, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Jain SK (1997), Liu SK (1998), Ettenberg SA (1999), Wong A (2002), Wong A (2002), Robertson H (1997), Donovan JA (1994), Park RK (1999), Erdreich-Epstein A (1999), Gesbert F (1998), Gesbert F (1998), Gesbert F (1998), Husson H (1997), Saci A (2002), Odai H (1997), Ng C (2008), Khan EM (2008), Bandyopadhyay S (2010), Jiang X (2003), Waterman H (2002), Miraoui H (2010), Ravid T (2004), Ingham RJ (1996), Erdreich-Epstein A (1997), Rellahan BL (2003), Izadi KD (1998), Wang Y (1999), Chu J (1998), Bonita DP (1997), Boussiotis VA (1997), Meisner H (1995), Meisner H (1995), Barber DL (1997), Shishido T (2000), Bartkiewicz M (1999), Buday L (1996), Tarcic G (2009), Belleudi F (2007), Brizzi MF (1996), Brenner B (2001), Donovan JA (1996), Donovan JA (1996), Donovan JA (1996), Gaston I (2004), Gaston I (2004), Tsygankov AY (1996), Tsygankov AY (1996), Hunter S (1997), Jain SK (1997), Levkowitz G (1996), Liu YC (1997), Odai H (1995), Odai H (1995), Meisner H (1995), Huang JY (2000), Panchamoorthy G (1996), Panchamoorthy G (1996), Yokouchi M (1997), Oda A (1996), Fukazawa T (1995), Fukazawa T (1995), Selbach M (2006), Brehme M (2009), Brehme M (2009), Fukazawa T (1995), Cerboni C (1998), Cerboni C (1998), Fixman ED (1997), Anderson SM (1997), Houtman JC (2006), Brizzi MF (1996), Scott RP (2005), Scott RP (2005), Bisson N (2011), Fukazawa T (1996), Fukazawa T (1996), Umehara H (2002), Taipale M (2014), Taipale M (2014), Grossmann A (2015), Grossmann A (2015), Igloi Z (2015), Huttlin EL (2017)	83
CYLD	2	ALB	1	affinity chromatography technology	Elliott PR (2016)	1
LMNA	2	KRT6A	1	two hybrid	Dittmer TA (2014)	1
HNRNPA1	1	KRT15	2	affinity chromatography technology	Roy R (2014)	1
PAPD5	3	KRT6A	1	affinity chromatography technology	Hein MY (2015)	1
RPS6KB2	3	HNRNPA1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study	Roy R (2014), Roy R (2014), Roy R (2014), Roy R (2014)	4
SHC1	0	KRT17	0	affinity chromatography technology	Brehme M (2009)	1
SMARCB1	1	TFIP11	5	two hybrid	Daakour S (2016)	1
CUL1	7	KRT13	2	affinity chromatography technology	Bennett EJ (2010)	1
ITGA4	4	GRB2	2	affinity chromatography technology	Byron A (2012)	1
KRT6A	1	KRT13	2	two hybrid	Rolland T (2014)	1
IQCB1	3	ALB	1	affinity chromatography technology	Sang L (2011)	1
ALB	1	KRT6A	1	affinity chromatography technology	Zhou M (2004)	1
CUL5	1	KRT13	2	affinity chromatography technology	Bennett EJ (2010)	1
ALB	1	KRT13	2	affinity chromatography technology	Zhou M (2004)	1
EPS15	1	AP2M1	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Brehme M (2009), Brehme M (2009), Li J (2013), Huttlin EL (2015), Huttlin EL (2017)	5
KRT38	4	KDM1A	2	two hybrid	Rolland T (2014)	1
KRT6A	1	WASHC3	2	two hybrid	Rual JF (2005)	1
EMC8	1	KRT6A	1	affinity chromatography technology	Christianson JC (2012)	1
CYLD	2	KRT17	0	affinity chromatography technology	Elliott PR (2016)	1
KRT38	4	HGS	5	two hybrid	Rolland T (2014)	1
KRT17	0	KDM1A	2	two hybrid	Weimann M (2013)	1
ITGA4	4	AP2M1	5	affinity chromatography technology	Byron A (2012)	1
KRT6A	1	TFIP11	5	two hybrid	Rolland T (2014)	1
CUL5	1	HNRNPA1	1	affinity chromatography technology	Bennett EJ (2010)	1
CUL1	7	KRT6A	1	affinity chromatography technology	Bennett EJ (2010)	1
EPS15	1	CRK	0	far western blotting, pull down, affinity chromatography technology, affinity chromatography technology	Schumacher C (1995), Schumacher C (1995), Brehme M (2009), Brehme M (2009)	4
KRT6A	1	TRIM54	1	two hybrid	Rolland T (2014)	1
EED	1	HNRNPA1	1	affinity chromatography technology	Cao Q (2014)	1
HGS	5	KRT40	0	two hybrid	Rolland T (2014)	1
KIFC3	3	KDM1A	2	two hybrid	Weimann M (2013)	1
KRT6A	1	KRT15	2	two hybrid, two hybrid	Rual JF (2005), Rolland T (2014)	2
