PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
TRIM25	5	MAVS	1	affinity chromatography technology	Liu B (2017)	1
TRAF2	1	MAPK9	3	imaging technique	Chen TC (2014)	1
TRAF6	0	DDX3X	52	affinity chromatography technology, affinity chromatography technology	Ewing RM (2007), Yu J (2016)	2
IRF3	4	AKT1	1	affinity chromatography technology	Joung SM (2011)	1
AKT1	1	FOXO1	2	enzymatic study, enzymatic study, enzymatic study, enzymatic study, imaging technique	Matsuzaki H (2005), Brent MM (2008), Rena G (1999), Tang ED (1999), Chen TC (2014)	5
USP19	1	TRIM21	0	affinity chromatography technology	Sowa ME (2009)	1
CREBBP	29	HDAC3	5	affinity chromatography technology, affinity chromatography technology, pull down, pull down	Chuang HC (2006), Chuang HC (2006), Chuang HC (2006), Chuang HC (2006)	4
TRAF2	1	TRAF3IP2	0	two hybrid, affinity chromatography technology, affinity chromatography technology	Rual JF (2005), Qian Y (2004), Sun D (2011)	3
IRF3	4	IRF7	2	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Au WC (2001), Au WC (2001), Higgs R (2008), Higgs R (2008)	4
TMEM173	0	IKBKE	2	affinity chromatography technology	Zhang Q (2017)	1
IRF3	4	SMC1A	15	affinity chromatography technology	Li X (2015)	1
IRF3	4	SYNGR3	0	affinity chromatography technology	Li X (2015)	1
PPP2CA	7	SLMAP	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid	Glatter T (2009), Hein MY (2015), Yadav L (2017), Yadav L (2017)	4
IRF3	4	DCTN1	6	affinity chromatography technology	Li X (2015)	1
TRIM26	1	TBK1	1	affinity chromatography technology, affinity chromatography technology	Ran Y (2016), Ran Y (2016)	2
XPO1	8	BCAS3	4	affinity chromatography technology	Kirli K (2015)	1
EP300	36	SMAD4	9	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, unspecified method, affinity chromatography technology	Kim RH (2000), Luciakova K (2008), Janknecht R (1998), Chung CL (2011), Shen X (1998), Dornan D (2003), Yang Y (2015)	7
HSP90AA1	7	USP19	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology	Gano JJ (2010), Lee JG (2014), Lee JG (2014), Lee JG (2014), He WT (2016), He WT (2016), He WT (2016)	7
TRAF3IP2	0	TRAF6	0	enzymatic study, affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid	Liu C (2009), Kanamori M (2002), Kanamori M (2002), Kanamori M (2002), Qian Y (2007), Qu F (2012), Wu NL (2014), Wu NL (2014), Rolland T (2014), Garg AV (2013), Sun D (2011), Yu H (2011)	12
TICAM1	3	TRAF3	1	affinity chromatography technology, affinity chromatography technology	Jiang Z (2004), Nguyen VP (2014)	2
IRF3	4	ANKRD40	1	affinity chromatography technology	Huttlin EL (2017)	1
TRAF6	0	ULK1	8	affinity chromatography technology, affinity chromatography technology	Nazio F (2013), Nazio F (2013)	2
IKBKE	2	TRAF3	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ng MH (2011), Charoenthongtrakul S (2013), Peng Y (2014), Gu L (2017), Fang R (2017)	5
HSP90AA1	7	FBXO17	1	affinity chromatography technology	Taipale M (2012)	1
TBK1	1	XIAP	0	enzymatic study, enzymatic study	Nakhaei P (2012), Kuranaga E (2006)	2
IKBKE	2	IRF3	4	affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study	Friedman CS (2008), Nakhaei P (2012), Bharaj P (2016), Zhang Q (2017)	4
FBXO7	1	MAPK9	3	enzymatic study	Teixeira FR (2016)	1
IKBKE	2	TANK	1	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Nomura F (2000), Nomura F (2000), Nomura F (2000), Gatot JS (2007), Renner F (2011), Shen RR (2012), Ryzhakov G (2007), So J (2015)	8
IRF5	0	SGTA	1	affinity chromatography technology, two hybrid	Wang J (2011), Wang J (2011)	2
CUL1	7	PSMA5	0	affinity chromatography technology	Bennett EJ (2010)	1
TRIM25	5	HSP90AA1	7	affinity chromatography technology	Choudhury NR (2017)	1
IRF3	4	TRAF2	1	affinity chromatography technology	Liu S (2015)	1
XPO1	8	CCDC88A	3	affinity chromatography technology	Kirli K (2015)	1
TRAF6	0	TBK1	1	affinity chromatography technology, affinity chromatography technology, pull down	Cai B (2017), Fang R (2017), Fang R (2017)	3
TRAF3IP2	0	IRF3	4	affinity chromatography technology	Ryzhakov G (2012)	1
TBK1	1	IKBKE	2	affinity chromatography technology, pull down, affinity chromatography technology, pull down	Li S (2011), Ikeda F (2007), Liu D (2015), Liu D (2015)	4
MAPK8	3	TRAF2	1	affinity chromatography technology	Gravestein LA (1998)	1
