PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
PDIA3	0	ITGB5	3	affinity chromatography technology	Jessop CE (2007)	1
ITGB5	3	ITGA3	4	affinity chromatography technology	de Nigris F (2007)	1
PDIA3	0	ITGB1	4	affinity chromatography technology	Jessop CE (2007)	1
FHL2	0	ITGB1	4	two hybrid, affinity chromatography technology, affinity chromatography technology	Wixler V (2000), Wixler V (2000), Wixler V (2000)	3
CFTR	5	FHL2	0	affinity chromatography technology	Pankow S (2015)	1
CFTR	5	CALR	1	affinity chromatography technology	Pankow S (2015)	1
FHL2	0	BIN1	2	two hybrid	Wixler V (2000)	1
CFTR	5	ITGA3	4	affinity chromatography technology	Pankow S (2015)	1
ITGA3	4	CD9	1	affinity chromatography technology, affinity chromatography technology	Park KR (2000), Hirano T (1999)	2
ITGA3	4	RABIF	0	two hybrid	Wixler V (1999)	1
ITGA3	4	EPHA2	3	affinity chromatography technology	Dutta D (2013)	1
CD151	2	ITGA3	4	pull down	Yauch RL (2000)	1
FBXO6	0	ITGB1	4	affinity chromatography technology	Liu B (2012)	1
CD9	1	ITGB1	4	affinity chromatography technology, affinity chromatography technology	Radford KJ (1996), Mazzocca A (2002)	2
ITGB4	11	ITGA3	4	affinity chromatography technology	de Nigris F (2007)	1
CALR	1	ITGA3	4	affinity chromatography technology	Leung-Hagesteijn CY (1994)	1
ITGB5	3	EPHA2	3	affinity chromatography technology	Dutta D (2013)	1
ITGA3	4	BIN1	2	two hybrid	Wixler V (1999)	1
CFTR	5	ITGB4	11	affinity chromatography technology	Pankow S (2015)	1
PDIA3	0	ITGA3	4	affinity chromatography technology	Jessop CE (2007)	1
FBXO6	0	ITGA3	4	affinity chromatography technology	Liu B (2012)	1
LGALS8	4	ITGB1	4	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Hadari YR (2000), Hadari YR (2000), Huttlin EL (2015), Huttlin EL (2017)	4
SCGB1D1	1	ITGA3	4	affinity chromatography technology	Huttlin EL (2017)	1
CD151	2	ITGB1	4	affinity chromatography technology	Mazzocca A (2002)	1
CFTR	5	ITGB1	4	affinity chromatography technology	Pankow S (2015)	1
CALR	1	PDIA3	0	affinity chromatography technology, biochemical, pull down, pull down, pull down, biochemical, affinity chromatography technology, affinity chromatography technology	Oliver JD (1999), Oliver JD (1999), Oliver JD (1999), Oliver JD (1999), Leach MR (2002), Wan C (2015), Tan P (2002), Tan P (2002)	8
TSPAN4	2	CD9	1	affinity chromatography technology, affinity chromatography technology	Tachibana I (1997), Tachibana I (1997)	2
CFTR	5	PDIA3	0	affinity chromatography technology	Pankow S (2015)	1
ITGB1	4	EPHA2	3	affinity chromatography technology	Dutta D (2013)	1
ITGB1	4	ITGA3	4	pull down, affinity chromatography technology	Dorfleutner A (2004), de Nigris F (2007)	2
FHL2	0	ITGA3	4	two hybrid, affinity chromatography technology, affinity chromatography technology	Wixler V (2000), Wixler V (2000), Wixler V (2000)	3
LGALS8	4	ITGA3	4	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Hadari YR (2000), Hadari YR (2000), Huttlin EL (2015), Huttlin EL (2017)	4
TSPAN4	2	ITGA3	4	affinity chromatography technology, affinity chromatography technology	Tachibana I (1997), Tachibana I (1997)	2
TSPAN4	2	ITGB1	4	affinity chromatography technology, affinity chromatography technology	Tachibana I (1997), Tachibana I (1997)	2