KRT6A	1	HGS	5	two hybrid	Rolland T (2014)	1
COPS5	0	KRT17	0	affinity chromatography technology	Bennett EJ (2010)	1
PAN2	3	ALB	1	affinity chromatography technology	Bett JS (2013)	1
GOLGA2	2	KDM1A	2	two hybrid	Rolland T (2014)	1
ITGA4	4	CBL	7	affinity chromatography technology	Byron A (2012)	1
GRB2	2	SHC1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, biochemical, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, unspecified method, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Blagoev B (2003), Skolnik EY (1993), Skolnik EY (1993), Puil L (1994), Satoh T (1996), Fixman ED (1996), Fixman ED (1996), Fixman ED (1996), Ishihara H (1997), Fournier E (1999), Ravichandran KS (1994), Lamprecht R (2002), Park RK (1999), Sakaguchi K (2001), Park RK (1999), Park RK (1999), Hallak H (2001), Yokote K (1994), Saci A (2002), Zhang S (1999), Lazar DF (1994), VanderKuur J (1995), Kanai M (1997), Spivak-Kroizman T (1994), Giordano V (1997), Drobot L (2005), Erdreich-Epstein A (1997), Takahashi Y (1999), Barber DL (1997), Ahn SC (2003), Odai H (1995), Panchamoorthy G (1996), Panchamoorthy G (1996), Brehme M (2009), Brehme M (2009), Brehme M (2009), Cerboni C (1998), Zhang L (1999), Brizzi MF (1996), Brizzi MF (1996), Liu BA (2012), Bisson N (2011), Fukazawa T (1996), Bisson N (2011), Umehara H (2002), Oksvold MP (2001), Oksvold MP (2001), Li J (2013), Li J (2013), Ueno H (1995), Prigent SA (1996), Wills MK (2014), Rausch O (1997), Ho JM (2002), Ho JM (2002), Yu WM (2006), Klint P (1995)	57
UBASH3B	4	CRK	0	affinity chromatography technology, affinity chromatography technology	Brehme M (2009), Brehme M (2009)	2
CUL5	1	CUL1	7	affinity chromatography technology	Bennett EJ (2010)	1
ITGA4	4	HNRNPA1	1	affinity chromatography technology	Byron A (2012)	1
COPS5	0	HNRNPA1	1	affinity chromatography technology	Bennett EJ (2010)	1
AP2M1	5	CRK	0	affinity chromatography technology	Brehme M (2009)	1
CRK	0	GRB2	2	pull down, far western blotting, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Riordan SM (2000), Matsuda M (1996), Okada S (1996), Okada S (1996), Garcia-Guzman M (2000), Brehme M (2009)	6
LMNA	2	TFIP11	5	bioid	Roux KJ (2012)	1
COPS5	0	SMARCB1	1	affinity chromatography technology	Bennett EJ (2010)	1
KIFC3	3	TRIM54	1	two hybrid	Rolland T (2014)	1
KRT6A	1	SGTA	1	two hybrid	Rolland T (2014)	1
EED	1	LMNA	2	affinity chromatography technology	Cao Q (2014)	1
AP2M1	5	KRT6A	1	affinity chromatography technology	Brehme M (2009)	1
CBL	7	SHC1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Park RK (1999), Gesbert F (1998), Erdreich-Epstein A (1997), Wang Y (1999), Brehme M (2009), Brehme M (2009), Cerboni C (1998), Brizzi MF (1996), Fukazawa T (1996)	9
CUL2	3	HNRNPA1	1	affinity chromatography technology	Bennett EJ (2010)	1
CCDC8	1	HNRNPA1	1	affinity chromatography technology	Hanson D (2014)	1
CRK	0	KRT15	2	affinity chromatography technology	Brehme M (2009)	1
PAN2	3	HNRNPA1	1	affinity chromatography technology	Bett JS (2013)	1
RPS6KB2	3	KRT6A	1	affinity chromatography technology	Roy R (2014)	1
CYLD	2	KRT13	2	affinity chromatography technology	Elliott PR (2016)	1
EPS15	1	KRT38	4	affinity chromatography technology	Brehme M (2009)	1
UBASH3B	4	KRT6A	1	affinity chromatography technology	Brehme M (2009)	1
LMNA	2	HNRNPA1	1	bioid, affinity chromatography technology	Roux KJ (2012), Roy R (2014)	2
IQCB1	3	KRT6A	1	affinity chromatography technology	Sang L (2011)	1
UBASH3B	4	CBL	7	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kowanetz K (2004), Kowanetz K (2004), Raguz J (2007), Hoeller D (2006), Peruzzi G (2007), Brehme M (2009)	6
EED	1	KDM1A	2	affinity chromatography technology	Cao Q (2014)	1
COPS5	0	KRT6A	1	affinity chromatography technology	Bennett EJ (2010)	1
KRT31	0	HGS	5	two hybrid	Rolland T (2014)	1
