PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
ITGB2	4	SHARPIN	1	far western blotting, pull down	De Franceschi N (2015), De Franceschi N (2015)	2
ITGAD	3	ITGB2	4	affinity chromatography technology	Van der Vieren M (1995)	1
VCAM1	2	ITGAD	3	pull down	Van der Vieren M (1999)	1
ITGAD	3	ICAM3	0	pull down	Van der Vieren M (1995)	1
ITGAD	3	SHARPIN	1	unspecified method	Pouwels J (2013)	1