PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
KCNJ4	5	DMD	6	affinity chromatography technology	Leonoudakis D (2004)	1
DLG4	11	KCNJ4	5	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Nehring RB (2000), Leonoudakis D (2004), Inanobe A (2002), Nehring RB (2000)	4
KCNJ4	5	LIN7B	0	two hybrid, affinity chromatography technology	Olsen O (2002), Olsen O (2002)	2
LIN7B	0	CASK	18	affinity chromatography technology	Leonoudakis D (2004)	1
KCNJ4	5	LIN7A	1	affinity chromatography technology	Leonoudakis D (2004)	1
KCNJ4	5	DLG2	4	affinity chromatography technology	Inanobe A (2002)	1
LIN7C	0	LIN7B	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
SNTA1	1	DMD	6	unspecified method, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ahn AH (1996), Yang B (1995), Gee SH (1998), Lyssand JS (2008), Huttlin EL (2017)	5
KCNJ4	5	CASK	18	affinity chromatography technology, affinity chromatography technology	Leonoudakis D (2004), Leonoudakis D (2004)	2
LIN7C	0	CASK	18	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Leonoudakis D (2004), So J (2015), Huttlin EL (2015), Huttlin EL (2017)	4
KCNJ4	5	SNTA1	1	affinity chromatography technology, unspecified method	Leonoudakis D (2004), Boisguerin P (2004)	2
KCNJ4	5	LIN7C	0	affinity chromatography technology, affinity chromatography technology	Leonoudakis D (2004), Leonoudakis D (2004)	2
CASK	18	DLG4	11	affinity chromatography technology, two hybrid	Chetkovich DM (2002), Chetkovich DM (2002)	2
KCNJ4	5	DLG1	2	affinity chromatography technology, affinity chromatography technology, pull down	Leonoudakis D (2004), Leonoudakis D (2004), Leonoudakis D (2001)	3
DLG1	2	LIN7A	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Leonoudakis D (2004), Leonoudakis D (2004), Hauri S (2013)	3
DLG1	2	LIN7C	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Leonoudakis D (2004), Leonoudakis D (2004), Huttlin EL (2015), Huttlin EL (2017)	4
DLG4	11	LIN7A	1	pull down	Jo K (1999)	1
LIN7B	0	DLG4	11	affinity chromatography technology	Jo K (1999)	1
LIN7A	1	CASK	18	affinity chromatography technology, two hybrid, affinity chromatography technology	Leonoudakis D (2004), Rolland T (2014), Hauri S (2013)	3
DLG2	4	DLG4	11	affinity chromatography technology	Hsueh YP (1997)	1
KCNJ4	5	GNGT2	0	affinity chromatography technology	Cohen NA (1996)	1
DLG1	2	CASK	18	affinity chromatography technology, pull down, affinity chromatography technology, two hybrid, affinity chromatography technology, pull down, two hybrid, affinity chromatography technology	Leonoudakis D (2004), Leonoudakis D (2004), Chetkovich DM (2002), Nix SL (2000), Nix SL (2000), Nix SL (2000), Nix SL (2000), So J (2015)	8