PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
EED	1	MTF2	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Hein MY (2015), Hauri S (2016), Hauri S (2016)	3
ELAVL1	0	BRD2	2	affinity chromatography technology	Abdelmohsen K (2009)	1
EHMT2	4	HDAC2	1	affinity chromatography technology, affinity chromatography technology	Bantscheff M (2011), Bantscheff M (2011)	2
RBBP7	1	EED	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Hein MY (2015), Huttlin EL (2017), Hauri S (2016), Hauri S (2016)	5
RBBP4	3	HDAC2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology	Zhang Y (2003), Hakimi MA (2003), Zhang Y (2002), Tong JK (1998), Sun JM (2007), Sun JM (2007), Adenuga D (2010), Xue Y (1998), Xue Y (1998), Cui S (2011), Havugimana PC (2012), Bantscheff M (2011), Wan C (2015), Hauri S (2016)	14
EED	1	TUBA1C	1	affinity chromatography technology	Hauri S (2016)	1
JARID2	7	NKX2-5	0	affinity chromatography technology, affinity chromatography technology, pull down, pull down	Kim TG (2004), Kim TG (2004), Kim TG (2004), Kim TG (2004)	4
RBBP4	3	TUBA1C	1	affinity chromatography technology	Hauri S (2016)	1
HDAC2	1	SETDB1	3	affinity chromatography technology	Yang L (2003)	1
EHMT2	4	EHMT1	18	affinity chromatography technology, affinity chromatography technology	Bantscheff M (2011), Hauri S (2016)	2
GATA4	4	SUZ12	0	affinity chromatography technology	He A (2012)	1
ELAVL1	0	JARID2	7	affinity chromatography technology	Abdelmohsen K (2009)	1
GATA4	4	EZH2	4	affinity chromatography technology, affinity chromatography technology	He A (2012), He A (2012)	2
HDAC2	1	EHMT1	18	affinity chromatography technology	Bantscheff M (2011)	1
JARID2	7	EZH1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Pasini D (2010), Pasini D (2010), Hauri S (2016), Hauri S (2016)	4
JARID2	7	AEBP2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Pasini D (2010), Huttlin EL (2015), Huttlin EL (2017), Hauri S (2016), Hauri S (2016)	5
EZH2	4	RBBP7	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Cao Q (2014), Huttlin EL (2015), Hein MY (2015), Huttlin EL (2017), Hauri S (2016), Hauri S (2016)	6
NANOG	0	SUZ12	0	affinity chromatography technology	Oliviero G (2015)	1
EZH2	4	HDAC2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical	van der Vlag J (1999), van der Vlag J (1999), Tong ZT (2012), Tong ZT (2012), Wan C (2015)	5
ELAVL1	0	SUZ12	0	affinity chromatography technology, affinity chromatography technology	Abdelmohsen K (2009), Cao Q (2014)	2
MTF2	4	RBBP4	3	affinity chromatography technology, affinity chromatography technology	Hauri S (2016), Hauri S (2016)	2
JARID2	7	SETDB1	3	affinity chromatography technology, affinity chromatography technology, pull down	Mysliwiec MR (2012), Mysliwiec MR (2012), Mysliwiec MR (2012)	3
EZH2	4	JARID2	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Li G (2010), Li G (2010), Li G (2010), Li G (2010), Pasini D (2010), Pasini D (2010), Pasini D (2010), Cao Q (2014), Hein MY (2015), Hauri S (2016), Hauri S (2016)	11
EED	1	AEBP2	1	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Cao R (2004), Huttlin EL (2015), Hein MY (2015), Huttlin EL (2017), Hauri S (2016), Hauri S (2016)	6
EZH1	1	RBBP7	1	affinity chromatography technology	Hauri S (2016)	1
POU5F1	0	SUZ12	0	affinity chromatography technology	Oliviero G (2015)	1
DDB2	1	SUZ12	0	affinity chromatography technology	Zhao R (2015)	1
EZH1	1	MTF2	4	affinity chromatography technology, affinity chromatography technology	Hauri S (2016), Hauri S (2016)	2
MTF2	4	SUZ12	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Li G (2010), Cao Q (2014), Huttlin EL (2017), Hauri S (2016), Hauri S (2016)	5
JARID2	7	POLR2H	0	affinity chromatography technology	Hauri S (2016)	1
SLAIN2	2	JARID2	7	affinity chromatography technology	Hein MY (2015)	1
MTF2	4	JARID2	7	affinity chromatography technology, affinity chromatography technology	Li G (2010), Hauri S (2016)	2
RBBP7	1	MTF2	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017), Hauri S (2016), Hauri S (2016)	4
RBBP4	3	RBBP7	1	biochemical, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Havugimana PC (2012), Kristensen AR (2012), Huttlin EL (2015), Wan C (2015), Huttlin EL (2017), Hauri S (2016), Hauri S (2016)	7
