PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
CFTR	5	VCP	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Vij N (2006), Ballar P (2010), Goldstein RF (2007), Goldstein RF (2007), Sun F (2006), Sun F (2006), Wang X (2006), Morito D (2008), Pankow S (2015)	9
ITGB4	11	ERBIN	5	two hybrid, pull down	Favre B (2001), Favre B (2001)	2
HNRNPU	12	ITGB4	11	biochemical	Havugimana PC (2012)	1
ARRDC3	0	ITGB4	11	affinity chromatography technology	Draheim KM (2010)	1
SHC1	0	ITGB4	11	far western blotting	Dans M (2001)	1
HNRNPD	3	EIF6	2	affinity chromatography technology	Hein MY (2015)	1
DST	13	ERBIN	5	two hybrid, pull down	Favre B (2001), Favre B (2001)	2
HNRNPD	3	BAG6	2	affinity chromatography technology	Hein MY (2015)	1
TNRC6A	6	ITGB4	11	affinity chromatography technology	Hein MY (2015)	1
HNRNPD	3	ITGB4	11	affinity chromatography technology	Hein MY (2015)	1
VCP	6	PLEC	39	affinity chromatography technology	Yu CC (2013)	1
GEMIN7	0	ITGB4	11	affinity chromatography technology	Hein MY (2015)	1
CFTR	5	ITGA3	4	affinity chromatography technology	Pankow S (2015)	1
BAG6	2	VCP	6	affinity chromatography technology, affinity chromatography technology, biochemical	Wang Q (2011), Yu CC (2013), Xu Y (2013)	3
ATF2	1	SMAD3	1	two hybrid, pull down, affinity chromatography technology	Sano Y (1999), Sano Y (1999), Sano Y (1999)	3
KLC3	3	ITGB4	11	affinity chromatography technology	Hein MY (2015)	1
CFTR	5	PLEC	39	affinity chromatography technology	Pankow S (2015)	1
SHC1	0	HNRNPU	12	affinity chromatography technology	Li J (2013)	1
KLC3	3	BAG6	2	affinity chromatography technology	Hein MY (2015)	1
VCP	6	ITGB4	11	affinity chromatography technology	Hein MY (2015)	1
SGTB	2	BAG6	2	affinity chromatography technology	Hein MY (2015)	1
EGFR	5	SHC1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, protein complementation assay, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, two hybrid, affinity chromatography technology, pull down, affinity chromatography technology	Schulze WX (2006), Sakaguchi K (1998), Tong J (2009), Crovello CS (1998), Graus-Porta D (1997), Oksvold MP (2001), Burke P (2001), Katayama H (1999), Tong J (2008), Zhang L (1999), Levkowitz G (1999), Fukazawa T (1996), Jones RB (2006), Sigismund S (2013), Foerster S (2013), Gotoh N (1994), Tong J (2014), Kotlyar M (2015), Petschnigg J (2014), Petschnigg J (2014), Li J (2013), Li J (2013), Prigent SA (1996), Prigent SA (1996), Grosse R (2000), Yao Z (2017), Wills MK (2014), Wills MK (2014), Kapoor GS (2010)	29
LPAR1	1	ITGB4	11	affinity chromatography technology	Zhao J (2011)	1
COL17A1	3	DST	13	imaging technique, two hybrid, two hybrid	Koster J (2003), Koster J (2003), Hopkinson SB (2000)	3
4586	0	ITGB4	11	affinity chromatography technology, affinity chromatography technology	Lakshmanan I (2016), Lakshmanan I (2016)	2
ITGB4	11	ITGA3	4	affinity chromatography technology	de Nigris F (2007)	1
SMAD2	5	SKI	3	pull down, affinity chromatography technology, affinity chromatography technology, pull down, pull down, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Harada J (2003), Luo K (1999), Tabata T (2009), Prunier C (2003), Prunier C (2003), Akiyoshi S (1999), Akiyoshi S (1999), Takeda M (2004), Inoue Y (2011), Ferrand N (2010), Chen W (2007), Brown KA (2008), He J (2003), Rashidian J (2015), Zhou F (2017)	15
ITGB4	11	EIF6	2	two hybrid, pull down	Biffo S (1997), Biffo S (1997)	2
VCP	6	ATXN1	2	affinity chromatography technology, pull down	Fujita K (2013), Fujita K (2013)	2
DST	13	ITGB4	11	two hybrid	Hopkinson SB (2000)	1
BAG6	2	ITGB4	11	affinity chromatography technology	Hein MY (2015)	1