CYLD	2	KRT6A	1	affinity chromatography technology	Elliott PR (2016)	1
TRIM23	3	KIFC3	3	two hybrid	Rolland T (2014)	1
IQCB1	3	KRT17	0	affinity chromatography technology	Sang L (2011)	1
EPS15	1	HGS	5	pull down, two hybrid, biochemical, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Bean AJ (2000), Bean AJ (2000), Bache KG (2003), Roxrud I (2008), Roxrud I (2008), Yan Q (2005), Gschweitl M (2016)	7
CUL1	7	HNRNPA1	1	affinity chromatography technology	Bennett EJ (2010)	1
CUL1	7	SGTA	1	biochemical	Wan C (2015)	1
TRIM23	3	KRT6A	1	two hybrid	Rolland T (2014)	1
CYLD	2	HNRNPA1	1	affinity chromatography technology	Elliott PR (2016)	1
SHC1	0	CRK	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Brehme M (2009), Brehme M (2009), Ota S (1998), Larsson H (1999)	4
CBL	7	KRT6A	1	affinity chromatography technology	Brehme M (2009)	1
KRT6A	1	KDM1A	2	two hybrid	Weimann M (2013)	1
CCDC8	1	ALB	1	affinity chromatography technology	Hanson D (2014)	1
GOLGA2	2	WASHC3	2	two hybrid	Rolland T (2014)	1
ITGA4	4	LMNA	2	affinity chromatography technology	Byron A (2012)	1
KRT6A	1	KRT31	0	two hybrid	Rolland T (2014)	1
GRB2	2	CYLD	2	affinity chromatography technology	Huttlin EL (2017)	1
SMARCB1	1	KRT15	2	two hybrid	Daakour S (2016)	1
CRK	0	KRT17	0	affinity chromatography technology	Brehme M (2009)	1
KRT6A	1	KRT17	0	two hybrid	Rual JF (2005)	1
RPS6KB2	3	ALB	1	affinity chromatography technology	Roy R (2014)	1
CCDC8	1	KRT6A	1	affinity chromatography technology	Hanson D (2014)	1
LMNA	2	CRK	0	bioid	Roux KJ (2012)	1
SHC1	0	UBASH3B	4	affinity chromatography technology, affinity chromatography technology	Brehme M (2009), Li J (2013)	2
CUL5	1	KRT6A	1	affinity chromatography technology	Bennett EJ (2010)	1
CUL2	3	KRT13	2	affinity chromatography technology	Bennett EJ (2010)	1
KDM1A	2	WASHC3	2	two hybrid	Rolland T (2014)	1
KIFC3	3	KRT15	2	two hybrid	Rolland T (2014)	1
KDM1A	2	TRIM54	1	two hybrid	Rolland T (2014)	1
CRK	0	CBL	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, affinity chromatography technology, pull down, two hybrid	Gesbert F (1998), Husson H (1997), Ingham RJ (1996), Ingham RJ (1996), Delehanty LL (2003), Garcia-Guzman M (2000), Garcia-Guzman M (2000), Barber DL (1997), Buday L (1996), Sawasdikosol S (1996), Sawasdikosol S (1996), Thien CB (1997), van Leeuwen JE (1999), Ribon V (1996), Lottin-Divoux S (2006), Reedquist KA (1996), Brehme M (2009), Brehme M (2009), Ota S (1998), Peterson ME (2008), Liu BA (2012), Fukazawa T (1996), Umehara H (2002), Grossmann A (2015)	24
CBL	7	KRT17	0	affinity chromatography technology	Brehme M (2009)	1
KIFC3	3	KRT31	0	two hybrid	Rolland T (2014)	1
KIFC3	3	KRT6A	1	two hybrid	Rolland T (2014)	1
SHC1	0	KRT13	2	affinity chromatography technology	Brehme M (2009)	1
CRK	0	KRT6A	1	affinity chromatography technology	Brehme M (2009)	1
CUL5	1	CUL2	3	affinity chromatography technology	Bennett EJ (2010)	1
HNRNPA1	1	ALB	1	affinity chromatography technology	Roy R (2014)	1
KRT6A	1	KRT40	0	two hybrid	Rolland T (2014)	1
SMARCB1	1	KRT6A	1	two hybrid	Daakour S (2016)	1
ITGA4	4	KRT6A	1	affinity chromatography technology	Byron A (2012)	1
GOLGA2	2	KRT6A	1	two hybrid	Rolland T (2014)	1
KRT6A	1	KRT38	4	two hybrid	Rolland T (2014)	1
PAN2	3	KRT6A	1	affinity chromatography technology	Bett JS (2013)	1
GRB2	2	HGS	5	affinity chromatography technology	Bisson N (2011)	1
KIFC3	3	KRT40	0	two hybrid	Rolland T (2014)	1
UBASH3B	4	GRB2	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	de Castro RO (2012), Li J (2013), Li J (2013)	3
COPS5	0	CUL2	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study	Sowa ME (2009), Choo YY (2011), Bennett EJ (2010), Bennett EJ (2010), Bennett EJ (2010), Olma MH (2009), Pick E (2012)	7
HNRNPA1	1	KRT6A	1	affinity chromatography technology	Roy R (2014)	1