PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
RACK1	2	PRKCE	6	far western blotting, affinity chromatography technology, affinity chromatography technology, pull down	Liedtke CM (2002), Liedtke CM (2002), Liedtke CM (2002), Liedtke CM (2002)	4
PRKCA	7	ITGB2	4	enzymatic study	Fagerholm S (2002)	1
PLAUR	0	KNG1	1	pull down	Mahdi F (2004)	1
ITGB2	4	SHARPIN	1	far western blotting, pull down	De Franceschi N (2015), De Franceschi N (2015)	2
PSMD4	1	ITGB2	4	affinity chromatography technology	Sabherwal Y (2006)	1
ITGB2	4	ITGAL	4	affinity chromatography technology	Liliental J (1998)	1
EGFR	5	YWHAB	1	two hybrid, protein complementation assay	Kotlyar M (2015), Petschnigg J (2014)	2
ITGB2	4	YWHAZ	1	affinity chromatography technology, affinity chromatography technology	Fagerholm S (2002), Fagerholm S (2002)	2
PRKCA	7	RACK1	2	affinity chromatography technology	Lee HS (2002)	1
PRKCB	4	EGFR	5	enzymatic study	Khaled Z (1995)	1
YWHAZ	1	PRKCA	7	affinity chromatography technology	Gannon-Murakami L (2002)	1
YWHAZ	1	PRKCD	2	affinity chromatography technology	Gannon-Murakami L (2002)	1
SYK	3	ITGB2	4	affinity chromatography technology	Miura Y (2000)	1
ITGB2	4	RACK1	2	two hybrid, pull down, affinity chromatography technology	Liliental J (1998), Liliental J (1998), Liliental J (1998)	3
KNG1	1	ITGB2	4	pull down	Sheng N (2000)	1
PRKCD	2	PRKCB	4	affinity chromatography technology	Varjosalo M (2013)	1
EGFR	5	YWHAZ	1	affinity chromatography technology, affinity chromatography technology, two hybrid, protein complementation assay, affinity chromatography technology	Tong J (2009), Foerster S (2013), Kotlyar M (2015), Petschnigg J (2014), Petschnigg J (2014)	5
CD226	0	ITGB2	4	affinity chromatography technology	Shibuya K (1999)	1
RANBP9	5	COPS5	0	two hybrid, affinity chromatography technology, affinity chromatography technology	Wang H (2013), Wang H (2013), Wang H (2013)	3
YWHAZ	1	COPS5	0	two hybrid, affinity chromatography technology	Bandyopadhyay S (2010), Bennett EJ (2010)	2
YWHAB	1	YWHAZ	1	affinity chromatography technology, biochemical, affinity chromatography technology	Couzens AL (2013), Wan C (2015), Hein MY (2015)	3
PRKCA	7	PRKCG	3	affinity chromatography technology	Huttlin EL (2017)	1
EGFR	5	PSMD4	1	protein complementation assay	Deribe YL (2009)	1
EGFR	5	PTK2B	6	affinity chromatography technology, affinity chromatography technology	Keely SJ (2000), Ivankovic-Dikic I (2000)	2
ITGB2	4	YWHAB	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Choi EY (2008), Fagerholm S (2002), Fagerholm S (2002)	3
SYK	3	PTK2B	6	affinity chromatography technology	Ganju RK (2000)	1
PRKCD	2	RANBP9	5	affinity chromatography technology	Rex EB (2010)	1
EGFR	5	ICAM1	6	affinity chromatography technology	Wu SL (2006)	1
EGFR	5	ITGB2	4	two hybrid, protein complementation assay	Kotlyar M (2015), Petschnigg J (2014)	2
ITGB2	4	PLAUR	0	affinity chromatography technology	Yebra M (1999)	1
PRKCD	2	PTK2B	6	affinity chromatography technology	Wrenn RW (2001)	1
PRKCA	7	PRKCB	4	affinity chromatography technology	Huttlin EL (2017)	1
ITGB2	4	VNN2	2	affinity chromatography technology	Watanabe T (2002)	1
ITGB2	4	ICAM1	6	pull down, pull down, pull down, pull down	Kotovuori A (1999), Lu C (2001), Huang C (1995), Rolen U (2009)	4
PRKCB	4	RACK1	2	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Ron D (1999), Ron D (1999), Chen S (2008), Sato T (2014), Sato T (2014), Sato T (2014)	6
ITGB2	4	COPS5	0	pull down, two hybrid	Bianchi E (2000), Bianchi E (2000)	2
EGFR	5	PRKCE	6	two hybrid, protein complementation assay	Kotlyar M (2015), Petschnigg J (2014)	2
ICAM1	6	ITGAL	4	pull down, x-ray crystallography, pull down	Lu C (2001), Shimaoka M (2003), Yusuf-Makagiansar H (2001)	3
ITGAD	3	ITGB2	4	affinity chromatography technology	Van der Vieren M (1995)	1
ITGB2	4	RANBP9	5	two hybrid, pull down, affinity chromatography technology	Denti S (2004), Denti S (2004), Denti S (2004)	3
PRKCE	6	YWHAZ	1	affinity chromatography technology, affinity chromatography technology	Gannon-Murakami L (2002), Gannon-Murakami L (2002)	2
PRKCG	3	ITGB2	4	enzymatic study	Fagerholm S (2002)	1
PTK2B	6	ITGB2	4	affinity chromatography technology	Miura Y (2000)	1
C3	7	ITGB2	4	pull down	Micklem KJ (1985)	1
PRKCB	4	ITGB2	4	enzymatic study	Fagerholm S (2002)	1
COPS5	0	RACK1	2	two hybrid, affinity chromatography technology	Wang J (2008), Bennett EJ (2010)	2
PRKCA	7	EGFR	5	affinity chromatography technology, affinity chromatography technology, two hybrid, protein complementation assay, affinity chromatography technology	Gauthier ML (2003), Gauthier ML (2003), Kotlyar M (2015), Petschnigg J (2014), Petschnigg J (2014)	5
FHL2	0	ITGB2	4	two hybrid, affinity chromatography technology, affinity chromatography technology	Wixler V (2000), Wixler V (2000), Wixler V (2000)	3
ITGB2	4	CYTH1	1	two hybrid, two hybrid, pull down	Rietzler M (1998), Geiger C (2000), Geiger C (2000)	3
PRKCE	6	ITGB2	4	enzymatic study	Fagerholm S (2002)	1
PRKCG	3	RANBP9	5	affinity chromatography technology	Rex EB (2010)	1
ITGB2	4	NOTCH2NL	1	two hybrid	Rolland T (2014)	1
ITGAD	3	SHARPIN	1	unspecified method	Pouwels J (2013)	1
EGFR	5	SYK	3	unspecified method	Jones RB (2006)	1
PRKCD	2	ITGB2	4	enzymatic study	Fagerholm S (2002)	1
ITGAL	4	SHARPIN	1	affinity chromatography technology, pull down, far western blotting, unspecified method, pull down, unspecified method, far western blotting, affinity chromatography technology	Pouwels J (2013), Pouwels J (2013), Pouwels J (2013), Pouwels J (2013), De Franceschi N (2015), De Franceschi N (2015), De Franceschi N (2015), De Franceschi N (2015)	8