EGFR	5	JUP	7	pull down, affinity chromatography technology, two hybrid, protein complementation assay	Hazan RB (1998), Tong J (2014), Kotlyar M (2015), Petschnigg J (2014)	4
CFTR	5	ITGB4	11	affinity chromatography technology	Pankow S (2015)	1
PPP2R3C	1	ITGB4	11	affinity chromatography technology	Hein MY (2015)	1
SKI	3	ITGB4	11	affinity chromatography technology	Rashidian J (2015)	1
ENPP2	3	ITGB4	11	affinity chromatography technology	Zhao J (2011)	1
ITGB4	11	JUP	7	biochemical	Havugimana PC (2012)	1
ATXN1	2	ITGB4	11	two hybrid	Lim J (2006)	1
CFTR	5	EGFR	5	affinity chromatography technology	Pankow S (2015)	1
HNRNPU	12	EIF6	2	biochemical	Havugimana PC (2012)	1
ILK	0	ITGB4	11	affinity chromatography technology	So J (2015)	1
MYH13	9	ITGB4	11	affinity chromatography technology	Hein MY (2015)	1
HNRNPU	12	HNRNPD	3	two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology	Hegele A (2012), Hegele A (2012), Hein MY (2015), Hein MY (2015)	4
GEMIN7	0	SHC1	0	two hybrid	Vinayagam A (2011)	1
MYO19	0	PLEC	39	affinity chromatography technology	Hein MY (2015)	1
ITGB4	11	PLEC	39	biochemical	Havugimana PC (2012)	1
ATF2	1	ITGB4	11	affinity chromatography technology	Lau E (2012)	1
CFTR	5	ERBIN	5	affinity chromatography technology	Wang X (2006)	1
SMAD3	1	SMAD2	5	affinity chromatography technology, genetic interference, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology	Nakao A (1997), Lebrun JJ (1999), Dumont E (2003), Brown KA (2008), Brown KA (2008), Wu RY (1997), Wu RY (1997), Tang Y (2003), Tang Y (2003), Wang J (2011), Huttlin EL (2015), Huttlin EL (2017)	12
SREBF2	5	ITGB4	11	two hybrid	Bandyopadhyay S (2010)	1
SREBF2	5	ATXN1	2	two hybrid	Bandyopadhyay S (2010)	1
SMAD2	5	ERBIN	5	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Warner DR (2003), Xi Q (2008), Brown KA (2008), Dai F (2007), Dai F (2007), Dai F (2007)	6
EGFR	5	SEL1L	2	affinity chromatography technology	Foerster S (2013)	1
SMAD3	1	ITGB4	11	affinity chromatography technology	Brown KA (2008)	1
ITGB4	11	SEL1L	2	affinity chromatography technology, affinity chromatography technology	Diaferia GR (2013), Diaferia GR (2013)	2
JUP	7	PLEC	39	biochemical	Havugimana PC (2012)	1
SMAD3	1	SREBF2	5	affinity chromatography technology, affinity chromatography technology	Grimsby S (2004), Grimsby S (2004)	2
MYO19	0	ITGB4	11	affinity chromatography technology	Hein MY (2015)	1
SMAD2	5	ITGB4	11	affinity chromatography technology	Brown KA (2008)	1
SGTB	2	ITGB4	11	affinity chromatography technology	Hein MY (2015)	1
CFTR	5	MYH13	9	affinity chromatography technology	Pankow S (2015)	1
SMAD3	1	ERBIN	5	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Warner DR (2003), Xi Q (2008), Brown KA (2008), Dai F (2007), Dai F (2007), Dai F (2007)	6
EGFR	5	ITGB4	11	affinity chromatography technology	Li J (2013)	1
COL17A1	3	ITGB4	11	two hybrid, affinity chromatography technology	Aho S (1998), Schaapveld RQ (1998)	2
EGFR	5	COL17A1	3	affinity chromatography technology	Li J (2013)	1
ALOX12	5	ITGB4	11	two hybrid, pull down, affinity chromatography technology	Tang K (2000), Tang K (2015), Tang K (2015)	3
SMAD3	1	SKI	3	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Harada J (2003), Ueki N (2003), Ueki N (2003), Tabata T (2009), Prunier C (2003), Liberati NT (2001), Akiyoshi S (1999), Akiyoshi S (1999), Takeda M (2004), Mizuide M (2003), Wu K (2003), Chen W (2007), Band AM (2009), Qin BY (2002), He J (2003), He J (2003), Jinnin M (2007), Jinnin M (2007), Rashidian J (2015)	19
MYO19	0	ERBIN	5	affinity chromatography technology	Hein MY (2015)	1
ENPP2	3	LPAR1	1	affinity chromatography technology, affinity chromatography technology	Zhao J (2011), Zhao J (2011)	2
ILK	0	SHC1	0	two hybrid	Vinayagam A (2011)	1
SKI	3	PLEC	39	affinity chromatography technology	Rashidian J (2015)	1