PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
KCNB2	0	KCNG3	2	two hybrid, two hybrid	Mederos Y Schnitzler M (2009), Mederos Y Schnitzler M (2009)	2
KCNB1	11	SNAP25	8	pull down	MacDonald PE (2002)	1
KCNB1	11	KCNV2	1	two hybrid, affinity chromatography technology	Ottschytsch N (2002), Ottschytsch N (2002)	2
KCNG1	0	KCNB1	11	two hybrid, two hybrid	Post MA (1996), Post MA (1996)	2
SRC	2	KCNB1	11	enzymatic study	Tiran Z (2003)	1
KCNG2	2	KCNB1	11	two hybrid	Zhu XR (1999)	1
KCNE5	0	KCNB1	11	fluorescent resonance energy transfe	David JP (2015)	1
PTPRE	1	KCNB1	11	affinity chromatography technology, pull down	Peretz A (2000), Peretz A (2000)	2
KCNH1	11	CALM1	0	pull down	Schoenherr R (2000)	1
KCNB1	11	KCNG4	2	two hybrid, fluorescent resonance energy transfe, affinity chromatography technology, two hybrid, fluorescent resonance energy transfe	Mederos Y Schnitzler M (2009), Mederos Y Schnitzler M (2009), Mederos Y Schnitzler M (2009), Mederos Y Schnitzler M (2009), David JP (2015)	5
KCNV1	0	KCNB1	11	pull down	Hugnot JP (1996)	1
SNAP25	8	STX1A	2	two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, pull down, x-ray crystallography, pull down, affinity chromatography technology	Stelzl U (2005), Stelzl U (2005), Dulubova I (1999), McMahon HT (1995), Gonelle-Gispert C (2000), Gonelle-Gispert C (2000), Ilardi JM (1999), Li Y (2001), Ravichandran V (1996), Chapman ER (1994), Chapman ER (1994), Chen X (2002), Steegmaier M (1998), Darios F (2010)	14
KCNB1	11	KCNH1	11	two hybrid, affinity chromatography technology	Ottschytsch N (2002), Ottschytsch N (2002)	2
KCNB1	11	KCNB1	11	two hybrid, two hybrid, two hybrid, fluorescent resonance energy transfe	Ottschytsch N (2002), Post MA (1996), Mederos Y Schnitzler M (2009), Mederos Y Schnitzler M (2009)	4
KCNB1	11	KCNB2	0	two hybrid, two hybrid	Mederos Y Schnitzler M (2009), Mederos Y Schnitzler M (2009)	2
KCNS3	3	KCNB2	0	affinity chromatography technology	Huttlin EL (2017)	1
NEDD4L	3	KCNB1	11	enzymatic study, pull down	Persaud A (2009), Persaud A (2009)	2
KCNB1	11	CALM1	0	pull down	Swain SM (2015)	1
KCNB2	0	KCNG4	2	two hybrid, two hybrid	Mederos Y Schnitzler M (2009), Mederos Y Schnitzler M (2009)	2
KCNB1	11	KCNG3	2	two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid, fluorescent resonance energy transfe, two hybrid	Ottschytsch N (2002), Ottschytsch N (2002), Sano Y (2002), Mederos Y Schnitzler M (2009), Mederos Y Schnitzler M (2009), Mederos Y Schnitzler M (2009)	6
KCNS3	3	KCNB1	11	affinity chromatography technology	Patel AJ (1997)	1
KCNV1	0	KCNB2	0	affinity chromatography technology	Hugnot JP (1996)	1
STX1A	2	KCNB1	11	affinity chromatography technology, affinity chromatography technology, pull down, pull down	Dai XQ (2012), Dai XQ (2012), Leung YM (2005), Leung YM (2005)	4
KCNE5	0	KCNG4	2	fluorescent resonance energy transfe	David JP (2015)	1