PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
VCP	6	RUVBL2	4	affinity chromatography technology	Fogeron ML (2013)	1
TSPAN2	0	ARF6	0	affinity chromatography technology	Huttlin EL (2017)	1
AP1G1	8	GGA1	0	affinity chromatography technology	Bai H (2004)	1
ASAP1	1	RAB11FIP3	2	affinity chromatography technology, affinity chromatography technology, pull down	Inoue H (2008), Inoue H (2008), Inoue H (2008)	3
AGAP1	6	APP	1	pull down	Olah J (2011)	1
ACAP1	0	RAB11FIP3	2	affinity chromatography technology	Inoue H (2008)	1
VCP	6	IQGAP1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique	Fogeron ML (2013), Itoh N (2017), Itoh N (2017), Itoh N (2017)	4
GGA1	0	APP	1	affinity chromatography technology, pull down	Wahle T (2006), Wahle T (2006)	2
ARF6	0	TBCE	1	biochemical	Wan C (2015)	1
STAU1	1	PABPC4	2	affinity chromatography technology	Milev MP (2012)	1
EGFR	5	DYNC1H1	41	protein complementation assay	Deribe YL (2009)	1
EIF6	2	YARS	3	affinity chromatography technology	Ewing RM (2007)	1
ARL4D	0	ARF6	0	imaging technique	Li CC (2007)	1
MT2A	0	ARF6	0	pull down	Venkateswarlu K (2005)	1
ITSN1	5	ARFIP2	0	two hybrid, protein complementation assay, affinity chromatography technology	Wong KA (2012), Wong KA (2012), Wong KA (2012)	3
RUVBL2	4	EIF6	2	biochemical	Wan C (2015)	1
CDK2	0	LRPPRC	7	affinity chromatography technology	Neganova I (2011)	1
RUVBL2	4	APP	1	pull down	Olah J (2011)	1
ARRB2	5	VCP	6	affinity chromatography technology	Xiao K (2007)	1
STAU1	1	APP	1	pull down	Olah J (2011)	1
HTR2A	1	ARF6	0	pull down	Johnson MS (2006)	1
CDK2	0	CLTC	12	affinity chromatography technology, affinity chromatography technology	Neganova I (2011), Hein MY (2015)	2
ARRB2	5	RAB11FIP5	1	affinity chromatography technology	Xiao K (2007)	1
PLD1	5	ARF6	0	affinity chromatography technology	Vitale N (2002)	1
AP1G1	8	CLTC	12	affinity chromatography technology, two hybrid, affinity chromatography technology	Zhu Y (2001), Knuehl C (2006), Zlatic SA (2011)	3
ARF6	0	GART	1	affinity chromatography technology	Ewing RM (2007)	1
EGFR	5	AP2A1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Foerster S (2013), Foerster S (2013), Tong J (2014), Li J (2013)	4
ARF6	0	PIP5K1C	4	affinity chromatography technology, affinity chromatography technology	Krauss M (2003), Krauss M (2006)	2
ARRB2	5	AP2A1	1	affinity chromatography technology	Xiao K (2007)	1
ARF6	0	GNAQ	1	affinity chromatography technology	Giguere P (2006)	1
FN1	17	AP2A1	1	affinity chromatography technology	Humphries JD (2009)	1
ARRB1	2	AP2A1	1	affinity chromatography technology	McLaughlin NJ (2006)	1
AGAP1	6	ARF6	0	enzymatic study	Luo R (2012)	1
ARF6	0	RAB11FIP3	2	pull down, imaging technique, affinity chromatography technology, pull down	Fielding AB (2005), Fielding AB (2005), Fielding AB (2005), Inoue H (2008)	4
MRPL38	2	ARF6	0	affinity chromatography technology	Huttlin EL (2017)	1
GGA3	6	ARF6	0	pull down, affinity chromatography technology, pull down, affinity chromatography technology	Cho HJ (2010), Frittoli E (2008), Jing J (2009), Li CC (2007)	4
ARF6	0	APP	1	pull down	Olah J (2011)	1
ARFIP2	0	ARF6	0	two hybrid, two hybrid, pull down, pull down	DSouza-Schorey C (1997), Shin OH (2001), Shin OH (2001), DSouza-Schorey C (1997)	4
