PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
PELI2	5	IRAK1	1	affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Butler MP (2007), Strelow A (2003), Strelow A (2003), Butler MP (2005), Schauvliege R (2006), Huoh YS (2014)	6
SARM1	3	IRAK1	1	affinity chromatography technology	Li S (2011)	1
TRAF6	0	IRAK2	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology	Wesche H (1999), Muzio M (1997), Keating SE (2007), Li S (2011), Li S (2011), Wang J (2011), Wang H (2015), Huttlin EL (2017)	8
TRAF6	0	IRAK3	0	affinity chromatography technology	Wesche H (1999)	1
IRAK2	3	N4BP2L2	3	affinity chromatography technology	Huttlin EL (2017)	1
TRIM25	5	IQSEC1	3	affinity chromatography technology	Choudhury NR (2017)	1
TOLLIP	3	TRAF6	0	affinity chromatography technology	Lee JY (2009)	1
MYD88	1	IRAK4	0	affinity chromatography technology, protein complementation assay, protein complementation assay, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid	Li S (2002), Ulrichts P (2008), Ulrichts P (2008), Zhou J (2011), Zhou J (2011), Burns K (2003), Burns K (2003), Strelow A (2003), Loiarro M (2007), Jeon J (2014), Rolland T (2014)	11
IRAK2	3	SNRNP200	15	affinity chromatography technology	Li S (2011)	1
MME	3	IRAK2	3	affinity chromatography technology	DallEra MA (2007)	1
MYD88	1	IRAK1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, genetic interference, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Chen BC (2002), Wesche H (1999), Li S (2002), Fitzgerald KA (2001), Fitzgerald KA (2001), Li S (2011), Neumann D (2007), Zhou J (2011), Burns K (2003), Mizobe T (2007), Loiarro M (2007), Choi KC (2006), Rao N (2005), Rao N (2005), Li CH (2006)	15
TRAF6	0	ZC3H12A	1	affinity chromatography technology	Wang W (2015)	1
TRIM25	5	HSP90AA1	7	affinity chromatography technology	Choudhury NR (2017)	1
IRAK2	3	STT3A	1	affinity chromatography technology, pull down	Li S (2011), Li S (2011)	2
IRAK2	3	IQCB1	3	affinity chromatography technology	Li S (2011)	1
IRAK2	3	TNFSF9	0	affinity chromatography technology	Ma J (2013)	1
PELI1	1	MYD88	1	affinity chromatography technology	Choi KC (2006)	1
PELI3	0	TRAF6	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology	Xiao H (2008), Jensen LE (2003), Jensen LE (2003), Butler MP (2005), Siednienko J (2012), Siednienko J (2012), Huoh YS (2014)	7
SARM1	3	STT3A	1	affinity chromatography technology, pull down	Li S (2011), Li S (2011)	2
PELI3	0	IRAK1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Xiao H (2008), Butler MP (2007), Jensen LE (2003), Jensen LE (2003), Butler MP (2005), Schauvliege R (2006), Huoh YS (2014)	7
PSEN1	11	CDC37	0	two hybrid, affinity chromatography technology	Soler-Lopez M (2011), Soler-Lopez M (2011)	2
SARM1	3	IRAK2	3	affinity chromatography technology, pull down	Li S (2011), Li S (2011)	2
IRAK2	3	PELI1	1	affinity chromatography technology	Butler MP (2007)	1
MYD88	1	IRAK2	3	affinity chromatography technology, genetic interference, affinity chromatography technology, affinity chromatography technology	Wesche H (1999), Fitzgerald KA (2001), Muzio M (1997), Zhou J (2011)	4
TLR3	2	TOLLIP	3	affinity chromatography technology	Li S (2011)	1
IRAK4	0	PELI2	5	affinity chromatography technology, two hybrid, affinity chromatography technology, enzymatic study	Butler MP (2007), Strelow A (2003), Strelow A (2003), Strelow A (2003)	4
