Gene-drug interactions (data source: DGIdb)
Gene Name Entrez ID Drug Name Chembl ID Interaction Types Sources publications
KCNH2 3757 CISAPRIDE CHEMBL1729 inhibitor, channel blocker PharmGKB, GuideToPharmacologyInteractions, DrugBank 15967876, 10510456, 9374794, 17408310, 12209010
KCNH2 3757 ASTEMIZOLE CHEMBL296419 inhibitor, channel blocker PharmGKB, GuideToPharmacologyInteractions, DrugBank 15272206, 10422790, 11575008, 10444235, 10376921
KCNH2 3757 CARVEDILOL CHEMBL723 inhibitor DrugBank 11164846, 16314852
KCNH2 3757 ROTTLERIN CHEMBL34241 activator GuideToPharmacologyInteractions
KCNH2 3757 FLUOXETINE CHEMBL41 PharmGKB
KCNH2 3757 AMIODARONE CHEMBL633 blocker TdgClinicalTrial, TEND, TTD
KCNH2 3757 LOVASTATIN CHEMBL503 PharmGKB
KCNH2 3757 MIBEFRADIL CHEMBL45816 PharmGKB
KCNH2 3757 LIDOFLAZINE CHEMBL92870 PharmGKB
KCNH2 3757 LORATADINE CHEMBL998 PharmGKB
KCNH2 3757 DRONEDARONE CHEMBL184412 TdgClinicalTrial, TEND, DrugBank 17896959
KCNH2 3757 AZIMILIDE CHEMBL123558 DrugBank 11573692, 11060832
KCNH2 3757 CHEMBL1418045 CHEMBL1418045 activator GuideToPharmacologyInteractions
KCNH2 3757 CHEMBL406931 CHEMBL406931 activator GuideToPharmacologyInteractions
KCNH2 3757 CHEMBL2158814 CHEMBL2158814 channel blocker GuideToPharmacologyInteractions
KCNH2 3757 DISOPYRAMIDE CHEMBL517 channel blocker GuideToPharmacologyInteractions
KCNH2 3757 TELITHROMYCIN CHEMBL1136 PharmGKB
KCNH2 3757 BUDIODARONE CHEMBL2105631 TdgClinicalTrial
KCNH2 3757 DESMETHEYLASTEMIZOLE CHEMBL60796 PharmGKB
KCNH2 3757 TERODILINE CHEMBL363295 PharmGKB
KCNH2 3757 PROCAINAMIDE CHEMBL640 PharmGKB
KCNH2 3757 GREPAFLOXACIN CHEMBL583 PharmGKB
KCNH2 3757 NERISPIRDINE CHEMBL2107762 blocker TTD
KCNH2 3757 PROBUCOL CHEMBL608 PharmGKB
KCNH2 3757 TERFENADINE CHEMBL17157 inhibitor, channel blocker PharmGKB, GuideToPharmacologyInteractions, DrugBank 11752352, 20636881, 15102940
KCNH2 3757 VERAPAMIL CHEMBL6966 inhibitor DrugBank 15892662, 17588331, 19125880, 15814090, 16507347, 15135665
KCNH2 3757 MICONAZOLE CHEMBL91 inhibitor DrugBank 15778703, 8760033
KCNH2 3757 SERTINDOLE CHEMBL12713 inhibitor PharmGKB, TdgClinicalTrial, DrugBank 11689132, 11511086, 9694935
KCNH2 3757 CHEMBL157885 CHEMBL157885 activator GuideToPharmacologyInteractions
KCNH2 3757 CHEMBL521083 CHEMBL521083 activator GuideToPharmacologyInteractions
KCNH2 3757 IBUTILIDE CHEMBL533 channel blocker TdgClinicalTrial, GuideToPharmacologyInteractions, TEND
KCNH2 3757 MOXIFLOXACIN CHEMBL32 PharmGKB, NCI 16474415
KCNH2 3757 ESTRADIOL CHEMBL135 NCI 18440994
KCNH2 3757 SOTALOL CHEMBL471 PharmGKB, TdgClinicalTrial, TEND
KCNH2 3757 PROPAFENONE CHEMBL631 blocker TdgClinicalTrial, TEND, TTD
KCNH2 3757 PYRILAMINE CHEMBL511 PharmGKB
KCNH2 3757 OLANZAPINE CHEMBL715 PharmGKB
KCNH2 3757 DOXEPIN CHEMBL1628227 PharmGKB
KCNH2 3757 PERHEXILINE CHEMBL75880 PharmGKB
KCNH2 3757 PRENYLAMINE CHEMBL24072 PharmGKB
KCNH2 3757 METHADONE CHEMBL651 PharmGKB
KCNH2 3757 DOFETILIDE CHEMBL473 inhibitor, blocker, channel blocker PharmGKB, TdgClinicalTrial, GuideToPharmacologyInteractions, TEND, DrugBank, TTD 11723241, 11698075, 11166283, 11752352, 15548764, 10712445, 10648647, 9486667
KCNH2 3757 PIMOZIDE CHEMBL1423 inhibitor PharmGKB, DrugBank 11377395, 10762666, 11511086, 11296551
KCNH2 3757 HALOFANTRINE CHEMBL1107 inhibitor DrugBank 12176129, 10952689
KCNH2 3757 CEFADROXIL CHEMBL1644 channel blocker GuideToPharmacologyInteractions
KCNH2 3757 CHEMBL1474918 CHEMBL1474918 gating inhibitor GuideToPharmacologyInteractions
KCNH2 3757 LEVOMETHADYL ACETATE CHEMBL1514 PharmGKB
KCNH2 3757 CIMETIDINE CHEMBL30 PharmGKB
KCNH2 3757 RISPERIDONE CHEMBL85 PharmGKB
KCNH2 3757 SPARFLOXACIN CHEMBL850 PharmGKB
KCNH2 3757 AMSACRINE CHEMBL43 inhibitor DrugBank 15148258
KCNH2 3757 CLARITHROMYCIN CHEMBL1741 DrugBank 12873512
KCNH2 3757 PROPOFOL CHEMBL526 NCI 16368812

Variant-drug associations (data source: PharmGKB)
Gene Name Variant Alleles Chemical Phenotype Category Significance Notes Sentence Publications Annotation ID
KCNH2 rs1137617 GG candesartan efficacy not stated Genotype GG is not associated with response to candesartan, imidapril or irbesartan in people with Essential hypertension as compared to genotypes AA + AG. 23613831 982009313
KCNH2 rs1137617 GG atenolol efficacy not stated however the analysis solely comparing genotypes is not shown and stats are given for GG genotype x gender or age comparisons. Genotype GG is associated with response to atenolol, bisoprolol, Celiprolol or doxazosin in people with Essential hypertension as compared to genotypes AA + AG. 23613831 982009266