CYTH2	2	ARF6	0	enzymatic study, affinity chromatography technology, pull down	Frank S (1998), Yano H (2008), Laroche G (2007)	3
ARF6	0	LRPPRC	7	affinity chromatography technology	Ewing RM (2007)	1
STAU1	1	IQGAP1	1	affinity chromatography technology	Milev MP (2012)	1
RAB11FIP4	2	RAB11FIP5	1	two hybrid	Wallace DM (2002)	1
ARRB2	5	AP3B1	3	affinity chromatography technology	Ewing RM (2007)	1
MEPCE	1	RUVBL2	4	affinity chromatography technology	Jeronimo C (2007)	1
ARF6	0	EIF6	2	affinity chromatography technology	Ewing RM (2007)	1
CYTH2	2	ARL4D	0	affinity chromatography technology, two hybrid, pull down, imaging technique	Li CC (2007), Li CC (2007), Li CC (2007), Li CC (2007)	4
SNRNP27	0	ARF6	0	affinity chromatography technology	Huttlin EL (2017)	1
CDK2	0	YARS	3	affinity chromatography technology	Neganova I (2011)	1
FN1	17	DYNC1H1	41	affinity chromatography technology	Humphries JD (2009)	1
ITSN1	5	CLTC	12	two hybrid	Wong KA (2012)	1
FOXA1	2	KIF23	0	affinity chromatography technology	Jozwik KM (2016)	1
TGOLN2	1	ARF6	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
ARF6	0	RAB11FIP4	2	affinity chromatography technology, imaging technique, pull down	Fielding AB (2005), Fielding AB (2005), Fielding AB (2005)	3
ARRB2	5	PABPC4	2	affinity chromatography technology	Xiao K (2007)	1
STAU1	1	CLTC	12	affinity chromatography technology	Milev MP (2012)	1
GGA1	0	CLTC	12	pull down, pull down, two hybrid, affinity chromatography technology, x-ray crystallography, pull down	Puertollano R (2001), Zhang F (2007), Knuehl C (2006), Knuehl C (2006), Knuehl C (2006), Inoue M (2007)	6
ARF6	0	EPPK1	24	affinity chromatography technology	Ewing RM (2007)	1
FN1	17	ARF6	0	affinity chromatography technology	Humphries JD (2009)	1
ARL4D	0	APP	1	pull down, pull down	Olah J (2011), Virok DP (2011)	2
ARRB1	2	AP3B1	3	affinity chromatography technology	Ewing RM (2007)	1
ARRB2	5	ARRB1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ewing RM (2007), Xiao K (2007), Xiao K (2007), Huttlin EL (2017)	4
EGFR	5	ARRB2	5	two hybrid, protein complementation assay	Kotlyar M (2015), Petschnigg J (2014)	2
AP3S2	0	AP3B1	3	biochemical, affinity chromatography technology	DellAngelica EC (1997), DellAngelica EC (1997)	2
FN1	17	KIAA0368	0	affinity chromatography technology	Humphries JD (2009)	1
VCP	6	APP	1	affinity chromatography technology	Jang JK (2017)	1
CDK2	0	VCP	6	affinity chromatography technology, affinity chromatography technology	Neganova I (2011), Fogeron ML (2013)	2
EGFR	5	RUVBL2	4	affinity chromatography technology	Yao Z (2017)	1
GGA1	0	GGA3	6	imaging technique, pull down, pull down	Ghosh P (2003), Ghosh P (2003), Ghosh P (2003)	3
YAF2	1	ARF6	0	affinity chromatography technology	Huttlin EL (2017)	1
ARF6	0	YARS	3	affinity chromatography technology	Ewing RM (2007)	1
FN1	17	RUVBL2	4	affinity chromatography technology	Humphries JD (2009)	1
EGFR	5	ARF6	0	protein complementation assay, affinity chromatography technology	Deribe YL (2009), Tong J (2014)	2
ARF6	0	DHPS	3	affinity chromatography technology	Ewing RM (2007)	1
GGA3	6	CLTC	12	pull down	Puertollano R (2001)	1
CYTH2	2	ARRB1	2	affinity chromatography technology, pull down	Claing A (2001), Claing A (2001)	2
ARF6	0	CLTC	12	affinity chromatography technology	Krauss M (2006)	1
CDK2	0	IQGAP1	1	affinity chromatography technology	Neganova I (2011)	1