AKT1	1	CREBBP	29	pull down, enzymatic study	Drendall CI (2010), Drendall CI (2010)	2
PIN1	0	SMAD2	5	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Nakano A (2009), Nakano A (2009), Matsuura I (2010), Matsuura I (2010)	4
PIN1	0	PPP2CA	7	biochemical	Havugimana PC (2012)	1
PIN1	0	DEAF1	12	two hybrid	Vinayagam A (2011)	1
TRIM25	5	SGTA	1	affinity chromatography technology	Choudhury NR (2017)	1
IRF3	4	IRF5	0	pull down	Barnes BJ (2001)	1
XPO1	8	FBXO7	1	pull down	Nelson DE (2011)	1
TICAM1	3	MAVS	1	affinity chromatography technology	Xu LG (2005)	1
XPO1	8	FOXO1	2	affinity chromatography technology	Kirli K (2015)	1
IKBKE	2	TRAF2	1	enzymatic study, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology	Shen RR (2012), Shen RR (2012), Shen RR (2012), Zhang W (2010), Zhou AY (2013), Zhou AY (2013), So J (2015), Fang R (2017)	8
SMAD4	9	SMAD2	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, x-ray crystallography, pull down, affinity chromatography technology, two hybrid, two hybrid, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Moren A (2003), Wotton D (1999), Mori N (2001), Wu JW (2002), Wu JW (2002), Nakao A (1997), Wicks SJ (2000), Wu JW (2001), Chen X (1997), Hanai J (1999), Lebrun JJ (1999), Poncelet AC (2001), Razani B (2001), Razani B (2001), Wang B (2008), Moren A (2005), Kurisaki K (2003), Prunier C (2003), Kato Y (2002), Xu J (2000), Wang L (2011), He W (2006), He W (2006), Dupont S (2009), Brown JD (1999), Pardali K (2000), Fu G (2011), Chen W (2007), Gao S (2009), Lin X (2003), Seo SR (2006), Brown KA (2008), Brown KA (2008), Halder SK (2005), Barrios-Rodiles M (2005), Barrios-Rodiles M (2005), Dai F (2007), Chacko BM (2004), Chacko BM (2004), Chacko BM (2004), Wu RY (1997), Wu RY (1997), Tomita M (2004), Colland F (2004), Tang Y (2003), Ding L (2009), Fattet L (2013), Wang J (2011), Ali A (2013), Yamakawa N (2002), Yamakawa N (2002), Li X (2015), Zhou F (2014), Yang Y (2015), Yan X (2016), Zhou F (2017)	56
IRF3	4	EP300	36	affinity chromatography technology, affinity chromatography technology, imaging technique, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, unspecified method, affinity chromatography technology, pull down	Li S (2011), Weaver BK (1998), Suhara W (2002), Suhara W (2002), Suhara W (2002), Wathelet MG (1998), Lin R (2001), Takahasi K (2010), Takahasi K (2010), Yang H (2002)	10
TANK	1	TRAF6	0	affinity chromatography technology, affinity chromatography technology, pull down	Wang W (2015), Wang W (2015), Wang W (2015)	3
IPO5	0	HK2	3	biochemical	Kristensen AR (2012)	1
XPO1	8	TICAM1	3	affinity chromatography technology	Kirli K (2015)	1
TICAM1	3	TBK1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Li S (2011), Piao W (2009), Sato S (2003), Sato S (2003), Hu YH (2015), Cai B (2017)	6
IRF3	4	MSRA	3	affinity chromatography technology	Huttlin EL (2017)	1
IRF7	2	DEAF1	12	affinity chromatography technology	Ordureau A (2013)	1
DDX58	3	IRF3	4	affinity chromatography technology, affinity chromatography technology	Friedman CS (2008), Xu LG (2005)	2
PIN1	0	ANKRD40	1	two hybrid	Rolland T (2014)	1
TRIM25	5	PPP2CA	7	affinity chromatography technology	Choudhury NR (2017)	1
SMAD4	9	FOXO1	2	affinity chromatography technology, affinity chromatography technology	Seoane J (2004), Seoane J (2004)	2
IKBKE	2	TRAF3IP2	0	affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology	Qu F (2012), Qu F (2012), Qu F (2012), Ryzhakov G (2012)	4
XIAP	0	AKT1	1	affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, imaging technique	Dan HC (2004), Dan HC (2004), Pramanik KC (2013), Pramanik KC (2013), Chen TC (2014)	5
TICAM1	3	TANK	1	affinity chromatography technology	Li S (2011)	1
TRAF2	1	XIAP	0	affinity chromatography technology	Vince JE (2009)	1
TRIM25	5	EP300	36	affinity chromatography technology, affinity chromatography technology	Choudhury NR (2017), Choudhury NR (2017)	2
AKT1	1	CCDC88A	3	two hybrid, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down	Enomoto A (2005), Enomoto A (2005), Anai M (2005), Anai M (2005), Anai M (2005)	5
MAPK9	3	MAPK8	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Varjosalo M (2013), Huttlin EL (2015), Huttlin EL (2017)	3
HSP90AA1	7	IKBKE	2	affinity chromatography technology	Taipale M (2012)	1
MAPK9	3	IRF3	4	affinity chromatography technology	Zhang B (2009)	1
