PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
ITGB2	4	SHARPIN	1	far western blotting, pull down	De Franceschi N (2015), De Franceschi N (2015)	2
ITGB2	4	ITGAL	4	affinity chromatography technology	Liliental J (1998)	1
ITGB2	4	ICAM1	6	pull down, pull down, pull down, pull down	Kotovuori A (1999), Lu C (2001), Huang C (1995), Rolen U (2009)	4
ITGAL	4	ESM1	0	affinity chromatography technology	Bechard D (2001)	1
ICAM1	6	ITGAL	4	pull down, x-ray crystallography, pull down	Lu C (2001), Shimaoka M (2003), Yusuf-Makagiansar H (2001)	3
CD82	2	ITGAL	4	affinity chromatography technology	Shibagaki N (1999)	1
ITGAL	4	SHARPIN	1	affinity chromatography technology, pull down, far western blotting, unspecified method, pull down, unspecified method, far western blotting, affinity chromatography technology	Pouwels J (2013), Pouwels J (2013), Pouwels J (2013), Pouwels J (2013), De Franceschi N (2015), De Franceschi N (2015), De Franceschi N (2015), De Franceschi N (2015)	8