AP3S2	0	ARF6	0	pull down	Austin C (2002)	1
EGFR	5	EXOC5	2	affinity chromatography technology	Foerster S (2013)	1
DYNC1H1	41	EPPK1	24	biochemical	Havugimana PC (2012)	1
ARF6	0	EXOC5	2	two hybrid, pull down, affinity chromatography technology	Prigent M (2003), Prigent M (2003), Prigent M (2003)	3
EGFR	5	ARRB1	2	two hybrid, protein complementation assay, affinity chromatography technology	Kotlyar M (2015), Petschnigg J (2014), Petschnigg J (2014)	3
ASAP1	1	ARF6	0	affinity chromatography technology, pull down	Yano H (2008), Klein S (2006)	2
CYTH1	1	ARRB2	5	affinity chromatography technology	Laroche G (2007)	1
ARF6	0	KIAA0368	0	affinity chromatography technology	Ewing RM (2007)	1
RAB11FIP4	2	KIAA0368	0	two hybrid	Gorbea C (2010)	1
EGFR	5	FN1	17	protein complementation assay	Deribe YL (2009)	1
ARRB1	2	ARF6	0	affinity chromatography technology, pull down	Claing A (2001), Claing A (2001)	2
ARF6	0	SNAP91	6	affinity chromatography technology	Krauss M (2006)	1
GGA1	0	ARF6	0	pull down, affinity chromatography technology	Takatsu H (2002), Fukaya M (2011)	2
AGAP1	6	KIF13B	13	affinity chromatography technology	Boldt K (2016)	1
ARF6	0	ACAP1	0	pull down, affinity chromatography technology	Klein S (2006), Klein S (2006)	2
FN1	17	VCP	6	affinity chromatography technology	Humphries JD (2009)	1
FN1	17	IQGAP1	1	affinity chromatography technology	Humphries JD (2009)	1
EGFR	5	KIAA0368	0	affinity chromatography technology	Tong J (2014)	1
DYNC1H1	41	YARS	3	biochemical	Havugimana PC (2012)	1
RUVBL2	4	ARF6	0	affinity chromatography technology	Jeronimo C (2007)	1
EGFR	5	APP	1	two hybrid, protein complementation assay	Kotlyar M (2015), Petschnigg J (2014)	2
VCP	6	ARF6	0	affinity chromatography technology	Yu CC (2013)	1
ARF6	0	ADAP1	3	affinity chromatography technology	Venkateswarlu K (2005)	1
ARF6	0	PABPC4	2	affinity chromatography technology	Ewing RM (2007)	1
ITSN1	5	ARF6	0	protein complementation assay	Wong KA (2012)	1
CLTC	12	EIF6	2	biochemical	Wan C (2015)	1
ARF6	0	AP1G1	8	affinity chromatography technology	Krauss M (2006)	1
CDK2	0	ARF6	0	biochemical	Wan C (2015)	1
FN1	17	PABPC4	2	affinity chromatography technology	Humphries JD (2009)	1
ARHGAP10	1	ARF6	0	pull down, pull down	Klein S (2006), Klein S (2006)	2
CYTH2	2	ARRB2	5	affinity chromatography technology, pull down	Claing A (2001), Claing A (2001)	2
FN1	17	GART	1	affinity chromatography technology	Humphries JD (2009)	1
STAU1	1	LRPPRC	7	affinity chromatography technology	Milev MP (2012)	1
VCP	6	EPPK1	24	affinity chromatography technology	Fogeron ML (2013)	1
VCP	6	GGA1	0	affinity chromatography technology	Yu CC (2013)	1
MUC20	4	ARF6	0	affinity chromatography technology	Huttlin EL (2017)	1
AP3B1	3	ARF6	0	pull down	Austin C (2002)	1
RAB11FIP4	2	RAB11FIP3	2	two hybrid, affinity chromatography technology	Wallace DM (2002), Huttlin EL (2017)	2
KIF23	0	ARF6	0	affinity chromatography technology	Makyio H (2012)	1
CYTH1	1	GNAQ	1	affinity chromatography technology, pull down	Laroche G (2007), Laroche G (2007)	2
IQSEC1	3	ARF6	0	biochemical	Someya A (2001)	1
FN1	17	CLTC	12	affinity chromatography technology	Humphries JD (2009)	1
FOXA1	2	STAU1	1	affinity chromatography technology	Jozwik KM (2016)	1
CYTH1	1	ARRB1	2	pull down, affinity chromatography technology	Laroche G (2007), Laroche G (2007)	2