TRIM25	5	DCTN1	6	affinity chromatography technology	Choudhury NR (2017)	1
FBXO17	1	IRF3	4	affinity chromatography technology, affinity chromatography technology	Peng D (2017), Peng D (2017)	2
TRAF6	0	XIAP	0	affinity chromatography technology, two hybrid, imaging technique	Sanna MG (2002), Woodsmith J (2012), Chen TC (2014)	3
HDAC3	5	AKT1	1	affinity chromatography technology	Zampetaki A (2010)	1
TRAF3	1	MAVS	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Nakhaei P (2009), Arnaud N (2011), Paz S (2011), Wang Y (2012), Saha SK (2006), Saha SK (2006), Ng MH (2011), Johnsen IB (2009), van Zuylen WJ (2012), Belgnaoui SM (2012), Chen X (2014), Wang P (2013), Wang P (2013), Minassian A (2015), Gu L (2017), Khan M (2016), Fang R (2017), Fang R (2017)	18
XPO1	8	5430	0	affinity chromatography technology	Kirli K (2015)	1
SMAD2	5	PEX19	2	two hybrid	Colland F (2004)	1
EP300	36	5430	0	affinity chromatography technology, affinity chromatography technology	Cho H (1998), Fousteri M (2006)	2
IRF3	4	HSP90AA1	7	affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, pull down	Yang K (2006), Yang K (2006), Yang K (2006), Liu XY (2010), Liu XY (2010)	5
CREBBP	29	TLR2	0	affinity chromatography technology	Melroe GT (2007)	1
HSP90AA1	7	XPO1	8	affinity chromatography technology	Falsone SF (2005)	1
RBL2	5	PPP2CA	7	pull down	Vuocolo S (2003)	1
FBXO7	1	HSP90AA1	7	affinity chromatography technology	Teixeira FR (2016)	1
TBK1	1	CUL1	7	affinity chromatography technology	Bouwmeester T (2004)	1
IRF3	4	SORT1	1	affinity chromatography technology	Li X (2015)	1
PSMA5	0	5430	0	biochemical	Wan C (2015)	1
IRF3	4	MOCOS	5	affinity chromatography technology	Huttlin EL (2017)	1
IRF3	4	USP19	1	affinity chromatography technology	Huttlin EL (2017)	1
IRF3	4	TUBB8	2	affinity chromatography technology	Li X (2015)	1
SMAD4	9	AKT1	1	affinity chromatography technology	Song K (2006)	1
IRF3	4	GLMN	2	affinity chromatography technology	Huttlin EL (2017)	1
TRIM21	0	IRF5	0	affinity chromatography technology, pull down	Lazzari E (2014), Lazzari E (2014)	2
SMC1A	15	SMC2	3	biochemical, biochemical	Havugimana PC (2012), Wan C (2015)	2
TRIM25	5	FBXO7	1	affinity chromatography technology	Choudhury NR (2017)	1
FBXO17	1	CUL1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Glenn KA (2008), Bennett EJ (2010), Huttlin EL (2015), Huttlin EL (2017), Reitsma JM (2017)	5
CUL1	7	PRDX1	1	affinity chromatography technology	Bennett EJ (2010)	1
IRF3	4	TOMM70	1	affinity chromatography technology, affinity chromatography technology, pull down	Liu XY (2010), Liu XY (2010), Liu XY (2010)	3
HSP90AA1	7	TBK1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Yang K (2006), Taipale M (2012), Liu XY (2010)	3
MAFB	1	IRF7	2	affinity chromatography technology	Kim H (2010)	1
IRF3	4	DOCK7	3	affinity chromatography technology	Huttlin EL (2017)	1
TRAF6	0	IKBKE	2	affinity chromatography technology	Fang R (2017)	1
TRIM25	5	CBL	7	affinity chromatography technology	Choudhury NR (2017)	1
SMAD4	9	IRF3	4	affinity chromatography technology	Qing J (2004)	1
CUL1	7	GLMN	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Tron AE (2012), Tron AE (2012), Duda DM (2012), Tron AE (2012), Huttlin EL (2017)	5
TBK1	1	TRAF2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Bouwmeester T (2004), Bonnard M (2000), Behrends C (2010), Li S (2011), Li S (2011), Shen RR (2012), Zhang W (2010), Huttlin EL (2017), Fang R (2017), Fang R (2017)	10
TICAM1	3	TRAF6	0	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid, pull down, affinity chromatography technology	Sasai M (2010), Sasai M (2010), Jiang Z (2004), Wang YY (2004), Sato S (2003), Sato S (2003), Sato S (2003), Takaki H (2009), Verstak B (2014), Hu YH (2015)	10
IRF3	4	TRIM21	0	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Yang K (2009), Yang K (2009), Yang K (2009), Yang K (2009), Stacey KB (2012), Higgs R (2008), Higgs R (2008)	7
TANK	1	TRAF2	1	affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, unspecified method	Bouwmeester T (2004), Rothe M (1996), Rothe M (1996), Nomura F (2000), Nomura F (2000), Pomerantz JL (1999), Behrends C (2010), Li S (2011), Li S (2011), Li C (2002), Shen RR (2012), Shen RR (2012), Wang J (2011), Huttlin EL (2017), Kim CM (2017)	15
MAPK8	3	EP300	36	enzymatic study	See RH (2001)	1
