PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
KCNA1	3	KCNA4	5	affinity chromatography technology, affinity chromatography technology	Coleman SK (1999), Coleman SK (1999)	2
KCNA5	2	KCNA2	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Albarwani S (2003), Nitabach MN (2001), Nitabach MN (2001)	3
KCNA3	3	KCNA1	3	affinity chromatography technology	Coleman SK (1999)	1
KCNA3	3	UBTF	8	affinity chromatography technology, affinity chromatography technology	Jang SH (2015), Jang SH (2015)	2
KCNA3	3	DLG4	11	affinity chromatography technology, affinity chromatography technology	Marks DR (2007), Doczi MA (2011)	2
DLG4	11	KCNA1	3	two hybrid, pull down	Eldstrom J (2002), Eldstrom J (2002)	2
CAV1	0	KCNA5	2	affinity chromatography technology, affinity chromatography technology	Vicente R (2008), Perez-Verdaguer M (2016)	2
KCNA3	3	NEDD4L	3	affinity chromatography technology, affinity chromatography technology	Velez P (2016), Velez P (2016)	2
KCNA5	2	TFRC	1	biochemical	Vicente R (2008)	1
KCNA3	3	KCNA4	5	affinity chromatography technology	Coleman SK (1999)	1
KCNA3	3	KCNA5	2	fluorescent resonance energy transfe, biochemical, affinity chromatography technology	Vicente R (2008), Vicente R (2008), Huttlin EL (2017)	3
KCNA3	3	KCNA2	6	affinity chromatography technology	Coleman SK (1999)	1
KCNA3	3	TFRC	1	biochemical	Vicente R (2008)	1
KCNA5	2	DLG1	2	affinity chromatography technology, affinity chromatography technology	Godreau D (2003), Mathur R (2006)	2
KCNA3	3	CD3D	0	fluorescent resonance energy transfe	Panyi G (2003)	1
KCNA5	2	DLG4	11	affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology	Eldstrom J (2003), Eldstrom J (2002), Eldstrom J (2002), Eldstrom J (2002), Mathur R (2006)	5
KCNA2	6	KCNA1	3	affinity chromatography technology, affinity chromatography technology	Coleman SK (1999), Coleman SK (1999)	2
KCNA2	6	CTTN	1	affinity chromatography technology, pull down, fluorescent resonance energy transfe, fluorescent resonance energy transfe	Hattan D (2002), Hattan D (2002), Williams MR (2007), Williams MR (2007)	4
KCNA3	3	BAX	3	pull down, pull down	Gulbins E (2010), Gulbins E (2010)	2
KCNA4	5	DLG1	2	two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid	Eldstrom J (2003), Inanobe A (2002), Kim E (1996), Kim E (1995)	4
KCNA2	6	KCNA4	5	affinity chromatography technology, affinity chromatography technology	Coleman SK (1999), Coleman SK (1999)	2
DLG1	2	KCNA3	3	affinity chromatography technology	Hanada T (1997)	1
HCLS1	0	KCNA3	3	imaging technique	Hajdu P (2015)	1
KCNA3	3	DEFB4A	0	affinity chromatography technology, pull down	Feng J (2015), Feng J (2015)	2
CTTN	1	KCNA3	3	imaging technique	Hajdu P (2015)	1
DLG4	11	KCNA2	6	two hybrid, pull down	Eldstrom J (2002), Eldstrom J (2002)	2
CAV1	0	TFRC	1	affinity chromatography technology	Hinrichs JW (2004)	1
KCNA4	5	DLG4	11	affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, far western blotting, pull down, pull down, imaging technique, pull down, two hybrid, pull down	Inanobe A (2002), Niethammer M (1998), Kim E (1996), Kim E (1996), Eldstrom J (2002), Eldstrom J (2002), Eldstrom J (2002), Niethammer M (1996), Piserchio A (2002), Imamura F (2002), Imamura F (2002), Imamura F (2002), Kim E (1995), Kim E (1995)	14
3742	0	KCNA3	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
KCNA3	3	CAV1	0	biochemical, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe	Vicente R (2008), Vicente R (2008), Perez-Verdaguer M (2016), Perez-Verdaguer M (2016)	4
KCNA5	2	KCNA4	5	affinity chromatography technology	Nitabach MN (2001)	1