JARID2	7	EHMT1	18	affinity chromatography technology	Shirato H (2009)	1
EED	1	EHMT1	18	unspecified method, affinity chromatography technology	Guil S (2012), Cao Q (2014)	2
EZH2	4	EHMT2	4	affinity chromatography technology	Hein MY (2015)	1
EED	1	RBBP4	3	biochemical, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Pasini D (2004), Cao R (2004), Hein MY (2015), Hauri S (2016), Hauri S (2016)	5
ALB	1	JARID2	7	affinity chromatography technology	Zhou M (2004)	1
EZH2	4	EHMT1	18	unspecified method	Guil S (2012)	1
ELAVL1	0	AEBP2	1	affinity chromatography technology	Abdelmohsen K (2009)	1
JARID2	7	HDAC2	1	affinity chromatography technology	Pasini D (2010)	1
ELAVL1	0	HDAC2	1	affinity chromatography technology	Abdelmohsen K (2009)	1
ELAVL1	0	MTF2	4	affinity chromatography technology	Abdelmohsen K (2009)	1
EED	1	EHMT2	4	affinity chromatography technology	Cao Q (2014)	1
GATA4	4	NKX2-5	0	affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, pull down, pull down	Garg V (2003), Durocher D (1997), Durocher D (1997), Zhu W (2000), Zhu W (2000), Kim TG (2004), Kim TG (2004)	7
EZH2	4	POU5F1	0	affinity chromatography technology	Hawkins PG (2010)	1
HDAC2	1	SUZ12	0	biochemical, affinity chromatography technology, biochemical	Havugimana PC (2012), Pasini D (2010), Wan C (2015)	3
GATA4	4	HDAC2	1	affinity chromatography technology	Trivedi CM (2010)	1
DDB2	1	JARID2	7	affinity chromatography technology, affinity chromatography technology	Fantini D (2017), Fantini D (2017)	2
EHMT2	4	POU5F1	0	affinity chromatography technology	Hawkins PG (2010)	1
POU5F1	0	JARID2	7	affinity chromatography technology	Oliviero G (2015)	1
AEBP2	1	RBBP7	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017), Hauri S (2016)	3
EZH2	4	MTF2	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Li G (2010), Li G (2010), Li G (2010), Cao Q (2014), Hauri S (2016), Hauri S (2016)	6
TUBA1C	1	CCT5	1	affinity chromatography technology	Hein MY (2015)	1
EED	1	SUZ12	0	biochemical, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, imaging technique, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Pasini D (2004), Cao R (2004), Margueron R (2008), Margueron R (2008), Shen X (2008), Pasini D (2008), Sarma K (2008), Pasini D (2010), Pasini D (2010), Cao Q (2014), Cao Q (2014), Cao Q (2014), Cao Q (2014), Cao Q (2014), Hein MY (2015), Chan YS (2013), Huttlin EL (2017), Zhang H (2016), Zhang H (2016), Wang X (2017), Hauri S (2016), Hauri S (2016)	22
EED	1	HDAC2	1	two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology	van der Vlag J (1999), van der Vlag J (1999), van der Vlag J (1999), van der Vlag J (1999), van der Vlag J (1999), Cao Q (2014)	6
NANOG	0	JARID2	7	affinity chromatography technology	Oliviero G (2015)	1
EZH2	4	SUZ12	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Su IH (2005), Aoto T (2008), Hansen KH (2008), Li G (2010), Margueron R (2008), Margueron R (2008), Shen X (2008), Pasini D (2008), Pasini D (2008), Sarma K (2008), Xu B (2011), Xu B (2011), Avdic V (2011), Kaneko S (2010), Kaneko S (2010), Yap DB (2011), Lee ST (2011), Havugimana PC (2012), Sahasrabuddhe AA (2014), Wang L (2013), Wu L (2013), Pasini D (2010), Pasini D (2010), Pasini D (2010), Cao Q (2014), Cao Q (2014), Cao Q (2014), Cao Q (2014), Wan C (2015), Hein MY (2015), Bhatnagar S (2014), Bhatnagar S (2014), Zhao R (2015), Wienken M (2016), Huttlin EL (2017), Zhang H (2016), Zhang H (2016), Mahara S (2016), Hauri S (2016), Hauri S (2016)	40
SETDB1	3	SUZ12	0	biochemical	Wang H (2003)	1
EZH2	4	AEBP2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Cao Q (2014), Huttlin EL (2015), Hein MY (2015), Huttlin EL (2017), Hauri S (2016), Hauri S (2016)	6
JARID2	7	BRD2	2	affinity chromatography technology	Hauri S (2016)	1
EZH1	1	EZH2	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Margueron R (2008), Margueron R (2008), Shen X (2008)	3
ELAVL1	0	RBBP4	3	affinity chromatography technology	Abdelmohsen K (2009)	1
EZH1	1	EED	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Margueron R (2008), Margueron R (2008), Shen X (2008), Jones CA (1998), van Lohuizen M (1998), Wang X (2017), Hauri S (2016), Hauri S (2016)	8
EZH2	4	RBBP4	3	affinity chromatography technology, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Li G (2010), Kaneko S (2010), Kaneko S (2010), Cao Q (2014), Hein MY (2015), Hauri S (2016), Hauri S (2016)	7