FBXO7	1	PSMA5	0	affinity chromatography technology	Teixeira FR (2016)	1
TMEM173	0	GLMN	2	affinity chromatography technology	Li S (2011)	1
RB1	2	MAPK8	3	affinity chromatography technology	Li H (2001)	1
HDAC3	5	RBL1	1	affinity chromatography technology	Lai A (1999)	1
PPIP5K1	0	IRF3	4	affinity chromatography technology	Friedman CS (2008)	1
TRAF2	1	TRAF6	0	two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, two hybrid, affinity chromatography technology	Rual JF (2005), Li S (2011), Davies CC (2005), Relaix F (1998), Rolland T (2014), Yu H (2011), Huttlin EL (2017)	7
HSP90AA1	7	AKT1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Haendeler J (2003), Kawauchi K (2005), Sato S (2000), Basso AD (2002), Su CH (2011), Klein JB (2005), Sun L (2012)	7
EP300	36	FOXO1	2	enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology	Brent MM (2008), Perrot V (2005), Perrot V (2005), Perrot V (2005), Perrot V (2005), Pramanik KC (2014), Pramanik KC (2014), Mahmud DL (2002), Li X (2015)	9
DDX58	3	IKBKE	2	affinity chromatography technology	Oshiumi H (2013)	1
TRIM21	0	CUL1	7	affinity chromatography technology, biochemical, pull down	Sabile A (2006), Sabile A (2006), Sabile A (2006)	3
IRF7	2	TRIM21	0	affinity chromatography technology	Higgs R (2010)	1
PIN1	0	EP300	36	pull down	Yi P (2005)	1
MAPK9	3	AKT1	1	enzymatic study	Xiao L (2010)	1
IRF3	4	TEX36	0	affinity chromatography technology	Li X (2015)	1
TOMM70	1	HSP90AA1	7	affinity chromatography technology, pull down	Liu XY (2010), Liu XY (2010)	2
IRF3	4	TRIM26	1	affinity chromatography technology, pull down, enzymatic study	Wang P (2015), Wang P (2015), Wang P (2015)	3
TBK1	1	MAVS	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology	Li S (2011), Xu LG (2005), Wang L (2012), Liu XY (2011), Liu S (2015), Fang R (2017), Zhang Q (2017)	7
PPP2CA	7	FBXO17	1	affinity chromatography technology, affinity chromatography technology	Peng D (2017), Peng D (2017)	2
IRF3	4	IPO5	0	affinity chromatography technology	Song S (2016)	1
PIN1	0	5430	0	affinity chromatography technology	Albert A (1999)	1
5430	0	EWSR1	2	affinity chromatography technology	Dutertre M (2010)	1
AKT1	1	FASN	15	two hybrid	Arroyo R (2015)	1
PIAS4	5	TICAM1	3	affinity chromatography technology	Zhang J (2004)	1
TRAF2	1	FBXO7	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kuiken HJ (2012), Chen CM (2014), Huttlin EL (2017)	3
PIN1	0	WRNIP1	3	pull down	Ingham RJ (2005)	1
DDX3X	52	TRAF3	1	pull down, affinity chromatography technology, affinity chromatography technology	Gu L (2017), Gu L (2017), Gu L (2017)	3
EP300	36	PPP2CA	7	affinity chromatography technology	Chen J (2005)	1
PIAS4	5	IRF3	4	affinity chromatography technology	Zhang J (2004)	1
IRF3	4	CCDC88A	3	affinity chromatography technology	Huttlin EL (2017)	1
HDAC3	5	IRF3	4	affinity chromatography technology	Alam S (2011)	1
MAPK8	3	IRF3	4	affinity chromatography technology, enzymatic study	Zhang B (2009), Zhang B (2009)	2
IRF5	0	MAVS	1	affinity chromatography technology, pull down	Li S (2011), Li S (2011)	2
TRIM25	5	TICAM1	3	affinity chromatography technology	Choudhury NR (2017)	1
MAFB	1	IKBKE	2	affinity chromatography technology	Kim H (2010)	1
DDX3X	52	IRF3	4	affinity chromatography technology	Gu L (2017)	1
TRIM25	5	PSMA5	0	affinity chromatography technology	Choudhury NR (2017)	1
TMEM173	0	TRAF2	1	affinity chromatography technology	Yao X (2016)	1
FBXO7	1	IRF3	4	enzymatic study	Teixeira FR (2016)	1
IRF3	4	MAVS	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Li S (2011), Wang Y (2012), Xu LG (2005), Liu S (2015), Liu S (2015), Zhou Z (2014)	6
IRF3	4	FOXO1	2	affinity chromatography technology	Lei CQ (2013)	1
XPO1	8	TUBB8	2	affinity chromatography technology	Kirli K (2015)	1
TRIM21	0	ULK1	8	affinity chromatography technology	Kimura T (2015)	1
HDAC3	5	PIN1	0	affinity chromatography technology	Rajendran P (2011)	1
CUL1	7	HSP90AA1	7	affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Taipale M (2012)	2
IRF3	4	RB1	2	affinity chromatography technology, pull down	Li S (2011), Li S (2011)	2
MAVS	1	IKBKE	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Paz S (2009), Li S (2011), Paz S (2011), Paz S (2011), Fang R (2017)	5