IRAK1	1	COQ8A	3	affinity chromatography technology	Li S (2011)	1
IRAK1	1	IQSEC1	3	affinity chromatography technology	Li S (2011)	1
TIRAP	1	SNRNP200	15	affinity chromatography technology	Li S (2011)	1
TRAF6	0	IRAK1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology	Wesche H (1999), Qian Y (2001), Cao Z (1996), Takatsuna H (2003), Li S (2002), Ling L (2000), Ling L (2000), Takaesu G (2001), Muzio M (1997), Chen F (2008), Li X (2001), Li X (2001), Xiong Y (2011), Xiong Y (2011), Tang H (2010), Muroi M (2011), Liu A (2012), Lee JY (2009), Lee JY (2009), Kollewe C (2004), Jiang Z (2002), Jensen LE (2001), Liu G (2007), Liu G (2007), Jiang Z (2003), Nguyen T (2009), Choi KC (2006), Rao N (2005), Rao N (2005), Lakshmanan U (2007), Lee HJ (2012), Lee HJ (2012), Zhang X (2013), Yao J (2007), Hu MM (2014), Jeon J (2014), Conze DB (2008), Tanishima M (2017)	38
IRAK4	0	PELI1	1	affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology	Butler MP (2007), Ordureau A (2008), Smith H (2009), Smith H (2011), Jiang Z (2003), Choi KC (2006)	6
MYD88	1	TRAF6	0	genetic interference, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Fitzgerald KA (2001), Zhou J (2011), Zhou J (2011), Zhang X (2013), Zhang X (2013), Hirata Y (2006)	6
TIRAP	1	IRAK2	3	genetic interference, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Fitzgerald KA (2001), Fitzgerald KA (2001), Fitzgerald KA (2001), Li S (2011)	4
IL1R1	0	MYD88	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Burns K (2000), Muzio M (1997), Jiang Z (2003), Chen R (2012), Burns K (1998), Jeon J (2014)	6
IRAK2	3	YTHDF1	1	affinity chromatography technology	Li S (2011)	1
TOLLIP	3	IRAK1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Burns K (2000), Brissoni B (2006), Li S (2011), Lee JY (2009), Yagasaki Y (2004), Neumann D (2007), Ohnuma K (2005), Ohnuma K (2005), Jensen LE (2001), Rao N (2005), Lee HJ (2012), Lei L (2016)	12
IRAK1	1	IRAK2	3	affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe, fluorescent resonance energy transfe	Li S (2011), Li S (2011), Ross K (2002), Ross K (2002)	4
TRAF6	0	TNFAIP3	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, two hybrid, enzymatic study, affinity chromatography technology, enzymatic study, two hybrid, two hybrid	Heyninck K (1999), Evans PC (2001), Lin SC (2008), Xiong Y (2011), Bremm A (2010), Kelly C (2012), Hayes SD (2012), Lin SC (2008), Garg AV (2013), Boone DL (2004), Schimmack G (2017), Schimmack G (2017)	12
IL1R1	0	IRAK1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Jiang Z (2003), Jiang Z (2002), Jiang Z (2002), Chen R (2012), Cao Z (1996), Cao Z (1996), Rao N (2005), Jeon J (2014)	8
IRAK2	3	CDC37	0	affinity chromatography technology	Li S (2011)	1
IL1R1	0	IRAK4	0	affinity chromatography technology	Jiang Z (2003)	1
IL1R1	0	TOLLIP	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Burns K (2000), Brissoni B (2006), Brissoni B (2006)	3
HSP90AA1	7	TNFAIP3	3	affinity chromatography technology	Taipale M (2012)	1
IRAK2	3	ZC3H12C	3	affinity chromatography technology	Li S (2011)	1
IRAK2	3	IL1R1	0	affinity chromatography technology	Muzio M (1997)	1
IRAK3	0	IRAK1	1	affinity chromatography technology, fluorescent resonance energy transfe, affinity chromatography technology	Li S (2011), Ross K (2002), Nguyen T (2009)	3