JARID2	7	EHMT2	4	affinity chromatography technology	Shirato H (2009)	1
JARID2	7	SUZ12	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Li G (2010), Pasini D (2010), Pasini D (2010), Pasini D (2010), Pasini D (2010), Cao Q (2014), Huttlin EL (2017), Hauri S (2016), Hauri S (2016)	9
EZH2	4	EED	1	two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, two hybrid, pull down, pull down, affinity chromatography technology, biochemical, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, imaging technique, pull down, biochemical, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	van Lohuizen M (1998), van Lohuizen M (1998), van Lohuizen M (1998), van der Vlag J (1999), van der Vlag J (1999), van der Vlag J (1999), Denisenko O (1998), Denisenko O (1998), Denisenko O (1998), Denisenko O (1998), Pasini D (2004), Cao R (2004), Su IH (2005), Hansen KH (2008), Margueron R (2008), Margueron R (2008), Shen X (2008), Shen X (2008), Hernandez-Munoz I (2005), Sarma K (2008), Sarma K (2008), Han Z (2007), Avdic V (2011), Kaneko S (2010), Kaneko S (2010), Yap DB (2011), Satijn DP (2001), Satijn DP (2001), Sewalt RG (1998), Sewalt RG (1998), Sewalt RG (1998), Sewalt RG (1998), Wang L (2013), Wu L (2013), Pasini D (2010), Cao Q (2014), Cao Q (2014), Cao Q (2014), Cao Q (2014), Cao Q (2014), Wan C (2015), Hein MY (2015), Hein MY (2015), Chan YS (2013), Zhang H (2016), Zhang H (2016), Wang X (2017), Hauri S (2016), Hauri S (2016)	49
AEBP2	1	EZH1	1	affinity chromatography technology, affinity chromatography technology	Hauri S (2016), Hauri S (2016)	2
JARID2	7	RBBP7	1	affinity chromatography technology, affinity chromatography technology	Pasini D (2010), Hauri S (2016)	2
JARID2	7	TUBA1C	1	affinity chromatography technology	Hauri S (2016)	1
HDAC2	1	RBBP7	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Hakimi MA (2003), Adenuga D (2010), Xue Y (1998), Havugimana PC (2012), Bantscheff M (2011), Huttlin EL (2015), Wan C (2015), Huttlin EL (2017), Hauri S (2016)	9
SUZ12	0	RBBP4	3	pull down, pull down, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Cao R (2004), Cao R (2004), Havugimana PC (2012), Pasini D (2010), Cao Q (2014), Huttlin EL (2017), Hauri S (2016), Hauri S (2016)	8
POU5F1	0	TUBA1C	1	affinity chromatography technology	Oliviero G (2015)	1
SUZ12	0	AEBP2	1	pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Cao R (2004), Cao R (2004), Pasini D (2010), Cao Q (2014), Huttlin EL (2015), Huttlin EL (2017), Hauri S (2016), Hauri S (2016)	8
JARID2	7	EED	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Pasini D (2010), Pasini D (2010), Hein MY (2015), Hauri S (2016), Hauri S (2016)	5
SETDB1	3	POU5F1	0	affinity chromatography technology, affinity chromatography technology	Yuan P (2009), Yuan P (2009)	2
DDB2	1	EZH2	4	affinity chromatography technology, affinity chromatography technology	Zhao R (2015), Zhao R (2015)	2
RBBP7	1	TUBA1C	1	affinity chromatography technology	Hauri S (2016)	1
GATA4	4	JARID2	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down	He A (2012), Kim TG (2004), Kim TG (2004), Kim TG (2004), Kim TG (2004)	5
RBBP4	3	AEBP2	1	pull down, affinity chromatography technology, affinity chromatography technology	Cao R (2004), Hauri S (2016), Hauri S (2016)	3
GATA4	4	EZH1	1	affinity chromatography technology	He A (2012)	1
JARID2	7	RBBP4	3	affinity chromatography technology, affinity chromatography technology	Pasini D (2010), Hauri S (2016)	2
SUZ12	0	RBBP7	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Pasini D (2010), Cao Q (2014), Huttlin EL (2015), Huttlin EL (2017), Hauri S (2016), Hauri S (2016)	6
EZH1	1	RBBP4	3	affinity chromatography technology	Hauri S (2016)	1
JARID2	7	CCT5	1	affinity chromatography technology	Hauri S (2016)	1
EZH2	4	ELAVL1	0	affinity chromatography technology	Cao Q (2014)	1
EZH1	1	SUZ12	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Margueron R (2008), Margueron R (2008), Shen X (2008), Pasini D (2010), Cao Q (2014), Huttlin EL (2017), Hauri S (2016), Hauri S (2016)	8
DDB2	1	CCT5	1	affinity chromatography technology	Hein MY (2015)	1
EED	1	ELAVL1	0	affinity chromatography technology	Cao Q (2014)	1