IRF3	4	CREBBP	29	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Kim T (1999), Li S (2011), Weaver BK (1998), Lin R (1998), Bibeau-Poirier A (2006), Lin R (1999), Johnson J (2007), Marson A (2004), Aksoy E (2007), Devaraj SG (2007), Devaraj SG (2007), Melroe GT (2007), Melroe GT (2007), Suhara W (2002), Wathelet MG (1998), Qin BY (2005), Qin BY (2005), Lin R (2001), Lubyova B (2004), Jennings S (2005), Sarkar SN (2004), Kim H (2010), Yang H (2002), Xing J (2013), Chen Y (2015)	25
EWSR1	2	SMAD4	9	two hybrid	Rual JF (2005)	1
PIN1	0	TRAF2	1	two hybrid, two hybrid	Rual JF (2005), Rolland T (2014)	2
IRF3	4	RBL1	1	affinity chromatography technology, pull down	Li S (2011), Li S (2011)	2
MAPK8	3	AKT1	1	enzymatic study	Xiao L (2010)	1
SMAD2	5	WRNIP1	3	affinity chromatography technology	Brown KA (2008)	1
IRF3	4	SALL2	2	affinity chromatography technology	Li X (2015)	1
SMAD4	9	HERC5	2	affinity chromatography technology, affinity chromatography technology	Coyle-Rink J (2002), Coyle-Rink J (2002)	2
AKT1	1	EP300	36	affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down	Lin WN (2008), Lee IT (2010), Sundaresan NR (2011), Howie HL (2011), Chen J (2004), Chen J (2004)	6
TRIM25	5	IRF3	4	affinity chromatography technology	Choudhury NR (2017)	1
PIAS4	5	IRF7	2	affinity chromatography technology	Zhang J (2004)	1
TRAF2	1	TRAF3	1	affinity chromatography technology, fluorescent resonance energy transfe, affinity chromatography technology, affinity chromatography technology	Li S (2011), He L (2004), He L (2004), Pullen SS (1998)	4
EWSR1	2	FASN	15	two hybrid	Rual JF (2005)	1
TOMM70	1	TMEM173	0	affinity chromatography technology, affinity chromatography technology	Liu XY (2010), Liu XY (2010)	2
TRAF3IP2	0	TRAF3	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Qian Y (2002), Qian Y (2004), Boisson B (2013)	3
ULK1	8	IRF3	4	affinity chromatography technology	Kimura T (2015)	1
EP300	36	EWSR1	2	two hybrid, bioid	Wang J (2011), Elzi DJ (2014)	2
IRF3	4	TRO	1	affinity chromatography technology	Li X (2015)	1
IRF3	4	CBL	7	affinity chromatography technology, affinity chromatography technology	Zhao X (2016), Zhao X (2016)	2
EWSR1	2	CREBBP	29	pull down, bioid	Araya N (2003), Elzi DJ (2014)	2
AKT1	1	PPP2CA	7	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study	Beaulieu JM (2008), Beaulieu JM (2008), Calvo N (2010), Calvo N (2010), Xiao L (2010), Guo J (2016), Guo J (2016), Guo J (2016)	8
CBL	7	TRAF2	1	affinity chromatography technology	Xu L (2017)	1
IPO5	0	XPO1	8	biochemical	Wan C (2015)	1
EP300	36	HDAC3	5	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down	Kadeppagari RK (2009), Gregoire S (2007), Gregoire S (2007), Sankar N (2008), Sankar N (2008)	5
XPO1	8	TBK1	1	affinity chromatography technology	Kirli K (2015)	1
TANK	1	IRF7	2	two hybrid, affinity chromatography technology	Gatot JS (2007), Gatot JS (2007)	2
RB1	2	EP300	36	affinity chromatography technology, affinity chromatography technology, enzymatic study	Iyer NG (2007), Iyer NG (2007), Chan HM (2001)	3
IRF3	4	C5orf34	0	affinity chromatography technology	Huttlin EL (2017)	1
TMEM173	0	MAVS	1	affinity chromatography technology, affinity chromatography technology	Wang Y (2012), Chen X (2014)	2
TBK1	1	IRF3	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, pull down, two hybrid, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down, pull down, affinity chromatography technology, enzymatic study	Friedman CS (2008), Li S (2011), Li S (2011), Cui J (2012), Piao W (2009), Nakhaei P (2012), Ikeda F (2007), Ikeda F (2007), Ng MH (2011), Wang L (2012), Yang K (2006), Yang K (2006), Liu XY (2010), Liu S (2015), Liu S (2015), Freischmidt A (2015), Zhang Q (2017), Zhang Q (2017)	18
XPO1	8	DDX3X	52	affinity chromatography technology	Kirli K (2015)	1
RBL2	5	RBL1	1	affinity chromatography technology	Litovchick L (2007)	1
IRF3	4	ADGRL2	6	affinity chromatography technology	Li X (2015)	1
RBL2	5	DCTN1	6	two hybrid	Kong LJ (2006)	1
IRF3	4	KIT	4	affinity chromatography technology	Li X (2015)	1
TRIM25	5	XPO1	8	affinity chromatography technology	Choudhury NR (2017)	1
IRF3	4	TLR2	0	affinity chromatography technology	Melroe GT (2007)	1
TRIM25	5	PRDX1	1	affinity chromatography technology, affinity chromatography technology	Choudhury NR (2017), Choudhury NR (2017)	2
TRAF3IP2	0	TBK1	1	affinity chromatography technology, affinity chromatography technology, enzymatic study	Qu F (2012), Qu F (2012), Qu F (2012)	3