IRAK1	1	BAG3	4	affinity chromatography technology	Li S (2011)	1
IRAK2	3	FASTKD5	3	affinity chromatography technology	Li S (2011)	1
IRAK2	3	ARAF	0	affinity chromatography technology, pull down	Li S (2011), Li S (2011)	2
IRAK2	3	TARDBP	4	affinity chromatography technology, pull down	Li S (2011), Li S (2011)	2
TRIM25	5	IRAK2	3	affinity chromatography technology	Choudhury NR (2017)	1
TIRAP	1	MYD88	1	genetic interference, two hybrid, two hybrid, affinity chromatography technology, protein complementation assay, protein complementation assay, protein complementation assay, protein complementation assay, protein complementation assay, affinity chromatography technology	Fitzgerald KA (2001), Fitzgerald KA (2001), Fitzgerald KA (2001), Fitzgerald KA (2001), Ulrichts P (2007), Ulrichts P (2007), Ulrichts P (2008), Ulrichts P (2010), Ulrichts P (2010), Ulrichts P (2010)	10
TIRAP	1	IRAK1	1	affinity chromatography technology, pull down	Li S (2011), Li S (2011)	2
HSP90AA1	7	ARAF	0	affinity chromatography technology, affinity chromatography technology	Taipale M (2012), Taipale M (2012)	2
TLR3	2	TRAF6	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Yang M (2011), Jiang Z (2003), Jiang Z (2003), Cusson-Hermance N (2005), Zinngrebe J (2016)	5
TRAF6	0	IRAK4	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Li S (2002), Li S (2002), Zhang X (2013)	3
IRAK4	0	IRAK2	3	affinity chromatography technology	Li S (2011)	1
TOLLIP	3	IRAK2	3	affinity chromatography technology, pull down	Li S (2011), Li S (2011)	2
IRAK4	0	TIRAP	1	protein complementation assay, affinity chromatography technology, pull down	Ulrichts P (2008), Li S (2011), Li S (2011)	3
TIRAP	1	TRAF6	0	genetic interference, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Fitzgerald KA (2001), Mansell A (2004), Verstak B (2009), Verstak B (2009), Ma J (2013)	5
IRAK1	1	TARDBP	4	affinity chromatography technology	Li S (2011)	1
IRAK1	1	HSP90AA1	7	affinity chromatography technology, affinity chromatography technology, biochemical	De Nardo D (2005), De Nardo D (2005), De Nardo D (2005)	3
IRAK4	0	IRAK1	1	affinity chromatography technology, enzymatic study, protein complementation assay, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology	Li S (2002), Li S (2002), Ulrichts P (2008), Li S (2011), Neumann D (2007), Burns K (2003), Liu G (2007), Strelow A (2003), Nguyen T (2009), Choi KC (2006), Rao N (2005), Rao N (2005), Jeon J (2014)	13
PELI1	1	IL1R1	0	affinity chromatography technology	Jiang Z (2003)	1
IL1R1	0	TRAF6	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Jiang Z (2003), Jiang Z (2002), Jiang Z (2003), Rafferty BJ (2010)	4
TIRAP	1	ARAF	0	affinity chromatography technology, pull down	Li S (2011), Li S (2011)	2
TRAF6	0	PSEN1	11	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique	Powell JC (2009), Elzinga BM (2009), Elzinga BM (2009), Yan R (2013), Yan R (2013), Gudey SK (2014), Gudey SK (2014)	7
HSP90AA1	7	IRAK2	3	affinity chromatography technology	Taipale M (2012)	1
PSEN1	11	IRAK2	3	affinity chromatography technology, affinity chromatography technology	Elzinga BM (2009), Elzinga BM (2009)	2
IRAK2	3	ZC3H12A	1	affinity chromatography technology, pull down	Li S (2011), Li S (2011)	2
IRAK2	3	SESTD1	1	affinity chromatography technology, affinity chromatography technology	Li S (2011), Huttlin EL (2017)	2