TBC1D22B	2	ARF6	0	affinity chromatography technology	Huttlin EL (2017)	1
CLTC	12	SNAP91	6	affinity chromatography technology	Slepnev VI (2000)	1
CYTH2	2	GNAQ	1	affinity chromatography technology, pull down	Giguere P (2006), Giguere P (2006)	2
MEPCE	1	ARF6	0	affinity chromatography technology	Jeronimo C (2007)	1
IQGAP1	1	CLTC	12	affinity chromatography technology	Hein MY (2015)	1
ARF6	0	DYNC1H1	41	affinity chromatography technology	Ewing RM (2007)	1
EGFR	5	LRPPRC	7	affinity chromatography technology	Tong J (2014)	1
FN1	17	LRPPRC	7	affinity chromatography technology	Humphries JD (2009)	1
ARRB2	5	DYNC1H1	41	affinity chromatography technology	Xiao K (2007)	1
FN1	17	YARS	3	affinity chromatography technology	Humphries JD (2009)	1
GGA3	6	CYTH2	2	pull down	Li CC (2007)	1
RUVBL2	4	DYNC1H1	41	biochemical	Wan C (2015)	1
ARRB1	2	RAB11FIP5	1	affinity chromatography technology	Xiao K (2007)	1
IQGAP1	1	AP2A1	1	affinity chromatography technology	Hein MY (2015)	1
USP6	1	APP	1	pull down	Olah J (2011)	1
ARF6	0	RAB11FIP5	1	pull down	Fielding AB (2005)	1
FOXA1	2	ARF6	0	affinity chromatography technology	Jozwik KM (2016)	1
THTPA	0	ARF6	0	affinity chromatography technology	Huttlin EL (2017)	1
ARF6	0	AP2A1	1	affinity chromatography technology	Krauss M (2006)	1
PDE4DIP	10	ARF6	0	affinity chromatography technology	Huttlin EL (2017)	1
EGFR	5	AP1G1	8	affinity chromatography technology, affinity chromatography technology	Foerster S (2013), Tong J (2014)	2
CDK2	0	DYNC1H1	41	affinity chromatography technology	Neganova I (2011)	1
EGFR	5	YARS	3	affinity chromatography technology	Tong J (2014)	1
FBXO8	1	ARF6	0	enzymatic study, imaging technique	Yano H (2008), Yano H (2008)	2
ARRB2	5	ARF6	0	affinity chromatography technology	Claing A (2001)	1
RALA	1	PLD1	5	pull down, pull down	Luo JQ (1997), Kim JH (1998)	2
STAU1	1	ARF6	0	affinity chromatography technology	Milev MP (2012)	1
MYADM	0	ARF6	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
MEPCE	1	SNRNP27	0	affinity chromatography technology	Jeronimo C (2007)	1
GPAA1	1	ARF6	0	affinity chromatography technology	Huttlin EL (2017)	1
CLTC	12	ARRB2	5	pull down	Goodman OB (1997)	1
ARF6	0	KIF13B	13	affinity chromatography technology	Venkateswarlu K (2005)	1
ARF6	0	CHRM3	1	affinity chromatography technology, pull down	Mitchell R (2003), Mitchell R (2003)	2
PDCD1	4	ARF6	0	affinity chromatography technology	Huttlin EL (2017)	1
ARFIP2	0	APP	1	pull down	Olah J (2011)	1
ARF6	0	IQGAP1	1	affinity chromatography technology	Ewing RM (2007)	1
TBC1D22B	2	EPPK1	24	affinity chromatography technology	Huttlin EL (2017)	1
EIF6	2	APP	1	pull down	Olah J (2011)	1
EGFR	5	IQGAP1	1	affinity chromatography technology	Casar B (2009)	1
RALA	1	ARF6	0	affinity chromatography technology	Xu L (2003)	1
USP6	1	ARF6	0	affinity chromatography technology, imaging technique	Martinu L (2004), Martinu L (2004)	2
CYTH1	1	ARF6	0	pull down	Laroche G (2007)	1
ARRB1	2	CLTC	12	affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe, pull down	Xiao K (2007), McLaughlin NJ (2006), McLaughlin NJ (2006), Goodman OB (1997)	4
CLTC	12	AP2A1	1	affinity chromatography technology	Hein MY (2015)	1
ITSN1	5	CYTH1	1	two hybrid	Wong KA (2012)	1
IQSEC1	3	GNAQ	1	affinity chromatography technology	Laroche G (2007)	1