TRIM25	5	DDX58	3	affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique	Gack MU (2007), Gack MU (2007), Gack MU (2007), Gack MU (2010), Nistal-Villan E (2010), Nistal-Villan E (2010), Inn KS (2011), Inn KS (2011), Maharaj NP (2011), Oshiumi H (2013), Weng L (2014), Xia ZP (2009), Feng M (2012), Gao D (2009), Gao D (2009), Jiang J (2016), Hu Y (2017), Hu Y (2017)	18
IRF3	4	SLMAP	3	affinity chromatography technology	Li X (2015)	1
5430	0	IRF3	4	imaging technique	Freaney JE (2013)	1
EP300	36	TRAF2	1	two hybrid	Wang J (2011)	1
5430	0	SMC1A	15	affinity chromatography technology	Kang H (2011)	1
IRF3	4	SGTA	1	affinity chromatography technology, two hybrid	Wang J (2011), Wang J (2011)	2
TBK1	1	IRF7	2	pull down	Ikeda F (2007)	1
DDX3X	52	MAVS	1	pull down, affinity chromatography technology	Gu L (2017), Gu L (2017)	2
IRF3	4	RBL2	5	affinity chromatography technology	Li S (2011)	1
TRAF3	1	TMEM173	0	affinity chromatography technology, affinity chromatography technology	Chen X (2014), Yao X (2016)	2
TANK	1	IRF3	4	affinity chromatography technology	Gatot JS (2007)	1
IRF3	4	ESYT2	2	affinity chromatography technology	Li X (2015)	1
SMAD2	5	AKT1	1	affinity chromatography technology	Song K (2006)	1
SMAD2	5	IRF3	4	affinity chromatography technology	Qing J (2004)	1
XPO1	8	IRF3	4	affinity chromatography technology	Kirli K (2015)	1
CUL1	7	PPP2CA	7	affinity chromatography technology	Bennett EJ (2010)	1
IRF3	4	SOCS1	1	affinity chromatography technology, affinity chromatography technology	Oliere S (2010), Oliere S (2010)	2
DDX58	3	CBL	7	affinity chromatography technology	Song Y (2017)	1
EWSR1	2	IRF3	4	two hybrid	Ravasi T (2010)	1
SMAD2	5	CREBBP	29	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, affinity chromatography technology	Xi Q (2008), Chan EC (2010), He W (2006), Chen W (2007), Colland F (2004), Cui Q (2005)	6
EP300	36	SMAD2	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology	Wotton D (1999), Pessah M (2001), Furumatsu T (2005), Wang J (2011), Suganuma T (2002)	5
TOMM70	1	TBK1	1	affinity chromatography technology	Liu XY (2010)	1
FBXO7	1	CUL1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Cenciarelli C (1999), Kirk R (2008), Hsu JM (2004), Hagens O (2006), Bennett EJ (2010), Hein MY (2015), Vingill S (2016), Huttlin EL (2017), Teixeira FR (2016), Reitsma JM (2017), Reitsma JM (2017)	11
USP19	1	DOCK7	3	affinity chromatography technology	Sowa ME (2009)	1
MAVS	1	TRAF2	1	affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Li S (2011), Xu LG (2005), Yu H (2011), Minassian A (2015), Khan M (2016), Fang R (2017), Fang R (2017)	7
IRF7	2	CREBBP	29	pull down	Yang H (2003)	1
EWSR1	2	TRAF2	1	two hybrid	Rolland T (2014)	1
KIT	4	SOCS1	1	two hybrid, affinity chromatography technology	De Sepulveda P (1999), De Sepulveda P (1999)	2
TBK1	1	TANK	1	affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid	Bouwmeester T (2004), Pomerantz JL (1999), Gatot JS (2007), Li S (2011), Li S (2011), Shen RR (2012), Ryzhakov G (2007), Wang J (2011), Seo S (2013), Saul VV (2014), Richter B (2016), Shostak K (2014)	12
IRF3	4	PSMA5	0	affinity chromatography technology	Li X (2015)	1
AKT1	1	DCTN1	6	two hybrid	Vinayagam A (2011)	1
DDX58	3	MAVS	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Gack MU (2010), Gack MU (2009), Nistal-Villan E (2010), Kawai T (2005), Li S (2011), Li S (2011), Inn KS (2011), Arnaud N (2011), Maharaj NP (2011), Meylan E (2005), Xu LG (2005), Cui J (2010), Wei C (2010), Zhang H (2015), Tan P (2017)	15
MAPK8	3	HSP90AA1	7	affinity chromatography technology	Nieto-Miguel T (2008)	1
HDAC3	5	RB1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Fajas L (2002), Lai A (1999), Lai A (1999), Dahiya A (2000)	4
CCDC88A	3	HDAC3	5	affinity chromatography technology	Hein MY (2015)	1
FOXO1	2	RB1	2	affinity chromatography technology	Li X (2015)	1
EP300	36	IRF5	0	affinity chromatography technology, pull down	Feng D (2010), Feng D (2010)	2
CREBBP	29	5430	0	biochemical, affinity chromatography technology	Cho H (1998), Cho H (1998)	2
TRIM25	5	ULK1	8	affinity chromatography technology	Choudhury NR (2017)	1
TRIM25	5	MAPK9	3	affinity chromatography technology	Choudhury NR (2017)	1
CREBBP	29	EP300	36	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Crusselle-Davis VJ (2007), Dohda T (2004), Dohda T (2004)	3