IRAK2	3	BAG3	4	affinity chromatography technology	Li S (2011)	1
PELI2	5	TRAF6	0	affinity chromatography technology, affinity chromatography technology	Jensen LE (2003), Huoh YS (2014)	2
CDC37	0	ARAF	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Taipale M (2014), Taipale M (2014), Li J (2013)	3
MYD88	1	IRAK3	0	affinity chromatography technology	Wesche H (1999)	1
HSP90AA1	7	IRAK3	0	affinity chromatography technology	Taipale M (2012)	1
IRAK2	3	TNFAIP3	3	affinity chromatography technology	Xiong Y (2011)	1
IRAK1	1	TNFAIP3	3	affinity chromatography technology	Xiong Y (2011)	1
IQCB1	3	TUBA4A	1	affinity chromatography technology	Sang L (2011)	1
IRAK1	1	SNRNP200	15	affinity chromatography technology	Li S (2011)	1
TARDBP	4	HSP90AA1	7	affinity chromatography technology	Zhang YJ (2010)	1
IRAK3	0	IRAK4	0	affinity chromatography technology	Li S (2011)	1
IRAK2	3	COQ8A	3	affinity chromatography technology	Li S (2011)	1
IRAK4	0	PELI3	0	affinity chromatography technology	Butler MP (2007)	1
IRAK1	1	CDC37	0	affinity chromatography technology, affinity chromatography technology, biochemical, biochemical	De Nardo D (2005), De Nardo D (2005), De Nardo D (2005), De Nardo D (2005)	4
SARM1	3	TRAF6	0	affinity chromatography technology	Murata H (2013)	1
IRAK2	3	PELI3	0	affinity chromatography technology	Butler MP (2007)	1
IRAK3	0	IRAK2	3	affinity chromatography technology	Li S (2011)	1
HSP90AA1	7	SNRNP200	15	affinity chromatography technology	Gano JJ (2010)	1
TRAF6	0	TRIM25	5	two hybrid	Woodsmith J (2012)	1
TLR3	2	IRAK2	3	affinity chromatography technology	Keating SE (2007)	1
IRAK2	3	TUBA4A	1	affinity chromatography technology	Huttlin EL (2017)	1
ARAF	0	TUBA4A	1	affinity chromatography technology	So J (2015)	1
IRAK2	3	IQSEC1	3	affinity chromatography technology	Li S (2011)	1
TRIM25	5	TARDBP	4	affinity chromatography technology	Choudhury NR (2017)	1
PELI1	1	TRAF6	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Jiang Z (2003), Jiang Z (2003), Choi KC (2006), Jensen LE (2003)	4
HSP90AA1	7	CDC37	0	x-ray crystallography, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology	Roe SM (2004), Silverstein AM (1998), Mollapour M (2010), Basso AD (2002), Tsutsumi S (2012), De Nardo D (2005), Sarkar S (2012), Gano JJ (2010), Taipale M (2012), Skarra DV (2011), Zhang H (2004), Taipale M (2014), Taipale M (2014), Mollapour M (2014), Hein MY (2015), Hein MY (2015), Li J (2013), Woodford MR (2016), Shao J (2003), Scholz GM (2001), Sun L (2012), Sun L (2012), Woodford MR (2016), Synoradzki K (2015)	24
SARM1	3	MYD88	1	protein complementation assay	Ulrichts P (2007)	1
BAG3	4	HSP90AA1	7	affinity chromatography technology	Chen Y (2013)	1
IRAK2	3	PELI2	5	affinity chromatography technology	Butler MP (2007)	1
IQCB1	3	HSP90AA1	7	affinity chromatography technology	Sang L (2011)	1
TLR3	2	MYD88	1	pull down	Doyle SE (2003)	1
TARDBP	4	SNRNP200	15	affinity chromatography technology	Freibaum BD (2010)	1
PELI1	1	IRAK1	1	affinity chromatography technology, enzymatic study, pull down, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Butler MP (2007), Ordureau A (2008), Lin CC (2008), Smith H (2009), Smith H (2011), Jiang Z (2003), Choi KC (2006), Choi KC (2006), Butler MP (2005), Schauvliege R (2006), Murphy M (2015)	11
TIRAP	1	TNFSF9	0	affinity chromatography technology	Ma J (2013)	1