IRF3	4	BCAS3	4	affinity chromatography technology	Li X (2015)	1
KIT	4	CBL	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Zeng S (2005), Brizzi MF (1996), Dong Y (2015)	3
IRF3	4	WRNIP1	3	affinity chromatography technology	Li X (2015)	1
XPO1	8	WRNIP1	3	affinity chromatography technology	Kirli K (2015)	1
IRF3	4	IRF3	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Gack MU (2009), Nakhaei P (2009), Maharaj NP (2011), Kondo T (2012), Hou F (2011), Lin R (1999), Suhara W (2002), Jennings S (2005), Kim H (2010), Liu S (2013), Chen X (2014), Peng Y (2014), Lee Y (2013), Yang H (2002), Liu S (2015), Kimura T (2015), Chen HW (2015), An T (2015), Minassian A (2015), Wang S (2013), Peng D (2017)	21
TRAF6	0	SOCS1	1	affinity chromatography technology	Zhou X (2015)	1
XPO1	8	MOCOS	5	affinity chromatography technology	Kirli K (2015)	1
HDAC3	5	XPO1	8	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Yang WM (2002), Lai IL (2007), Kirli K (2015)	3
SMAD4	9	IRF7	2	pull down, affinity chromatography technology	Qing J (2004), Qing J (2004)	2
TRIM25	5	USP19	1	affinity chromatography technology	Choudhury NR (2017)	1
TICAM1	3	TRAF2	1	two hybrid, affinity chromatography technology, enzymatic study, affinity chromatography technology, two hybrid	Sasai M (2010), Sasai M (2010), Sasai M (2010), Jiang Z (2004), Takaki H (2009)	5
IRF3	4	PRDX1	1	two hybrid	Rual JF (2005)	1
CUL1	7	SGTA	1	biochemical	Wan C (2015)	1
TRAF3	1	TBK1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Kayagaki N (2007), Mankouri J (2010), Mankouri J (2010), Tzieply N (2012), Wang Y (2012), Ng MH (2011), Charoenthongtrakul S (2013), van Zuylen WJ (2012), van Zuylen WJ (2012), Karim R (2013), Chen X (2014), Peng Y (2014), Wang S (2013), Zhou Y (2016), Cai B (2017), Fang R (2017), Fang R (2017)	17
TMEM173	0	IRF3	4	affinity chromatography technology, affinity chromatography technology	Chen X (2014), Liu S (2015)	2
CUL1	7	EWSR1	2	affinity chromatography technology	Bennett EJ (2010)	1
XPO1	8	CBL	7	affinity chromatography technology	Kirli K (2015)	1
SGTA	1	HSP90AA1	7	far western blotting, pull down	Angeletti PC (2002), Paul A (2014)	2
XIAP	0	IRF3	4	affinity chromatography technology	Nakhaei P (2012)	1
TRIM25	5	CREBBP	29	affinity chromatography technology, affinity chromatography technology	Choudhury NR (2017), Choudhury NR (2017)	2
EWSR1	2	TRAF3	1	two hybrid	Wang J (2011)	1
MAFB	1	IRF3	4	affinity chromatography technology, affinity chromatography technology	Kim H (2010), Kim H (2010)	2
IRF3	4	HK2	3	affinity chromatography technology	Li X (2015)	1
TRIM25	5	CCDC88A	3	affinity chromatography technology	Choudhury NR (2017)	1
XPO1	8	C5orf34	0	affinity chromatography technology	Kirli K (2015)	1
HSP90AA1	7	HK2	3	affinity chromatography technology	Hein MY (2015)	1
SMAD4	9	CREBBP	29	affinity chromatography technology	Yang Y (2015)	1
TRAF6	0	AKT1	1	enzymatic study, affinity chromatography technology, affinity chromatography technology	Yang WL (2009), Mitra S (2011), Mitra S (2011)	3
IRF7	2	MAVS	1	affinity chromatography technology	Xu LG (2005)	1
PIAS4	5	SMAD2	5	affinity chromatography technology, two hybrid, affinity chromatography technology	Imoto S (2003), Long J (2003), Long J (2003)	3
DDX58	3	TBK1	1	affinity chromatography technology	Oshiumi H (2013)	1
TRAF6	0	IRF7	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kawai T (2004), Young JA (2011), Hu Y (2011), Ning S (2008), Ning S (2008), Naiki Y (2015), Naiki Y (2015)	7
CUL1	7	AKT1	1	affinity chromatography technology	Reitsma JM (2017)	1
TBK1	1	TMEM173	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Tsuchida T (2010), Li S (2011), Zhang J (2012), Zhang J (2012), Chen X (2014), Ni G (2017), Zhang Q (2017)	7
TOMM70	1	TRAF6	0	affinity chromatography technology	Liu XY (2010)	1
CBL	7	MAPK8	3	affinity chromatography technology, enzymatic study	Miao H (2002), Miao H (2002)	2
IRF3	4	TRAF3	1	affinity chromatography technology, affinity chromatography technology	Ng MH (2011), Gu L (2017)	2
IRF3	4	HERC5	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study	Shi HX (2010), Shi HX (2010), Shi HX (2010), Shi HX (2010)	4
PIN1	0	DDX3X	52	pull down	Ingham RJ (2005)	1
CUL1	7	IRF3	4	affinity chromatography technology	Bibeau-Poirier A (2006)	1
MAVS	1	TRAF6	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Li S (2011), Wang Y (2012), Xu LG (2005), Wang P (2013), Wang P (2013), Shi Z (2015), Shi Z (2015), Minassian A (2015), Khan M (2016), Fang R (2017), Fang R (2017)	11
PSMA5	0	PEX19	2	biochemical	Wan C (2015)	1
DDX58	3	WRNIP1	3	affinity chromatography technology, pull down, affinity chromatography technology, imaging technique, affinity chromatography technology	Li S (2011), Li S (2011), Tan P (2017), Tan P (2017), Tan P (2017)	5
EWSR1	2	SALL2	2	two hybrid	Rual JF (2005)	1
XPO1	8	TRIM26	1	affinity chromatography technology	Kirli K (2015)	1
SMAD2	5	IRF7	2	pull down, affinity chromatography technology	Qing J (2004), Qing J (2004)	2
TANK	1	TRAF3	1	affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, pull down, x-ray crystallography, pull down, affinity chromatography technology	Bouwmeester T (2004), Rothe M (1996), Gatot JS (2007), Li S (2011), Li C (2003), Li C (2002), Li C (2002), Ng MH (2011)	8
SORT1	1	XIAP	0	affinity chromatography technology	Hein MY (2015)	1
EP300	36	SMC1A	15	affinity chromatography technology	Wong MM (2014)	1
IRF3	4	PIN1	0	affinity chromatography technology, affinity chromatography technology	Saitoh T (2006), Saitoh T (2006)	2
FBXO7	1	FASN	15	affinity chromatography technology	Teixeira FR (2016)	1
TRAF3IP2	0	HSP90AA1	7	affinity chromatography technology, affinity chromatography technology	Wu L (2014), Boisson B (2013)	2
TRAF6	0	TRIM25	5	two hybrid	Woodsmith J (2012)	1
IRF7	2	EP300	36	pull down	Yang H (2003)	1
IRF3	4	DEAF1	12	affinity chromatography technology	Ordureau A (2013)	1
CREBBP	29	IRF5	0	affinity chromatography technology, pull down	Feng D (2010), Feng D (2010)	2
IRF3	4	FASN	15	affinity chromatography technology	Li X (2015)	1
TRIM25	5	PPIP5K1	0	affinity chromatography technology	Choudhury NR (2017)	1
HSP90AA1	7	RB1	2	genetic interference	Srivas R (2016)	1
TRIM25	5	SMAD4	9	affinity chromatography technology	Choudhury NR (2017)	1
XPO1	8	DOCK7	3	affinity chromatography technology	Kirli K (2015)	1
IRF3	4	SMC2	3	affinity chromatography technology	Li X (2015)	1
IRF3	4	TRAF6	0	affinity chromatography technology	Liu S (2015)	1
CUL1	7	DDX3X	52	affinity chromatography technology	Bennett EJ (2010)	1
MAVS	1	TOMM70	1	affinity chromatography technology, affinity chromatography technology	Liu XY (2010), Liu XY (2010)	2
IRF3	4	ASMTL	0	affinity chromatography technology	Li X (2015)	1
RBL2	5	CUL1	7	affinity chromatography technology	Bhattacharya S (2003)	1
XPO1	8	PEX19	2	affinity chromatography technology	Kirli K (2015)	1
IRF3	4	PPP2CA	7	affinity chromatography technology	Peng D (2017)	1
PIAS4	5	SMAD4	9	affinity chromatography technology, two hybrid, affinity chromatography technology, pull down, affinity chromatography technology	Imoto S (2003), Long J (2003), Long J (2003), Long J (2003), Lee PS (2003)	5
SMAD4	9	RBL1	1	affinity chromatography technology	Chen CR (2002)	1
MAVS	1	WRNIP1	3	affinity chromatography technology, imaging technique	Tan P (2017), Tan P (2017)	2
AKT1	1	TBK1	1	affinity chromatography technology, affinity chromatography technology, enzymatic study	Joung SM (2011), Joung SM (2011), Joung SM (2011)	3
CBL	7	TRIM21	0	affinity chromatography technology	Brehme M (2009)	1
USP19	1	XIAP	0	affinity chromatography technology, affinity chromatography technology	Mei Y (2011), Mei Y (2011)	2
IKBKE	2	DDX3X	52	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Schroeder M (2008), Schroeder M (2008), Gu L (2017), Gu L (2017)	4
TRAF6	0	IRF5	0	affinity chromatography technology	Takaoka A (2005)	1
SMAD4	9	BCAS3	4	two hybrid	Arroyo R (2015)	1
EWSR1	2	HDAC3	5	two hybrid	Ravasi T (2010)	1
IRF3	4	PEX19	2	two hybrid	Wang J (2011)	1
TRIM25	5	ESYT2	2	affinity chromatography technology	Choudhury NR (2017)	1
XPO1	8	SMAD4	9	affinity chromatography technology	Kirli K (2015)	1
HSP90AA1	7	FASN	15	affinity chromatography technology, affinity chromatography technology	Falsone SF (2005), Skarra DV (2011)	2
IKBKE	2	XIAP	0	enzymatic study	Nakhaei P (2012)	1
FOXO1	2	CREBBP	29	two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Nasrin N (2000), Nasrin N (2000), Kitamura YI (2005), Daitoku H (2004), Daitoku H (2004), Daitoku H (2004), Daitoku H (2004), Pramanik KC (2014), Pramanik KC (2014), Li X (2015)	10
IRF3	4	TICAM1	3	affinity chromatography technology	Liu S (2015)	1